Amino acid dipepetide frequency for Flavobacteriaceae bacterium 144Ye

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.752AlaAla: 3.752 ± 0.073	0.54AlaCys: 0.54 ± 0.028	3.161AlaAsp: 3.161 ± 0.065	4.001AlaGlu: 4.001 ± 0.08	3.476AlaPhe: 3.476 ± 0.065	3.68AlaGly: 3.68 ± 0.082	1.085AlaHis: 1.085 ± 0.038	5.435AlaIle: 5.435 ± 0.083	4.667AlaLys: 4.667 ± 0.086	6.348AlaLeu: 6.348 ± 0.098	1.469AlaMet: 1.469 ± 0.045	3.691AlaAsn: 3.691 ± 0.066	1.781AlaPro: 1.781 ± 0.055	2.413AlaGln: 2.413 ± 0.05	1.76AlaArg: 1.76 ± 0.049	4.23AlaSer: 4.23 ± 0.076	3.855AlaThr: 3.855 ± 0.094	3.993AlaVal: 3.993 ± 0.071	0.571AlaTrp: 0.571 ± 0.026	2.54AlaTyr: 2.54 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.468CysAla: 0.468 ± 0.023	0.115CysCys: 0.115 ± 0.011	0.499CysAsp: 0.499 ± 0.028	0.516CysGlu: 0.516 ± 0.029	0.428CysPhe: 0.428 ± 0.021	0.67CysGly: 0.67 ± 0.037	0.171CysHis: 0.171 ± 0.015	0.597CysIle: 0.597 ± 0.028	0.479CysLys: 0.479 ± 0.02	0.673CysLeu: 0.673 ± 0.024	0.146CysMet: 0.146 ± 0.013	0.453CysAsn: 0.453 ± 0.025	0.339CysPro: 0.339 ± 0.023	0.204CysGln: 0.204 ± 0.015	0.178CysArg: 0.178 ± 0.012	0.596CysSer: 0.596 ± 0.03	0.397CysThr: 0.397 ± 0.029	0.482CysVal: 0.482 ± 0.022	0.067CysTrp: 0.067 ± 0.009	0.287CysTyr: 0.287 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.973AspAla: 3.973 ± 0.068	0.493AspCys: 0.493 ± 0.027	3.545AspAsp: 3.545 ± 0.068	4.018AspGlu: 4.018 ± 0.074	3.607AspPhe: 3.607 ± 0.068	3.749AspGly: 3.749 ± 0.08	0.819AspHis: 0.819 ± 0.025	4.728AspIle: 4.728 ± 0.08	4.22AspLys: 4.22 ± 0.077	5.11AspLeu: 5.11 ± 0.071	1.183AspMet: 1.183 ± 0.037	3.672AspAsn: 3.672 ± 0.062	1.542AspPro: 1.542 ± 0.045	1.335AspGln: 1.335 ± 0.037	1.707AspArg: 1.707 ± 0.043	3.359AspSer: 3.359 ± 0.072	3.204AspThr: 3.204 ± 0.056	4.129AspVal: 4.129 ± 0.079	0.755AspTrp: 0.755 ± 0.026	3.107AspTyr: 3.107 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.692GluAla: 4.692 ± 0.09	0.38GluCys: 0.38 ± 0.024	3.971GluAsp: 3.971 ± 0.065	4.7GluGlu: 4.7 ± 0.104	3.174GluPhe: 3.174 ± 0.062	3.587GluGly: 3.587 ± 0.055	1.354GluHis: 1.354 ± 0.039	5.282GluIle: 5.282 ± 0.083	5.193GluLys: 5.193 ± 0.098	6.194GluLeu: 6.194 ± 0.091	1.456GluMet: 1.456 ± 0.043	4.496GluAsn: 4.496 ± 0.074	1.52GluPro: 1.52 ± 0.041	2.391GluGln: 2.391 ± 0.053	2.462GluArg: 2.462 ± 0.059	3.436GluSer: 3.436 ± 0.058	4.066GluThr: 4.066 ± 0.062	4.339GluVal: 4.339 ± 0.081	0.604GluTrp: 0.604 ± 0.029	2.431GluTyr: 2.431 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.822PheAla: 2.822 ± 0.06	0.458PheCys: 0.458 ± 0.023	3.385PheAsp: 3.385 ± 0.058	3.533PheGlu: 3.533 ± 0.06	2.575PhePhe: 2.575 ± 0.072	3.631PheGly: 3.631 ± 0.071	0.829PheHis: 0.829 ± 0.027	3.738PheIle: 3.738 ± 0.074	4.007PheLys: 4.007 ± 0.069	4.491PheLeu: 4.491 ± 0.078	1.105PheMet: 1.105 ± 0.037	3.713PheAsn: 3.713 ± 0.069	1.63PhePro: 1.63 ± 0.038	1.502PheGln: 1.502 ± 0.039	1.423PheArg: 1.423 ± 0.04	4.086PheSer: 4.086 ± 0.077	3.208PheThr: 3.208 ± 0.06	3.011PheVal: 3.011 ± 0.067	0.547PheTrp: 0.547 ± 0.026	2.234PheTyr: 2.234 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	3.851GlyAla: 3.851 ± 0.079	0.584GlyCys: 0.584 ± 0.035	3.444GlyAsp: 3.444 ± 0.075	3.624GlyGlu: 3.624 ± 0.067	3.606GlyPhe: 3.606 ± 0.067	4.152GlyGly: 4.152 ± 0.102	1.097GlyHis: 1.097 ± 0.036	4.976GlyIle: 4.976 ± 0.082	4.573GlyLys: 4.573 ± 0.077	5.483GlyLeu: 5.483 ± 0.088	1.49GlyMet: 1.49 ± 0.043	3.688GlyAsn: 3.688 ± 0.086	1.216GlyPro: 1.216 ± 0.042	1.849GlyGln: 1.849 ± 0.045	1.893GlyArg: 1.893 ± 0.055	3.937GlySer: 3.937 ± 0.083	4.123GlyThr: 4.123 ± 0.109	4.312GlyVal: 4.312 ± 0.08	0.699GlyTrp: 0.699 ± 0.028	2.755GlyTyr: 2.755 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.888HisAla: 0.888 ± 0.032	0.194HisCys: 0.194 ± 0.014	0.874HisAsp: 0.874 ± 0.032	0.989HisGlu: 0.989 ± 0.034	1.129HisPhe: 1.129 ± 0.037	1.02HisGly: 1.02 ± 0.033	0.483HisHis: 0.483 ± 0.025	1.506HisIle: 1.506 ± 0.036	1.272HisLys: 1.272 ± 0.039	1.835HisLeu: 1.835 ± 0.042	0.332HisMet: 0.332 ± 0.019	1.149HisAsn: 1.149 ± 0.033	0.828HisPro: 0.828 ± 0.035	0.733HisGln: 0.733 ± 0.028	0.596HisArg: 0.596 ± 0.03	1.026HisSer: 1.026 ± 0.033	0.955HisThr: 0.955 ± 0.031	0.965HisVal: 0.965 ± 0.037	0.217HisTrp: 0.217 ± 0.017	0.868HisTyr: 0.868 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.485IleAla: 5.485 ± 0.092	0.607IleCys: 0.607 ± 0.024	5.205IleAsp: 5.205 ± 0.082	5.569IleGlu: 5.569 ± 0.097	3.365IlePhe: 3.365 ± 0.067	4.916IleGly: 4.916 ± 0.086	1.23IleHis: 1.23 ± 0.036	5.959IleIle: 5.959 ± 0.093	6.003IleLys: 6.003 ± 0.1	6.661IleLeu: 6.661 ± 0.104	1.326IleMet: 1.326 ± 0.038	5.06IleAsn: 5.06 ± 0.086	3.079IlePro: 3.079 ± 0.056	2.422IleGln: 2.422 ± 0.053	2.204IleArg: 2.204 ± 0.048	5.629IleSer: 5.629 ± 0.086	5.041IleThr: 5.041 ± 0.088	5.003IleVal: 5.003 ± 0.075	0.632IleTrp: 0.632 ± 0.026	2.869IleTyr: 2.869 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.234LysAla: 5.234 ± 0.09	0.338LysCys: 0.338 ± 0.02	4.754LysAsp: 4.754 ± 0.086	5.581LysGlu: 5.581 ± 0.104	2.834LysPhe: 2.834 ± 0.06	4.26LysGly: 4.26 ± 0.073	1.66LysHis: 1.66 ± 0.038	5.587LysIle: 5.587 ± 0.104	6.231LysLys: 6.231 ± 0.11	6.801LysLeu: 6.801 ± 0.097	1.776LysMet: 1.776 ± 0.047	4.919LysAsn: 4.919 ± 0.087	2.521LysPro: 2.521 ± 0.053	3.163LysGln: 3.163 ± 0.066	3.098LysArg: 3.098 ± 0.061	4.646LysSer: 4.646 ± 0.083	5.097LysThr: 5.097 ± 0.086	4.757LysVal: 4.757 ± 0.074	0.691LysTrp: 0.691 ± 0.026	2.868LysTyr: 2.868 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	5.399LeuAla: 5.399 ± 0.08	0.695LeuCys: 0.695 ± 0.03	5.109LeuAsp: 5.109 ± 0.069	5.993LeuGlu: 5.993 ± 0.083	4.889LeuPhe: 4.889 ± 0.092	5.656LeuGly: 5.656 ± 0.086	1.534LeuHis: 1.534 ± 0.042	6.89LeuIle: 6.89 ± 0.105	8.105LeuLys: 8.105 ± 0.112	8.39LeuLeu: 8.39 ± 0.134	2.024LeuMet: 2.024 ± 0.052	6.06LeuAsn: 6.06 ± 0.09	3.376LeuPro: 3.376 ± 0.058	3.21LeuGln: 3.21 ± 0.062	2.931LeuArg: 2.931 ± 0.065	6.702LeuSer: 6.702 ± 0.088	5.132LeuThr: 5.132 ± 0.067	5.55LeuVal: 5.55 ± 0.077	0.753LeuTrp: 0.753 ± 0.03	3.162LeuTyr: 3.162 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.546MetAla: 1.546 ± 0.042	0.131MetCys: 0.131 ± 0.012	1.105MetAsp: 1.105 ± 0.033	1.269MetGlu: 1.269 ± 0.036	0.894MetPhe: 0.894 ± 0.031	1.138MetGly: 1.138 ± 0.038	0.404MetHis: 0.404 ± 0.02	1.467MetIle: 1.467 ± 0.044	2.1MetLys: 2.1 ± 0.054	2.001MetLeu: 2.001 ± 0.052	0.547MetMet: 0.547 ± 0.025	1.279MetAsn: 1.279 ± 0.035	0.782MetPro: 0.782 ± 0.03	0.839MetGln: 0.839 ± 0.03	0.791MetArg: 0.791 ± 0.026	1.489MetSer: 1.489 ± 0.039	1.2MetThr: 1.2 ± 0.031	1.346MetVal: 1.346 ± 0.036	0.139MetTrp: 0.139 ± 0.012	0.732MetTyr: 0.732 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	4.122AsnAla: 4.122 ± 0.069	0.549AsnCys: 0.549 ± 0.028	3.74AsnAsp: 3.74 ± 0.069	4.044AsnGlu: 4.044 ± 0.078	3.069AsnPhe: 3.069 ± 0.063	4.158AsnGly: 4.158 ± 0.088	1.099AsnHis: 1.099 ± 0.035	4.987AsnIle: 4.987 ± 0.077	4.44AsnLys: 4.44 ± 0.081	5.556AsnLeu: 5.556 ± 0.088	1.337AsnMet: 1.337 ± 0.039	4.547AsnAsn: 4.547 ± 0.09	2.81AsnPro: 2.81 ± 0.057	2.219AsnGln: 2.219 ± 0.047	2.042AsnArg: 2.042 ± 0.049	4.182AsnSer: 4.182 ± 0.074	4.37AsnThr: 4.37 ± 0.094	3.851AsnVal: 3.851 ± 0.069	0.804AsnTrp: 0.804 ± 0.032	3.035AsnTyr: 3.035 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.62ProAla: 1.62 ± 0.043	0.213ProCys: 0.213 ± 0.015	1.93ProAsp: 1.93 ± 0.052	2.815ProGlu: 2.815 ± 0.055	1.805ProPhe: 1.805 ± 0.049	1.677ProGly: 1.677 ± 0.05	0.602ProHis: 0.602 ± 0.023	2.574ProIle: 2.574 ± 0.053	2.561ProLys: 2.561 ± 0.056	2.818ProLeu: 2.818 ± 0.052	0.691ProMet: 0.691 ± 0.028	2.408ProAsn: 2.408 ± 0.056	0.765ProPro: 0.765 ± 0.039	1.128ProGln: 1.128 ± 0.033	0.863ProArg: 0.863 ± 0.031	2.208ProSer: 2.208 ± 0.055	2.048ProThr: 2.048 ± 0.052	2.218ProVal: 2.218 ± 0.056	0.292ProTrp: 0.292 ± 0.018	1.387ProTyr: 1.387 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.963GlnAla: 1.963 ± 0.046	0.184GlnCys: 0.184 ± 0.016	1.907GlnAsp: 1.907 ± 0.046	2.222GlnGlu: 2.222 ± 0.052	1.776GlnPhe: 1.776 ± 0.043	1.763GlnGly: 1.763 ± 0.044	0.694GlnHis: 0.694 ± 0.028	2.556GlnIle: 2.556 ± 0.052	2.599GlnLys: 2.599 ± 0.057	3.611GlnLeu: 3.611 ± 0.07	0.807GlnMet: 0.807 ± 0.029	2.237GlnAsn: 2.237 ± 0.05	1.236GlnPro: 1.236 ± 0.034	1.577GlnGln: 1.577 ± 0.047	1.242GlnArg: 1.242 ± 0.034	2.001GlnSer: 2.001 ± 0.041	2.033GlnThr: 2.033 ± 0.055	1.957GlnVal: 1.957 ± 0.047	0.331GlnTrp: 0.331 ± 0.018	1.407GlnTyr: 1.407 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	1.968ArgAla: 1.968 ± 0.045	0.187ArgCys: 0.187 ± 0.012	1.677ArgAsp: 1.677 ± 0.046	2.025ArgGlu: 2.025 ± 0.052	1.848ArgPhe: 1.848 ± 0.047	1.722ArgGly: 1.722 ± 0.046	0.587ArgHis: 0.587 ± 0.024	2.626ArgIle: 2.626 ± 0.054	2.494ArgLys: 2.494 ± 0.056	3.101ArgLeu: 3.101 ± 0.062	0.767ArgMet: 0.767 ± 0.027	1.877ArgAsn: 1.877 ± 0.042	1.009ArgPro: 1.009 ± 0.031	1.127ArgGln: 1.127 ± 0.036	1.236ArgArg: 1.236 ± 0.039	1.718ArgSer: 1.718 ± 0.041	1.782ArgThr: 1.782 ± 0.045	2.098ArgVal: 2.098 ± 0.053	0.346ArgTrp: 0.346 ± 0.017	1.494ArgTyr: 1.494 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.767SerAla: 3.767 ± 0.076	0.657SerCys: 0.657 ± 0.033	3.631SerAsp: 3.631 ± 0.055	4.038SerGlu: 4.038 ± 0.07	3.633SerPhe: 3.633 ± 0.07	4.711SerGly: 4.711 ± 0.089	1.122SerHis: 1.122 ± 0.031	5.418SerIle: 5.418 ± 0.077	5.306SerLys: 5.306 ± 0.086	5.835SerLeu: 5.835 ± 0.091	1.28SerMet: 1.28 ± 0.035	4.377SerAsn: 4.377 ± 0.082	2.053SerPro: 2.053 ± 0.045	2.269SerGln: 2.269 ± 0.049	1.919SerArg: 1.919 ± 0.045	4.351SerSer: 4.351 ± 0.093	3.892SerThr: 3.892 ± 0.075	4.242SerVal: 4.242 ± 0.08	0.719SerTrp: 0.719 ± 0.033	2.793SerTyr: 2.793 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	3.775ThrAla: 3.775 ± 0.085	0.421ThrCys: 0.421 ± 0.026	3.339ThrAsp: 3.339 ± 0.062	3.596ThrGlu: 3.596 ± 0.06	3.285ThrPhe: 3.285 ± 0.054	3.845ThrGly: 3.845 ± 0.088	1.109ThrHis: 1.109 ± 0.034	5.48ThrIle: 5.48 ± 0.088	4.017ThrLys: 4.017 ± 0.075	5.774ThrLeu: 5.774 ± 0.08	1.029ThrMet: 1.029 ± 0.033	3.789ThrAsn: 3.789 ± 0.072	2.443ThrPro: 2.443 ± 0.065	2.081ThrGln: 2.081 ± 0.062	1.609ThrArg: 1.609 ± 0.04	4.268ThrSer: 4.268 ± 0.086	4.021ThrThr: 4.021 ± 0.091	4.3ThrVal: 4.3 ± 0.104	0.627ThrTrp: 0.627 ± 0.03	2.742ThrTyr: 2.742 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	4.183ValAla: 4.183 ± 0.068	0.569ValCys: 0.569 ± 0.023	3.829ValAsp: 3.829 ± 0.072	4.187ValGlu: 4.187 ± 0.063	3.56ValPhe: 3.56 ± 0.071	3.829ValGly: 3.829 ± 0.081	0.963ValHis: 0.963 ± 0.033	4.905ValIle: 4.905 ± 0.075	4.545ValLys: 4.545 ± 0.071	6.192ValLeu: 6.192 ± 0.08	1.377ValMet: 1.377 ± 0.038	3.893ValAsn: 3.893 ± 0.064	2.093ValPro: 2.093 ± 0.046	1.698ValGln: 1.698 ± 0.043	1.848ValArg: 1.848 ± 0.045	4.685ValSer: 4.685 ± 0.075	3.956ValThr: 3.956 ± 0.124	4.576ValVal: 4.576 ± 0.081	0.599ValTrp: 0.599 ± 0.025	2.617ValTyr: 2.617 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.539TrpAla: 0.539 ± 0.024	0.096TrpCys: 0.096 ± 0.01	0.585TrpAsp: 0.585 ± 0.024	0.632TrpGlu: 0.632 ± 0.028	0.547TrpPhe: 0.547 ± 0.024	0.572TrpGly: 0.572 ± 0.031	0.209TrpHis: 0.209 ± 0.015	0.71TrpIle: 0.71 ± 0.029	0.749TrpLys: 0.749 ± 0.034	0.933TrpLeu: 0.933 ± 0.028	0.286TrpMet: 0.286 ± 0.017	0.715TrpAsn: 0.715 ± 0.029	0.193TrpPro: 0.193 ± 0.016	0.373TrpGln: 0.373 ± 0.02	0.402TrpArg: 0.402 ± 0.022	0.669TrpSer: 0.669 ± 0.028	0.586TrpThr: 0.586 ± 0.031	0.635TrpVal: 0.635 ± 0.026	0.148TrpTrp: 0.148 ± 0.013	0.446TrpTyr: 0.446 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.398TyrAla: 2.398 ± 0.047	0.356TyrCys: 0.356 ± 0.02	2.567TyrAsp: 2.567 ± 0.057	2.374TyrGlu: 2.374 ± 0.048	2.427TyrPhe: 2.427 ± 0.053	2.617TyrGly: 2.617 ± 0.057	0.808TyrHis: 0.808 ± 0.029	2.841TyrIle: 2.841 ± 0.059	3.254TyrLys: 3.254 ± 0.058	3.755TyrLeu: 3.755 ± 0.065	0.77TyrMet: 0.77 ± 0.031	2.94TyrAsn: 2.94 ± 0.063	1.406TyrPro: 1.406 ± 0.039	1.574TyrGln: 1.574 ± 0.045	1.487TyrArg: 1.487 ± 0.038	2.794TyrSer: 2.794 ± 0.062	2.583TyrThr: 2.583 ± 0.065	2.34TyrVal: 2.34 ± 0.051	0.485TyrTrp: 0.485 ± 0.027	1.98TyrTyr: 1.98 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2918 proteins (1003851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---