Amino acid dipepetide frequency for Salmonella sp. NCTC 7297

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.851AlaAla: 9.851 ± 0.169
1.26AlaCys: 1.26 ± 0.045
4.961AlaAsp: 4.961 ± 0.099
5.31AlaGlu: 5.31 ± 0.102
3.531AlaPhe: 3.531 ± 0.093
7.847AlaGly: 7.847 ± 0.124
1.925AlaHis: 1.925 ± 0.057
5.804AlaIle: 5.804 ± 0.112
3.948AlaLys: 3.948 ± 0.09
10.871AlaLeu: 10.871 ± 0.133
3.197AlaMet: 3.197 ± 0.074
3.135AlaAsn: 3.135 ± 0.068
3.661AlaPro: 3.661 ± 0.083
4.409AlaGln: 4.409 ± 0.092
5.714AlaArg: 5.714 ± 0.111
5.48AlaSer: 5.48 ± 0.097
4.916AlaThr: 4.916 ± 0.089
6.422AlaVal: 6.422 ± 0.111
1.621AlaTrp: 1.621 ± 0.055
2.035AlaTyr: 2.035 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.247CysAla: 1.247 ± 0.042
0.299CysCys: 0.299 ± 0.025
0.658CysAsp: 0.658 ± 0.036
0.611CysGlu: 0.611 ± 0.032
0.517CysPhe: 0.517 ± 0.033
1.184CysGly: 1.184 ± 0.044
0.374CysHis: 0.374 ± 0.029
0.651CysIle: 0.651 ± 0.035
0.419CysLys: 0.419 ± 0.025
1.252CysLeu: 1.252 ± 0.047
0.401CysMet: 0.401 ± 0.027
0.367CysAsn: 0.367 ± 0.029
0.571CysPro: 0.571 ± 0.032
0.494CysGln: 0.494 ± 0.028
0.977CysArg: 0.977 ± 0.042
0.851CysSer: 0.851 ± 0.037
0.559CysThr: 0.559 ± 0.033
0.863CysVal: 0.863 ± 0.037
0.337CysTrp: 0.337 ± 0.025
0.347CysTyr: 0.347 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.165AspAla: 5.165 ± 0.107
0.522AspCys: 0.522 ± 0.029
2.946AspAsp: 2.946 ± 0.081
3.287AspGlu: 3.287 ± 0.076
1.995AspPhe: 1.995 ± 0.06
3.844AspGly: 3.844 ± 0.097
0.978AspHis: 0.978 ± 0.039
3.557AspIle: 3.557 ± 0.081
2.534AspLys: 2.534 ± 0.072
4.342AspLeu: 4.342 ± 0.085
1.407AspMet: 1.407 ± 0.054
2.294AspAsn: 2.294 ± 0.065
2.067AspPro: 2.067 ± 0.065
1.509AspGln: 1.509 ± 0.059
2.589AspArg: 2.589 ± 0.059
2.823AspSer: 2.823 ± 0.072
2.646AspThr: 2.646 ± 0.08
3.709AspVal: 3.709 ± 0.089
0.77AspTrp: 0.77 ± 0.034
1.868AspTyr: 1.868 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.918GluAla: 4.918 ± 0.101
0.497GluCys: 0.497 ± 0.03
2.23GluAsp: 2.23 ± 0.071
3.102GluGlu: 3.102 ± 0.079
1.721GluPhe: 1.721 ± 0.054
3.357GluGly: 3.357 ± 0.075
1.272GluHis: 1.272 ± 0.048
3.185GluIle: 3.185 ± 0.079
3.157GluLys: 3.157 ± 0.075
5.46GluLeu: 5.46 ± 0.089
1.734GluMet: 1.734 ± 0.056
2.31GluAsn: 2.31 ± 0.068
1.878GluPro: 1.878 ± 0.058
3.023GluGln: 3.023 ± 0.072
3.609GluArg: 3.609 ± 0.087
2.809GluSer: 2.809 ± 0.069
2.92GluThr: 2.92 ± 0.064
3.292GluVal: 3.292 ± 0.085
0.763GluTrp: 0.763 ± 0.035
1.579GluTyr: 1.579 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.544PheAla: 3.544 ± 0.085
0.704PheCys: 0.704 ± 0.034
2.155PheAsp: 2.155 ± 0.057
1.644PheGlu: 1.644 ± 0.055
1.881PhePhe: 1.881 ± 0.067
2.97PheGly: 2.97 ± 0.083
0.903PheHis: 0.903 ± 0.041
2.774PheIle: 2.774 ± 0.079
1.219PheLys: 1.219 ± 0.045
3.437PheLeu: 3.437 ± 0.088
1.148PheMet: 1.148 ± 0.041
1.751PheAsn: 1.751 ± 0.052
1.596PhePro: 1.596 ± 0.047
1.113PheGln: 1.113 ± 0.052
2.178PheArg: 2.178 ± 0.063
3.035PheSer: 3.035 ± 0.083
2.519PheThr: 2.519 ± 0.061
2.432PheVal: 2.432 ± 0.072
0.639PheTrp: 0.639 ± 0.035
1.24PheTyr: 1.24 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
6.245GlyAla: 6.245 ± 0.117
1.2GlyCys: 1.2 ± 0.047
3.796GlyAsp: 3.796 ± 0.087
4.314GlyGlu: 4.314 ± 0.082
3.165GlyPhe: 3.165 ± 0.073
5.497GlyGly: 5.497 ± 0.127
1.623GlyHis: 1.623 ± 0.058
4.894GlyIle: 4.894 ± 0.098
3.858GlyLys: 3.858 ± 0.084
6.909GlyLeu: 6.909 ± 0.133
2.447GlyMet: 2.447 ± 0.064
3.068GlyAsn: 3.068 ± 0.093
2.002GlyPro: 2.002 ± 0.063
2.828GlyGln: 2.828 ± 0.071
4.187GlyArg: 4.187 ± 0.09
4.021GlySer: 4.021 ± 0.078
3.631GlyThr: 3.631 ± 0.086
5.641GlyVal: 5.641 ± 0.096
1.275GlyTrp: 1.275 ± 0.051
2.524GlyTyr: 2.524 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.976HisAla: 1.976 ± 0.064
0.379HisCys: 0.379 ± 0.025
1.209HisAsp: 1.209 ± 0.043
1.067HisGlu: 1.067 ± 0.044
1.103HisPhe: 1.103 ± 0.046
1.759HisGly: 1.759 ± 0.057
0.851HisHis: 0.851 ± 0.042
1.416HisIle: 1.416 ± 0.046
0.768HisLys: 0.768 ± 0.035
2.32HisLeu: 2.32 ± 0.066
0.594HisMet: 0.594 ± 0.033
0.865HisAsn: 0.865 ± 0.041
1.347HisPro: 1.347 ± 0.047
1.187HisGln: 1.187 ± 0.048
1.417HisArg: 1.417 ± 0.052
1.319HisSer: 1.319 ± 0.05
1.137HisThr: 1.137 ± 0.043
1.337HisVal: 1.337 ± 0.044
0.382HisTrp: 0.382 ± 0.023
0.923HisTyr: 0.923 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.429IleAla: 6.429 ± 0.12
0.893IleCys: 0.893 ± 0.041
3.537IleAsp: 3.537 ± 0.08
3.088IleGlu: 3.088 ± 0.074
2.18IlePhe: 2.18 ± 0.069
4.32IleGly: 4.32 ± 0.095
1.427IleHis: 1.427 ± 0.048
3.602IleIle: 3.602 ± 0.086
2.397IleLys: 2.397 ± 0.07
5.13IleLeu: 5.13 ± 0.103
1.389IleMet: 1.389 ± 0.057
2.713IleAsn: 2.713 ± 0.082
2.911IlePro: 2.911 ± 0.074
1.851IleGln: 1.851 ± 0.056
3.37IleArg: 3.37 ± 0.071
3.91IleSer: 3.91 ± 0.081
3.814IleThr: 3.814 ± 0.085
3.94IleVal: 3.94 ± 0.094
0.811IleTrp: 0.811 ± 0.035
1.609IleTyr: 1.609 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.2LysAla: 4.2 ± 0.088
0.351LysCys: 0.351 ± 0.028
1.898LysAsp: 1.898 ± 0.058
2.269LysGlu: 2.269 ± 0.068
1.235LysPhe: 1.235 ± 0.046
2.885LysGly: 2.885 ± 0.079
0.88LysHis: 0.88 ± 0.039
2.499LysIle: 2.499 ± 0.07
2.339LysLys: 2.339 ± 0.072
4.19LysLeu: 4.19 ± 0.081
1.317LysMet: 1.317 ± 0.052
1.883LysAsn: 1.883 ± 0.059
2.198LysPro: 2.198 ± 0.059
1.848LysGln: 1.848 ± 0.061
2.971LysArg: 2.971 ± 0.072
2.461LysSer: 2.461 ± 0.072
2.709LysThr: 2.709 ± 0.068
2.729LysVal: 2.729 ± 0.065
0.484LysTrp: 0.484 ± 0.03
1.209LysTyr: 1.209 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
10.637LeuAla: 10.637 ± 0.147
1.407LeuCys: 1.407 ± 0.047
5.021LeuAsp: 5.021 ± 0.103
5.045LeuGlu: 5.045 ± 0.099
4.222LeuPhe: 4.222 ± 0.081
6.497LeuGly: 6.497 ± 0.135
2.259LeuHis: 2.259 ± 0.066
5.731LeuIle: 5.731 ± 0.126
4.524LeuLys: 4.524 ± 0.095
11.096LeuLeu: 11.096 ± 0.196
3.055LeuMet: 3.055 ± 0.078
4.243LeuAsn: 4.243 ± 0.09
5.722LeuPro: 5.722 ± 0.124
3.861LeuGln: 3.861 ± 0.091
6.572LeuArg: 6.572 ± 0.111
7.185LeuSer: 7.185 ± 0.115
6.41LeuThr: 6.41 ± 0.123
6.599LeuVal: 6.599 ± 0.116
1.421LeuTrp: 1.421 ± 0.054
2.644LeuTyr: 2.644 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
3.028MetAla: 3.028 ± 0.077
0.249MetCys: 0.249 ± 0.022
1.289MetAsp: 1.289 ± 0.055
1.285MetGlu: 1.285 ± 0.05
0.935MetPhe: 0.935 ± 0.04
2.025MetGly: 2.025 ± 0.057
0.526MetHis: 0.526 ± 0.032
1.641MetIle: 1.641 ± 0.053
1.537MetLys: 1.537 ± 0.055
3.367MetLeu: 3.367 ± 0.085
1.012MetMet: 1.012 ± 0.042
1.172MetAsn: 1.172 ± 0.044
1.613MetPro: 1.613 ± 0.049
1.35MetGln: 1.35 ± 0.046
1.805MetArg: 1.805 ± 0.048
1.986MetSer: 1.986 ± 0.063
1.948MetThr: 1.948 ± 0.054
2.123MetVal: 2.123 ± 0.067
0.287MetTrp: 0.287 ± 0.019
0.604MetTyr: 0.604 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.794AsnAla: 3.794 ± 0.086
0.431AsnCys: 0.431 ± 0.028
2.143AsnAsp: 2.143 ± 0.063
1.898AsnGlu: 1.898 ± 0.053
1.335AsnPhe: 1.335 ± 0.051
3.093AsnGly: 3.093 ± 0.089
0.945AsnHis: 0.945 ± 0.037
2.534AsnIle: 2.534 ± 0.065
1.623AsnLys: 1.623 ± 0.061
3.447AsnLeu: 3.447 ± 0.077
0.99AsnMet: 0.99 ± 0.043
1.728AsnAsn: 1.728 ± 0.065
2.065AsnPro: 2.065 ± 0.058
1.512AsnGln: 1.512 ± 0.051
2.01AsnArg: 2.01 ± 0.066
2.195AsnSer: 2.195 ± 0.075
2.148AsnThr: 2.148 ± 0.068
2.653AsnVal: 2.653 ± 0.063
0.613AsnTrp: 0.613 ± 0.034
1.239AsnTyr: 1.239 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.681ProAla: 4.681 ± 0.083
0.497ProCys: 0.497 ± 0.028
2.746ProAsp: 2.746 ± 0.072
3.205ProGlu: 3.205 ± 0.077
1.81ProPhe: 1.81 ± 0.049
3.719ProGly: 3.719 ± 0.086
1.087ProHis: 1.087 ± 0.039
1.936ProIle: 1.936 ± 0.064
1.479ProLys: 1.479 ± 0.053
5.078ProLeu: 5.078 ± 0.096
1.195ProMet: 1.195 ± 0.049
1.29ProAsn: 1.29 ± 0.054
1.925ProPro: 1.925 ± 0.068
2.127ProGln: 2.127 ± 0.059
2.222ProArg: 2.222 ± 0.067
2.195ProSer: 2.195 ± 0.06
2.197ProThr: 2.197 ± 0.065
3.936ProVal: 3.936 ± 0.084
0.775ProTrp: 0.775 ± 0.034
1.227ProTyr: 1.227 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.347GlnAla: 4.347 ± 0.096
0.461GlnCys: 0.461 ± 0.028
1.716GlnAsp: 1.716 ± 0.059
2.16GlnGlu: 2.16 ± 0.058
1.466GlnPhe: 1.466 ± 0.051
2.871GlnGly: 2.871 ± 0.073
1.199GlnHis: 1.199 ± 0.048
2.259GlnIle: 2.259 ± 0.061
1.826GlnLys: 1.826 ± 0.06
4.549GlnLeu: 4.549 ± 0.1
1.227GlnMet: 1.227 ± 0.046
1.526GlnAsn: 1.526 ± 0.053
2.012GlnPro: 2.012 ± 0.067
2.885GlnGln: 2.885 ± 0.099
3.178GlnArg: 3.178 ± 0.082
2.274GlnSer: 2.274 ± 0.065
2.337GlnThr: 2.337 ± 0.062
2.679GlnVal: 2.679 ± 0.069
0.688GlnTrp: 0.688 ± 0.037
1.222GlnTyr: 1.222 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
4.908ArgAla: 4.908 ± 0.088
0.911ArgCys: 0.911 ± 0.038
3.075ArgAsp: 3.075 ± 0.079
3.669ArgGlu: 3.669 ± 0.087
2.806ArgPhe: 2.806 ± 0.067
3.561ArgGly: 3.561 ± 0.085
1.918ArgHis: 1.918 ± 0.059
3.656ArgIle: 3.656 ± 0.075
2.592ArgLys: 2.592 ± 0.071
6.727ArgLeu: 6.727 ± 0.126
2.188ArgMet: 2.188 ± 0.067
2.127ArgAsn: 2.127 ± 0.061
2.471ArgPro: 2.471 ± 0.066
3.344ArgGln: 3.344 ± 0.077
4.948ArgArg: 4.948 ± 0.106
3.073ArgSer: 3.073 ± 0.071
2.699ArgThr: 2.699 ± 0.074
3.841ArgVal: 3.841 ± 0.077
1.287ArgTrp: 1.287 ± 0.053
2.384ArgTyr: 2.384 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
5.687SerAla: 5.687 ± 0.103
0.734SerCys: 0.734 ± 0.038
3.03SerAsp: 3.03 ± 0.077
2.971SerGlu: 2.971 ± 0.063
2.244SerPhe: 2.244 ± 0.058
5.387SerGly: 5.387 ± 0.099
1.397SerHis: 1.397 ± 0.053
3.173SerIle: 3.173 ± 0.062
2.003SerLys: 2.003 ± 0.061
6.721SerLeu: 6.721 ± 0.105
1.636SerMet: 1.636 ± 0.046
1.908SerAsn: 1.908 ± 0.057
2.985SerPro: 2.985 ± 0.078
2.432SerGln: 2.432 ± 0.066
3.744SerArg: 3.744 ± 0.086
3.698SerSer: 3.698 ± 0.082
3.1SerThr: 3.1 ± 0.076
4.273SerVal: 4.273 ± 0.091
1.008SerTrp: 1.008 ± 0.043
1.546SerTyr: 1.546 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.136ThrAla: 5.136 ± 0.094
0.638ThrCys: 0.638 ± 0.033
2.714ThrAsp: 2.714 ± 0.075
2.457ThrGlu: 2.457 ± 0.065
2.24ThrPhe: 2.24 ± 0.055
4.699ThrGly: 4.699 ± 0.091
1.279ThrHis: 1.279 ± 0.042
3.182ThrIle: 3.182 ± 0.083
1.618ThrLys: 1.618 ± 0.059
7.236ThrLeu: 7.236 ± 0.115
1.28ThrMet: 1.28 ± 0.049
1.641ThrAsn: 1.641 ± 0.058
3.325ThrPro: 3.325 ± 0.066
2.217ThrGln: 2.217 ± 0.069
3.245ThrArg: 3.245 ± 0.082
3.016ThrSer: 3.016 ± 0.066
3.18ThrThr: 3.18 ± 0.086
4.115ThrVal: 4.115 ± 0.087
0.846ThrTrp: 0.846 ± 0.033
1.255ThrTyr: 1.255 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
6.527ValAla: 6.527 ± 0.118
0.891ValCys: 0.891 ± 0.038
3.537ValAsp: 3.537 ± 0.075
3.661ValGlu: 3.661 ± 0.082
2.602ValPhe: 2.602 ± 0.071
4.472ValGly: 4.472 ± 0.092
1.217ValHis: 1.217 ± 0.049
4.459ValIle: 4.459 ± 0.088
3.155ValLys: 3.155 ± 0.074
6.828ValLeu: 6.828 ± 0.112
2.33ValMet: 2.33 ± 0.061
2.858ValAsn: 2.858 ± 0.076
2.88ValPro: 2.88 ± 0.07
2.222ValGln: 2.222 ± 0.065
3.823ValArg: 3.823 ± 0.073
4.584ValSer: 4.584 ± 0.09
4.243ValThr: 4.243 ± 0.082
5.093ValVal: 5.093 ± 0.105
0.992ValTrp: 0.992 ± 0.042
1.766ValTyr: 1.766 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
1.103TrpAla: 1.103 ± 0.05
0.209TrpCys: 0.209 ± 0.017
0.616TrpAsp: 0.616 ± 0.032
0.603TrpGlu: 0.603 ± 0.032
0.686TrpPhe: 0.686 ± 0.034
0.868TrpGly: 0.868 ± 0.04
0.452TrpHis: 0.452 ± 0.026
0.856TrpIle: 0.856 ± 0.033
0.638TrpLys: 0.638 ± 0.034
2.165TrpLeu: 2.165 ± 0.072
0.541TrpMet: 0.541 ± 0.03
0.477TrpAsn: 0.477 ± 0.027
0.714TrpPro: 0.714 ± 0.033
1.13TrpGln: 1.13 ± 0.047
1.529TrpArg: 1.529 ± 0.064
0.9TrpSer: 0.9 ± 0.038
0.693TrpThr: 0.693 ± 0.04
0.875TrpVal: 0.875 ± 0.042
0.26TrpTrp: 0.26 ± 0.019
0.414TrpTyr: 0.414 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.474TyrAla: 2.474 ± 0.07
0.444TyrCys: 0.444 ± 0.028
1.574TyrAsp: 1.574 ± 0.059
1.172TyrGlu: 1.172 ± 0.043
1.21TyrPhe: 1.21 ± 0.043
2.269TyrGly: 2.269 ± 0.063
0.846TyrHis: 0.846 ± 0.039
1.512TyrIle: 1.512 ± 0.043
0.921TyrLys: 0.921 ± 0.038
3.025TyrLeu: 3.025 ± 0.072
0.691TyrMet: 0.691 ± 0.035
1.04TyrAsn: 1.04 ± 0.045
1.386TyrPro: 1.386 ± 0.05
1.537TyrGln: 1.537 ± 0.055
2.098TyrArg: 2.098 ± 0.065
1.863TyrSer: 1.863 ± 0.048
1.514TyrThr: 1.514 ± 0.045
1.588TyrVal: 1.588 ± 0.062
0.471TyrTrp: 0.471 ± 0.028
0.985TyrTyr: 0.985 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3497 proteins (599048 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski