Amino acid dipepetide frequency for Hoeflea sp. IMCC20628

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.875AlaAla: 14.875 ± 0.142
0.997AlaCys: 0.997 ± 0.027
6.891AlaAsp: 6.891 ± 0.071
7.252AlaGlu: 7.252 ± 0.087
4.496AlaPhe: 4.496 ± 0.057
10.017AlaGly: 10.017 ± 0.085
2.161AlaHis: 2.161 ± 0.041
6.791AlaIle: 6.791 ± 0.075
4.244AlaLys: 4.244 ± 0.062
12.135AlaLeu: 12.135 ± 0.115
3.606AlaMet: 3.606 ± 0.046
3.124AlaAsn: 3.124 ± 0.044
4.843AlaPro: 4.843 ± 0.084
3.555AlaGln: 3.555 ± 0.054
7.538AlaArg: 7.538 ± 0.07
6.716AlaSer: 6.716 ± 0.079
5.807AlaThr: 5.807 ± 0.069
8.185AlaVal: 8.185 ± 0.066
1.387AlaTrp: 1.387 ± 0.033
2.503AlaTyr: 2.503 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.951CysAla: 0.951 ± 0.026
0.114CysCys: 0.114 ± 0.01
0.557CysAsp: 0.557 ± 0.02
0.462CysGlu: 0.462 ± 0.018
0.383CysPhe: 0.383 ± 0.016
0.95CysGly: 0.95 ± 0.027
0.285CysHis: 0.285 ± 0.014
0.432CysIle: 0.432 ± 0.02
0.268CysLys: 0.268 ± 0.015
0.811CysLeu: 0.811 ± 0.025
0.213CysMet: 0.213 ± 0.015
0.221CysAsn: 0.221 ± 0.011
0.455CysPro: 0.455 ± 0.018
0.264CysGln: 0.264 ± 0.017
0.562CysArg: 0.562 ± 0.02
0.483CysSer: 0.483 ± 0.02
0.449CysThr: 0.449 ± 0.021
0.579CysVal: 0.579 ± 0.023
0.103CysTrp: 0.103 ± 0.008
0.221CysTyr: 0.221 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.611AspAla: 6.611 ± 0.074
0.538AspCys: 0.538 ± 0.024
3.35AspAsp: 3.35 ± 0.065
3.623AspGlu: 3.623 ± 0.058
2.364AspPhe: 2.364 ± 0.036
5.338AspGly: 5.338 ± 0.069
1.44AspHis: 1.44 ± 0.034
3.554AspIle: 3.554 ± 0.054
2.073AspLys: 2.073 ± 0.041
5.825AspLeu: 5.825 ± 0.063
1.695AspMet: 1.695 ± 0.035
1.558AspAsn: 1.558 ± 0.033
3.417AspPro: 3.417 ± 0.051
1.9AspGln: 1.9 ± 0.038
4.08AspArg: 4.08 ± 0.057
2.407AspSer: 2.407 ± 0.046
2.97AspThr: 2.97 ± 0.053
4.157AspVal: 4.157 ± 0.058
0.976AspTrp: 0.976 ± 0.026
1.607AspTyr: 1.607 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.271GluAla: 7.271 ± 0.077
0.388GluCys: 0.388 ± 0.016
2.942GluAsp: 2.942 ± 0.05
3.006GluGlu: 3.006 ± 0.057
2.019GluPhe: 2.019 ± 0.036
4.099GluGly: 4.099 ± 0.053
1.165GluHis: 1.165 ± 0.033
3.918GluIle: 3.918 ± 0.059
2.332GluLys: 2.332 ± 0.042
5.365GluLeu: 5.365 ± 0.069
1.729GluMet: 1.729 ± 0.04
1.883GluAsn: 1.883 ± 0.034
2.585GluPro: 2.585 ± 0.047
2.003GluGln: 2.003 ± 0.04
4.104GluArg: 4.104 ± 0.058
2.603GluSer: 2.603 ± 0.043
3.906GluThr: 3.906 ± 0.054
3.702GluVal: 3.702 ± 0.049
0.688GluTrp: 0.688 ± 0.025
1.01GluTyr: 1.01 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.704PheAla: 4.704 ± 0.061
0.468PheCys: 0.468 ± 0.018
2.861PheAsp: 2.861 ± 0.043
2.293PheGlu: 2.293 ± 0.04
1.599PhePhe: 1.599 ± 0.038
3.835PheGly: 3.835 ± 0.053
0.79PheHis: 0.79 ± 0.024
1.992PheIle: 1.992 ± 0.04
1.18PheLys: 1.18 ± 0.027
3.558PheLeu: 3.558 ± 0.054
0.949PheMet: 0.949 ± 0.026
1.184PheAsn: 1.184 ± 0.026
1.578PhePro: 1.578 ± 0.034
1.058PheGln: 1.058 ± 0.027
2.158PheArg: 2.158 ± 0.04
2.607PheSer: 2.607 ± 0.044
2.08PheThr: 2.08 ± 0.044
2.915PheVal: 2.915 ± 0.049
0.582PheTrp: 0.582 ± 0.021
0.955PheTyr: 0.955 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
8.567GlyAla: 8.567 ± 0.084
0.837GlyCys: 0.837 ± 0.027
4.592GlyAsp: 4.592 ± 0.061
4.707GlyGlu: 4.707 ± 0.061
3.965GlyPhe: 3.965 ± 0.05
7.12GlyGly: 7.12 ± 0.098
1.927GlyHis: 1.927 ± 0.04
4.956GlyIle: 4.956 ± 0.062
3.675GlyLys: 3.675 ± 0.06
8.891GlyLeu: 8.891 ± 0.088
2.61GlyMet: 2.61 ± 0.046
2.359GlyAsn: 2.359 ± 0.053
3.254GlyPro: 3.254 ± 0.058
2.806GlyGln: 2.806 ± 0.044
5.219GlyArg: 5.219 ± 0.063
4.915GlySer: 4.915 ± 0.066
4.349GlyThr: 4.349 ± 0.062
6.172GlyVal: 6.172 ± 0.076
1.344GlyTrp: 1.344 ± 0.031
2.358GlyTyr: 2.358 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.241HisAla: 2.241 ± 0.047
0.263HisCys: 0.263 ± 0.014
1.238HisAsp: 1.238 ± 0.03
1.053HisGlu: 1.053 ± 0.028
0.888HisPhe: 0.888 ± 0.027
1.942HisGly: 1.942 ± 0.036
0.574HisHis: 0.574 ± 0.023
1.01HisIle: 1.01 ± 0.03
0.599HisLys: 0.599 ± 0.021
2.007HisLeu: 2.007 ± 0.042
0.569HisMet: 0.569 ± 0.021
0.521HisAsn: 0.521 ± 0.017
1.258HisPro: 1.258 ± 0.03
0.644HisGln: 0.644 ± 0.022
1.257HisArg: 1.257 ± 0.033
1.078HisSer: 1.078 ± 0.03
0.883HisThr: 0.883 ± 0.026
1.563HisVal: 1.563 ± 0.033
0.329HisTrp: 0.329 ± 0.016
0.562HisTyr: 0.562 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.749IleAla: 7.749 ± 0.084
0.593IleCys: 0.593 ± 0.022
3.925IleAsp: 3.925 ± 0.058
3.804IleGlu: 3.804 ± 0.053
1.96IlePhe: 1.96 ± 0.042
5.359IleGly: 5.359 ± 0.066
1.019IleHis: 1.019 ± 0.026
3.01IleIle: 3.01 ± 0.052
1.823IleLys: 1.823 ± 0.041
4.978IleLeu: 4.978 ± 0.071
1.259IleMet: 1.259 ± 0.028
1.749IleAsn: 1.749 ± 0.034
2.439IlePro: 2.439 ± 0.042
1.272IleGln: 1.272 ± 0.035
3.372IleArg: 3.372 ± 0.055
3.714IleSer: 3.714 ± 0.055
3.091IleThr: 3.091 ± 0.047
4.434IleVal: 4.434 ± 0.061
0.725IleTrp: 0.725 ± 0.022
1.294IleTyr: 1.294 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.506LysAla: 4.506 ± 0.068
0.186LysCys: 0.186 ± 0.013
1.923LysAsp: 1.923 ± 0.046
1.518LysGlu: 1.518 ± 0.035
1.043LysPhe: 1.043 ± 0.031
2.743LysGly: 2.743 ± 0.048
0.716LysHis: 0.716 ± 0.025
2.175LysIle: 2.175 ± 0.045
1.452LysLys: 1.452 ± 0.044
3.604LysLeu: 3.604 ± 0.059
0.99LysMet: 0.99 ± 0.024
1.064LysAsn: 1.064 ± 0.028
2.274LysPro: 2.274 ± 0.044
1.172LysGln: 1.172 ± 0.028
2.388LysArg: 2.388 ± 0.038
2.411LysSer: 2.411 ± 0.045
2.472LysThr: 2.472 ± 0.04
2.493LysVal: 2.493 ± 0.045
0.417LysTrp: 0.417 ± 0.017
0.702LysTyr: 0.702 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
12.496LeuAla: 12.496 ± 0.112
0.885LeuCys: 0.885 ± 0.027
5.93LeuAsp: 5.93 ± 0.06
5.318LeuGlu: 5.318 ± 0.061
3.657LeuPhe: 3.657 ± 0.057
7.966LeuGly: 7.966 ± 0.079
1.698LeuHis: 1.698 ± 0.037
5.562LeuIle: 5.562 ± 0.08
3.913LeuLys: 3.913 ± 0.062
8.806LeuLeu: 8.806 ± 0.099
2.585LeuMet: 2.585 ± 0.044
2.776LeuAsn: 2.776 ± 0.045
5.054LeuPro: 5.054 ± 0.063
2.521LeuGln: 2.521 ± 0.039
5.706LeuArg: 5.706 ± 0.069
6.841LeuSer: 6.841 ± 0.067
5.723LeuThr: 5.723 ± 0.068
7.368LeuVal: 7.368 ± 0.085
1.121LeuTrp: 1.121 ± 0.029
2.02LeuTyr: 2.02 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.35MetAla: 3.35 ± 0.044
0.2MetCys: 0.2 ± 0.012
1.352MetAsp: 1.352 ± 0.028
1.252MetGlu: 1.252 ± 0.029
0.905MetPhe: 0.905 ± 0.024
2.014MetGly: 2.014 ± 0.043
0.493MetHis: 0.493 ± 0.02
1.811MetIle: 1.811 ± 0.038
1.165MetLys: 1.165 ± 0.028
2.683MetLeu: 2.683 ± 0.049
0.85MetMet: 0.85 ± 0.029
0.976MetAsn: 0.976 ± 0.028
1.575MetPro: 1.575 ± 0.036
0.924MetGln: 0.924 ± 0.025
1.813MetArg: 1.813 ± 0.037
1.979MetSer: 1.979 ± 0.035
2.083MetThr: 2.083 ± 0.034
1.999MetVal: 1.999 ± 0.033
0.248MetTrp: 0.248 ± 0.013
0.346MetTyr: 0.346 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.254AsnAla: 3.254 ± 0.051
0.282AsnCys: 0.282 ± 0.013
1.66AsnAsp: 1.66 ± 0.037
1.422AsnGlu: 1.422 ± 0.029
1.093AsnPhe: 1.093 ± 0.033
2.554AsnGly: 2.554 ± 0.048
0.583AsnHis: 0.583 ± 0.019
1.56AsnIle: 1.56 ± 0.033
0.857AsnLys: 0.857 ± 0.024
2.726AsnLeu: 2.726 ± 0.041
0.755AsnMet: 0.755 ± 0.022
0.827AsnAsn: 0.827 ± 0.029
1.935AsnPro: 1.935 ± 0.033
0.901AsnGln: 0.901 ± 0.027
1.957AsnArg: 1.957 ± 0.035
1.543AsnSer: 1.543 ± 0.036
1.388AsnThr: 1.388 ± 0.031
2.022AsnVal: 2.022 ± 0.041
0.502AsnTrp: 0.502 ± 0.017
0.78AsnTyr: 0.78 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
5.411ProAla: 5.411 ± 0.082
0.303ProCys: 0.303 ± 0.014
3.868ProAsp: 3.868 ± 0.06
3.716ProGlu: 3.716 ± 0.053
1.965ProPhe: 1.965 ± 0.042
4.364ProGly: 4.364 ± 0.058
1.016ProHis: 1.016 ± 0.027
2.213ProIle: 2.213 ± 0.038
1.782ProLys: 1.782 ± 0.037
4.419ProLeu: 4.419 ± 0.06
1.236ProMet: 1.236 ± 0.025
1.278ProAsn: 1.278 ± 0.032
1.938ProPro: 1.938 ± 0.042
1.531ProGln: 1.531 ± 0.038
2.371ProArg: 2.371 ± 0.042
2.742ProSer: 2.742 ± 0.046
2.241ProThr: 2.241 ± 0.041
4.335ProVal: 4.335 ± 0.058
0.634ProTrp: 0.634 ± 0.022
1.15ProTyr: 1.15 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.837GlnAla: 3.837 ± 0.048
0.235GlnCys: 0.235 ± 0.013
1.454GlnAsp: 1.454 ± 0.038
1.349GlnGlu: 1.349 ± 0.034
1.124GlnPhe: 1.124 ± 0.023
2.144GlnGly: 2.144 ± 0.039
0.581GlnHis: 0.581 ± 0.022
2.018GlnIle: 2.018 ± 0.04
1.164GlnLys: 1.164 ± 0.026
2.809GlnLeu: 2.809 ± 0.044
1.021GlnMet: 1.021 ± 0.027
0.921GlnAsn: 0.921 ± 0.027
1.641GlnPro: 1.641 ± 0.037
1.117GlnGln: 1.117 ± 0.029
2.009GlnArg: 2.009 ± 0.039
2.028GlnSer: 2.028 ± 0.043
1.907GlnThr: 1.907 ± 0.04
2.177GlnVal: 2.177 ± 0.041
0.376GlnTrp: 0.376 ± 0.015
0.564GlnTyr: 0.564 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
6.543ArgAla: 6.543 ± 0.075
0.459ArgCys: 0.459 ± 0.017
3.792ArgAsp: 3.792 ± 0.05
3.578ArgGlu: 3.578 ± 0.049
2.713ArgPhe: 2.713 ± 0.044
4.187ArgGly: 4.187 ± 0.061
1.562ArgHis: 1.562 ± 0.033
3.912ArgIle: 3.912 ± 0.06
2.454ArgLys: 2.454 ± 0.039
6.825ArgLeu: 6.825 ± 0.081
1.912ArgMet: 1.912 ± 0.035
1.859ArgAsn: 1.859 ± 0.033
2.993ArgPro: 2.993 ± 0.051
2.377ArgGln: 2.377 ± 0.043
4.316ArgArg: 4.316 ± 0.066
3.595ArgSer: 3.595 ± 0.057
3.254ArgThr: 3.254 ± 0.055
4.099ArgVal: 4.099 ± 0.049
0.787ArgTrp: 0.787 ± 0.025
1.548ArgTyr: 1.548 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
6.485SerAla: 6.485 ± 0.068
0.506SerCys: 0.506 ± 0.02
3.521SerAsp: 3.521 ± 0.05
3.232SerGlu: 3.232 ± 0.049
2.548SerPhe: 2.548 ± 0.045
6.296SerGly: 6.296 ± 0.076
1.237SerHis: 1.237 ± 0.026
3.338SerIle: 3.338 ± 0.046
2.02SerLys: 2.02 ± 0.042
5.675SerLeu: 5.675 ± 0.071
1.631SerMet: 1.631 ± 0.032
1.705SerAsn: 1.705 ± 0.037
2.749SerPro: 2.749 ± 0.044
1.757SerGln: 1.757 ± 0.036
3.65SerArg: 3.65 ± 0.058
3.373SerSer: 3.373 ± 0.056
2.956SerThr: 2.956 ± 0.042
4.423SerVal: 4.423 ± 0.06
0.786SerTrp: 0.786 ± 0.023
1.441SerTyr: 1.441 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
6.272ThrAla: 6.272 ± 0.066
0.46ThrCys: 0.46 ± 0.018
3.221ThrAsp: 3.221 ± 0.05
2.926ThrGlu: 2.926 ± 0.052
1.985ThrPhe: 1.985 ± 0.035
5.533ThrGly: 5.533 ± 0.066
1.037ThrHis: 1.037 ± 0.027
3.132ThrIle: 3.132 ± 0.044
1.727ThrLys: 1.727 ± 0.038
5.659ThrLeu: 5.659 ± 0.065
1.391ThrMet: 1.391 ± 0.031
1.44ThrAsn: 1.44 ± 0.034
3.211ThrPro: 3.211 ± 0.053
1.489ThrGln: 1.489 ± 0.029
3.218ThrArg: 3.218 ± 0.046
3.129ThrSer: 3.129 ± 0.05
2.972ThrThr: 2.972 ± 0.045
4.446ThrVal: 4.446 ± 0.066
0.655ThrTrp: 0.655 ± 0.022
1.207ThrTyr: 1.207 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
8.468ValAla: 8.468 ± 0.08
0.649ValCys: 0.649 ± 0.023
4.198ValAsp: 4.198 ± 0.053
4.405ValGlu: 4.405 ± 0.059
3.062ValPhe: 3.062 ± 0.045
5.247ValGly: 5.247 ± 0.068
1.388ValHis: 1.388 ± 0.032
4.491ValIle: 4.491 ± 0.057
2.31ValLys: 2.31 ± 0.045
7.3ValLeu: 7.3 ± 0.097
2.112ValMet: 2.112 ± 0.04
2.038ValAsn: 2.038 ± 0.035
3.504ValPro: 3.504 ± 0.048
1.879ValGln: 1.879 ± 0.037
4.464ValArg: 4.464 ± 0.053
4.913ValSer: 4.913 ± 0.063
4.614ValThr: 4.614 ± 0.058
5.562ValVal: 5.562 ± 0.069
0.94ValTrp: 0.94 ± 0.026
1.504ValTyr: 1.504 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.156TrpAla: 1.156 ± 0.028
0.141TrpCys: 0.141 ± 0.01
0.681TrpAsp: 0.681 ± 0.023
0.551TrpGlu: 0.551 ± 0.022
0.597TrpPhe: 0.597 ± 0.019
0.862TrpGly: 0.862 ± 0.026
0.322TrpHis: 0.322 ± 0.014
0.717TrpIle: 0.717 ± 0.024
0.507TrpLys: 0.507 ± 0.019
1.59TrpLeu: 1.59 ± 0.036
0.394TrpMet: 0.394 ± 0.016
0.455TrpAsn: 0.455 ± 0.018
0.688TrpPro: 0.688 ± 0.022
0.551TrpGln: 0.551 ± 0.02
0.984TrpArg: 0.984 ± 0.027
0.841TrpSer: 0.841 ± 0.026
0.787TrpThr: 0.787 ± 0.024
0.815TrpVal: 0.815 ± 0.027
0.212TrpTrp: 0.212 ± 0.013
0.302TrpTyr: 0.302 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.374TyrAla: 2.374 ± 0.045
0.259TyrCys: 0.259 ± 0.013
1.529TyrAsp: 1.529 ± 0.033
1.251TyrGlu: 1.251 ± 0.029
0.978TyrPhe: 0.978 ± 0.029
2.05TyrGly: 2.05 ± 0.038
0.486TyrHis: 0.486 ± 0.017
0.979TyrIle: 0.979 ± 0.027
0.704TyrLys: 0.704 ± 0.021
2.283TyrLeu: 2.283 ± 0.041
0.509TyrMet: 0.509 ± 0.018
0.663TyrAsn: 0.663 ± 0.024
1.121TyrPro: 1.121 ± 0.03
0.756TyrGln: 0.756 ± 0.023
1.598TyrArg: 1.598 ± 0.033
1.412TyrSer: 1.412 ± 0.032
1.179TyrThr: 1.179 ± 0.028
1.602TyrVal: 1.602 ± 0.031
0.342TyrTrp: 0.342 ± 0.017
0.624TyrTyr: 0.624 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4739 proteins (1486412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski