Amino acid dipepetide frequency for Pepper golden mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.849AlaAla: 2.849 ± 1.252
0.712AlaCys: 0.712 ± 0.722
0.712AlaAsp: 0.712 ± 0.658
2.137AlaGlu: 2.137 ± 1.167
2.137AlaPhe: 2.137 ± 0.809
3.561AlaGly: 3.561 ± 1.388
1.425AlaHis: 1.425 ± 0.711
2.849AlaIle: 2.849 ± 2.079
3.561AlaLys: 3.561 ± 1.028
4.986AlaLeu: 4.986 ± 1.733
0.0AlaMet: 0.0 ± 0.0
4.274AlaAsn: 4.274 ± 1.376
3.561AlaPro: 3.561 ± 0.818
4.986AlaGln: 4.986 ± 2.199
4.274AlaArg: 4.274 ± 1.428
9.259AlaSer: 9.259 ± 2.649
2.137AlaThr: 2.137 ± 1.429
2.849AlaVal: 2.849 ± 1.69
1.425AlaTrp: 1.425 ± 0.755
0.712AlaTyr: 0.712 ± 0.722
0.0AlaXaa: 0.0 ± 0.0
Cys
2.137CysAla: 2.137 ± 1.311
0.0CysCys: 0.0 ± 0.0
0.712CysAsp: 0.712 ± 0.577
1.425CysGlu: 1.425 ± 0.755
0.0CysPhe: 0.0 ± 0.0
1.425CysGly: 1.425 ± 0.775
0.0CysHis: 0.0 ± 0.0
1.425CysIle: 1.425 ± 0.839
2.849CysLys: 2.849 ± 1.052
0.712CysLeu: 0.712 ± 0.577
0.712CysMet: 0.712 ± 0.6
3.561CysAsn: 3.561 ± 1.185
0.712CysPro: 0.712 ± 0.658
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.712CysSer: 0.712 ± 0.652
1.425CysThr: 1.425 ± 0.853
1.425CysVal: 1.425 ± 0.839
1.425CysTrp: 1.425 ± 1.316
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.137AspAla: 2.137 ± 1.133
0.0AspCys: 0.0 ± 0.0
3.561AspAsp: 3.561 ± 2.052
2.849AspGlu: 2.849 ± 0.481
2.849AspPhe: 2.849 ± 0.698
2.137AspGly: 2.137 ± 1.116
0.712AspHis: 0.712 ± 0.6
6.41AspIle: 6.41 ± 1.701
1.425AspLys: 1.425 ± 0.826
4.274AspLeu: 4.274 ± 1.322
0.712AspMet: 0.712 ± 0.577
1.425AspAsn: 1.425 ± 0.839
2.849AspPro: 2.849 ± 1.224
0.712AspGln: 0.712 ± 0.6
3.561AspArg: 3.561 ± 1.467
4.986AspSer: 4.986 ± 1.08
2.849AspThr: 2.849 ± 1.375
4.986AspVal: 4.986 ± 1.601
0.712AspTrp: 0.712 ± 0.577
1.425AspTyr: 1.425 ± 0.719
0.0AspXaa: 0.0 ± 0.0
Glu
2.849GluAla: 2.849 ± 1.054
0.712GluCys: 0.712 ± 0.6
1.425GluAsp: 1.425 ± 0.729
2.137GluGlu: 2.137 ± 1.116
1.425GluPhe: 1.425 ± 0.954
3.561GluGly: 3.561 ± 1.234
2.137GluHis: 2.137 ± 0.909
2.137GluIle: 2.137 ± 1.299
0.712GluLys: 0.712 ± 0.658
3.561GluLeu: 3.561 ± 1.875
0.712GluMet: 0.712 ± 0.577
4.986GluAsn: 4.986 ± 1.896
1.425GluPro: 1.425 ± 0.853
1.425GluGln: 1.425 ± 1.445
2.137GluArg: 2.137 ± 0.634
3.561GluSer: 3.561 ± 1.75
0.0GluThr: 0.0 ± 0.0
1.425GluVal: 1.425 ± 0.905
0.0GluTrp: 0.0 ± 0.0
3.561GluTyr: 3.561 ± 1.185
0.0GluXaa: 0.0 ± 0.0
Phe
1.425PheAla: 1.425 ± 0.817
0.712PheCys: 0.712 ± 0.722
2.849PheAsp: 2.849 ± 0.798
0.712PheGlu: 0.712 ± 0.722
2.137PhePhe: 2.137 ± 0.809
2.137PheGly: 2.137 ± 0.718
0.712PheHis: 0.712 ± 0.577
2.137PheIle: 2.137 ± 0.85
4.274PheLys: 4.274 ± 2.094
2.849PheLeu: 2.849 ± 1.294
0.0PheMet: 0.0 ± 0.0
4.274PheAsn: 4.274 ± 0.539
2.849PhePro: 2.849 ± 1.173
2.849PheGln: 2.849 ± 1.179
3.561PheArg: 3.561 ± 1.43
4.274PheSer: 4.274 ± 2.15
2.137PheThr: 2.137 ± 1.001
2.137PheVal: 2.137 ± 1.244
2.137PheTrp: 2.137 ± 1.455
1.425PheTyr: 1.425 ± 0.866
0.0PheXaa: 0.0 ± 0.0
Gly
2.137GlyAla: 2.137 ± 0.85
1.425GlyCys: 1.425 ± 0.954
2.849GlyAsp: 2.849 ± 1.681
3.561GlyGlu: 3.561 ± 1.21
1.425GlyPhe: 1.425 ± 0.775
3.561GlyGly: 3.561 ± 1.399
0.712GlyHis: 0.712 ± 0.577
2.849GlyIle: 2.849 ± 0.914
6.41GlyLys: 6.41 ± 2.343
2.137GlyLeu: 2.137 ± 1.801
0.712GlyMet: 0.712 ± 0.843
1.425GlyAsn: 1.425 ± 0.853
4.986GlyPro: 4.986 ± 0.987
2.849GlyGln: 2.849 ± 1.294
2.137GlyArg: 2.137 ± 0.909
3.561GlySer: 3.561 ± 0.931
4.274GlyThr: 4.274 ± 1.92
2.849GlyVal: 2.849 ± 2.633
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
2.137HisAla: 2.137 ± 0.718
2.137HisCys: 2.137 ± 0.792
2.849HisAsp: 2.849 ± 1.111
2.137HisGlu: 2.137 ± 0.911
1.425HisPhe: 1.425 ± 0.817
0.712HisGly: 0.712 ± 0.658
0.712HisHis: 0.712 ± 0.652
1.425HisIle: 1.425 ± 0.998
0.712HisLys: 0.712 ± 0.606
2.137HisLeu: 2.137 ± 1.116
0.0HisMet: 0.0 ± 0.0
4.274HisAsn: 4.274 ± 1.418
2.137HisPro: 2.137 ± 1.157
3.561HisGln: 3.561 ± 1.329
4.274HisArg: 4.274 ± 2.066
2.849HisSer: 2.849 ± 1.009
2.849HisThr: 2.849 ± 1.427
2.849HisVal: 2.849 ± 0.86
1.425HisTrp: 1.425 ± 1.154
0.712HisTyr: 0.712 ± 0.6
0.0HisXaa: 0.0 ± 0.0
Ile
1.425IleAla: 1.425 ± 0.775
0.0IleCys: 0.0 ± 0.0
2.849IleAsp: 2.849 ± 1.173
4.986IleGlu: 4.986 ± 1.637
2.849IlePhe: 2.849 ± 1.921
1.425IleGly: 1.425 ± 0.729
2.137IleHis: 2.137 ± 1.232
0.712IleIle: 0.712 ± 0.577
6.41IleLys: 6.41 ± 1.826
2.137IleLeu: 2.137 ± 0.634
0.0IleMet: 0.0 ± 0.0
2.849IleAsn: 2.849 ± 1.164
4.274IlePro: 4.274 ± 1.584
1.425IleGln: 1.425 ± 0.729
2.849IleArg: 2.849 ± 1.039
4.986IleSer: 4.986 ± 1.104
6.41IleThr: 6.41 ± 0.979
4.986IleVal: 4.986 ± 1.488
1.425IleTrp: 1.425 ± 0.826
2.849IleTyr: 2.849 ± 1.279
0.0IleXaa: 0.0 ± 0.0
Lys
4.986LysAla: 4.986 ± 1.331
1.425LysCys: 1.425 ± 0.729
7.123LysAsp: 7.123 ± 3.107
1.425LysGlu: 1.425 ± 1.154
2.137LysPhe: 2.137 ± 0.897
2.137LysGly: 2.137 ± 0.634
1.425LysHis: 1.425 ± 0.719
4.986LysIle: 4.986 ± 1.901
0.712LysLys: 0.712 ± 0.652
3.561LysLeu: 3.561 ± 1.137
2.137LysMet: 2.137 ± 0.811
4.274LysAsn: 4.274 ± 1.604
2.849LysPro: 2.849 ± 0.985
0.712LysGln: 0.712 ± 0.6
5.698LysArg: 5.698 ± 3.306
4.986LysSer: 4.986 ± 0.549
2.137LysThr: 2.137 ± 1.116
5.698LysVal: 5.698 ± 3.261
0.712LysTrp: 0.712 ± 0.577
1.425LysTyr: 1.425 ± 0.755
0.0LysXaa: 0.0 ± 0.0
Leu
2.137LeuAla: 2.137 ± 0.911
0.712LeuCys: 0.712 ± 0.577
2.849LeuAsp: 2.849 ± 1.136
3.561LeuGlu: 3.561 ± 1.152
2.137LeuPhe: 2.137 ± 1.209
4.274LeuGly: 4.274 ± 0.593
6.41LeuHis: 6.41 ± 1.961
2.137LeuIle: 2.137 ± 1.116
7.123LeuLys: 7.123 ± 1.226
1.425LeuLeu: 1.425 ± 1.445
0.712LeuMet: 0.712 ± 0.722
2.849LeuAsn: 2.849 ± 1.261
1.425LeuPro: 1.425 ± 0.775
3.561LeuGln: 3.561 ± 2.322
4.986LeuArg: 4.986 ± 1.49
7.835LeuSer: 7.835 ± 2.406
3.561LeuThr: 3.561 ± 1.875
3.561LeuVal: 3.561 ± 1.528
0.0LeuTrp: 0.0 ± 0.0
3.561LeuTyr: 3.561 ± 1.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.849MetAla: 2.849 ± 1.333
0.712MetCys: 0.712 ± 0.722
2.849MetAsp: 2.849 ± 1.427
0.712MetGlu: 0.712 ± 0.6
0.712MetPhe: 0.712 ± 0.722
0.712MetGly: 0.712 ± 0.722
1.425MetHis: 1.425 ± 0.839
0.0MetIle: 0.0 ± 0.0
1.425MetLys: 1.425 ± 0.719
2.137MetLeu: 2.137 ± 1.001
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.425MetPro: 1.425 ± 1.154
0.712MetGln: 0.712 ± 0.577
0.0MetArg: 0.0 ± 0.0
2.849MetSer: 2.849 ± 1.422
1.425MetThr: 1.425 ± 0.817
1.425MetVal: 1.425 ± 0.853
0.712MetTrp: 0.712 ± 0.577
2.137MetTyr: 2.137 ± 1.437
0.0MetXaa: 0.0 ± 0.0
Asn
7.123AsnAla: 7.123 ± 2.74
3.561AsnCys: 3.561 ± 1.256
2.137AsnAsp: 2.137 ± 0.787
3.561AsnGlu: 3.561 ± 1.488
0.0AsnPhe: 0.0 ± 0.0
2.137AsnGly: 2.137 ± 1.003
3.561AsnHis: 3.561 ± 2.22
5.698AsnIle: 5.698 ± 1.723
2.137AsnLys: 2.137 ± 1.116
2.137AsnLeu: 2.137 ± 0.85
2.137AsnMet: 2.137 ± 1.376
3.561AsnAsn: 3.561 ± 0.79
2.849AsnPro: 2.849 ± 0.712
2.137AsnGln: 2.137 ± 1.504
1.425AsnArg: 1.425 ± 0.853
2.849AsnSer: 2.849 ± 1.039
0.0AsnThr: 0.0 ± 0.0
3.561AsnVal: 3.561 ± 1.621
0.0AsnTrp: 0.0 ± 0.0
5.698AsnTyr: 5.698 ± 1.078
0.0AsnXaa: 0.0 ± 0.0
Pro
0.712ProAla: 0.712 ± 0.6
0.712ProCys: 0.712 ± 0.722
1.425ProAsp: 1.425 ± 0.755
1.425ProGlu: 1.425 ± 0.712
1.425ProPhe: 1.425 ± 0.793
2.137ProGly: 2.137 ± 1.192
2.849ProHis: 2.849 ± 1.186
5.698ProIle: 5.698 ± 2.345
4.986ProLys: 4.986 ± 1.207
3.561ProLeu: 3.561 ± 1.857
2.137ProMet: 2.137 ± 1.36
2.137ProAsn: 2.137 ± 0.85
2.849ProPro: 2.849 ± 1.717
2.849ProGln: 2.849 ± 1.55
1.425ProArg: 1.425 ± 0.755
6.41ProSer: 6.41 ± 2.196
1.425ProThr: 1.425 ± 0.793
3.561ProVal: 3.561 ± 1.269
2.137ProTrp: 2.137 ± 0.758
2.849ProTyr: 2.849 ± 0.481
0.0ProXaa: 0.0 ± 0.0
Gln
2.849GlnAla: 2.849 ± 0.712
1.425GlnCys: 1.425 ± 1.154
2.137GlnAsp: 2.137 ± 1.311
0.712GlnGlu: 0.712 ± 0.722
2.849GlnPhe: 2.849 ± 1.437
0.712GlnGly: 0.712 ± 0.652
2.137GlnHis: 2.137 ± 1.001
0.712GlnIle: 0.712 ± 0.577
0.712GlnLys: 0.712 ± 0.577
4.274GlnLeu: 4.274 ± 2.1
0.712GlnMet: 0.712 ± 0.561
0.712GlnAsn: 0.712 ± 0.652
2.849GlnPro: 2.849 ± 1.414
0.712GlnGln: 0.712 ± 0.6
4.986GlnArg: 4.986 ± 1.962
2.137GlnSer: 2.137 ± 0.718
0.0GlnThr: 0.0 ± 0.0
4.274GlnVal: 4.274 ± 1.438
0.712GlnTrp: 0.712 ± 0.6
2.849GlnTyr: 2.849 ± 0.985
0.0GlnXaa: 0.0 ± 0.0
Arg
4.274ArgAla: 4.274 ± 1.618
1.425ArgCys: 1.425 ± 0.719
3.561ArgAsp: 3.561 ± 2.25
2.137ArgGlu: 2.137 ± 0.792
7.835ArgPhe: 7.835 ± 2.749
2.849ArgGly: 2.849 ± 1.732
1.425ArgHis: 1.425 ± 0.853
4.986ArgIle: 4.986 ± 2.293
2.137ArgLys: 2.137 ± 0.787
4.274ArgLeu: 4.274 ± 0.877
0.712ArgMet: 0.712 ± 0.6
2.137ArgAsn: 2.137 ± 1.244
4.274ArgPro: 4.274 ± 1.219
0.712ArgGln: 0.712 ± 0.6
7.835ArgArg: 7.835 ± 3.03
7.123ArgSer: 7.123 ± 1.261
4.274ArgThr: 4.274 ± 1.445
5.698ArgVal: 5.698 ± 1.391
0.0ArgTrp: 0.0 ± 0.0
1.425ArgTyr: 1.425 ± 1.316
0.712ArgXaa: 0.712 ± 0.722
Ser
5.698SerAla: 5.698 ± 2.211
1.425SerCys: 1.425 ± 0.719
2.849SerAsp: 2.849 ± 0.481
0.0SerGlu: 0.0 ± 0.0
4.274SerPhe: 4.274 ± 0.562
6.41SerGly: 6.41 ± 0.996
4.274SerHis: 4.274 ± 2.15
5.698SerIle: 5.698 ± 2.05
5.698SerLys: 5.698 ± 0.669
4.986SerLeu: 4.986 ± 2.159
2.849SerMet: 2.849 ± 1.245
6.41SerAsn: 6.41 ± 1.2
3.561SerPro: 3.561 ± 1.864
2.849SerGln: 2.849 ± 1.422
7.835SerArg: 7.835 ± 1.681
9.259SerSer: 9.259 ± 3.278
6.41SerThr: 6.41 ± 1.531
4.274SerVal: 4.274 ± 1.603
1.425SerTrp: 1.425 ± 1.201
3.561SerTyr: 3.561 ± 1.446
0.0SerXaa: 0.0 ± 0.0
Thr
4.986ThrAla: 4.986 ± 1.537
0.712ThrCys: 0.712 ± 0.658
1.425ThrAsp: 1.425 ± 0.817
1.425ThrGlu: 1.425 ± 0.839
4.274ThrPhe: 4.274 ± 2.293
3.561ThrGly: 3.561 ± 1.184
3.561ThrHis: 3.561 ± 1.18
0.0ThrIle: 0.0 ± 0.0
0.712ThrLys: 0.712 ± 0.577
2.849ThrLeu: 2.849 ± 0.914
1.425ThrMet: 1.425 ± 0.719
2.137ThrAsn: 2.137 ± 1.445
2.849ThrPro: 2.849 ± 1.632
0.712ThrGln: 0.712 ± 0.658
2.849ThrArg: 2.849 ± 1.349
4.986ThrSer: 4.986 ± 1.908
3.561ThrThr: 3.561 ± 1.203
5.698ThrVal: 5.698 ± 1.971
0.0ThrTrp: 0.0 ± 0.0
2.137ThrTyr: 2.137 ± 0.75
0.0ThrXaa: 0.0 ± 0.0
Val
1.425ValAla: 1.425 ± 0.712
0.712ValCys: 0.712 ± 0.658
3.561ValAsp: 3.561 ± 1.802
2.849ValGlu: 2.849 ± 0.747
3.561ValPhe: 3.561 ± 1.988
4.274ValGly: 4.274 ± 1.835
3.561ValHis: 3.561 ± 1.39
4.986ValIle: 4.986 ± 1.488
5.698ValLys: 5.698 ± 1.593
7.123ValLeu: 7.123 ± 2.038
4.986ValMet: 4.986 ± 2.519
3.561ValAsn: 3.561 ± 1.171
2.849ValPro: 2.849 ± 0.712
3.561ValGln: 3.561 ± 0.966
4.274ValArg: 4.274 ± 1.53
4.986ValSer: 4.986 ± 1.207
1.425ValThr: 1.425 ± 1.445
3.561ValVal: 3.561 ± 0.923
0.712ValTrp: 0.712 ± 0.606
4.274ValTyr: 4.274 ± 1.436
0.0ValXaa: 0.0 ± 0.0
Trp
2.137TrpAla: 2.137 ± 1.157
0.0TrpCys: 0.0 ± 0.0
0.712TrpAsp: 0.712 ± 0.652
1.425TrpGlu: 1.425 ± 0.817
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.425TrpLys: 1.425 ± 0.755
0.712TrpLeu: 0.712 ± 0.722
1.425TrpMet: 1.425 ± 0.853
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.712TrpGln: 0.712 ± 0.577
1.425TrpArg: 1.425 ± 0.839
0.712TrpSer: 0.712 ± 0.658
2.849TrpThr: 2.849 ± 1.144
1.425TrpVal: 1.425 ± 0.755
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.137TyrAla: 2.137 ± 1.437
1.425TyrCys: 1.425 ± 0.712
2.137TyrAsp: 2.137 ± 1.437
0.712TyrGlu: 0.712 ± 0.722
2.137TyrPhe: 2.137 ± 0.758
2.849TyrGly: 2.849 ± 0.481
2.137TyrHis: 2.137 ± 1.167
2.137TyrIle: 2.137 ± 1.116
1.425TyrLys: 1.425 ± 1.154
4.986TyrLeu: 4.986 ± 1.834
1.425TyrMet: 1.425 ± 0.801
1.425TyrAsn: 1.425 ± 0.755
2.137TyrPro: 2.137 ± 1.116
1.425TyrGln: 1.425 ± 0.711
4.274TyrArg: 4.274 ± 2.516
1.425TyrSer: 1.425 ± 0.755
0.712TyrThr: 0.712 ± 0.658
5.698TyrVal: 5.698 ± 2.005
0.0TyrTrp: 0.0 ± 0.0
2.137TyrTyr: 2.137 ± 1.232
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.712XaaCys: 0.712 ± 0.722
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski