Amino acid dipepetide frequency for Anas platyrhynchos platyrhynchos (Northern mallard)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.612AlaAla: 7.612 ± 0.041	1.406AlaCys: 1.406 ± 0.01	3.053AlaAsp: 3.053 ± 0.015	5.069AlaGlu: 5.069 ± 0.028	2.428AlaPhe: 2.428 ± 0.013	5.053AlaGly: 5.053 ± 0.029	1.43AlaHis: 1.43 ± 0.009	2.776AlaIle: 2.776 ± 0.016	3.559AlaLys: 3.559 ± 0.016	6.721AlaLeu: 6.721 ± 0.029	1.5AlaMet: 1.5 ± 0.01	2.171AlaAsn: 2.171 ± 0.012	4.051AlaPro: 4.051 ± 0.03	2.993AlaGln: 2.993 ± 0.019	3.557AlaArg: 3.557 ± 0.016	5.666AlaSer: 5.666 ± 0.023	3.408AlaThr: 3.408 ± 0.019	5.065AlaVal: 5.065 ± 0.021	0.757AlaTrp: 0.757 ± 0.008	1.504AlaTyr: 1.504 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	1.303CysAla: 1.303 ± 0.011	0.705CysCys: 0.705 ± 0.009	1.009CysAsp: 1.009 ± 0.011	1.307CysGlu: 1.307 ± 0.014	0.884CysPhe: 0.884 ± 0.009	1.52CysGly: 1.52 ± 0.015	0.665CysHis: 0.665 ± 0.009	1.057CysIle: 1.057 ± 0.011	1.253CysLys: 1.253 ± 0.011	2.153CysLeu: 2.153 ± 0.015	0.458CysMet: 0.458 ± 0.006	0.845CysAsn: 0.845 ± 0.009	1.42CysPro: 1.42 ± 0.013	1.058CysGln: 1.058 ± 0.011	1.371CysArg: 1.371 ± 0.012	2.148CysSer: 2.148 ± 0.015	1.204CysThr: 1.204 ± 0.012	1.349CysVal: 1.349 ± 0.014	0.322CysTrp: 0.322 ± 0.005	0.616CysTyr: 0.616 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	2.897AspAla: 2.897 ± 0.014	1.072AspCys: 1.072 ± 0.011	2.732AspAsp: 2.732 ± 0.018	3.565AspGlu: 3.565 ± 0.018	2.108AspPhe: 2.108 ± 0.011	3.339AspGly: 3.339 ± 0.021	1.1AspHis: 1.1 ± 0.008	2.668AspIle: 2.668 ± 0.016	2.655AspLys: 2.655 ± 0.014	4.837AspLeu: 4.837 ± 0.021	1.09AspMet: 1.09 ± 0.008	1.845AspAsn: 1.845 ± 0.014	2.636AspPro: 2.636 ± 0.016	1.786AspGln: 1.786 ± 0.012	2.338AspArg: 2.338 ± 0.015	4.179AspSer: 4.179 ± 0.022	2.531AspThr: 2.531 ± 0.012	3.196AspVal: 3.196 ± 0.018	0.6AspTrp: 0.6 ± 0.007	1.483AspTyr: 1.483 ± 0.012	0.001AspXaa: 0.001 ± 0.0
Glu	4.883GluAla: 4.883 ± 0.026	1.272GluCys: 1.272 ± 0.017	4.384GluAsp: 4.384 ± 0.022	8.049GluGlu: 8.049 ± 0.056	1.999GluPhe: 1.999 ± 0.014	4.146GluGly: 4.146 ± 0.018	1.554GluHis: 1.554 ± 0.011	3.261GluIle: 3.261 ± 0.016	5.576GluLys: 5.576 ± 0.036	6.351GluLeu: 6.351 ± 0.034	1.735GluMet: 1.735 ± 0.014	3.306GluAsn: 3.306 ± 0.02	2.957GluPro: 2.957 ± 0.018	3.302GluGln: 3.302 ± 0.025	4.089GluArg: 4.089 ± 0.026	4.559GluSer: 4.559 ± 0.022	3.536GluThr: 3.536 ± 0.018	4.157GluVal: 4.157 ± 0.017	0.689GluTrp: 0.689 ± 0.006	1.687GluTyr: 1.687 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	2.048PheAla: 2.048 ± 0.013	0.942PheCys: 0.942 ± 0.009	1.66PheAsp: 1.66 ± 0.011	1.945PheGlu: 1.945 ± 0.013	1.706PhePhe: 1.706 ± 0.015	2.143PheGly: 2.143 ± 0.015	0.993PheHis: 0.993 ± 0.008	1.858PheIle: 1.858 ± 0.013	1.785PheLys: 1.785 ± 0.013	3.874PheLeu: 3.874 ± 0.021	0.744PheMet: 0.744 ± 0.008	1.403PheAsn: 1.403 ± 0.01	1.952PhePro: 1.952 ± 0.014	1.675PheGln: 1.675 ± 0.012	1.81PheArg: 1.81 ± 0.011	3.33PheSer: 3.33 ± 0.016	2.018PheThr: 2.018 ± 0.012	2.169PheVal: 2.169 ± 0.014	0.507PheTrp: 0.507 ± 0.006	1.202PheTyr: 1.202 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	4.598GlyAla: 4.598 ± 0.026	1.456GlyCys: 1.456 ± 0.011	3.125GlyAsp: 3.125 ± 0.02	3.996GlyGlu: 3.996 ± 0.024	2.381GlyPhe: 2.381 ± 0.015	5.356GlyGly: 5.356 ± 0.041	1.619GlyHis: 1.619 ± 0.013	2.832GlyIle: 2.832 ± 0.016	3.78GlyLys: 3.78 ± 0.018	5.436GlyLeu: 5.436 ± 0.024	1.361GlyMet: 1.361 ± 0.012	2.545GlyAsn: 2.545 ± 0.015	3.403GlyPro: 3.403 ± 0.037	2.694GlyGln: 2.694 ± 0.017	3.956GlyArg: 3.956 ± 0.021	5.761GlySer: 5.761 ± 0.028	3.702GlyThr: 3.702 ± 0.022	3.61GlyVal: 3.61 ± 0.018	0.903GlyTrp: 0.903 ± 0.01	1.762GlyTyr: 1.762 ± 0.014	0.003GlyXaa: 0.003 ± 0.0
His	1.387HisAla: 1.387 ± 0.009	0.707HisCys: 0.707 ± 0.008	0.893HisAsp: 0.893 ± 0.008	1.341HisGlu: 1.341 ± 0.011	1.007HisPhe: 1.007 ± 0.008	1.632HisGly: 1.632 ± 0.011	0.918HisHis: 0.918 ± 0.01	1.251HisIle: 1.251 ± 0.01	1.282HisLys: 1.282 ± 0.011	2.773HisLeu: 2.773 ± 0.015	0.566HisMet: 0.566 ± 0.006	0.918HisAsn: 0.918 ± 0.008	1.679HisPro: 1.679 ± 0.014	1.195HisGln: 1.195 ± 0.009	1.554HisArg: 1.554 ± 0.01	2.237HisSer: 2.237 ± 0.014	1.298HisThr: 1.298 ± 0.01	1.46HisVal: 1.46 ± 0.01	0.321HisTrp: 0.321 ± 0.005	0.798HisTyr: 0.798 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	2.794IleAla: 2.794 ± 0.015	1.097IleCys: 1.097 ± 0.011	2.097IleAsp: 2.097 ± 0.014	2.674IleGlu: 2.674 ± 0.016	1.902IlePhe: 1.902 ± 0.014	2.267IleGly: 2.267 ± 0.013	1.226IleHis: 1.226 ± 0.01	2.394IleIle: 2.394 ± 0.014	2.765IleLys: 2.765 ± 0.015	4.456IleLeu: 4.456 ± 0.021	0.995IleMet: 0.995 ± 0.008	2.009IleAsn: 2.009 ± 0.013	2.654IlePro: 2.654 ± 0.014	2.296IleGln: 2.296 ± 0.014	2.365IleArg: 2.365 ± 0.014	3.896IleSer: 3.896 ± 0.017	2.666IleThr: 2.666 ± 0.016	2.606IleVal: 2.606 ± 0.015	0.522IleTrp: 0.522 ± 0.006	1.409IleTyr: 1.409 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.988LysAla: 3.988 ± 0.017	1.161LysCys: 1.161 ± 0.01	3.278LysAsp: 3.278 ± 0.016	5.386LysGlu: 5.386 ± 0.033	1.725LysPhe: 1.725 ± 0.013	3.26LysGly: 3.26 ± 0.021	1.49LysHis: 1.49 ± 0.011	2.923LysIle: 2.923 ± 0.013	5.036LysLys: 5.036 ± 0.031	5.335LysLeu: 5.335 ± 0.026	1.524LysMet: 1.524 ± 0.011	2.618LysAsn: 2.618 ± 0.014	3.018LysPro: 3.018 ± 0.019	2.892LysGln: 2.892 ± 0.019	3.394LysArg: 3.394 ± 0.019	4.199LysSer: 4.199 ± 0.022	3.235LysThr: 3.235 ± 0.018	3.466LysVal: 3.466 ± 0.017	0.609LysTrp: 0.609 ± 0.007	1.678LysTyr: 1.678 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.298LeuAla: 6.298 ± 0.028	2.208LeuCys: 2.208 ± 0.015	4.591LeuAsp: 4.591 ± 0.019	6.898LeuGlu: 6.898 ± 0.041	3.34LeuPhe: 3.34 ± 0.019	5.482LeuGly: 5.482 ± 0.025	2.688LeuHis: 2.688 ± 0.017	3.807LeuIle: 3.807 ± 0.019	5.961LeuLys: 5.961 ± 0.03	10.116LeuLeu: 10.116 ± 0.038	1.919LeuMet: 1.919 ± 0.013	3.63LeuAsn: 3.63 ± 0.018	5.86LeuPro: 5.86 ± 0.027	5.657LeuGln: 5.657 ± 0.032	5.517LeuArg: 5.517 ± 0.026	7.798LeuSer: 7.798 ± 0.024	4.774LeuThr: 4.774 ± 0.019	5.148LeuVal: 5.148 ± 0.023	1.083LeuTrp: 1.083 ± 0.01	2.522LeuTyr: 2.522 ± 0.016	0.001LeuXaa: 0.001 ± 0.0
Met	1.747MetAla: 1.747 ± 0.011	0.421MetCys: 0.421 ± 0.006	1.211MetAsp: 1.211 ± 0.009	1.879MetGlu: 1.879 ± 0.014	0.739MetPhe: 0.739 ± 0.007	1.334MetGly: 1.334 ± 0.011	0.499MetHis: 0.499 ± 0.006	0.844MetIle: 0.844 ± 0.008	1.528MetLys: 1.528 ± 0.01	1.957MetLeu: 1.957 ± 0.013	0.551MetMet: 0.551 ± 0.007	0.912MetAsn: 0.912 ± 0.009	1.087MetPro: 1.087 ± 0.012	1.027MetGln: 1.027 ± 0.008	1.06MetArg: 1.06 ± 0.008	1.589MetSer: 1.589 ± 0.011	1.077MetThr: 1.077 ± 0.008	1.368MetVal: 1.368 ± 0.009	0.244MetTrp: 0.244 ± 0.004	0.608MetTyr: 0.608 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.28AsnAla: 2.28 ± 0.014	0.913AsnCys: 0.913 ± 0.009	1.644AsnAsp: 1.644 ± 0.013	2.479AsnGlu: 2.479 ± 0.015	1.471AsnPhe: 1.471 ± 0.012	2.744AsnGly: 2.744 ± 0.018	0.933AsnHis: 0.933 ± 0.008	2.276AsnIle: 2.276 ± 0.012	2.443AsnLys: 2.443 ± 0.015	3.788AsnLeu: 3.788 ± 0.019	0.963AsnMet: 0.963 ± 0.007	1.737AsnAsn: 1.737 ± 0.014	2.183AsnPro: 2.183 ± 0.014	1.693AsnGln: 1.693 ± 0.011	1.903AsnArg: 1.903 ± 0.012	3.395AsnSer: 3.395 ± 0.018	2.173AsnThr: 2.173 ± 0.013	2.362AsnVal: 2.362 ± 0.014	0.475AsnTrp: 0.475 ± 0.006	1.187AsnTyr: 1.187 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	4.99ProAla: 4.99 ± 0.033	1.265ProCys: 1.265 ± 0.013	2.598ProAsp: 2.598 ± 0.014	4.015ProGlu: 4.015 ± 0.021	1.86ProPhe: 1.86 ± 0.014	4.744ProGly: 4.744 ± 0.046	1.453ProHis: 1.453 ± 0.012	1.871ProIle: 1.871 ± 0.013	2.776ProLys: 2.776 ± 0.018	5.029ProLeu: 5.029 ± 0.025	0.976ProMet: 0.976 ± 0.008	1.862ProAsn: 1.862 ± 0.012	5.829ProPro: 5.829 ± 0.057	2.715ProGln: 2.715 ± 0.02	3.278ProArg: 3.278 ± 0.019	5.533ProSer: 5.533 ± 0.029	2.843ProThr: 2.843 ± 0.019	3.884ProVal: 3.884 ± 0.021	0.66ProTrp: 0.66 ± 0.007	1.365ProTyr: 1.365 ± 0.01	0.003ProXaa: 0.003 ± 0.0
Gln	3.182GlnAla: 3.182 ± 0.018	0.961GlnCys: 0.961 ± 0.011	2.222GlnAsp: 2.222 ± 0.013	3.776GlnGlu: 3.776 ± 0.028	1.352GlnPhe: 1.352 ± 0.009	2.689GlnGly: 2.689 ± 0.016	1.386GlnHis: 1.386 ± 0.011	2.092GlnIle: 2.092 ± 0.013	3.1GlnLys: 3.1 ± 0.019	4.554GlnLeu: 4.554 ± 0.025	1.116GlnMet: 1.116 ± 0.01	1.979GlnAsn: 1.979 ± 0.014	2.754GlnPro: 2.754 ± 0.023	3.338GlnGln: 3.338 ± 0.036	2.885GlnArg: 2.885 ± 0.018	3.291GlnSer: 3.291 ± 0.017	2.333GlnThr: 2.333 ± 0.016	2.662GlnVal: 2.662 ± 0.015	0.522GlnTrp: 0.522 ± 0.006	1.215GlnTyr: 1.215 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	3.847ArgAla: 3.847 ± 0.02	1.305ArgCys: 1.305 ± 0.015	2.679ArgAsp: 2.679 ± 0.018	3.852ArgGlu: 3.852 ± 0.025	1.783ArgPhe: 1.783 ± 0.012	3.808ArgGly: 3.808 ± 0.025	1.487ArgHis: 1.487 ± 0.011	2.423ArgIle: 2.423 ± 0.015	3.624ArgLys: 3.624 ± 0.015	5.099ArgLeu: 5.099 ± 0.027	1.194ArgMet: 1.194 ± 0.009	2.205ArgAsn: 2.205 ± 0.012	3.025ArgPro: 3.025 ± 0.018	2.586ArgGln: 2.586 ± 0.017	4.49ArgArg: 4.49 ± 0.03	4.374ArgSer: 4.374 ± 0.027	2.776ArgThr: 2.776 ± 0.013	3.015ArgVal: 3.015 ± 0.016	0.736ArgTrp: 0.736 ± 0.008	1.484ArgTyr: 1.484 ± 0.01	0.001ArgXaa: 0.001 ± 0.0
Ser	5.584SerAla: 5.584 ± 0.026	1.97SerCys: 1.97 ± 0.014	3.944SerAsp: 3.944 ± 0.02	5.24SerGlu: 5.24 ± 0.026	3.039SerPhe: 3.039 ± 0.015	5.396SerGly: 5.396 ± 0.026	2.074SerHis: 2.074 ± 0.012	3.415SerIle: 3.415 ± 0.017	4.383SerLys: 4.383 ± 0.019	7.969SerLeu: 7.969 ± 0.027	1.635SerMet: 1.635 ± 0.01	2.996SerAsn: 2.996 ± 0.017	6.059SerPro: 6.059 ± 0.038	3.806SerGln: 3.806 ± 0.019	4.431SerArg: 4.431 ± 0.023	9.822SerSer: 9.822 ± 0.06	4.717SerThr: 4.717 ± 0.024	5.085SerVal: 5.085 ± 0.022	1.036SerTrp: 1.036 ± 0.008	2.112SerTyr: 2.112 ± 0.013	0.001SerXaa: 0.001 ± 0.0
Thr	4.05ThrAla: 4.05 ± 0.019	1.29ThrCys: 1.29 ± 0.016	2.654ThrAsp: 2.654 ± 0.017	3.749ThrGlu: 3.749 ± 0.02	1.978ThrPhe: 1.978 ± 0.012	3.521ThrGly: 3.521 ± 0.02	1.158ThrHis: 1.158 ± 0.01	2.37ThrIle: 2.37 ± 0.016	2.786ThrLys: 2.786 ± 0.016	4.887ThrLeu: 4.887 ± 0.019	1.102ThrMet: 1.102 ± 0.008	1.903ThrAsn: 1.903 ± 0.011	3.367ThrPro: 3.367 ± 0.02	2.155ThrGln: 2.155 ± 0.014	2.404ThrArg: 2.404 ± 0.013	4.803ThrSer: 4.803 ± 0.023	3.02ThrThr: 3.02 ± 0.022	3.899ThrVal: 3.899 ± 0.023	0.669ThrTrp: 0.669 ± 0.007	1.428ThrTyr: 1.428 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	4.087ValAla: 4.087 ± 0.02	1.515ValCys: 1.515 ± 0.012	2.877ValAsp: 2.877 ± 0.017	3.802ValGlu: 3.802 ± 0.017	2.415ValPhe: 2.415 ± 0.014	3.312ValGly: 3.312 ± 0.019	1.494ValHis: 1.494 ± 0.011	2.97ValIle: 2.97 ± 0.019	3.559ValLys: 3.559 ± 0.017	6.146ValLeu: 6.146 ± 0.025	1.331ValMet: 1.331 ± 0.01	2.43ValAsn: 2.43 ± 0.016	3.87ValPro: 3.87 ± 0.022	2.792ValGln: 2.792 ± 0.015	3.033ValArg: 3.033 ± 0.015	4.977ValSer: 4.977 ± 0.022	3.797ValThr: 3.797 ± 0.022	3.999ValVal: 3.999 ± 0.022	0.704ValTrp: 0.704 ± 0.007	1.632ValTyr: 1.632 ± 0.011	0.001ValXaa: 0.001 ± 0.0
Trp	0.76TrpAla: 0.76 ± 0.008	0.268TrpCys: 0.268 ± 0.004	0.657TrpAsp: 0.657 ± 0.007	0.762TrpGlu: 0.762 ± 0.009	0.421TrpPhe: 0.421 ± 0.006	0.838TrpGly: 0.838 ± 0.012	0.312TrpHis: 0.312 ± 0.005	0.541TrpIle: 0.541 ± 0.006	0.815TrpLys: 0.815 ± 0.007	1.205TrpLeu: 1.205 ± 0.009	0.308TrpMet: 0.308 ± 0.004	0.545TrpAsn: 0.545 ± 0.006	0.486TrpPro: 0.486 ± 0.007	0.551TrpGln: 0.551 ± 0.006	0.748TrpArg: 0.748 ± 0.008	0.872TrpSer: 0.872 ± 0.009	0.603TrpThr: 0.603 ± 0.007	0.691TrpVal: 0.691 ± 0.007	0.215TrpTrp: 0.215 ± 0.004	0.335TrpTyr: 0.335 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.442TyrAla: 1.442 ± 0.01	0.715TyrCys: 0.715 ± 0.008	1.348TyrAsp: 1.348 ± 0.011	1.707TyrGlu: 1.707 ± 0.011	1.227TyrPhe: 1.227 ± 0.01	1.694TyrGly: 1.694 ± 0.013	0.738TyrHis: 0.738 ± 0.007	1.461TyrIle: 1.461 ± 0.011	1.548TyrLys: 1.548 ± 0.011	2.611TyrLeu: 2.611 ± 0.016	0.612TyrMet: 0.612 ± 0.007	1.185TyrAsn: 1.185 ± 0.009	1.256TyrPro: 1.256 ± 0.008	1.2TyrGln: 1.2 ± 0.008	1.607TyrArg: 1.607 ± 0.011	2.282TyrSer: 2.282 ± 0.014	1.482TyrThr: 1.482 ± 0.011	1.552TyrVal: 1.552 ± 0.011	0.359TyrTrp: 0.359 ± 0.006	0.991TyrTyr: 0.991 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.454XaaXaa: 0.454 ± 0.087

Statistics based on 27053 proteins (16497361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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