Amino acid dipepetide frequency for Paraoerskovia marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.49AlaAla: 19.49 ± 0.234	0.865AlaCys: 0.865 ± 0.036	9.207AlaAsp: 9.207 ± 0.117	8.36AlaGlu: 8.36 ± 0.128	3.384AlaPhe: 3.384 ± 0.073	12.509AlaGly: 12.509 ± 0.145	2.47AlaHis: 2.47 ± 0.059	4.334AlaIle: 4.334 ± 0.091	2.06AlaLys: 2.06 ± 0.06	13.462AlaLeu: 13.462 ± 0.158	2.47AlaMet: 2.47 ± 0.053	1.983AlaAsn: 1.983 ± 0.046	6.572AlaPro: 6.572 ± 0.117	3.76AlaGln: 3.76 ± 0.075	9.932AlaArg: 9.932 ± 0.154	6.805AlaSer: 6.805 ± 0.102	8.076AlaThr: 8.076 ± 0.112	12.786AlaVal: 12.786 ± 0.148	1.996AlaTrp: 1.996 ± 0.045	2.368AlaTyr: 2.368 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.785CysAla: 0.785 ± 0.037	0.06CysCys: 0.06 ± 0.009	0.421CysAsp: 0.421 ± 0.023	0.35CysGlu: 0.35 ± 0.025	0.177CysPhe: 0.177 ± 0.015	0.693CysGly: 0.693 ± 0.03	0.116CysHis: 0.116 ± 0.011	0.187CysIle: 0.187 ± 0.016	0.064CysLys: 0.064 ± 0.009	0.507CysLeu: 0.507 ± 0.023	0.085CysMet: 0.085 ± 0.008	0.097CysAsn: 0.097 ± 0.013	0.428CysPro: 0.428 ± 0.024	0.14CysGln: 0.14 ± 0.012	0.344CysArg: 0.344 ± 0.021	0.431CysSer: 0.431 ± 0.025	0.531CysThr: 0.531 ± 0.04	0.5CysVal: 0.5 ± 0.025	0.093CysTrp: 0.093 ± 0.01	0.115CysTyr: 0.115 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.701AspAla: 9.701 ± 0.138	0.362AspCys: 0.362 ± 0.031	5.823AspAsp: 5.823 ± 0.137	4.977AspGlu: 4.977 ± 0.069	1.474AspPhe: 1.474 ± 0.044	7.692AspGly: 7.692 ± 0.138	1.392AspHis: 1.392 ± 0.042	1.735AspIle: 1.735 ± 0.05	0.896AspLys: 0.896 ± 0.038	7.194AspLeu: 7.194 ± 0.097	0.766AspMet: 0.766 ± 0.027	0.864AspAsn: 0.864 ± 0.04	4.931AspPro: 4.931 ± 0.138	1.686AspGln: 1.686 ± 0.041	4.503AspArg: 4.503 ± 0.083	2.75AspSer: 2.75 ± 0.061	3.115AspThr: 3.115 ± 0.065	7.775AspVal: 7.775 ± 0.104	0.91AspTrp: 0.91 ± 0.036	1.219AspTyr: 1.219 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	7.231GluAla: 7.231 ± 0.113	0.343GluCys: 0.343 ± 0.026	3.397GluAsp: 3.397 ± 0.086	3.145GluGlu: 3.145 ± 0.073	1.616GluPhe: 1.616 ± 0.043	4.19GluGly: 4.19 ± 0.076	1.629GluHis: 1.629 ± 0.045	3.059GluIle: 3.059 ± 0.063	1.263GluLys: 1.263 ± 0.053	6.155GluLeu: 6.155 ± 0.08	1.027GluMet: 1.027 ± 0.035	1.39GluAsn: 1.39 ± 0.046	3.674GluPro: 3.674 ± 0.089	2.134GluGln: 2.134 ± 0.053	5.09GluArg: 5.09 ± 0.108	3.407GluSer: 3.407 ± 0.071	3.526GluThr: 3.526 ± 0.073	5.23GluVal: 5.23 ± 0.082	0.7GluTrp: 0.7 ± 0.031	1.129GluTyr: 1.129 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.449PheAla: 3.449 ± 0.061	0.21PheCys: 0.21 ± 0.012	2.179PheAsp: 2.179 ± 0.047	1.549PheGlu: 1.549 ± 0.046	0.846PhePhe: 0.846 ± 0.034	2.842PheGly: 2.842 ± 0.059	0.455PheHis: 0.455 ± 0.024	0.791PheIle: 0.791 ± 0.033	0.378PheLys: 0.378 ± 0.025	2.389PheLeu: 2.389 ± 0.064	0.392PheMet: 0.392 ± 0.021	0.553PheAsn: 0.553 ± 0.027	1.195PhePro: 1.195 ± 0.044	0.591PheGln: 0.591 ± 0.028	1.617PheArg: 1.617 ± 0.045	1.548PheSer: 1.548 ± 0.045	1.797PheThr: 1.797 ± 0.042	2.837PheVal: 2.837 ± 0.066	0.443PheTrp: 0.443 ± 0.023	0.603PheTyr: 0.603 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.377GlyAla: 11.377 ± 0.145	0.63GlyCys: 0.63 ± 0.028	5.824GlyAsp: 5.824 ± 0.113	5.282GlyGlu: 5.282 ± 0.098	2.808GlyPhe: 2.808 ± 0.064	7.95GlyGly: 7.95 ± 0.115	1.858GlyHis: 1.858 ± 0.049	3.751GlyIle: 3.751 ± 0.075	1.913GlyLys: 1.913 ± 0.057	8.912GlyLeu: 8.912 ± 0.124	1.922GlyMet: 1.922 ± 0.048	1.511GlyAsn: 1.511 ± 0.053	4.714GlyPro: 4.714 ± 0.101	2.432GlyGln: 2.432 ± 0.048	6.535GlyArg: 6.535 ± 0.107	5.828GlySer: 5.828 ± 0.1	6.397GlyThr: 6.397 ± 0.097	8.451GlyVal: 8.451 ± 0.106	1.686GlyTrp: 1.686 ± 0.05	2.111GlyTyr: 2.111 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.547HisAla: 2.547 ± 0.064	0.129HisCys: 0.129 ± 0.011	1.439HisAsp: 1.439 ± 0.044	1.149HisGlu: 1.149 ± 0.038	0.476HisPhe: 0.476 ± 0.025	2.06HisGly: 2.06 ± 0.053	0.56HisHis: 0.56 ± 0.027	0.436HisIle: 0.436 ± 0.025	0.243HisLys: 0.243 ± 0.016	2.203HisLeu: 2.203 ± 0.052	0.284HisMet: 0.284 ± 0.018	0.299HisAsn: 0.299 ± 0.017	1.422HisPro: 1.422 ± 0.044	0.506HisGln: 0.506 ± 0.022	1.661HisArg: 1.661 ± 0.046	0.779HisSer: 0.779 ± 0.033	0.995HisThr: 0.995 ± 0.04	2.039HisVal: 2.039 ± 0.05	0.254HisTrp: 0.254 ± 0.017	0.381HisTyr: 0.381 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.031IleAla: 5.031 ± 0.086	0.244IleCys: 0.244 ± 0.016	2.816IleAsp: 2.816 ± 0.058	2.186IleGlu: 2.186 ± 0.05	0.973IlePhe: 0.973 ± 0.036	3.524IleGly: 3.524 ± 0.073	0.572IleHis: 0.572 ± 0.029	1.098IleIle: 1.098 ± 0.045	0.63IleLys: 0.63 ± 0.034	2.997IleLeu: 2.997 ± 0.069	0.512IleMet: 0.512 ± 0.025	0.692IleAsn: 0.692 ± 0.025	1.9IlePro: 1.9 ± 0.047	0.721IleGln: 0.721 ± 0.036	2.068IleArg: 2.068 ± 0.056	1.933IleSer: 1.933 ± 0.051	2.302IleThr: 2.302 ± 0.069	3.611IleVal: 3.611 ± 0.076	0.426IleTrp: 0.426 ± 0.025	0.623IleTyr: 0.623 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	1.969LysAla: 1.969 ± 0.059	0.072LysCys: 0.072 ± 0.01	1.073LysAsp: 1.073 ± 0.041	0.863LysGlu: 0.863 ± 0.036	0.419LysPhe: 0.419 ± 0.023	1.282LysGly: 1.282 ± 0.046	0.362LysHis: 0.362 ± 0.021	0.87LysIle: 0.87 ± 0.032	0.661LysLys: 0.661 ± 0.04	1.303LysLeu: 1.303 ± 0.056	0.312LysMet: 0.312 ± 0.018	0.429LysAsn: 0.429 ± 0.024	0.945LysPro: 0.945 ± 0.043	0.507LysGln: 0.507 ± 0.025	1.105LysArg: 1.105 ± 0.044	1.046LysSer: 1.046 ± 0.035	1.059LysThr: 1.059 ± 0.043	1.527LysVal: 1.527 ± 0.056	0.163LysTrp: 0.163 ± 0.014	0.385LysTyr: 0.385 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.569LeuAla: 14.569 ± 0.166	0.539LeuCys: 0.539 ± 0.024	7.515LeuAsp: 7.515 ± 0.098	5.122LeuGlu: 5.122 ± 0.092	2.234LeuPhe: 2.234 ± 0.058	9.367LeuGly: 9.367 ± 0.128	1.839LeuHis: 1.839 ± 0.049	2.905LeuIle: 2.905 ± 0.08	1.289LeuLys: 1.289 ± 0.048	9.509LeuLeu: 9.509 ± 0.152	1.492LeuMet: 1.492 ± 0.053	1.531LeuAsn: 1.531 ± 0.044	5.359LeuPro: 5.359 ± 0.087	2.064LeuGln: 2.064 ± 0.048	7.325LeuArg: 7.325 ± 0.099	4.953LeuSer: 4.953 ± 0.082	6.312LeuThr: 6.312 ± 0.093	10.403LeuVal: 10.403 ± 0.142	1.221LeuTrp: 1.221 ± 0.043	1.509LeuTyr: 1.509 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	1.96MetAla: 1.96 ± 0.05	0.111MetCys: 0.111 ± 0.01	0.904MetAsp: 0.904 ± 0.035	0.692MetGlu: 0.692 ± 0.031	0.491MetPhe: 0.491 ± 0.025	1.168MetGly: 1.168 ± 0.042	0.354MetHis: 0.354 ± 0.018	0.765MetIle: 0.765 ± 0.03	0.321MetLys: 0.321 ± 0.019	1.753MetLeu: 1.753 ± 0.047	0.287MetMet: 0.287 ± 0.02	0.425MetAsn: 0.425 ± 0.023	1.0MetPro: 1.0 ± 0.037	0.44MetGln: 0.44 ± 0.024	1.29MetArg: 1.29 ± 0.037	1.467MetSer: 1.467 ± 0.041	1.745MetThr: 1.745 ± 0.041	1.332MetVal: 1.332 ± 0.049	0.194MetTrp: 0.194 ± 0.015	0.272MetTyr: 0.272 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.144AsnAla: 2.144 ± 0.051	0.156AsnCys: 0.156 ± 0.026	1.177AsnAsp: 1.177 ± 0.051	0.893AsnGlu: 0.893 ± 0.033	0.495AsnPhe: 0.495 ± 0.028	1.633AsnGly: 1.633 ± 0.054	0.364AsnHis: 0.364 ± 0.02	0.656AsnIle: 0.656 ± 0.029	0.327AsnLys: 0.327 ± 0.022	1.777AsnLeu: 1.777 ± 0.048	0.306AsnMet: 0.306 ± 0.019	0.416AsnAsn: 0.416 ± 0.022	1.394AsnPro: 1.394 ± 0.041	0.465AsnGln: 0.465 ± 0.028	1.061AsnArg: 1.061 ± 0.036	0.819AsnSer: 0.819 ± 0.03	1.07AsnThr: 1.07 ± 0.066	1.598AsnVal: 1.598 ± 0.042	0.247AsnTrp: 0.247 ± 0.02	0.438AsnTyr: 0.438 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.462ProAla: 7.462 ± 0.109	0.268ProCys: 0.268 ± 0.02	4.568ProAsp: 4.568 ± 0.095	4.315ProGlu: 4.315 ± 0.086	1.476ProPhe: 1.476 ± 0.045	5.669ProGly: 5.669 ± 0.094	1.144ProHis: 1.144 ± 0.036	1.474ProIle: 1.474 ± 0.042	0.786ProLys: 0.786 ± 0.035	4.609ProLeu: 4.609 ± 0.068	0.883ProMet: 0.883 ± 0.03	0.826ProAsn: 0.826 ± 0.031	2.68ProPro: 2.68 ± 0.085	1.47ProGln: 1.47 ± 0.041	3.679ProArg: 3.679 ± 0.08	3.275ProSer: 3.275 ± 0.069	4.006ProThr: 4.006 ± 0.092	5.641ProVal: 5.641 ± 0.094	0.921ProTrp: 0.921 ± 0.035	1.043ProTyr: 1.043 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.174GlnAla: 3.174 ± 0.067	0.152GlnCys: 0.152 ± 0.016	1.491GlnAsp: 1.491 ± 0.044	1.338GlnGlu: 1.338 ± 0.041	0.673GlnPhe: 0.673 ± 0.028	2.044GlnGly: 2.044 ± 0.05	0.584GlnHis: 0.584 ± 0.024	1.263GlnIle: 1.263 ± 0.039	0.503GlnLys: 0.503 ± 0.029	2.372GlnLeu: 2.372 ± 0.059	0.524GlnMet: 0.524 ± 0.028	0.568GlnAsn: 0.568 ± 0.03	1.349GlnPro: 1.349 ± 0.042	0.926GlnGln: 0.926 ± 0.037	2.03GlnArg: 2.03 ± 0.059	1.261GlnSer: 1.261 ± 0.041	1.532GlnThr: 1.532 ± 0.041	2.835GlnVal: 2.835 ± 0.054	0.408GlnTrp: 0.408 ± 0.021	0.574GlnTyr: 0.574 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.449ArgAla: 9.449 ± 0.145	0.429ArgCys: 0.429 ± 0.022	4.333ArgAsp: 4.333 ± 0.085	4.34ArgGlu: 4.34 ± 0.088	2.005ArgPhe: 2.005 ± 0.045	5.614ArgGly: 5.614 ± 0.095	1.562ArgHis: 1.562 ± 0.047	2.765ArgIle: 2.765 ± 0.059	1.207ArgLys: 1.207 ± 0.046	7.015ArgLeu: 7.015 ± 0.114	1.517ArgMet: 1.517 ± 0.044	1.191ArgAsn: 1.191 ± 0.041	3.971ArgPro: 3.971 ± 0.067	1.797ArgGln: 1.797 ± 0.049	7.303ArgArg: 7.303 ± 0.133	4.357ArgSer: 4.357 ± 0.086	4.991ArgThr: 4.991 ± 0.091	6.167ArgVal: 6.167 ± 0.101	1.411ArgTrp: 1.411 ± 0.048	1.508ArgTyr: 1.508 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	7.233SerAla: 7.233 ± 0.093	0.326SerCys: 0.326 ± 0.023	3.525SerAsp: 3.525 ± 0.084	2.884SerGlu: 2.884 ± 0.067	1.641SerPhe: 1.641 ± 0.046	5.779SerGly: 5.779 ± 0.092	0.967SerHis: 0.967 ± 0.035	2.057SerIle: 2.057 ± 0.057	0.893SerLys: 0.893 ± 0.034	4.937SerLeu: 4.937 ± 0.083	1.122SerMet: 1.122 ± 0.037	1.051SerAsn: 1.051 ± 0.043	3.116SerPro: 3.116 ± 0.067	1.295SerGln: 1.295 ± 0.037	3.713SerArg: 3.713 ± 0.076	3.681SerSer: 3.681 ± 0.091	4.303SerThr: 4.303 ± 0.084	5.178SerVal: 5.178 ± 0.104	0.937SerTrp: 0.937 ± 0.031	1.078SerTyr: 1.078 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	8.154ThrAla: 8.154 ± 0.115	0.419ThrCys: 0.419 ± 0.024	4.322ThrAsp: 4.322 ± 0.093	3.461ThrGlu: 3.461 ± 0.083	2.01ThrPhe: 2.01 ± 0.051	6.449ThrGly: 6.449 ± 0.109	1.125ThrHis: 1.125 ± 0.036	2.491ThrIle: 2.491 ± 0.062	0.991ThrLys: 0.991 ± 0.036	6.003ThrLeu: 6.003 ± 0.082	1.037ThrMet: 1.037 ± 0.034	1.191ThrAsn: 1.191 ± 0.05	4.225ThrPro: 4.225 ± 0.086	1.437ThrGln: 1.437 ± 0.048	3.901ThrArg: 3.901 ± 0.078	4.193ThrSer: 4.193 ± 0.071	4.962ThrThr: 4.962 ± 0.106	6.887ThrVal: 6.887 ± 0.18	1.085ThrTrp: 1.085 ± 0.044	1.56ThrTyr: 1.56 ± 0.101	0.0ThrXaa: 0.0 ± 0.0
Val	13.168ValAla: 13.168 ± 0.142	0.564ValCys: 0.564 ± 0.03	7.409ValAsp: 7.409 ± 0.105	6.492ValGlu: 6.492 ± 0.097	2.31ValPhe: 2.31 ± 0.057	8.506ValGly: 8.506 ± 0.115	1.932ValHis: 1.932 ± 0.042	3.123ValIle: 3.123 ± 0.055	1.384ValLys: 1.384 ± 0.042	10.424ValLeu: 10.424 ± 0.133	1.505ValMet: 1.505 ± 0.041	1.622ValAsn: 1.622 ± 0.044	5.599ValPro: 5.599 ± 0.101	2.221ValGln: 2.221 ± 0.05	7.15ValArg: 7.15 ± 0.101	5.024ValSer: 5.024 ± 0.085	6.739ValThr: 6.739 ± 0.175	12.362ValVal: 12.362 ± 0.187	1.186ValTrp: 1.186 ± 0.037	1.533ValTyr: 1.533 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.632TrpAla: 1.632 ± 0.05	0.121TrpCys: 0.121 ± 0.014	0.956TrpAsp: 0.956 ± 0.038	0.771TrpGlu: 0.771 ± 0.033	0.532TrpPhe: 0.532 ± 0.029	1.093TrpGly: 1.093 ± 0.038	0.275TrpHis: 0.275 ± 0.017	0.592TrpIle: 0.592 ± 0.025	0.246TrpLys: 0.246 ± 0.016	1.543TrpLeu: 1.543 ± 0.045	0.311TrpMet: 0.311 ± 0.019	0.41TrpAsn: 0.41 ± 0.023	0.72TrpPro: 0.72 ± 0.03	0.481TrpGln: 0.481 ± 0.02	1.168TrpArg: 1.168 ± 0.04	1.055TrpSer: 1.055 ± 0.04	1.141TrpThr: 1.141 ± 0.043	1.237TrpVal: 1.237 ± 0.042	0.437TrpTrp: 0.437 ± 0.026	0.307TrpTyr: 0.307 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.366TyrAla: 2.366 ± 0.047	0.12TyrCys: 0.12 ± 0.013	1.385TyrAsp: 1.385 ± 0.046	1.166TyrGlu: 1.166 ± 0.04	0.621TyrPhe: 0.621 ± 0.025	1.827TyrGly: 1.827 ± 0.048	0.301TyrHis: 0.301 ± 0.021	0.506TyrIle: 0.506 ± 0.026	0.297TyrLys: 0.297 ± 0.022	1.997TyrLeu: 1.997 ± 0.053	0.22TyrMet: 0.22 ± 0.019	0.385TyrAsn: 0.385 ± 0.028	1.001TyrPro: 1.001 ± 0.036	0.531TyrGln: 0.531 ± 0.023	1.456TyrArg: 1.456 ± 0.045	1.104TyrSer: 1.104 ± 0.051	1.305TyrThr: 1.305 ± 0.066	1.856TyrVal: 1.856 ± 0.047	0.311TyrTrp: 0.311 ± 0.018	0.414TyrTyr: 0.414 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2637 proteins (905901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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