Amino acid dipepetide frequency for Mycobacterium phage Henu3 PeY-2017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.932AlaAla: 12.932 ± 1.54
1.002AlaCys: 1.002 ± 0.2
5.869AlaAsp: 5.869 ± 0.474
5.726AlaGlu: 5.726 ± 0.614
3.34AlaPhe: 3.34 ± 0.412
9.544AlaGly: 9.544 ± 1.09
2.243AlaHis: 2.243 ± 0.354
3.483AlaIle: 3.483 ± 0.517
3.388AlaLys: 3.388 ± 0.412
7.349AlaLeu: 7.349 ± 0.772
2.291AlaMet: 2.291 ± 0.276
2.577AlaAsn: 2.577 ± 0.345
4.82AlaPro: 4.82 ± 0.748
3.149AlaGln: 3.149 ± 0.458
6.776AlaArg: 6.776 ± 0.774
6.681AlaSer: 6.681 ± 0.744
5.917AlaThr: 5.917 ± 0.602
6.681AlaVal: 6.681 ± 0.534
2.195AlaTrp: 2.195 ± 0.351
1.956AlaTyr: 1.956 ± 0.325
0.0AlaXaa: 0.0 ± 0.0
Cys
1.336CysAla: 1.336 ± 0.295
0.286CysCys: 0.286 ± 0.149
0.811CysAsp: 0.811 ± 0.247
0.716CysGlu: 0.716 ± 0.172
0.382CysPhe: 0.382 ± 0.131
2.243CysGly: 2.243 ± 0.423
0.429CysHis: 0.429 ± 0.127
0.239CysIle: 0.239 ± 0.118
0.573CysLys: 0.573 ± 0.183
0.954CysLeu: 0.954 ± 0.231
0.095CysMet: 0.095 ± 0.069
0.477CysAsn: 0.477 ± 0.146
1.766CysPro: 1.766 ± 0.358
0.429CysGln: 0.429 ± 0.172
1.288CysArg: 1.288 ± 0.272
1.288CysSer: 1.288 ± 0.344
0.954CysThr: 0.954 ± 0.262
0.716CysVal: 0.716 ± 0.191
0.334CysTrp: 0.334 ± 0.118
0.143CysTyr: 0.143 ± 0.09
0.0CysXaa: 0.0 ± 0.0
Asp
5.392AspAla: 5.392 ± 0.516
0.811AspCys: 0.811 ± 0.164
3.436AspAsp: 3.436 ± 0.521
2.529AspGlu: 2.529 ± 0.37
1.336AspPhe: 1.336 ± 0.256
5.488AspGly: 5.488 ± 0.476
1.384AspHis: 1.384 ± 0.262
1.813AspIle: 1.813 ± 0.304
1.098AspLys: 1.098 ± 0.217
5.01AspLeu: 5.01 ± 0.504
0.907AspMet: 0.907 ± 0.195
1.766AspAsn: 1.766 ± 0.389
4.199AspPro: 4.199 ± 0.503
2.291AspGln: 2.291 ± 0.31
5.297AspArg: 5.297 ± 0.563
3.054AspSer: 3.054 ± 0.485
3.388AspThr: 3.388 ± 0.35
4.438AspVal: 4.438 ± 0.615
1.098AspTrp: 1.098 ± 0.218
1.288AspTyr: 1.288 ± 0.255
0.0AspXaa: 0.0 ± 0.0
Glu
4.104GluAla: 4.104 ± 0.44
0.62GluCys: 0.62 ± 0.157
2.625GluAsp: 2.625 ± 0.3
2.147GluGlu: 2.147 ± 0.423
1.432GluPhe: 1.432 ± 0.271
3.388GluGly: 3.388 ± 0.351
1.718GluHis: 1.718 ± 0.347
1.766GluIle: 1.766 ± 0.278
1.193GluLys: 1.193 ± 0.24
5.058GluLeu: 5.058 ± 0.486
1.002GluMet: 1.002 ± 0.215
1.861GluAsn: 1.861 ± 0.251
3.102GluPro: 3.102 ± 0.41
2.147GluGln: 2.147 ± 0.374
4.295GluArg: 4.295 ± 0.544
3.102GluSer: 3.102 ± 0.51
3.674GluThr: 3.674 ± 0.499
2.863GluVal: 2.863 ± 0.414
1.002GluTrp: 1.002 ± 0.193
1.432GluTyr: 1.432 ± 0.305
0.0GluXaa: 0.0 ± 0.0
Phe
2.863PheAla: 2.863 ± 0.375
0.286PheCys: 0.286 ± 0.127
2.291PheAsp: 2.291 ± 0.407
1.67PheGlu: 1.67 ± 0.261
1.002PhePhe: 1.002 ± 0.244
2.863PheGly: 2.863 ± 0.628
0.668PheHis: 0.668 ± 0.205
1.288PheIle: 1.288 ± 0.332
0.859PheLys: 0.859 ± 0.215
2.291PheLeu: 2.291 ± 0.321
0.573PheMet: 0.573 ± 0.171
1.241PheAsn: 1.241 ± 0.299
1.956PhePro: 1.956 ± 0.305
1.193PheGln: 1.193 ± 0.258
2.147PheArg: 2.147 ± 0.326
1.766PheSer: 1.766 ± 0.268
1.956PheThr: 1.956 ± 0.308
1.956PheVal: 1.956 ± 0.27
0.668PheTrp: 0.668 ± 0.152
0.573PheTyr: 0.573 ± 0.191
0.0PheXaa: 0.0 ± 0.0
Gly
8.446GlyAla: 8.446 ± 0.869
1.432GlyCys: 1.432 ± 0.318
4.724GlyAsp: 4.724 ± 0.446
3.579GlyGlu: 3.579 ± 0.444
2.815GlyPhe: 2.815 ± 0.398
8.971GlyGly: 8.971 ± 1.659
2.625GlyHis: 2.625 ± 0.383
3.913GlyIle: 3.913 ± 0.596
1.813GlyLys: 1.813 ± 0.28
5.822GlyLeu: 5.822 ± 0.584
2.052GlyMet: 2.052 ± 0.447
3.627GlyAsn: 3.627 ± 0.369
4.581GlyPro: 4.581 ± 0.703
2.243GlyGln: 2.243 ± 0.432
6.06GlyArg: 6.06 ± 0.649
6.347GlySer: 6.347 ± 0.691
6.203GlyThr: 6.203 ± 0.666
6.585GlyVal: 6.585 ± 0.625
2.1GlyTrp: 2.1 ± 0.331
1.575GlyTyr: 1.575 ± 0.273
0.0GlyXaa: 0.0 ± 0.0
His
2.338HisAla: 2.338 ± 0.436
0.811HisCys: 0.811 ± 0.247
1.288HisAsp: 1.288 ± 0.218
1.241HisGlu: 1.241 ± 0.228
0.477HisPhe: 0.477 ± 0.138
1.67HisGly: 1.67 ± 0.297
1.67HisHis: 1.67 ± 0.375
1.384HisIle: 1.384 ± 0.282
1.05HisLys: 1.05 ± 0.223
2.291HisLeu: 2.291 ± 0.425
0.525HisMet: 0.525 ± 0.166
0.573HisAsn: 0.573 ± 0.162
2.529HisPro: 2.529 ± 0.42
1.336HisGln: 1.336 ± 0.305
3.865HisArg: 3.865 ± 0.752
1.241HisSer: 1.241 ± 0.227
2.386HisThr: 2.386 ± 0.451
2.004HisVal: 2.004 ± 0.4
0.573HisTrp: 0.573 ± 0.148
0.62HisTyr: 0.62 ± 0.178
0.0HisXaa: 0.0 ± 0.0
Ile
4.247IleAla: 4.247 ± 0.51
0.573IleCys: 0.573 ± 0.151
3.006IleAsp: 3.006 ± 0.401
2.529IleGlu: 2.529 ± 0.371
0.716IlePhe: 0.716 ± 0.22
3.818IleGly: 3.818 ± 0.452
1.527IleHis: 1.527 ± 0.374
1.241IleIle: 1.241 ± 0.277
1.145IleLys: 1.145 ± 0.247
2.052IleLeu: 2.052 ± 0.345
0.573IleMet: 0.573 ± 0.231
2.004IleAsn: 2.004 ± 0.281
2.72IlePro: 2.72 ± 0.337
1.145IleGln: 1.145 ± 0.22
2.911IleArg: 2.911 ± 0.456
2.147IleSer: 2.147 ± 0.415
2.959IleThr: 2.959 ± 0.352
2.768IleVal: 2.768 ± 0.386
0.716IleTrp: 0.716 ± 0.202
0.573IleTyr: 0.573 ± 0.148
0.0IleXaa: 0.0 ± 0.0
Lys
3.197LysAla: 3.197 ± 0.541
0.382LysCys: 0.382 ± 0.128
1.145LysAsp: 1.145 ± 0.248
1.241LysGlu: 1.241 ± 0.244
0.907LysPhe: 0.907 ± 0.165
2.147LysGly: 2.147 ± 0.348
0.764LysHis: 0.764 ± 0.212
0.907LysIle: 0.907 ± 0.278
1.098LysLys: 1.098 ± 0.312
2.195LysLeu: 2.195 ± 0.344
0.382LysMet: 0.382 ± 0.119
0.716LysAsn: 0.716 ± 0.193
2.1LysPro: 2.1 ± 0.342
1.622LysGln: 1.622 ± 0.267
1.622LysArg: 1.622 ± 0.283
1.766LysSer: 1.766 ± 0.281
1.956LysThr: 1.956 ± 0.319
1.67LysVal: 1.67 ± 0.288
0.764LysTrp: 0.764 ± 0.228
0.716LysTyr: 0.716 ± 0.2
0.0LysXaa: 0.0 ± 0.0
Leu
7.396LeuAla: 7.396 ± 0.77
0.907LeuCys: 0.907 ± 0.207
4.104LeuAsp: 4.104 ± 0.436
3.483LeuGlu: 3.483 ± 0.401
2.291LeuPhe: 2.291 ± 0.296
4.772LeuGly: 4.772 ± 0.493
2.243LeuHis: 2.243 ± 0.42
2.815LeuIle: 2.815 ± 0.375
2.004LeuLys: 2.004 ± 0.347
5.583LeuLeu: 5.583 ± 0.612
1.861LeuMet: 1.861 ± 0.297
3.293LeuAsn: 3.293 ± 0.405
6.347LeuPro: 6.347 ± 0.676
2.863LeuGln: 2.863 ± 0.381
7.73LeuArg: 7.73 ± 0.953
5.488LeuSer: 5.488 ± 0.547
4.867LeuThr: 4.867 ± 0.571
5.488LeuVal: 5.488 ± 0.492
0.907LeuTrp: 0.907 ± 0.225
1.718LeuTyr: 1.718 ± 0.33
0.0LeuXaa: 0.0 ± 0.0
Met
2.004MetAla: 2.004 ± 0.286
0.143MetCys: 0.143 ± 0.092
0.716MetAsp: 0.716 ± 0.205
1.002MetGlu: 1.002 ± 0.186
0.811MetPhe: 0.811 ± 0.27
1.813MetGly: 1.813 ± 0.278
0.095MetHis: 0.095 ± 0.067
0.668MetIle: 0.668 ± 0.166
0.573MetLys: 0.573 ± 0.169
2.1MetLeu: 2.1 ± 0.273
0.573MetMet: 0.573 ± 0.206
0.477MetAsn: 0.477 ± 0.153
1.718MetPro: 1.718 ± 0.28
0.477MetGln: 0.477 ± 0.164
1.622MetArg: 1.622 ± 0.315
2.386MetSer: 2.386 ± 0.379
1.575MetThr: 1.575 ± 0.28
1.527MetVal: 1.527 ± 0.29
0.477MetTrp: 0.477 ± 0.179
0.239MetTyr: 0.239 ± 0.1
0.0MetXaa: 0.0 ± 0.0
Asn
3.293AsnAla: 3.293 ± 0.437
0.573AsnCys: 0.573 ± 0.169
1.956AsnAsp: 1.956 ± 0.298
1.718AsnGlu: 1.718 ± 0.302
1.05AsnPhe: 1.05 ± 0.268
3.483AsnGly: 3.483 ± 0.495
0.954AsnHis: 0.954 ± 0.2
1.622AsnIle: 1.622 ± 0.432
0.907AsnLys: 0.907 ± 0.213
2.291AsnLeu: 2.291 ± 0.356
0.477AsnMet: 0.477 ± 0.141
1.67AsnAsn: 1.67 ± 0.292
3.34AsnPro: 3.34 ± 0.491
1.002AsnGln: 1.002 ± 0.255
2.911AsnArg: 2.911 ± 0.483
2.291AsnSer: 2.291 ± 0.411
1.813AsnThr: 1.813 ± 0.326
1.956AsnVal: 1.956 ± 0.267
0.764AsnTrp: 0.764 ± 0.202
0.764AsnTyr: 0.764 ± 0.19
0.0AsnXaa: 0.0 ± 0.0
Pro
5.44ProAla: 5.44 ± 0.654
1.098ProCys: 1.098 ± 0.262
4.008ProAsp: 4.008 ± 0.43
3.77ProGlu: 3.77 ± 0.443
2.1ProPhe: 2.1 ± 0.362
6.681ProGly: 6.681 ± 0.661
2.052ProHis: 2.052 ± 0.346
2.291ProIle: 2.291 ± 0.323
1.956ProLys: 1.956 ± 0.313
5.631ProLeu: 5.631 ± 0.533
1.336ProMet: 1.336 ± 0.281
2.291ProAsn: 2.291 ± 0.388
5.774ProPro: 5.774 ± 0.77
2.815ProGln: 2.815 ± 0.38
4.82ProArg: 4.82 ± 0.615
4.629ProSer: 4.629 ± 0.479
4.963ProThr: 4.963 ± 0.623
4.676ProVal: 4.676 ± 0.471
1.05ProTrp: 1.05 ± 0.231
1.479ProTyr: 1.479 ± 0.245
0.0ProXaa: 0.0 ± 0.0
Gln
3.722GlnAla: 3.722 ± 0.551
0.477GlnCys: 0.477 ± 0.149
1.241GlnAsp: 1.241 ± 0.223
1.336GlnGlu: 1.336 ± 0.298
1.145GlnPhe: 1.145 ± 0.203
2.052GlnGly: 2.052 ± 0.423
1.527GlnHis: 1.527 ± 0.363
1.813GlnIle: 1.813 ± 0.338
1.145GlnLys: 1.145 ± 0.198
2.959GlnLeu: 2.959 ± 0.402
0.668GlnMet: 0.668 ± 0.17
1.002GlnAsn: 1.002 ± 0.227
2.768GlnPro: 2.768 ± 0.345
1.622GlnGln: 1.622 ± 0.24
4.199GlnArg: 4.199 ± 0.673
2.052GlnSer: 2.052 ± 0.3
2.577GlnThr: 2.577 ± 0.392
2.004GlnVal: 2.004 ± 0.266
0.668GlnTrp: 0.668 ± 0.176
0.907GlnTyr: 0.907 ± 0.228
0.0GlnXaa: 0.0 ± 0.0
Arg
6.442ArgAla: 6.442 ± 0.606
1.956ArgCys: 1.956 ± 0.373
3.627ArgAsp: 3.627 ± 0.42
3.531ArgGlu: 3.531 ± 0.529
2.625ArgPhe: 2.625 ± 0.403
5.345ArgGly: 5.345 ± 0.505
3.054ArgHis: 3.054 ± 0.511
4.533ArgIle: 4.533 ± 0.7
2.338ArgLys: 2.338 ± 0.344
6.967ArgLeu: 6.967 ± 0.805
2.386ArgMet: 2.386 ± 0.319
3.293ArgAsn: 3.293 ± 0.453
5.01ArgPro: 5.01 ± 0.556
3.149ArgGln: 3.149 ± 0.505
8.923ArgArg: 8.923 ± 1.154
5.917ArgSer: 5.917 ± 0.774
4.867ArgThr: 4.867 ± 0.641
5.535ArgVal: 5.535 ± 0.609
1.909ArgTrp: 1.909 ± 0.306
2.291ArgTyr: 2.291 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
6.919SerAla: 6.919 ± 0.977
1.098SerCys: 1.098 ± 0.239
4.39SerAsp: 4.39 ± 0.563
2.577SerGlu: 2.577 ± 0.344
2.147SerPhe: 2.147 ± 0.417
6.108SerGly: 6.108 ± 0.59
1.909SerHis: 1.909 ± 0.325
2.291SerIle: 2.291 ± 0.386
1.575SerLys: 1.575 ± 0.279
4.152SerLeu: 4.152 ± 0.503
1.479SerMet: 1.479 ± 0.285
2.481SerAsn: 2.481 ± 0.35
4.486SerPro: 4.486 ± 0.522
1.956SerGln: 1.956 ± 0.295
5.488SerArg: 5.488 ± 0.684
6.633SerSer: 6.633 ± 0.83
5.058SerThr: 5.058 ± 0.825
5.01SerVal: 5.01 ± 0.475
1.432SerTrp: 1.432 ± 0.268
1.288SerTyr: 1.288 ± 0.215
0.0SerXaa: 0.0 ± 0.0
Thr
7.158ThrAla: 7.158 ± 0.538
1.288ThrCys: 1.288 ± 0.369
3.961ThrAsp: 3.961 ± 0.631
3.388ThrGlu: 3.388 ± 0.376
1.956ThrPhe: 1.956 ± 0.323
6.203ThrGly: 6.203 ± 0.522
2.195ThrHis: 2.195 ± 0.422
3.054ThrIle: 3.054 ± 0.452
1.479ThrLys: 1.479 ± 0.309
4.342ThrLeu: 4.342 ± 0.492
1.384ThrMet: 1.384 ± 0.296
2.434ThrAsn: 2.434 ± 0.367
5.154ThrPro: 5.154 ± 0.656
1.861ThrGln: 1.861 ± 0.278
4.629ThrArg: 4.629 ± 0.563
4.39ThrSer: 4.39 ± 0.553
5.201ThrThr: 5.201 ± 0.662
5.679ThrVal: 5.679 ± 0.519
0.907ThrTrp: 0.907 ± 0.28
1.479ThrTyr: 1.479 ± 0.283
0.0ThrXaa: 0.0 ± 0.0
Val
6.728ValAla: 6.728 ± 0.477
1.241ValCys: 1.241 ± 0.228
4.724ValAsp: 4.724 ± 0.488
4.199ValGlu: 4.199 ± 0.396
2.291ValPhe: 2.291 ± 0.394
6.108ValGly: 6.108 ± 0.552
1.766ValHis: 1.766 ± 0.325
2.338ValIle: 2.338 ± 0.352
1.813ValLys: 1.813 ± 0.34
5.822ValLeu: 5.822 ± 0.671
1.288ValMet: 1.288 ± 0.215
2.052ValAsn: 2.052 ± 0.292
4.199ValPro: 4.199 ± 0.393
3.054ValGln: 3.054 ± 0.337
4.963ValArg: 4.963 ± 0.534
4.772ValSer: 4.772 ± 0.526
5.535ValThr: 5.535 ± 0.515
6.872ValVal: 6.872 ± 0.741
1.145ValTrp: 1.145 ± 0.205
1.002ValTyr: 1.002 ± 0.197
0.0ValXaa: 0.0 ± 0.0
Trp
1.813TrpAla: 1.813 ± 0.243
0.191TrpCys: 0.191 ± 0.1
1.098TrpAsp: 1.098 ± 0.259
0.907TrpGlu: 0.907 ± 0.271
0.62TrpPhe: 0.62 ± 0.162
0.859TrpGly: 0.859 ± 0.194
0.764TrpHis: 0.764 ± 0.228
0.954TrpIle: 0.954 ± 0.18
0.764TrpLys: 0.764 ± 0.155
1.813TrpLeu: 1.813 ± 0.296
0.764TrpMet: 0.764 ± 0.18
0.477TrpAsn: 0.477 ± 0.143
1.002TrpPro: 1.002 ± 0.232
0.811TrpGln: 0.811 ± 0.183
2.004TrpArg: 2.004 ± 0.337
1.384TrpSer: 1.384 ± 0.287
1.002TrpThr: 1.002 ± 0.227
1.622TrpVal: 1.622 ± 0.389
0.716TrpTrp: 0.716 ± 0.148
0.429TrpTyr: 0.429 ± 0.135
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.147TyrAla: 2.147 ± 0.333
0.286TyrCys: 0.286 ± 0.133
1.002TyrAsp: 1.002 ± 0.256
1.241TyrGlu: 1.241 ± 0.268
0.668TyrPhe: 0.668 ± 0.17
1.956TyrGly: 1.956 ± 0.422
0.286TyrHis: 0.286 ± 0.098
0.954TyrIle: 0.954 ± 0.226
0.525TyrLys: 0.525 ± 0.183
1.479TyrLeu: 1.479 ± 0.268
0.382TyrMet: 0.382 ± 0.138
0.525TyrAsn: 0.525 ± 0.172
1.288TyrPro: 1.288 ± 0.239
0.716TyrGln: 0.716 ± 0.164
2.147TyrArg: 2.147 ± 0.386
1.145TyrSer: 1.145 ± 0.231
1.288TyrThr: 1.288 ± 0.292
1.861TyrVal: 1.861 ± 0.291
0.573TyrTrp: 0.573 ± 0.158
0.477TyrTyr: 0.477 ± 0.149
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (20957 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski