Amino acid dipepetide frequency for Mycobacterium virus Fionnbarth

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.236AlaAla: 20.236 ± 1.68
1.079AlaCys: 1.079 ± 0.25
7.987AlaAsp: 7.987 ± 0.727
11.332AlaGlu: 11.332 ± 1.101
3.076AlaPhe: 3.076 ± 0.575
10.523AlaGly: 10.523 ± 1.211
2.428AlaHis: 2.428 ± 0.414
5.342AlaIle: 5.342 ± 0.671
3.562AlaLys: 3.562 ± 0.32
10.253AlaLeu: 10.253 ± 0.728
3.184AlaMet: 3.184 ± 0.526
3.346AlaAsn: 3.346 ± 0.36
5.612AlaPro: 5.612 ± 0.742
5.342AlaGln: 5.342 ± 0.508
9.282AlaArg: 9.282 ± 0.892
5.127AlaSer: 5.127 ± 0.557
5.558AlaThr: 5.558 ± 0.7
9.12AlaVal: 9.12 ± 0.684
2.051AlaTrp: 2.051 ± 0.339
3.022AlaTyr: 3.022 ± 0.352
0.0AlaXaa: 0.0 ± 0.0
Cys
1.295CysAla: 1.295 ± 0.331
0.162CysCys: 0.162 ± 0.084
0.702CysAsp: 0.702 ± 0.178
0.594CysGlu: 0.594 ± 0.194
0.378CysPhe: 0.378 ± 0.17
1.187CysGly: 1.187 ± 0.258
0.324CysHis: 0.324 ± 0.144
0.54CysIle: 0.54 ± 0.14
0.432CysLys: 0.432 ± 0.161
0.702CysLeu: 0.702 ± 0.245
0.108CysMet: 0.108 ± 0.088
0.162CysAsn: 0.162 ± 0.097
0.809CysPro: 0.809 ± 0.227
0.378CysGln: 0.378 ± 0.149
1.133CysArg: 1.133 ± 0.255
1.025CysSer: 1.025 ± 0.228
0.432CysThr: 0.432 ± 0.161
0.378CysVal: 0.378 ± 0.16
0.108CysTrp: 0.108 ± 0.075
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
7.609AspAla: 7.609 ± 0.637
0.594AspCys: 0.594 ± 0.199
6.907AspAsp: 6.907 ± 0.91
5.612AspGlu: 5.612 ± 0.555
2.159AspPhe: 2.159 ± 0.367
6.907AspGly: 6.907 ± 0.599
0.971AspHis: 0.971 ± 0.283
1.133AspIle: 1.133 ± 0.259
1.889AspLys: 1.889 ± 0.299
5.234AspLeu: 5.234 ± 0.6
1.295AspMet: 1.295 ± 0.3
1.673AspAsn: 1.673 ± 0.326
4.641AspPro: 4.641 ± 0.545
1.835AspGln: 1.835 ± 0.327
5.504AspArg: 5.504 ± 0.631
2.806AspSer: 2.806 ± 0.394
3.292AspThr: 3.292 ± 0.379
4.209AspVal: 4.209 ± 0.487
0.863AspTrp: 0.863 ± 0.182
1.079AspTyr: 1.079 ± 0.246
0.0AspXaa: 0.0 ± 0.0
Glu
8.149GluAla: 8.149 ± 0.862
0.755GluCys: 0.755 ± 0.248
2.644GluAsp: 2.644 ± 0.367
1.835GluGlu: 1.835 ± 0.405
1.025GluPhe: 1.025 ± 0.262
4.047GluGly: 4.047 ± 0.487
1.781GluHis: 1.781 ± 0.342
1.511GluIle: 1.511 ± 0.358
2.536GluLys: 2.536 ± 0.408
8.364GluLeu: 8.364 ± 0.71
1.187GluMet: 1.187 ± 0.223
1.133GluAsn: 1.133 ± 0.243
3.13GluPro: 3.13 ± 0.428
2.698GluGln: 2.698 ± 0.412
5.127GluArg: 5.127 ± 0.797
2.374GluSer: 2.374 ± 0.391
3.076GluThr: 3.076 ± 0.464
5.127GluVal: 5.127 ± 0.632
1.079GluTrp: 1.079 ± 0.18
1.727GluTyr: 1.727 ± 0.291
0.0GluXaa: 0.0 ± 0.0
Phe
2.536PheAla: 2.536 ± 0.375
0.216PheCys: 0.216 ± 0.112
2.698PheAsp: 2.698 ± 0.286
1.943PheGlu: 1.943 ± 0.382
0.594PhePhe: 0.594 ± 0.18
3.346PheGly: 3.346 ± 0.44
0.702PheHis: 0.702 ± 0.198
1.133PheIle: 1.133 ± 0.239
0.809PheLys: 0.809 ± 0.237
1.835PheLeu: 1.835 ± 0.291
0.594PheMet: 0.594 ± 0.17
0.917PheAsn: 0.917 ± 0.209
0.971PhePro: 0.971 ± 0.29
0.755PheGln: 0.755 ± 0.189
1.565PheArg: 1.565 ± 0.316
1.295PheSer: 1.295 ± 0.239
1.781PheThr: 1.781 ± 0.329
2.536PheVal: 2.536 ± 0.321
0.324PheTrp: 0.324 ± 0.114
0.648PheTyr: 0.648 ± 0.196
0.0PheXaa: 0.0 ± 0.0
Gly
8.85GlyAla: 8.85 ± 0.895
0.971GlyCys: 0.971 ± 0.238
6.044GlyAsp: 6.044 ± 0.713
5.99GlyGlu: 5.99 ± 0.626
2.105GlyPhe: 2.105 ± 0.413
9.228GlyGly: 9.228 ± 1.11
1.727GlyHis: 1.727 ± 0.352
3.292GlyIle: 3.292 ± 0.499
3.67GlyLys: 3.67 ± 0.497
6.206GlyLeu: 6.206 ± 1.029
1.565GlyMet: 1.565 ± 0.255
3.13GlyAsn: 3.13 ± 0.389
3.831GlyPro: 3.831 ± 0.566
3.238GlyGln: 3.238 ± 0.449
6.26GlyArg: 6.26 ± 0.479
4.857GlySer: 4.857 ± 0.717
5.612GlyThr: 5.612 ± 0.727
5.936GlyVal: 5.936 ± 0.643
1.781GlyTrp: 1.781 ± 0.34
2.482GlyTyr: 2.482 ± 0.37
0.0GlyXaa: 0.0 ± 0.0
His
1.727HisAla: 1.727 ± 0.346
0.216HisCys: 0.216 ± 0.108
1.241HisAsp: 1.241 ± 0.292
0.863HisGlu: 0.863 ± 0.23
0.755HisPhe: 0.755 ± 0.172
2.266HisGly: 2.266 ± 0.452
0.755HisHis: 0.755 ± 0.155
1.025HisIle: 1.025 ± 0.316
0.648HisLys: 0.648 ± 0.231
1.565HisLeu: 1.565 ± 0.292
0.378HisMet: 0.378 ± 0.132
0.486HisAsn: 0.486 ± 0.137
0.971HisPro: 0.971 ± 0.228
0.594HisGln: 0.594 ± 0.172
2.213HisArg: 2.213 ± 0.382
0.917HisSer: 0.917 ± 0.228
0.755HisThr: 0.755 ± 0.206
2.428HisVal: 2.428 ± 0.406
0.324HisTrp: 0.324 ± 0.134
0.594HisTyr: 0.594 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
4.209IleAla: 4.209 ± 0.46
0.162IleCys: 0.162 ± 0.093
3.4IleAsp: 3.4 ± 0.394
3.238IleGlu: 3.238 ± 0.502
0.809IlePhe: 0.809 ± 0.235
3.939IleGly: 3.939 ± 0.567
0.486IleHis: 0.486 ± 0.151
1.187IleIle: 1.187 ± 0.251
1.619IleLys: 1.619 ± 0.49
2.159IleLeu: 2.159 ± 0.311
0.27IleMet: 0.27 ± 0.116
1.727IleAsn: 1.727 ± 0.315
2.105IlePro: 2.105 ± 0.452
0.702IleGln: 0.702 ± 0.246
2.536IleArg: 2.536 ± 0.372
1.619IleSer: 1.619 ± 0.362
2.752IleThr: 2.752 ± 0.405
3.346IleVal: 3.346 ± 0.438
0.594IleTrp: 0.594 ± 0.204
0.809IleTyr: 0.809 ± 0.202
0.0IleXaa: 0.0 ± 0.0
Lys
5.234LysAla: 5.234 ± 0.643
0.648LysCys: 0.648 ± 0.195
1.457LysAsp: 1.457 ± 0.323
0.917LysGlu: 0.917 ± 0.197
0.809LysPhe: 0.809 ± 0.205
1.943LysGly: 1.943 ± 0.324
0.971LysHis: 0.971 ± 0.224
1.133LysIle: 1.133 ± 0.219
0.809LysLys: 0.809 ± 0.258
2.968LysLeu: 2.968 ± 0.298
1.133LysMet: 1.133 ± 0.208
1.133LysAsn: 1.133 ± 0.24
2.266LysPro: 2.266 ± 0.364
1.295LysGln: 1.295 ± 0.266
2.482LysArg: 2.482 ± 0.317
1.889LysSer: 1.889 ± 0.35
2.105LysThr: 2.105 ± 0.418
2.266LysVal: 2.266 ± 0.35
0.486LysTrp: 0.486 ± 0.152
0.594LysTyr: 0.594 ± 0.172
0.0LysXaa: 0.0 ± 0.0
Leu
11.926LeuAla: 11.926 ± 0.831
0.809LeuCys: 0.809 ± 0.253
7.663LeuAsp: 7.663 ± 0.735
2.159LeuGlu: 2.159 ± 0.316
2.428LeuPhe: 2.428 ± 0.322
6.907LeuGly: 6.907 ± 0.671
1.187LeuHis: 1.187 ± 0.302
3.4LeuIle: 3.4 ± 0.404
2.266LeuLys: 2.266 ± 0.395
6.152LeuLeu: 6.152 ± 0.569
1.457LeuMet: 1.457 ± 0.263
2.536LeuAsn: 2.536 ± 0.304
4.155LeuPro: 4.155 ± 0.587
3.13LeuGln: 3.13 ± 0.474
7.069LeuArg: 7.069 ± 0.525
5.288LeuSer: 5.288 ± 0.492
5.396LeuThr: 5.396 ± 0.538
6.206LeuVal: 6.206 ± 0.658
1.457LeuTrp: 1.457 ± 0.323
2.051LeuTyr: 2.051 ± 0.263
0.0LeuXaa: 0.0 ± 0.0
Met
1.619MetAla: 1.619 ± 0.26
0.0MetCys: 0.0 ± 0.0
0.648MetAsp: 0.648 ± 0.151
0.594MetGlu: 0.594 ± 0.232
0.594MetPhe: 0.594 ± 0.206
1.241MetGly: 1.241 ± 0.244
0.324MetHis: 0.324 ± 0.113
0.917MetIle: 0.917 ± 0.239
0.54MetLys: 0.54 ± 0.171
2.159MetLeu: 2.159 ± 0.369
0.108MetMet: 0.108 ± 0.094
0.917MetAsn: 0.917 ± 0.23
1.133MetPro: 1.133 ± 0.265
0.594MetGln: 0.594 ± 0.171
1.295MetArg: 1.295 ± 0.214
1.781MetSer: 1.781 ± 0.341
2.482MetThr: 2.482 ± 0.356
1.295MetVal: 1.295 ± 0.208
0.432MetTrp: 0.432 ± 0.137
0.324MetTyr: 0.324 ± 0.148
0.0MetXaa: 0.0 ± 0.0
Asn
3.454AsnAla: 3.454 ± 0.599
0.27AsnCys: 0.27 ± 0.118
1.457AsnAsp: 1.457 ± 0.263
1.133AsnGlu: 1.133 ± 0.207
0.702AsnPhe: 0.702 ± 0.16
3.13AsnGly: 3.13 ± 0.457
0.378AsnHis: 0.378 ± 0.128
0.809AsnIle: 0.809 ± 0.239
0.863AsnLys: 0.863 ± 0.187
2.428AsnLeu: 2.428 ± 0.399
0.432AsnMet: 0.432 ± 0.128
1.079AsnAsn: 1.079 ± 0.247
2.968AsnPro: 2.968 ± 0.494
0.702AsnGln: 0.702 ± 0.246
2.32AsnArg: 2.32 ± 0.511
0.917AsnSer: 0.917 ± 0.242
2.105AsnThr: 2.105 ± 0.409
2.914AsnVal: 2.914 ± 0.413
0.486AsnTrp: 0.486 ± 0.136
0.755AsnTyr: 0.755 ± 0.186
0.0AsnXaa: 0.0 ± 0.0
Pro
9.228ProAla: 9.228 ± 0.861
0.27ProCys: 0.27 ± 0.115
2.806ProAsp: 2.806 ± 0.374
4.479ProGlu: 4.479 ± 0.596
1.619ProPhe: 1.619 ± 0.29
6.53ProGly: 6.53 ± 0.559
1.349ProHis: 1.349 ± 0.358
2.698ProIle: 2.698 ± 0.304
1.403ProLys: 1.403 ± 0.251
3.67ProLeu: 3.67 ± 0.429
0.54ProMet: 0.54 ± 0.161
1.241ProAsn: 1.241 ± 0.313
3.885ProPro: 3.885 ± 0.568
1.457ProGln: 1.457 ± 0.294
2.968ProArg: 2.968 ± 0.438
2.752ProSer: 2.752 ± 0.429
4.155ProThr: 4.155 ± 0.55
4.425ProVal: 4.425 ± 0.542
0.486ProTrp: 0.486 ± 0.142
1.835ProTyr: 1.835 ± 0.306
0.0ProXaa: 0.0 ± 0.0
Gln
5.72GlnAla: 5.72 ± 0.733
0.594GlnCys: 0.594 ± 0.162
1.619GlnAsp: 1.619 ± 0.295
1.079GlnGlu: 1.079 ± 0.259
0.971GlnPhe: 0.971 ± 0.227
2.266GlnGly: 2.266 ± 0.318
1.187GlnHis: 1.187 ± 0.25
1.187GlnIle: 1.187 ± 0.215
1.241GlnLys: 1.241 ± 0.258
3.67GlnLeu: 3.67 ± 0.508
0.971GlnMet: 0.971 ± 0.224
0.755GlnAsn: 0.755 ± 0.212
2.374GlnPro: 2.374 ± 0.395
1.889GlnGln: 1.889 ± 0.407
2.86GlnArg: 2.86 ± 0.392
1.457GlnSer: 1.457 ± 0.256
1.511GlnThr: 1.511 ± 0.256
1.943GlnVal: 1.943 ± 0.337
0.702GlnTrp: 0.702 ± 0.186
0.971GlnTyr: 0.971 ± 0.211
0.0GlnXaa: 0.0 ± 0.0
Arg
8.256ArgAla: 8.256 ± 0.893
1.403ArgCys: 1.403 ± 0.336
4.587ArgAsp: 4.587 ± 0.594
4.047ArgGlu: 4.047 ± 0.495
2.266ArgPhe: 2.266 ± 0.362
4.155ArgGly: 4.155 ± 0.612
1.727ArgHis: 1.727 ± 0.387
3.184ArgIle: 3.184 ± 0.465
2.968ArgLys: 2.968 ± 0.347
7.825ArgLeu: 7.825 ± 0.644
2.159ArgMet: 2.159 ± 0.339
2.536ArgAsn: 2.536 ± 0.335
4.317ArgPro: 4.317 ± 0.549
3.508ArgGln: 3.508 ± 0.444
7.501ArgArg: 7.501 ± 0.837
3.616ArgSer: 3.616 ± 0.515
3.777ArgThr: 3.777 ± 0.43
4.965ArgVal: 4.965 ± 0.586
2.32ArgTrp: 2.32 ± 0.398
1.889ArgTyr: 1.889 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
6.152SerAla: 6.152 ± 0.853
0.594SerCys: 0.594 ± 0.175
2.914SerAsp: 2.914 ± 0.374
2.051SerGlu: 2.051 ± 0.33
1.889SerPhe: 1.889 ± 0.308
4.209SerGly: 4.209 ± 0.605
0.809SerHis: 0.809 ± 0.226
1.835SerIle: 1.835 ± 0.31
1.403SerLys: 1.403 ± 0.263
4.047SerLeu: 4.047 ± 0.538
0.863SerMet: 0.863 ± 0.228
1.727SerAsn: 1.727 ± 0.371
3.076SerPro: 3.076 ± 0.436
1.241SerGln: 1.241 ± 0.317
3.184SerArg: 3.184 ± 0.396
3.4SerSer: 3.4 ± 0.48
3.67SerThr: 3.67 ± 0.527
3.67SerVal: 3.67 ± 0.419
1.241SerTrp: 1.241 ± 0.234
1.565SerTyr: 1.565 ± 0.307
0.0SerXaa: 0.0 ± 0.0
Thr
6.745ThrAla: 6.745 ± 0.89
0.54ThrCys: 0.54 ± 0.178
3.454ThrAsp: 3.454 ± 0.435
3.616ThrGlu: 3.616 ± 0.417
2.105ThrPhe: 2.105 ± 0.285
5.45ThrGly: 5.45 ± 0.611
1.241ThrHis: 1.241 ± 0.303
3.562ThrIle: 3.562 ± 0.512
1.997ThrLys: 1.997 ± 0.331
4.317ThrLeu: 4.317 ± 0.602
0.971ThrMet: 0.971 ± 0.211
1.511ThrAsn: 1.511 ± 0.331
4.263ThrPro: 4.263 ± 0.445
1.295ThrGln: 1.295 ± 0.269
3.885ThrArg: 3.885 ± 0.564
2.374ThrSer: 2.374 ± 0.457
3.831ThrThr: 3.831 ± 0.567
5.72ThrVal: 5.72 ± 0.566
1.349ThrTrp: 1.349 ± 0.26
1.511ThrTyr: 1.511 ± 0.289
0.0ThrXaa: 0.0 ± 0.0
Val
9.767ValAla: 9.767 ± 0.794
0.755ValCys: 0.755 ± 0.229
5.504ValAsp: 5.504 ± 0.632
5.504ValGlu: 5.504 ± 0.507
1.835ValPhe: 1.835 ± 0.286
5.882ValGly: 5.882 ± 0.723
1.295ValHis: 1.295 ± 0.328
2.698ValIle: 2.698 ± 0.322
2.59ValLys: 2.59 ± 0.409
6.206ValLeu: 6.206 ± 0.72
1.025ValMet: 1.025 ± 0.242
1.835ValAsn: 1.835 ± 0.287
4.803ValPro: 4.803 ± 0.534
2.266ValGln: 2.266 ± 0.327
5.288ValArg: 5.288 ± 0.568
3.723ValSer: 3.723 ± 0.488
4.911ValThr: 4.911 ± 0.485
6.691ValVal: 6.691 ± 0.768
1.673ValTrp: 1.673 ± 0.283
2.213ValTyr: 2.213 ± 0.331
0.0ValXaa: 0.0 ± 0.0
Trp
1.673TrpAla: 1.673 ± 0.315
0.324TrpCys: 0.324 ± 0.122
0.809TrpAsp: 0.809 ± 0.162
0.755TrpGlu: 0.755 ± 0.208
0.648TrpPhe: 0.648 ± 0.191
1.187TrpGly: 1.187 ± 0.269
0.702TrpHis: 0.702 ± 0.171
0.486TrpIle: 0.486 ± 0.164
0.432TrpLys: 0.432 ± 0.117
1.943TrpLeu: 1.943 ± 0.342
0.378TrpMet: 0.378 ± 0.122
0.648TrpAsn: 0.648 ± 0.196
0.971TrpPro: 0.971 ± 0.214
1.403TrpGln: 1.403 ± 0.206
2.213TrpArg: 2.213 ± 0.393
0.809TrpSer: 0.809 ± 0.21
1.403TrpThr: 1.403 ± 0.302
1.187TrpVal: 1.187 ± 0.3
0.432TrpTrp: 0.432 ± 0.162
0.324TrpTyr: 0.324 ± 0.116
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.076TyrAla: 3.076 ± 0.376
0.486TyrCys: 0.486 ± 0.21
1.727TyrAsp: 1.727 ± 0.344
1.565TyrGlu: 1.565 ± 0.349
0.432TyrPhe: 0.432 ± 0.137
2.428TyrGly: 2.428 ± 0.406
0.378TyrHis: 0.378 ± 0.139
0.594TyrIle: 0.594 ± 0.187
0.863TyrLys: 0.863 ± 0.256
1.943TyrLeu: 1.943 ± 0.411
0.324TyrMet: 0.324 ± 0.138
0.809TyrAsn: 0.809 ± 0.162
1.511TyrPro: 1.511 ± 0.368
0.648TyrGln: 0.648 ± 0.207
2.32TyrArg: 2.32 ± 0.328
1.511TyrSer: 1.511 ± 0.247
1.133TyrThr: 1.133 ± 0.224
2.105TyrVal: 2.105 ± 0.335
0.54TyrTrp: 0.54 ± 0.159
0.702TyrTyr: 0.702 ± 0.167
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 94 proteins (18532 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski