Amino acid dipepetide frequency for Pycnoporus cinnabarinus (Cinnabar-red polypore) (Trametes cinnabarina)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.424AlaAla: 10.424 ± 0.065	1.069AlaCys: 1.069 ± 0.016	4.854AlaAsp: 4.854 ± 0.031	5.679AlaGlu: 5.679 ± 0.052	3.394AlaPhe: 3.394 ± 0.031	5.722AlaGly: 5.722 ± 0.032	2.453AlaHis: 2.453 ± 0.02	4.183AlaIle: 4.183 ± 0.029	4.128AlaLys: 4.128 ± 0.035	9.055AlaLeu: 9.055 ± 0.056	2.007AlaMet: 2.007 ± 0.02	2.861AlaAsn: 2.861 ± 0.026	6.127AlaPro: 6.127 ± 0.051	3.851AlaGln: 3.851 ± 0.026	6.144AlaArg: 6.144 ± 0.041	8.248AlaSer: 8.248 ± 0.06	5.52AlaThr: 5.52 ± 0.034	5.925AlaVal: 5.925 ± 0.036	1.222AlaTrp: 1.222 ± 0.015	2.386AlaTyr: 2.386 ± 0.026	0.01AlaXaa: 0.01 ± 0.001
Cys	1.022CysAla: 1.022 ± 0.015	0.208CysCys: 0.208 ± 0.008	0.633CysAsp: 0.633 ± 0.012	0.577CysGlu: 0.577 ± 0.011	0.448CysPhe: 0.448 ± 0.01	0.803CysGly: 0.803 ± 0.013	0.298CysHis: 0.298 ± 0.009	0.593CysIle: 0.593 ± 0.011	0.479CysLys: 0.479 ± 0.01	1.08CysLeu: 1.08 ± 0.017	0.26CysMet: 0.26 ± 0.007	0.352CysAsn: 0.352 ± 0.009	0.731CysPro: 0.731 ± 0.016	0.366CysGln: 0.366 ± 0.009	0.708CysArg: 0.708 ± 0.013	0.796CysSer: 0.796 ± 0.013	0.661CysThr: 0.661 ± 0.013	0.748CysVal: 0.748 ± 0.014	0.186CysTrp: 0.186 ± 0.006	0.313CysTyr: 0.313 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.571AspAla: 5.571 ± 0.034	0.605AspCys: 0.605 ± 0.01	4.407AspAsp: 4.407 ± 0.043	4.561AspGlu: 4.561 ± 0.04	2.097AspPhe: 2.097 ± 0.022	4.043AspGly: 4.043 ± 0.031	1.302AspHis: 1.302 ± 0.017	2.884AspIle: 2.884 ± 0.028	2.103AspLys: 2.103 ± 0.022	5.013AspLeu: 5.013 ± 0.041	1.198AspMet: 1.198 ± 0.016	1.598AspAsn: 1.598 ± 0.019	3.78AspPro: 3.78 ± 0.03	1.601AspGln: 1.601 ± 0.018	3.039AspArg: 3.039 ± 0.026	3.921AspSer: 3.921 ± 0.028	2.826AspThr: 2.826 ± 0.026	4.249AspVal: 4.249 ± 0.028	0.899AspTrp: 0.899 ± 0.013	1.504AspTyr: 1.504 ± 0.021	0.003AspXaa: 0.003 ± 0.001
Glu	5.502GluAla: 5.502 ± 0.042	0.602GluCys: 0.602 ± 0.012	4.455GluAsp: 4.455 ± 0.04	5.706GluGlu: 5.706 ± 0.055	1.838GluPhe: 1.838 ± 0.021	3.768GluGly: 3.768 ± 0.034	1.61GluHis: 1.61 ± 0.019	2.606GluIle: 2.606 ± 0.028	3.137GluLys: 3.137 ± 0.032	5.594GluLeu: 5.594 ± 0.041	1.234GluMet: 1.234 ± 0.016	1.822GluAsn: 1.822 ± 0.02	3.036GluPro: 3.036 ± 0.03	2.409GluGln: 2.409 ± 0.025	4.536GluArg: 4.536 ± 0.042	3.86GluSer: 3.86 ± 0.032	2.942GluThr: 2.942 ± 0.024	3.717GluVal: 3.717 ± 0.029	0.9GluTrp: 0.9 ± 0.015	1.568GluTyr: 1.568 ± 0.02	0.003GluXaa: 0.003 ± 0.001
Phe	3.33PheAla: 3.33 ± 0.029	0.486PheCys: 0.486 ± 0.012	2.199PheAsp: 2.199 ± 0.023	1.946PheGlu: 1.946 ± 0.023	1.452PhePhe: 1.452 ± 0.023	2.578PheGly: 2.578 ± 0.03	0.897PheHis: 0.897 ± 0.014	1.603PheIle: 1.603 ± 0.019	1.417PheLys: 1.417 ± 0.016	3.318PheLeu: 3.318 ± 0.028	0.721PheMet: 0.721 ± 0.012	1.235PheAsn: 1.235 ± 0.016	2.042PhePro: 2.042 ± 0.021	1.141PheGln: 1.141 ± 0.016	1.946PheArg: 1.946 ± 0.021	2.882PheSer: 2.882 ± 0.025	2.058PheThr: 2.058 ± 0.022	2.526PheVal: 2.526 ± 0.028	0.565PheTrp: 0.565 ± 0.011	0.994PheTyr: 0.994 ± 0.015	0.002PheXaa: 0.002 ± 0.001
Gly	5.409GlyAla: 5.409 ± 0.035	0.76GlyCys: 0.76 ± 0.013	3.406GlyAsp: 3.406 ± 0.029	3.564GlyGlu: 3.564 ± 0.029	2.42GlyPhe: 2.42 ± 0.027	5.121GlyGly: 5.121 ± 0.05	1.702GlyHis: 1.702 ± 0.02	2.973GlyIle: 2.973 ± 0.03	3.213GlyLys: 3.213 ± 0.029	5.528GlyLeu: 5.528 ± 0.039	1.45GlyMet: 1.45 ± 0.024	1.982GlyAsn: 1.982 ± 0.022	3.622GlyPro: 3.622 ± 0.03	2.305GlyGln: 2.305 ± 0.022	4.149GlyArg: 4.149 ± 0.034	5.465GlySer: 5.465 ± 0.041	3.946GlyThr: 3.946 ± 0.032	4.13GlyVal: 4.13 ± 0.031	1.05GlyTrp: 1.05 ± 0.015	1.783GlyTyr: 1.783 ± 0.022	0.008GlyXaa: 0.008 ± 0.001
His	2.526HisAla: 2.526 ± 0.025	0.331HisCys: 0.331 ± 0.008	1.376HisAsp: 1.376 ± 0.017	1.312HisGlu: 1.312 ± 0.015	0.975HisPhe: 0.975 ± 0.015	1.711HisGly: 1.711 ± 0.02	0.933HisHis: 0.933 ± 0.02	1.307HisIle: 1.307 ± 0.016	0.895HisLys: 0.895 ± 0.014	2.515HisLeu: 2.515 ± 0.025	0.474HisMet: 0.474 ± 0.01	0.803HisAsn: 0.803 ± 0.013	2.109HisPro: 2.109 ± 0.024	0.896HisGln: 0.896 ± 0.014	1.714HisArg: 1.714 ± 0.018	2.028HisSer: 2.028 ± 0.025	1.45HisThr: 1.45 ± 0.019	1.763HisVal: 1.763 ± 0.019	0.367HisTrp: 0.367 ± 0.008	0.741HisTyr: 0.741 ± 0.012	0.001HisXaa: 0.001 ± 0.001
Ile	4.235IleAla: 4.235 ± 0.034	0.592IleCys: 0.592 ± 0.01	2.671IleAsp: 2.671 ± 0.027	2.544IleGlu: 2.544 ± 0.026	1.676IlePhe: 1.676 ± 0.02	2.674IleGly: 2.674 ± 0.026	1.116IleHis: 1.116 ± 0.015	2.078IleIle: 2.078 ± 0.023	1.846IleLys: 1.846 ± 0.025	4.196IleLeu: 4.196 ± 0.032	0.849IleMet: 0.849 ± 0.013	1.382IleAsn: 1.382 ± 0.018	3.2IlePro: 3.2 ± 0.023	1.539IleGln: 1.539 ± 0.02	2.761IleArg: 2.761 ± 0.025	3.329IleSer: 3.329 ± 0.025	2.482IleThr: 2.482 ± 0.026	3.082IleVal: 3.082 ± 0.029	0.652IleTrp: 0.652 ± 0.014	1.198IleTyr: 1.198 ± 0.018	0.002IleXaa: 0.002 ± 0.001
Lys	4.399LysAla: 4.399 ± 0.04	0.399LysCys: 0.399 ± 0.009	2.382LysAsp: 2.382 ± 0.023	3.026LysGlu: 3.026 ± 0.029	1.212LysPhe: 1.212 ± 0.016	2.77LysGly: 2.77 ± 0.029	1.134LysHis: 1.134 ± 0.017	1.767LysIle: 1.767 ± 0.021	2.877LysLys: 2.877 ± 0.044	3.82LysLeu: 3.82 ± 0.032	0.837LysMet: 0.837 ± 0.014	1.306LysAsn: 1.306 ± 0.017	2.648LysPro: 2.648 ± 0.027	1.642LysGln: 1.642 ± 0.019	3.448LysArg: 3.448 ± 0.031	2.858LysSer: 2.858 ± 0.028	2.414LysThr: 2.414 ± 0.026	2.622LysVal: 2.622 ± 0.025	0.618LysTrp: 0.618 ± 0.01	1.153LysTyr: 1.153 ± 0.017	0.002LysXaa: 0.002 ± 0.001
Leu	8.602LeuAla: 8.602 ± 0.048	1.131LeuCys: 1.131 ± 0.014	5.247LeuAsp: 5.247 ± 0.035	5.446LeuGlu: 5.446 ± 0.038	3.262LeuPhe: 3.262 ± 0.031	5.496LeuGly: 5.496 ± 0.035	2.537LeuHis: 2.537 ± 0.027	3.6LeuIle: 3.6 ± 0.032	3.903LeuLys: 3.903 ± 0.033	8.555LeuLeu: 8.555 ± 0.068	1.679LeuMet: 1.679 ± 0.019	2.854LeuAsn: 2.854 ± 0.025	6.501LeuPro: 6.501 ± 0.043	3.696LeuGln: 3.696 ± 0.029	6.575LeuArg: 6.575 ± 0.04	7.692LeuSer: 7.692 ± 0.045	5.13LeuThr: 5.13 ± 0.031	5.689LeuVal: 5.689 ± 0.043	1.18LeuTrp: 1.18 ± 0.018	2.386LeuTyr: 2.386 ± 0.027	0.008LeuXaa: 0.008 ± 0.002
Met	1.896MetAla: 1.896 ± 0.019	0.232MetCys: 0.232 ± 0.008	1.192MetAsp: 1.192 ± 0.017	1.105MetGlu: 1.105 ± 0.017	0.684MetPhe: 0.684 ± 0.013	1.155MetGly: 1.155 ± 0.02	0.566MetHis: 0.566 ± 0.011	0.804MetIle: 0.804 ± 0.014	0.84MetLys: 0.84 ± 0.014	1.816MetLeu: 1.816 ± 0.023	0.443MetMet: 0.443 ± 0.011	0.652MetAsn: 0.652 ± 0.013	1.321MetPro: 1.321 ± 0.015	0.842MetGln: 0.842 ± 0.014	1.371MetArg: 1.371 ± 0.016	1.882MetSer: 1.882 ± 0.022	1.122MetThr: 1.122 ± 0.015	1.136MetVal: 1.136 ± 0.016	0.248MetTrp: 0.248 ± 0.007	0.512MetTyr: 0.512 ± 0.01	0.001MetXaa: 0.001 ± 0.001
Asn	3.241AsnAla: 3.241 ± 0.027	0.343AsnCys: 0.343 ± 0.008	1.624AsnAsp: 1.624 ± 0.021	1.617AsnGlu: 1.617 ± 0.022	1.123AsnPhe: 1.123 ± 0.016	2.46AsnGly: 2.46 ± 0.026	0.739AsnHis: 0.739 ± 0.012	1.582AsnIle: 1.582 ± 0.019	1.188AsnLys: 1.188 ± 0.018	2.853AsnLeu: 2.853 ± 0.027	0.659AsnMet: 0.659 ± 0.013	1.051AsnAsn: 1.051 ± 0.016	2.273AsnPro: 2.273 ± 0.025	0.983AsnGln: 0.983 ± 0.015	1.605AsnArg: 1.605 ± 0.019	2.131AsnSer: 2.131 ± 0.021	1.759AsnThr: 1.759 ± 0.019	2.278AsnVal: 2.278 ± 0.024	0.436AsnTrp: 0.436 ± 0.01	0.824AsnTyr: 0.824 ± 0.015	0.002AsnXaa: 0.002 ± 0.001
Pro	6.687ProAla: 6.687 ± 0.054	0.527ProCys: 0.527 ± 0.011	3.676ProAsp: 3.676 ± 0.031	4.134ProGlu: 4.134 ± 0.03	2.225ProPhe: 2.225 ± 0.024	4.149ProGly: 4.149 ± 0.033	1.742ProHis: 1.742 ± 0.021	2.639ProIle: 2.639 ± 0.03	2.493ProLys: 2.493 ± 0.025	5.62ProLeu: 5.62 ± 0.039	1.092ProMet: 1.092 ± 0.016	2.049ProAsn: 2.049 ± 0.02	7.467ProPro: 7.467 ± 0.096	2.565ProGln: 2.565 ± 0.032	4.11ProArg: 4.11 ± 0.032	7.582ProSer: 7.582 ± 0.062	4.519ProThr: 4.519 ± 0.039	4.19ProVal: 4.19 ± 0.033	0.716ProTrp: 0.716 ± 0.013	1.673ProTyr: 1.673 ± 0.019	0.009ProXaa: 0.009 ± 0.001
Gln	3.657GlnAla: 3.657 ± 0.031	0.424GlnCys: 0.424 ± 0.01	1.915GlnAsp: 1.915 ± 0.02	2.279GlnGlu: 2.279 ± 0.024	1.19GlnPhe: 1.19 ± 0.018	2.135GlnGly: 2.135 ± 0.022	1.126GlnHis: 1.126 ± 0.019	1.526GlnIle: 1.526 ± 0.019	1.581GlnLys: 1.581 ± 0.018	3.409GlnLeu: 3.409 ± 0.031	0.746GlnMet: 0.746 ± 0.013	1.211GlnAsn: 1.211 ± 0.015	2.622GlnPro: 2.622 ± 0.026	2.158GlnGln: 2.158 ± 0.044	2.663GlnArg: 2.663 ± 0.023	2.928GlnSer: 2.928 ± 0.026	2.114GlnThr: 2.114 ± 0.019	2.162GlnVal: 2.162 ± 0.023	0.56GlnTrp: 0.56 ± 0.009	1.07GlnTyr: 1.07 ± 0.015	0.002GlnXaa: 0.002 ± 0.001
Arg	6.114ArgAla: 6.114 ± 0.047	0.742ArgCys: 0.742 ± 0.014	3.528ArgAsp: 3.528 ± 0.032	4.187ArgGlu: 4.187 ± 0.034	2.223ArgPhe: 2.223 ± 0.022	3.739ArgGly: 3.739 ± 0.032	1.712ArgHis: 1.712 ± 0.02	2.971ArgIle: 2.971 ± 0.028	3.391ArgLys: 3.391 ± 0.033	5.985ArgLeu: 5.985 ± 0.041	1.396ArgMet: 1.396 ± 0.017	1.976ArgAsn: 1.976 ± 0.02	4.12ArgPro: 4.12 ± 0.038	2.449ArgGln: 2.449 ± 0.026	5.717ArgArg: 5.717 ± 0.046	5.156ArgSer: 5.156 ± 0.041	3.864ArgThr: 3.864 ± 0.03	3.877ArgVal: 3.877 ± 0.031	0.995ArgTrp: 0.995 ± 0.015	1.742ArgTyr: 1.742 ± 0.022	0.005ArgXaa: 0.005 ± 0.001
Ser	7.875SerAla: 7.875 ± 0.054	0.789SerCys: 0.789 ± 0.015	4.409SerAsp: 4.409 ± 0.038	4.098SerGlu: 4.098 ± 0.033	2.808SerPhe: 2.808 ± 0.026	5.543SerGly: 5.543 ± 0.042	2.056SerHis: 2.056 ± 0.022	3.433SerIle: 3.433 ± 0.033	3.154SerLys: 3.154 ± 0.029	7.292SerLeu: 7.292 ± 0.04	1.605SerMet: 1.605 ± 0.02	2.366SerAsn: 2.366 ± 0.022	6.686SerPro: 6.686 ± 0.062	3.092SerGln: 3.092 ± 0.032	5.214SerArg: 5.214 ± 0.043	9.727SerSer: 9.727 ± 0.083	5.658SerThr: 5.658 ± 0.048	4.859SerVal: 4.859 ± 0.032	0.987SerTrp: 0.987 ± 0.015	1.838SerTyr: 1.838 ± 0.022	0.008SerXaa: 0.008 ± 0.001
Thr	5.445ThrAla: 5.445 ± 0.039	0.68ThrCys: 0.68 ± 0.014	2.765ThrAsp: 2.765 ± 0.026	2.795ThrGlu: 2.795 ± 0.022	2.283ThrPhe: 2.283 ± 0.022	3.732ThrGly: 3.732 ± 0.03	1.474ThrHis: 1.474 ± 0.017	2.732ThrIle: 2.732 ± 0.029	2.129ThrLys: 2.129 ± 0.022	5.582ThrLeu: 5.582 ± 0.04	1.083ThrMet: 1.083 ± 0.016	1.742ThrAsn: 1.742 ± 0.021	4.848ThrPro: 4.848 ± 0.04	1.969ThrGln: 1.969 ± 0.02	3.395ThrArg: 3.395 ± 0.027	5.371ThrSer: 5.371 ± 0.045	3.842ThrThr: 3.842 ± 0.031	3.935ThrVal: 3.935 ± 0.032	0.766ThrTrp: 0.766 ± 0.013	1.59ThrTyr: 1.59 ± 0.019	0.003ThrXaa: 0.003 ± 0.001
Val	5.79ValAla: 5.79 ± 0.035	0.808ValCys: 0.808 ± 0.013	3.906ValAsp: 3.906 ± 0.031	3.948ValGlu: 3.948 ± 0.035	2.443ValPhe: 2.443 ± 0.022	3.761ValGly: 3.761 ± 0.032	1.726ValHis: 1.726 ± 0.019	2.886ValIle: 2.886 ± 0.025	2.777ValLys: 2.777 ± 0.026	6.096ValLeu: 6.096 ± 0.042	1.229ValMet: 1.229 ± 0.018	2.054ValAsn: 2.054 ± 0.023	4.467ValPro: 4.467 ± 0.034	2.511ValGln: 2.511 ± 0.022	4.133ValArg: 4.133 ± 0.028	4.799ValSer: 4.799 ± 0.031	3.455ValThr: 3.455 ± 0.029	4.58ValVal: 4.58 ± 0.031	0.951ValTrp: 0.951 ± 0.016	1.801ValTyr: 1.801 ± 0.017	0.005ValXaa: 0.005 ± 0.001
Trp	1.119TrpAla: 1.119 ± 0.018	0.175TrpCys: 0.175 ± 0.006	0.91TrpAsp: 0.91 ± 0.014	0.857TrpGlu: 0.857 ± 0.014	0.552TrpPhe: 0.552 ± 0.01	0.819TrpGly: 0.819 ± 0.014	0.367TrpHis: 0.367 ± 0.009	0.665TrpIle: 0.665 ± 0.011	0.727TrpLys: 0.727 ± 0.011	1.293TrpLeu: 1.293 ± 0.017	0.326TrpMet: 0.326 ± 0.007	0.529TrpAsn: 0.529 ± 0.01	0.645TrpPro: 0.645 ± 0.012	0.525TrpGln: 0.525 ± 0.011	1.02TrpArg: 1.02 ± 0.013	0.997TrpSer: 0.997 ± 0.015	0.877TrpThr: 0.877 ± 0.015	0.877TrpVal: 0.877 ± 0.014	0.286TrpTrp: 0.286 ± 0.008	0.406TrpTyr: 0.406 ± 0.011	0.001TrpXaa: 0.001 ± 0.0
Tyr	2.411TyrAla: 2.411 ± 0.021	0.359TyrCys: 0.359 ± 0.009	1.644TyrAsp: 1.644 ± 0.018	1.461TyrGlu: 1.461 ± 0.019	1.03TyrPhe: 1.03 ± 0.016	1.801TyrGly: 1.801 ± 0.022	0.735TyrHis: 0.735 ± 0.012	1.27TyrIle: 1.27 ± 0.02	1.054TyrLys: 1.054 ± 0.016	2.54TyrLeu: 2.54 ± 0.024	0.529TyrMet: 0.529 ± 0.011	0.943TyrAsn: 0.943 ± 0.015	1.61TyrPro: 1.61 ± 0.02	0.937TyrGln: 0.937 ± 0.014	1.638TyrArg: 1.638 ± 0.019	1.834TyrSer: 1.834 ± 0.021	1.521TyrThr: 1.521 ± 0.017	1.777TyrVal: 1.777 ± 0.017	0.388TyrTrp: 0.388 ± 0.01	0.845TyrTyr: 0.845 ± 0.013	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.008XaaAla: 0.008 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.004XaaGlu: 0.004 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.005XaaGly: 0.005 ± 0.001	0.003XaaHis: 0.003 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.001XaaLys: 0.001 ± 0.0	0.008XaaLeu: 0.008 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.008XaaPro: 0.008 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.005XaaArg: 0.005 ± 0.001	0.009XaaSer: 0.009 ± 0.002	0.004XaaThr: 0.004 ± 0.001	0.005XaaVal: 0.005 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	1.285XaaXaa: 1.285 ± 0.108

Statistics based on 10180 proteins (4930602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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