Amino acid dipepetide frequency for Micromonas pusilla virus PL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.361AlaAla: 4.361 ± 0.399
1.078AlaCys: 1.078 ± 0.13
2.487AlaAsp: 2.487 ± 0.192
2.769AlaGlu: 2.769 ± 0.245
1.923AlaPhe: 1.923 ± 0.196
4.079AlaGly: 4.079 ± 0.333
0.879AlaHis: 0.879 ± 0.132
3.25AlaIle: 3.25 ± 0.236
3.465AlaLys: 3.465 ± 0.256
4.477AlaLeu: 4.477 ± 0.327
1.559AlaMet: 1.559 ± 0.157
3.051AlaAsn: 3.051 ± 0.303
2.189AlaPro: 2.189 ± 0.229
1.807AlaGln: 1.807 ± 0.195
2.984AlaArg: 2.984 ± 0.262
4.029AlaSer: 4.029 ± 0.391
4.195AlaThr: 4.195 ± 0.362
2.968AlaVal: 2.968 ± 0.218
0.663AlaTrp: 0.663 ± 0.109
2.255AlaTyr: 2.255 ± 0.208
0.0AlaXaa: 0.0 ± 0.0
Cys
0.696CysAla: 0.696 ± 0.115
0.282CysCys: 0.282 ± 0.073
0.928CysAsp: 0.928 ± 0.127
1.045CysGlu: 1.045 ± 0.143
0.68CysPhe: 0.68 ± 0.115
1.343CysGly: 1.343 ± 0.162
0.216CysHis: 0.216 ± 0.08
0.912CysIle: 0.912 ± 0.131
1.227CysLys: 1.227 ± 0.163
1.161CysLeu: 1.161 ± 0.161
0.597CysMet: 0.597 ± 0.099
0.696CysAsn: 0.696 ± 0.103
1.061CysPro: 1.061 ± 0.15
0.414CysGln: 0.414 ± 0.078
0.879CysArg: 0.879 ± 0.124
0.995CysSer: 0.995 ± 0.157
0.613CysThr: 0.613 ± 0.126
1.011CysVal: 1.011 ± 0.139
0.083CysTrp: 0.083 ± 0.042
0.58CysTyr: 0.58 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
3.15AspAla: 3.15 ± 0.255
0.879AspCys: 0.879 ± 0.132
3.283AspAsp: 3.283 ± 0.253
4.377AspGlu: 4.377 ± 0.328
2.968AspPhe: 2.968 ± 0.205
4.543AspGly: 4.543 ± 0.381
0.928AspHis: 0.928 ± 0.129
3.996AspIle: 3.996 ± 0.273
2.885AspLys: 2.885 ± 0.258
5.355AspLeu: 5.355 ± 0.409
1.542AspMet: 1.542 ± 0.182
2.686AspAsn: 2.686 ± 0.211
2.189AspPro: 2.189 ± 0.2
1.409AspGln: 1.409 ± 0.14
2.238AspArg: 2.238 ± 0.207
2.968AspSer: 2.968 ± 0.243
4.045AspThr: 4.045 ± 0.27
4.261AspVal: 4.261 ± 0.308
0.928AspTrp: 0.928 ± 0.13
2.603AspTyr: 2.603 ± 0.231
0.0AspXaa: 0.0 ± 0.0
Glu
3.183GluAla: 3.183 ± 0.24
1.243GluCys: 1.243 ± 0.156
4.062GluAsp: 4.062 ± 0.342
5.14GluGlu: 5.14 ± 0.502
3.084GluPhe: 3.084 ± 0.218
3.266GluGly: 3.266 ± 0.24
1.177GluHis: 1.177 ± 0.125
4.676GluIle: 4.676 ± 0.346
5.19GluLys: 5.19 ± 0.369
5.422GluLeu: 5.422 ± 0.325
2.023GluMet: 2.023 ± 0.196
3.349GluAsn: 3.349 ± 0.247
2.454GluPro: 2.454 ± 0.248
2.056GluGln: 2.056 ± 0.21
3.2GluArg: 3.2 ± 0.281
3.648GluSer: 3.648 ± 0.237
3.979GluThr: 3.979 ± 0.315
4.709GluVal: 4.709 ± 0.3
0.978GluTrp: 0.978 ± 0.145
2.553GluTyr: 2.553 ± 0.234
0.0GluXaa: 0.0 ± 0.0
Phe
1.89PheAla: 1.89 ± 0.249
0.928PheCys: 0.928 ± 0.148
2.885PheAsp: 2.885 ± 0.181
2.802PheGlu: 2.802 ± 0.241
1.907PhePhe: 1.907 ± 0.234
2.719PheGly: 2.719 ± 0.263
1.011PheHis: 1.011 ± 0.125
2.951PheIle: 2.951 ± 0.231
3.415PheLys: 3.415 ± 0.248
3.515PheLeu: 3.515 ± 0.276
1.442PheMet: 1.442 ± 0.167
2.321PheAsn: 2.321 ± 0.181
1.376PhePro: 1.376 ± 0.197
1.045PheGln: 1.045 ± 0.118
1.724PheArg: 1.724 ± 0.195
3.266PheSer: 3.266 ± 0.242
2.918PheThr: 2.918 ± 0.192
3.217PheVal: 3.217 ± 0.215
0.398PheTrp: 0.398 ± 0.076
1.675PheTyr: 1.675 ± 0.173
0.0PheXaa: 0.0 ± 0.0
Gly
3.946GlyAla: 3.946 ± 0.325
1.111GlyCys: 1.111 ± 0.171
4.278GlyAsp: 4.278 ± 0.329
3.88GlyGlu: 3.88 ± 0.28
2.785GlyPhe: 2.785 ± 0.225
6.284GlyGly: 6.284 ± 0.48
1.393GlyHis: 1.393 ± 0.16
4.493GlyIle: 4.493 ± 0.344
3.996GlyLys: 3.996 ± 0.26
5.04GlyLeu: 5.04 ± 0.342
1.559GlyMet: 1.559 ± 0.158
4.045GlyAsn: 4.045 ± 0.436
2.454GlyPro: 2.454 ± 0.232
1.675GlyGln: 1.675 ± 0.17
2.802GlyArg: 2.802 ± 0.245
4.941GlySer: 4.941 ± 0.525
5.007GlyThr: 5.007 ± 0.526
4.775GlyVal: 4.775 ± 0.332
0.58GlyTrp: 0.58 ± 0.099
2.885GlyTyr: 2.885 ± 0.267
0.0GlyXaa: 0.0 ± 0.0
His
1.144HisAla: 1.144 ± 0.157
0.298HisCys: 0.298 ± 0.063
1.028HisAsp: 1.028 ± 0.123
1.161HisGlu: 1.161 ± 0.148
1.045HisPhe: 1.045 ± 0.14
1.625HisGly: 1.625 ± 0.24
0.431HisHis: 0.431 ± 0.08
1.608HisIle: 1.608 ± 0.175
1.393HisLys: 1.393 ± 0.144
1.89HisLeu: 1.89 ± 0.186
0.514HisMet: 0.514 ± 0.087
0.928HisAsn: 0.928 ± 0.117
1.045HisPro: 1.045 ± 0.13
0.746HisGln: 0.746 ± 0.098
0.879HisArg: 0.879 ± 0.111
0.978HisSer: 0.978 ± 0.12
1.243HisThr: 1.243 ± 0.166
1.144HisVal: 1.144 ± 0.169
0.315HisTrp: 0.315 ± 0.063
0.928HisTyr: 0.928 ± 0.125
0.0HisXaa: 0.0 ± 0.0
Ile
3.73IleAla: 3.73 ± 0.268
0.746IleCys: 0.746 ± 0.108
4.559IleAsp: 4.559 ± 0.289
4.874IleGlu: 4.874 ± 0.299
3.15IlePhe: 3.15 ± 0.261
3.664IleGly: 3.664 ± 0.301
1.724IleHis: 1.724 ± 0.176
4.112IleIle: 4.112 ± 0.274
4.427IleLys: 4.427 ± 0.302
5.554IleLeu: 5.554 ± 0.297
1.542IleMet: 1.542 ± 0.198
3.018IleAsn: 3.018 ± 0.265
2.686IlePro: 2.686 ± 0.212
2.868IleGln: 2.868 ± 0.207
2.885IleArg: 2.885 ± 0.201
4.377IleSer: 4.377 ± 0.305
3.996IleThr: 3.996 ± 0.287
4.394IleVal: 4.394 ± 0.322
0.564IleTrp: 0.564 ± 0.098
2.62IleTyr: 2.62 ± 0.19
0.0IleXaa: 0.0 ± 0.0
Lys
3.266LysAla: 3.266 ± 0.266
1.161LysCys: 1.161 ± 0.147
3.614LysAsp: 3.614 ± 0.296
4.626LysGlu: 4.626 ± 0.375
3.084LysPhe: 3.084 ± 0.245
3.498LysGly: 3.498 ± 0.267
1.442LysHis: 1.442 ± 0.191
4.908LysIle: 4.908 ± 0.274
7.262LysLys: 7.262 ± 0.624
5.604LysLeu: 5.604 ± 0.324
2.553LysMet: 2.553 ± 0.227
4.692LysAsn: 4.692 ± 0.392
2.885LysPro: 2.885 ± 0.217
2.172LysGln: 2.172 ± 0.212
3.73LysArg: 3.73 ± 0.331
4.642LysSer: 4.642 ± 0.308
4.062LysThr: 4.062 ± 0.245
4.692LysVal: 4.692 ± 0.321
0.879LysTrp: 0.879 ± 0.145
2.968LysTyr: 2.968 ± 0.247
0.0LysXaa: 0.0 ± 0.0
Leu
4.775LeuAla: 4.775 ± 0.324
0.912LeuCys: 0.912 ± 0.122
4.642LeuAsp: 4.642 ± 0.299
5.703LeuGlu: 5.703 ± 0.387
3.067LeuPhe: 3.067 ± 0.229
4.526LeuGly: 4.526 ± 0.288
1.608LeuHis: 1.608 ± 0.163
5.206LeuIle: 5.206 ± 0.321
6.499LeuLys: 6.499 ± 0.413
5.67LeuLeu: 5.67 ± 0.402
2.271LeuMet: 2.271 ± 0.183
4.195LeuAsn: 4.195 ± 0.27
3.515LeuPro: 3.515 ± 0.269
2.553LeuGln: 2.553 ± 0.224
4.178LeuArg: 4.178 ± 0.265
5.405LeuSer: 5.405 ± 0.289
5.422LeuThr: 5.422 ± 0.369
5.471LeuVal: 5.471 ± 0.339
0.846LeuTrp: 0.846 ± 0.136
3.233LeuTyr: 3.233 ± 0.236
0.0LeuXaa: 0.0 ± 0.0
Met
1.293MetAla: 1.293 ± 0.162
0.68MetCys: 0.68 ± 0.107
1.608MetAsp: 1.608 ± 0.177
1.791MetGlu: 1.791 ± 0.173
1.459MetPhe: 1.459 ± 0.162
1.608MetGly: 1.608 ± 0.195
0.597MetHis: 0.597 ± 0.118
1.774MetIle: 1.774 ± 0.225
2.487MetLys: 2.487 ± 0.213
1.641MetLeu: 1.641 ± 0.186
0.928MetMet: 0.928 ± 0.144
1.89MetAsn: 1.89 ± 0.202
0.962MetPro: 0.962 ± 0.121
0.779MetGln: 0.779 ± 0.136
1.194MetArg: 1.194 ± 0.156
2.354MetSer: 2.354 ± 0.23
1.675MetThr: 1.675 ± 0.177
1.625MetVal: 1.625 ± 0.161
0.315MetTrp: 0.315 ± 0.068
1.21MetTyr: 1.21 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
3.598AsnAla: 3.598 ± 0.437
0.696AsnCys: 0.696 ± 0.111
2.603AsnAsp: 2.603 ± 0.189
3.001AsnGlu: 3.001 ± 0.264
2.603AsnPhe: 2.603 ± 0.236
3.863AsnGly: 3.863 ± 0.282
1.061AsnHis: 1.061 ± 0.122
4.228AsnIle: 4.228 ± 0.301
3.532AsnLys: 3.532 ± 0.378
4.493AsnLeu: 4.493 ± 0.329
1.409AsnMet: 1.409 ± 0.151
3.382AsnAsn: 3.382 ± 0.397
2.437AsnPro: 2.437 ± 0.213
1.757AsnGln: 1.757 ± 0.167
2.388AsnArg: 2.388 ± 0.228
3.034AsnSer: 3.034 ± 0.274
4.443AsnThr: 4.443 ± 0.441
5.654AsnVal: 5.654 ± 0.517
0.696AsnTrp: 0.696 ± 0.108
2.404AsnTyr: 2.404 ± 0.236
0.0AsnXaa: 0.0 ± 0.0
Pro
2.172ProAla: 2.172 ± 0.255
0.58ProCys: 0.58 ± 0.114
2.122ProAsp: 2.122 ± 0.173
3.548ProGlu: 3.548 ± 0.282
1.641ProPhe: 1.641 ± 0.173
2.586ProGly: 2.586 ± 0.221
0.912ProHis: 0.912 ± 0.117
2.205ProIle: 2.205 ± 0.205
2.885ProLys: 2.885 ± 0.263
3.034ProLeu: 3.034 ± 0.262
1.31ProMet: 1.31 ± 0.132
2.155ProAsn: 2.155 ± 0.212
2.752ProPro: 2.752 ± 0.245
1.774ProGln: 1.774 ± 0.184
2.122ProArg: 2.122 ± 0.169
2.437ProSer: 2.437 ± 0.178
2.868ProThr: 2.868 ± 0.22
2.868ProVal: 2.868 ± 0.235
0.414ProTrp: 0.414 ± 0.074
1.542ProTyr: 1.542 ± 0.152
0.0ProXaa: 0.0 ± 0.0
Gln
1.724GlnAla: 1.724 ± 0.186
0.497GlnCys: 0.497 ± 0.08
1.824GlnAsp: 1.824 ± 0.15
2.255GlnGlu: 2.255 ± 0.241
1.26GlnPhe: 1.26 ± 0.16
1.874GlnGly: 1.874 ± 0.17
0.58GlnHis: 0.58 ± 0.087
1.973GlnIle: 1.973 ± 0.208
2.52GlnLys: 2.52 ± 0.224
2.62GlnLeu: 2.62 ± 0.226
0.779GlnMet: 0.779 ± 0.139
1.973GlnAsn: 1.973 ± 0.171
1.641GlnPro: 1.641 ± 0.18
1.161GlnGln: 1.161 ± 0.135
1.691GlnArg: 1.691 ± 0.212
1.724GlnSer: 1.724 ± 0.158
2.288GlnThr: 2.288 ± 0.237
2.023GlnVal: 2.023 ± 0.178
0.414GlnTrp: 0.414 ± 0.089
1.078GlnTyr: 1.078 ± 0.114
0.0GlnXaa: 0.0 ± 0.0
Arg
2.222ArgAla: 2.222 ± 0.222
1.011ArgCys: 1.011 ± 0.134
2.653ArgAsp: 2.653 ± 0.22
3.449ArgGlu: 3.449 ± 0.327
2.023ArgPhe: 2.023 ± 0.166
2.968ArgGly: 2.968 ± 0.236
0.962ArgHis: 0.962 ± 0.125
2.968ArgIle: 2.968 ± 0.231
3.415ArgLys: 3.415 ± 0.287
4.344ArgLeu: 4.344 ± 0.255
1.127ArgMet: 1.127 ± 0.173
2.736ArgAsn: 2.736 ± 0.25
1.724ArgPro: 1.724 ± 0.177
1.675ArgGln: 1.675 ± 0.171
2.752ArgArg: 2.752 ± 0.304
2.338ArgSer: 2.338 ± 0.171
2.371ArgThr: 2.371 ± 0.201
3.979ArgVal: 3.979 ± 0.354
0.514ArgTrp: 0.514 ± 0.089
1.791ArgTyr: 1.791 ± 0.176
0.0ArgXaa: 0.0 ± 0.0
Ser
3.565SerAla: 3.565 ± 0.297
0.796SerCys: 0.796 ± 0.119
3.598SerAsp: 3.598 ± 0.262
3.946SerGlu: 3.946 ± 0.279
2.703SerPhe: 2.703 ± 0.254
5.073SerGly: 5.073 ± 0.403
0.995SerHis: 0.995 ± 0.146
4.493SerIle: 4.493 ± 0.292
4.228SerLys: 4.228 ± 0.291
5.073SerLeu: 5.073 ± 0.271
1.757SerMet: 1.757 ± 0.203
5.869SerAsn: 5.869 ± 0.782
2.222SerPro: 2.222 ± 0.202
2.189SerGln: 2.189 ± 0.187
2.968SerArg: 2.968 ± 0.193
4.692SerSer: 4.692 ± 0.426
4.443SerThr: 4.443 ± 0.37
4.162SerVal: 4.162 ± 0.296
0.663SerTrp: 0.663 ± 0.102
2.122SerTyr: 2.122 ± 0.208
0.0SerXaa: 0.0 ± 0.0
Thr
3.432ThrAla: 3.432 ± 0.333
0.796ThrCys: 0.796 ± 0.118
3.565ThrAsp: 3.565 ± 0.394
3.167ThrGlu: 3.167 ± 0.222
3.117ThrPhe: 3.117 ± 0.224
5.306ThrGly: 5.306 ± 0.495
1.525ThrHis: 1.525 ± 0.189
4.012ThrIle: 4.012 ± 0.242
4.344ThrLys: 4.344 ± 0.304
5.737ThrLeu: 5.737 ± 0.428
1.575ThrMet: 1.575 ± 0.172
3.681ThrAsn: 3.681 ± 0.282
3.299ThrPro: 3.299 ± 0.263
2.454ThrGln: 2.454 ± 0.212
2.951ThrArg: 2.951 ± 0.223
5.206ThrSer: 5.206 ± 0.464
5.339ThrThr: 5.339 ± 0.532
3.714ThrVal: 3.714 ± 0.273
0.895ThrTrp: 0.895 ± 0.136
2.686ThrTyr: 2.686 ± 0.268
0.0ThrXaa: 0.0 ± 0.0
Val
4.029ValAla: 4.029 ± 0.289
0.895ValCys: 0.895 ± 0.137
4.128ValAsp: 4.128 ± 0.298
4.327ValGlu: 4.327 ± 0.259
2.537ValPhe: 2.537 ± 0.229
5.753ValGly: 5.753 ± 0.679
1.608ValHis: 1.608 ± 0.183
3.78ValIle: 3.78 ± 0.288
4.775ValLys: 4.775 ± 0.326
5.04ValLeu: 5.04 ± 0.339
1.757ValMet: 1.757 ± 0.188
3.73ValAsn: 3.73 ± 0.283
3.117ValPro: 3.117 ± 0.249
2.172ValGln: 2.172 ± 0.191
3.084ValArg: 3.084 ± 0.218
5.107ValSer: 5.107 ± 0.316
4.327ValThr: 4.327 ± 0.432
4.908ValVal: 4.908 ± 0.352
0.763ValTrp: 0.763 ± 0.111
3.018ValTyr: 3.018 ± 0.212
0.0ValXaa: 0.0 ± 0.0
Trp
0.381TrpAla: 0.381 ± 0.085
0.282TrpCys: 0.282 ± 0.07
0.647TrpAsp: 0.647 ± 0.099
0.862TrpGlu: 0.862 ± 0.13
0.547TrpPhe: 0.547 ± 0.1
0.763TrpGly: 0.763 ± 0.11
0.265TrpHis: 0.265 ± 0.066
0.796TrpIle: 0.796 ± 0.123
0.928TrpLys: 0.928 ± 0.127
0.862TrpLeu: 0.862 ± 0.124
0.282TrpMet: 0.282 ± 0.068
0.812TrpAsn: 0.812 ± 0.113
0.464TrpPro: 0.464 ± 0.086
0.282TrpGln: 0.282 ± 0.073
0.464TrpArg: 0.464 ± 0.095
0.812TrpSer: 0.812 ± 0.137
0.746TrpThr: 0.746 ± 0.109
0.829TrpVal: 0.829 ± 0.116
0.199TrpTrp: 0.199 ± 0.06
0.365TrpTyr: 0.365 ± 0.065
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.907TyrAla: 1.907 ± 0.158
0.547TyrCys: 0.547 ± 0.099
2.719TyrAsp: 2.719 ± 0.224
2.669TyrGlu: 2.669 ± 0.251
1.824TyrPhe: 1.824 ± 0.182
2.586TyrGly: 2.586 ± 0.25
1.028TyrHis: 1.028 ± 0.125
3.15TyrIle: 3.15 ± 0.26
2.868TyrLys: 2.868 ± 0.212
3.167TyrLeu: 3.167 ± 0.286
1.326TyrMet: 1.326 ± 0.135
2.072TyrAsn: 2.072 ± 0.197
1.459TyrPro: 1.459 ± 0.145
0.912TyrGln: 0.912 ± 0.118
1.907TyrArg: 1.907 ± 0.184
2.603TyrSer: 2.603 ± 0.248
2.819TyrThr: 2.819 ± 0.237
2.454TyrVal: 2.454 ± 0.205
0.481TyrTrp: 0.481 ± 0.094
1.575TyrTyr: 1.575 ± 0.187
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 259 proteins (60315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski