Amino acid dipepetide frequency for Rubellimicrobium mesophilum DSM 19309

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.695AlaAla: 17.695 ± 0.151	1.117AlaCys: 1.117 ± 0.032	6.508AlaAsp: 6.508 ± 0.074	8.78AlaGlu: 8.78 ± 0.098	4.229AlaPhe: 4.229 ± 0.06	11.724AlaGly: 11.724 ± 0.117	2.433AlaHis: 2.433 ± 0.047	5.358AlaIle: 5.358 ± 0.06	2.943AlaLys: 2.943 ± 0.06	14.993AlaLeu: 14.993 ± 0.142	3.765AlaMet: 3.765 ± 0.057	2.397AlaAsn: 2.397 ± 0.046	6.674AlaPro: 6.674 ± 0.08	4.452AlaGln: 4.452 ± 0.065	11.012AlaArg: 11.012 ± 0.119	5.997AlaSer: 5.997 ± 0.064	6.528AlaThr: 6.528 ± 0.082	8.95AlaVal: 8.95 ± 0.096	1.961AlaTrp: 1.961 ± 0.043	2.446AlaTyr: 2.446 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.927CysAla: 0.927 ± 0.029	0.113CysCys: 0.113 ± 0.009	0.528CysAsp: 0.528 ± 0.02	0.446CysGlu: 0.446 ± 0.017	0.255CysPhe: 0.255 ± 0.013	0.961CysGly: 0.961 ± 0.027	0.245CysHis: 0.245 ± 0.015	0.325CysIle: 0.325 ± 0.016	0.124CysLys: 0.124 ± 0.009	0.833CysLeu: 0.833 ± 0.024	0.153CysMet: 0.153 ± 0.009	0.164CysAsn: 0.164 ± 0.012	0.533CysPro: 0.533 ± 0.022	0.23CysGln: 0.23 ± 0.012	0.707CysArg: 0.707 ± 0.026	0.43CysSer: 0.43 ± 0.019	0.363CysThr: 0.363 ± 0.017	0.53CysVal: 0.53 ± 0.02	0.15CysTrp: 0.15 ± 0.01	0.16CysTyr: 0.16 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.007AspAla: 7.007 ± 0.086	0.456AspCys: 0.456 ± 0.019	3.144AspAsp: 3.144 ± 0.078	3.466AspGlu: 3.466 ± 0.055	1.956AspPhe: 1.956 ± 0.039	5.613AspGly: 5.613 ± 0.085	1.285AspHis: 1.285 ± 0.035	2.301AspIle: 2.301 ± 0.041	1.056AspLys: 1.056 ± 0.029	7.036AspLeu: 7.036 ± 0.08	1.258AspMet: 1.258 ± 0.032	1.011AspAsn: 1.011 ± 0.031	4.147AspPro: 4.147 ± 0.058	1.732AspGln: 1.732 ± 0.037	5.121AspArg: 5.121 ± 0.066	2.02AspSer: 2.02 ± 0.039	2.469AspThr: 2.469 ± 0.062	4.015AspVal: 4.015 ± 0.054	1.26AspTrp: 1.26 ± 0.035	1.388AspTyr: 1.388 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	9.589GluAla: 9.589 ± 0.115	0.314GluCys: 0.314 ± 0.015	3.341GluAsp: 3.341 ± 0.048	4.203GluGlu: 4.203 ± 0.07	1.666GluPhe: 1.666 ± 0.037	6.098GluGly: 6.098 ± 0.071	1.16GluHis: 1.16 ± 0.032	2.837GluIle: 2.837 ± 0.052	1.447GluLys: 1.447 ± 0.037	4.97GluLeu: 4.97 ± 0.065	1.62GluMet: 1.62 ± 0.034	1.229GluAsn: 1.229 ± 0.033	3.246GluPro: 3.246 ± 0.062	1.801GluGln: 1.801 ± 0.042	5.359GluArg: 5.359 ± 0.076	2.377GluSer: 2.377 ± 0.037	3.222GluThr: 3.222 ± 0.049	5.189GluVal: 5.189 ± 0.065	0.779GluTrp: 0.779 ± 0.024	0.767GluTyr: 0.767 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.116PheAla: 4.116 ± 0.062	0.347PheCys: 0.347 ± 0.017	2.424PheAsp: 2.424 ± 0.045	1.943PheGlu: 1.943 ± 0.037	1.119PhePhe: 1.119 ± 0.039	3.476PheGly: 3.476 ± 0.047	0.717PheHis: 0.717 ± 0.023	1.176PheIle: 1.176 ± 0.029	0.615PheLys: 0.615 ± 0.025	3.317PheLeu: 3.317 ± 0.06	0.635PheMet: 0.635 ± 0.022	0.769PheAsn: 0.769 ± 0.024	1.546PhePro: 1.546 ± 0.035	0.993PheGln: 0.993 ± 0.023	2.359PheArg: 2.359 ± 0.04	1.644PheSer: 1.644 ± 0.035	1.741PheThr: 1.741 ± 0.038	2.657PheVal: 2.657 ± 0.043	0.565PheTrp: 0.565 ± 0.02	0.742PheTyr: 0.742 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.817GlyAla: 10.817 ± 0.106	0.864GlyCys: 0.864 ± 0.03	4.863GlyAsp: 4.863 ± 0.077	5.595GlyGlu: 5.595 ± 0.07	3.433GlyPhe: 3.433 ± 0.053	8.67GlyGly: 8.67 ± 0.128	2.166GlyHis: 2.166 ± 0.042	4.018GlyIle: 4.018 ± 0.057	2.354GlyLys: 2.354 ± 0.05	10.338GlyLeu: 10.338 ± 0.098	2.435GlyMet: 2.435 ± 0.043	2.007GlyAsn: 2.007 ± 0.057	4.874GlyPro: 4.874 ± 0.059	3.446GlyGln: 3.446 ± 0.059	8.158GlyArg: 8.158 ± 0.087	4.619GlySer: 4.619 ± 0.062	5.274GlyThr: 5.274 ± 0.068	6.581GlyVal: 6.581 ± 0.075	1.715GlyTrp: 1.715 ± 0.039	2.077GlyTyr: 2.077 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.387HisAla: 2.387 ± 0.053	0.212HisCys: 0.212 ± 0.012	1.333HisAsp: 1.333 ± 0.034	1.189HisGlu: 1.189 ± 0.036	0.744HisPhe: 0.744 ± 0.02	2.202HisGly: 2.202 ± 0.049	0.592HisHis: 0.592 ± 0.022	0.715HisIle: 0.715 ± 0.025	0.391HisLys: 0.391 ± 0.016	2.328HisLeu: 2.328 ± 0.044	0.473HisMet: 0.473 ± 0.019	0.353HisAsn: 0.353 ± 0.017	1.632HisPro: 1.632 ± 0.039	0.596HisGln: 0.596 ± 0.024	1.869HisArg: 1.869 ± 0.044	0.787HisSer: 0.787 ± 0.025	0.692HisThr: 0.692 ± 0.023	1.653HisVal: 1.653 ± 0.036	0.339HisTrp: 0.339 ± 0.017	0.463HisTyr: 0.463 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.732IleAla: 5.732 ± 0.071	0.384IleCys: 0.384 ± 0.018	2.856IleAsp: 2.856 ± 0.051	3.023IleGlu: 3.023 ± 0.049	1.254IlePhe: 1.254 ± 0.037	4.067IleGly: 4.067 ± 0.06	0.833IleHis: 0.833 ± 0.026	1.339IleIle: 1.339 ± 0.037	0.793IleLys: 0.793 ± 0.024	4.218IleLeu: 4.218 ± 0.056	0.733IleMet: 0.733 ± 0.023	0.944IleAsn: 0.944 ± 0.026	2.202IlePro: 2.202 ± 0.045	1.007IleGln: 1.007 ± 0.024	3.113IleArg: 3.113 ± 0.052	1.909IleSer: 1.909 ± 0.038	2.092IleThr: 2.092 ± 0.037	3.438IleVal: 3.438 ± 0.052	0.538IleTrp: 0.538 ± 0.021	0.873IleTyr: 0.873 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.294LysAla: 3.294 ± 0.059	0.109LysCys: 0.109 ± 0.009	1.333LysAsp: 1.333 ± 0.036	1.137LysGlu: 1.137 ± 0.03	0.551LysPhe: 0.551 ± 0.02	2.325LysGly: 2.325 ± 0.039	0.413LysHis: 0.413 ± 0.02	0.872LysIle: 0.872 ± 0.026	0.601LysLys: 0.601 ± 0.028	2.105LysLeu: 2.105 ± 0.046	0.485LysMet: 0.485 ± 0.021	0.423LysAsn: 0.423 ± 0.019	1.316LysPro: 1.316 ± 0.037	0.562LysGln: 0.562 ± 0.025	1.666LysArg: 1.666 ± 0.043	1.122LysSer: 1.122 ± 0.029	1.121LysThr: 1.121 ± 0.027	1.92LysVal: 1.92 ± 0.04	0.261LysTrp: 0.261 ± 0.012	0.386LysTyr: 0.386 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.122LeuAla: 15.122 ± 0.145	0.918LeuCys: 0.918 ± 0.025	6.543LeuAsp: 6.543 ± 0.083	5.105LeuGlu: 5.105 ± 0.061	3.127LeuPhe: 3.127 ± 0.054	9.974LeuGly: 9.974 ± 0.116	2.131LeuHis: 2.131 ± 0.037	4.132LeuIle: 4.132 ± 0.07	2.451LeuLys: 2.451 ± 0.043	10.561LeuLeu: 10.561 ± 0.124	2.268LeuMet: 2.268 ± 0.042	2.214LeuAsn: 2.214 ± 0.043	6.225LeuPro: 6.225 ± 0.075	2.653LeuGln: 2.653 ± 0.045	9.04LeuArg: 9.04 ± 0.095	6.317LeuSer: 6.317 ± 0.06	5.575LeuThr: 5.575 ± 0.074	7.827LeuVal: 7.827 ± 0.095	1.54LeuTrp: 1.54 ± 0.037	1.877LeuTyr: 1.877 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.46MetAla: 3.46 ± 0.048	0.135MetCys: 0.135 ± 0.009	1.301MetAsp: 1.301 ± 0.034	1.225MetGlu: 1.225 ± 0.03	0.634MetPhe: 0.634 ± 0.023	2.124MetGly: 2.124 ± 0.042	0.371MetHis: 0.371 ± 0.015	1.142MetIle: 1.142 ± 0.032	0.656MetLys: 0.656 ± 0.021	2.269MetLeu: 2.269 ± 0.043	0.578MetMet: 0.578 ± 0.021	0.669MetAsn: 0.669 ± 0.023	1.46MetPro: 1.46 ± 0.034	0.654MetGln: 0.654 ± 0.024	1.889MetArg: 1.889 ± 0.04	1.378MetSer: 1.378 ± 0.031	1.948MetThr: 1.948 ± 0.038	1.675MetVal: 1.675 ± 0.034	0.225MetTrp: 0.225 ± 0.015	0.257MetTyr: 0.257 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.633AsnAla: 2.633 ± 0.051	0.195AsnCys: 0.195 ± 0.013	1.243AsnAsp: 1.243 ± 0.043	1.011AsnGlu: 1.011 ± 0.029	0.74AsnPhe: 0.74 ± 0.026	2.043AsnGly: 2.043 ± 0.047	0.422AsnHis: 0.422 ± 0.017	0.92AsnIle: 0.92 ± 0.028	0.397AsnLys: 0.397 ± 0.017	2.328AsnLeu: 2.328 ± 0.039	0.453AsnMet: 0.453 ± 0.019	0.494AsnAsn: 0.494 ± 0.021	1.621AsnPro: 1.621 ± 0.037	0.595AsnGln: 0.595 ± 0.022	1.433AsnArg: 1.433 ± 0.031	0.911AsnSer: 0.911 ± 0.027	0.923AsnThr: 0.923 ± 0.03	1.627AsnVal: 1.627 ± 0.039	0.349AsnTrp: 0.349 ± 0.017	0.505AsnTyr: 0.505 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.931ProAla: 6.931 ± 0.082	0.455ProCys: 0.455 ± 0.017	4.142ProAsp: 4.142 ± 0.058	4.881ProGlu: 4.881 ± 0.062	1.973ProPhe: 1.973 ± 0.041	5.842ProGly: 5.842 ± 0.07	1.185ProHis: 1.185 ± 0.031	2.0ProIle: 2.0 ± 0.036	1.286ProLys: 1.286 ± 0.029	5.414ProLeu: 5.414 ± 0.067	1.396ProMet: 1.396 ± 0.032	1.149ProAsn: 1.149 ± 0.034	3.286ProPro: 3.286 ± 0.067	1.645ProGln: 1.645 ± 0.033	4.295ProArg: 4.295 ± 0.076	3.124ProSer: 3.124 ± 0.05	2.714ProThr: 2.714 ± 0.041	4.517ProVal: 4.517 ± 0.07	0.944ProTrp: 0.944 ± 0.029	1.122ProTyr: 1.122 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.528GlnAla: 4.528 ± 0.067	0.155GlnCys: 0.155 ± 0.01	1.711GlnAsp: 1.711 ± 0.032	1.681GlnGlu: 1.681 ± 0.039	0.869GlnPhe: 0.869 ± 0.026	3.097GlnGly: 3.097 ± 0.055	0.549GlnHis: 0.549 ± 0.019	1.388GlnIle: 1.388 ± 0.035	0.706GlnLys: 0.706 ± 0.019	2.514GlnLeu: 2.514 ± 0.048	0.784GlnMet: 0.784 ± 0.022	0.619GlnAsn: 0.619 ± 0.022	1.744GlnPro: 1.744 ± 0.036	0.963GlnGln: 0.963 ± 0.031	2.365GlnArg: 2.365 ± 0.042	1.43GlnSer: 1.43 ± 0.033	1.424GlnThr: 1.424 ± 0.034	2.53GlnVal: 2.53 ± 0.044	0.404GlnTrp: 0.404 ± 0.016	0.435GlnTyr: 0.435 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.087ArgAla: 10.087 ± 0.106	0.563ArgCys: 0.563 ± 0.021	4.807ArgAsp: 4.807 ± 0.063	5.11ArgGlu: 5.11 ± 0.065	2.778ArgPhe: 2.778 ± 0.046	6.196ArgGly: 6.196 ± 0.086	2.112ArgHis: 2.112 ± 0.047	3.931ArgIle: 3.931 ± 0.058	1.714ArgLys: 1.714 ± 0.039	9.481ArgLeu: 9.481 ± 0.09	2.095ArgMet: 2.095 ± 0.04	1.6ArgAsn: 1.6 ± 0.03	5.107ArgPro: 5.107 ± 0.07	2.558ArgGln: 2.558 ± 0.044	7.654ArgArg: 7.654 ± 0.116	3.892ArgSer: 3.892 ± 0.063	3.761ArgThr: 3.761 ± 0.055	5.734ArgVal: 5.734 ± 0.073	1.299ArgTrp: 1.299 ± 0.032	1.426ArgTyr: 1.426 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.537SerAla: 5.537 ± 0.066	0.412SerCys: 0.412 ± 0.018	2.795SerAsp: 2.795 ± 0.046	2.642SerGlu: 2.642 ± 0.045	1.954SerPhe: 1.954 ± 0.039	5.275SerGly: 5.275 ± 0.071	0.999SerHis: 0.999 ± 0.026	1.888SerIle: 1.888 ± 0.042	1.01SerLys: 1.01 ± 0.03	5.041SerLeu: 5.041 ± 0.072	1.224SerMet: 1.224 ± 0.032	1.036SerAsn: 1.036 ± 0.027	3.126SerPro: 3.126 ± 0.051	1.389SerGln: 1.389 ± 0.035	3.977SerArg: 3.977 ± 0.057	2.597SerSer: 2.597 ± 0.058	2.523SerThr: 2.523 ± 0.041	3.498SerVal: 3.498 ± 0.053	0.808SerTrp: 0.808 ± 0.026	1.08SerTyr: 1.08 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.888ThrAla: 5.888 ± 0.074	0.474ThrCys: 0.474 ± 0.019	2.857ThrAsp: 2.857 ± 0.049	2.82ThrGlu: 2.82 ± 0.051	1.91ThrPhe: 1.91 ± 0.04	5.395ThrGly: 5.395 ± 0.069	1.058ThrHis: 1.058 ± 0.026	2.262ThrIle: 2.262 ± 0.041	1.062ThrLys: 1.062 ± 0.029	5.948ThrLeu: 5.948 ± 0.072	1.149ThrMet: 1.149 ± 0.031	1.035ThrAsn: 1.035 ± 0.03	3.404ThrPro: 3.404 ± 0.053	1.393ThrGln: 1.393 ± 0.036	3.669ThrArg: 3.669 ± 0.061	2.656ThrSer: 2.656 ± 0.046	2.778ThrThr: 2.778 ± 0.055	4.224ThrVal: 4.224 ± 0.058	0.818ThrTrp: 0.818 ± 0.027	1.139ThrTyr: 1.139 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.142ValAla: 10.142 ± 0.095	0.601ValCys: 0.601 ± 0.021	3.857ValAsp: 3.857 ± 0.06	5.033ValGlu: 5.033 ± 0.062	2.441ValPhe: 2.441 ± 0.044	6.058ValGly: 6.058 ± 0.08	1.454ValHis: 1.454 ± 0.03	3.423ValIle: 3.423 ± 0.053	1.633ValLys: 1.633 ± 0.044	8.128ValLeu: 8.128 ± 0.088	1.798ValMet: 1.798 ± 0.042	1.811ValAsn: 1.811 ± 0.042	4.25ValPro: 4.25 ± 0.064	2.144ValGln: 2.144 ± 0.042	5.277ValArg: 5.277 ± 0.073	3.743ValSer: 3.743 ± 0.052	4.883ValThr: 4.883 ± 0.073	6.237ValVal: 6.237 ± 0.089	1.083ValTrp: 1.083 ± 0.032	1.277ValTyr: 1.277 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.707TrpAla: 1.707 ± 0.039	0.146TrpCys: 0.146 ± 0.011	0.838TrpAsp: 0.838 ± 0.026	0.774TrpGlu: 0.774 ± 0.023	0.584TrpPhe: 0.584 ± 0.02	1.232TrpGly: 1.232 ± 0.031	0.383TrpHis: 0.383 ± 0.018	0.69TrpIle: 0.69 ± 0.025	0.372TrpLys: 0.372 ± 0.018	1.792TrpLeu: 1.792 ± 0.038	0.387TrpMet: 0.387 ± 0.019	0.431TrpAsn: 0.431 ± 0.02	0.877TrpPro: 0.877 ± 0.028	0.537TrpGln: 0.537 ± 0.021	1.452TrpArg: 1.452 ± 0.037	0.911TrpSer: 0.911 ± 0.028	1.002TrpThr: 1.002 ± 0.029	0.973TrpVal: 0.973 ± 0.03	0.281TrpTrp: 0.281 ± 0.014	0.26TrpTyr: 0.26 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.362TyrAla: 2.362 ± 0.04	0.207TyrCys: 0.207 ± 0.012	1.316TyrAsp: 1.316 ± 0.034	1.155TyrGlu: 1.155 ± 0.029	0.683TyrPhe: 0.683 ± 0.022	1.93TyrGly: 1.93 ± 0.046	0.443TyrHis: 0.443 ± 0.019	0.631TyrIle: 0.631 ± 0.024	0.392TyrLys: 0.392 ± 0.018	1.988TyrLeu: 1.988 ± 0.042	0.358TyrMet: 0.358 ± 0.017	0.486TyrAsn: 0.486 ± 0.018	1.032TyrPro: 1.032 ± 0.027	0.548TyrGln: 0.548 ± 0.022	1.49TyrArg: 1.49 ± 0.031	0.942TyrSer: 0.942 ± 0.028	0.904TyrThr: 0.904 ± 0.024	1.5TyrVal: 1.5 ± 0.031	0.312TyrTrp: 0.312 ± 0.017	0.482TyrTyr: 0.482 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4946 proteins (1389346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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