Amino acid dipepetide frequency for Staphylococcus virus CNPH82

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.992AlaAla: 1.992 ± 0.379
0.369AlaCys: 0.369 ± 0.167
2.14AlaAsp: 2.14 ± 0.446
3.025AlaGlu: 3.025 ± 0.593
2.214AlaPhe: 2.214 ± 0.7
3.247AlaGly: 3.247 ± 0.565
1.402AlaHis: 1.402 ± 0.325
5.239AlaIle: 5.239 ± 0.768
4.87AlaLys: 4.87 ± 0.744
4.501AlaLeu: 4.501 ± 0.842
1.771AlaMet: 1.771 ± 0.364
4.279AlaAsn: 4.279 ± 0.535
1.402AlaPro: 1.402 ± 0.28
2.73AlaGln: 2.73 ± 0.554
1.697AlaArg: 1.697 ± 0.274
3.763AlaSer: 3.763 ± 0.845
3.099AlaThr: 3.099 ± 0.5
2.509AlaVal: 2.509 ± 0.629
0.812AlaTrp: 0.812 ± 0.203
1.771AlaTyr: 1.771 ± 0.367
0.0AlaXaa: 0.0 ± 0.0
Cys
0.221CysAla: 0.221 ± 0.099
0.0CysCys: 0.0 ± 0.0
0.295CysAsp: 0.295 ± 0.165
0.221CysGlu: 0.221 ± 0.112
0.221CysPhe: 0.221 ± 0.128
0.664CysGly: 0.664 ± 0.212
0.148CysHis: 0.148 ± 0.093
0.443CysIle: 0.443 ± 0.193
0.885CysLys: 0.885 ± 0.284
0.59CysLeu: 0.59 ± 0.188
0.0CysMet: 0.0 ± 0.0
0.812CysAsn: 0.812 ± 0.218
0.369CysPro: 0.369 ± 0.18
0.074CysGln: 0.074 ± 0.06
0.221CysArg: 0.221 ± 0.118
0.443CysSer: 0.443 ± 0.234
0.148CysThr: 0.148 ± 0.104
0.443CysVal: 0.443 ± 0.155
0.074CysTrp: 0.074 ± 0.078
0.369CysTyr: 0.369 ± 0.175
0.0CysXaa: 0.0 ± 0.0
Asp
3.247AspAla: 3.247 ± 0.619
0.295AspCys: 0.295 ± 0.147
3.984AspAsp: 3.984 ± 0.679
5.755AspGlu: 5.755 ± 0.859
3.025AspPhe: 3.025 ± 0.48
4.722AspGly: 4.722 ± 0.563
0.443AspHis: 0.443 ± 0.168
4.944AspIle: 4.944 ± 0.693
5.239AspLys: 5.239 ± 0.543
5.608AspLeu: 5.608 ± 0.736
1.623AspMet: 1.623 ± 0.424
4.944AspAsn: 4.944 ± 0.681
1.107AspPro: 1.107 ± 0.232
1.402AspGln: 1.402 ± 0.441
2.509AspArg: 2.509 ± 0.487
3.025AspSer: 3.025 ± 0.468
4.058AspThr: 4.058 ± 0.541
4.058AspVal: 4.058 ± 0.51
0.959AspTrp: 0.959 ± 0.22
3.025AspTyr: 3.025 ± 0.433
0.0AspXaa: 0.0 ± 0.0
Glu
2.951GluAla: 2.951 ± 0.625
0.369GluCys: 0.369 ± 0.151
3.837GluAsp: 3.837 ± 0.607
5.239GluGlu: 5.239 ± 1.096
2.804GluPhe: 2.804 ± 0.526
2.214GluGly: 2.214 ± 0.41
1.476GluHis: 1.476 ± 0.37
5.017GluIle: 5.017 ± 0.641
5.829GluLys: 5.829 ± 0.743
8.338GluLeu: 8.338 ± 1.112
1.992GluMet: 1.992 ± 0.459
4.87GluAsn: 4.87 ± 0.543
1.697GluPro: 1.697 ± 0.335
4.058GluGln: 4.058 ± 0.598
4.575GluArg: 4.575 ± 0.666
3.689GluSer: 3.689 ± 0.558
3.542GluThr: 3.542 ± 0.441
5.386GluVal: 5.386 ± 0.669
1.402GluTrp: 1.402 ± 0.342
3.984GluTyr: 3.984 ± 0.465
0.0GluXaa: 0.0 ± 0.0
Phe
1.771PheAla: 1.771 ± 0.318
0.148PheCys: 0.148 ± 0.09
2.804PheAsp: 2.804 ± 0.369
2.214PheGlu: 2.214 ± 0.366
1.402PhePhe: 1.402 ± 0.339
2.066PheGly: 2.066 ± 0.762
0.812PheHis: 0.812 ± 0.191
3.099PheIle: 3.099 ± 0.561
3.173PheLys: 3.173 ± 0.338
1.992PheLeu: 1.992 ± 0.303
1.476PheMet: 1.476 ± 0.336
3.247PheAsn: 3.247 ± 0.466
0.369PhePro: 0.369 ± 0.15
1.623PheGln: 1.623 ± 0.467
1.623PheArg: 1.623 ± 0.424
2.066PheSer: 2.066 ± 0.401
2.582PheThr: 2.582 ± 0.491
3.025PheVal: 3.025 ± 0.537
0.221PheTrp: 0.221 ± 0.166
2.214PheTyr: 2.214 ± 0.434
0.0PheXaa: 0.0 ± 0.0
Gly
3.911GlyAla: 3.911 ± 0.716
0.812GlyCys: 0.812 ± 0.215
2.878GlyAsp: 2.878 ± 0.523
3.394GlyGlu: 3.394 ± 0.461
2.214GlyPhe: 2.214 ± 0.366
3.468GlyGly: 3.468 ± 0.581
1.254GlyHis: 1.254 ± 0.366
5.608GlyIle: 5.608 ± 0.654
5.681GlyLys: 5.681 ± 0.656
4.132GlyLeu: 4.132 ± 0.67
1.771GlyMet: 1.771 ± 0.414
3.615GlyAsn: 3.615 ± 0.617
0.664GlyPro: 0.664 ± 0.195
2.878GlyGln: 2.878 ± 0.392
3.173GlyArg: 3.173 ± 0.338
3.025GlySer: 3.025 ± 0.71
3.689GlyThr: 3.689 ± 0.528
5.386GlyVal: 5.386 ± 0.71
0.812GlyTrp: 0.812 ± 0.297
3.32GlyTyr: 3.32 ± 0.516
0.0GlyXaa: 0.0 ± 0.0
His
1.254HisAla: 1.254 ± 0.302
0.074HisCys: 0.074 ± 0.066
0.812HisAsp: 0.812 ± 0.208
0.959HisGlu: 0.959 ± 0.283
0.516HisPhe: 0.516 ± 0.17
0.959HisGly: 0.959 ± 0.224
0.812HisHis: 0.812 ± 0.314
0.959HisIle: 0.959 ± 0.283
1.549HisLys: 1.549 ± 0.365
1.623HisLeu: 1.623 ± 0.32
0.221HisMet: 0.221 ± 0.124
1.181HisAsn: 1.181 ± 0.258
0.812HisPro: 0.812 ± 0.224
0.59HisGln: 0.59 ± 0.251
0.295HisArg: 0.295 ± 0.14
1.402HisSer: 1.402 ± 0.297
1.402HisThr: 1.402 ± 0.305
1.107HisVal: 1.107 ± 0.269
0.074HisTrp: 0.074 ± 0.074
0.885HisTyr: 0.885 ± 0.241
0.0HisXaa: 0.0 ± 0.0
Ile
4.796IleAla: 4.796 ± 0.599
0.369IleCys: 0.369 ± 0.175
5.534IleAsp: 5.534 ± 0.768
6.345IleGlu: 6.345 ± 0.796
1.992IlePhe: 1.992 ± 0.454
5.091IleGly: 5.091 ± 0.78
0.664IleHis: 0.664 ± 0.214
4.501IleIle: 4.501 ± 0.735
9.297IleLys: 9.297 ± 0.773
3.984IleLeu: 3.984 ± 0.584
1.476IleMet: 1.476 ± 0.515
4.501IleAsn: 4.501 ± 0.596
2.287IlePro: 2.287 ± 0.333
2.287IleGln: 2.287 ± 0.294
1.992IleArg: 1.992 ± 0.29
4.648IleSer: 4.648 ± 0.803
5.091IleThr: 5.091 ± 0.631
3.247IleVal: 3.247 ± 0.48
1.033IleTrp: 1.033 ± 0.31
2.509IleTyr: 2.509 ± 0.528
0.0IleXaa: 0.0 ± 0.0
Lys
4.87LysAla: 4.87 ± 0.627
0.443LysCys: 0.443 ± 0.207
6.272LysAsp: 6.272 ± 0.751
7.969LysGlu: 7.969 ± 1.035
3.099LysPhe: 3.099 ± 0.425
5.977LysGly: 5.977 ± 0.565
2.14LysHis: 2.14 ± 0.399
4.87LysIle: 4.87 ± 0.703
6.714LysLys: 6.714 ± 0.885
7.231LysLeu: 7.231 ± 0.904
2.73LysMet: 2.73 ± 0.569
6.198LysAsn: 6.198 ± 0.897
3.099LysPro: 3.099 ± 0.651
4.575LysGln: 4.575 ± 0.572
5.017LysArg: 5.017 ± 0.706
5.091LysSer: 5.091 ± 0.699
6.345LysThr: 6.345 ± 0.809
5.312LysVal: 5.312 ± 0.599
0.885LysTrp: 0.885 ± 0.235
4.501LysTyr: 4.501 ± 0.765
0.0LysXaa: 0.0 ± 0.0
Leu
3.837LeuAla: 3.837 ± 0.689
0.369LeuCys: 0.369 ± 0.261
5.755LeuAsp: 5.755 ± 0.631
6.345LeuGlu: 6.345 ± 0.852
3.025LeuPhe: 3.025 ± 0.563
4.722LeuGly: 4.722 ± 0.771
1.107LeuHis: 1.107 ± 0.286
5.239LeuIle: 5.239 ± 0.746
7.747LeuLys: 7.747 ± 0.865
5.165LeuLeu: 5.165 ± 0.597
1.771LeuMet: 1.771 ± 0.298
5.017LeuAsn: 5.017 ± 0.47
2.361LeuPro: 2.361 ± 0.405
3.394LeuGln: 3.394 ± 0.537
3.763LeuArg: 3.763 ± 0.57
4.722LeuSer: 4.722 ± 0.826
3.837LeuThr: 3.837 ± 0.455
3.763LeuVal: 3.763 ± 0.406
1.107LeuTrp: 1.107 ± 0.343
3.025LeuTyr: 3.025 ± 0.55
0.0LeuXaa: 0.0 ± 0.0
Met
1.697MetAla: 1.697 ± 0.496
0.148MetCys: 0.148 ± 0.111
1.476MetAsp: 1.476 ± 0.356
1.328MetGlu: 1.328 ± 0.274
0.812MetPhe: 0.812 ± 0.258
0.959MetGly: 0.959 ± 0.247
0.148MetHis: 0.148 ± 0.095
1.476MetIle: 1.476 ± 0.251
2.73MetLys: 2.73 ± 0.372
2.14MetLeu: 2.14 ± 0.458
0.812MetMet: 0.812 ± 0.28
1.697MetAsn: 1.697 ± 0.341
0.959MetPro: 0.959 ± 0.247
0.885MetGln: 0.885 ± 0.297
0.812MetArg: 0.812 ± 0.228
1.845MetSer: 1.845 ± 0.366
1.992MetThr: 1.992 ± 0.404
0.959MetVal: 0.959 ± 0.265
0.59MetTrp: 0.59 ± 0.201
1.254MetTyr: 1.254 ± 0.323
0.0MetXaa: 0.0 ± 0.0
Asn
3.394AsnAla: 3.394 ± 0.594
0.885AsnCys: 0.885 ± 0.336
4.722AsnAsp: 4.722 ± 0.648
4.353AsnGlu: 4.353 ± 0.584
2.656AsnPhe: 2.656 ± 0.393
5.46AsnGly: 5.46 ± 0.677
1.328AsnHis: 1.328 ± 0.296
4.722AsnIle: 4.722 ± 0.693
6.272AsnLys: 6.272 ± 0.761
4.722AsnLeu: 4.722 ± 0.625
0.443AsnMet: 0.443 ± 0.159
6.124AsnAsn: 6.124 ± 1.134
2.509AsnPro: 2.509 ± 0.4
2.878AsnGln: 2.878 ± 0.563
3.32AsnArg: 3.32 ± 0.55
4.058AsnSer: 4.058 ± 0.43
3.32AsnThr: 3.32 ± 0.636
4.87AsnVal: 4.87 ± 0.563
0.885AsnTrp: 0.885 ± 0.239
2.73AsnTyr: 2.73 ± 0.514
0.0AsnXaa: 0.0 ± 0.0
Pro
1.254ProAla: 1.254 ± 0.266
0.148ProCys: 0.148 ± 0.094
1.623ProAsp: 1.623 ± 0.313
2.066ProGlu: 2.066 ± 0.404
1.697ProPhe: 1.697 ± 0.429
1.181ProGly: 1.181 ± 0.361
0.443ProHis: 0.443 ± 0.151
2.435ProIle: 2.435 ± 0.594
3.173ProLys: 3.173 ± 0.556
1.549ProLeu: 1.549 ± 0.318
0.516ProMet: 0.516 ± 0.176
1.623ProAsn: 1.623 ± 0.452
0.959ProPro: 0.959 ± 0.29
1.181ProGln: 1.181 ± 0.315
1.845ProArg: 1.845 ± 0.368
1.992ProSer: 1.992 ± 0.556
1.254ProThr: 1.254 ± 0.316
1.623ProVal: 1.623 ± 0.334
0.148ProTrp: 0.148 ± 0.101
1.328ProTyr: 1.328 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
2.804GlnAla: 2.804 ± 0.603
0.369GlnCys: 0.369 ± 0.159
2.509GlnAsp: 2.509 ± 0.482
2.804GlnGlu: 2.804 ± 0.393
1.181GlnPhe: 1.181 ± 0.262
2.656GlnGly: 2.656 ± 0.464
0.738GlnHis: 0.738 ± 0.26
3.247GlnIle: 3.247 ± 0.382
3.615GlnLys: 3.615 ± 0.543
3.247GlnLeu: 3.247 ± 0.54
1.107GlnMet: 1.107 ± 0.279
2.509GlnAsn: 2.509 ± 0.465
1.181GlnPro: 1.181 ± 0.264
1.992GlnGln: 1.992 ± 0.535
2.14GlnArg: 2.14 ± 0.331
2.804GlnSer: 2.804 ± 0.387
2.214GlnThr: 2.214 ± 0.501
1.845GlnVal: 1.845 ± 0.545
0.516GlnTrp: 0.516 ± 0.196
1.402GlnTyr: 1.402 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
1.918ArgAla: 1.918 ± 0.568
0.516ArgCys: 0.516 ± 0.205
3.247ArgAsp: 3.247 ± 0.506
3.763ArgGlu: 3.763 ± 0.569
1.623ArgPhe: 1.623 ± 0.251
2.14ArgGly: 2.14 ± 0.401
0.738ArgHis: 0.738 ± 0.202
2.656ArgIle: 2.656 ± 0.429
4.206ArgLys: 4.206 ± 0.66
3.911ArgLeu: 3.911 ± 0.444
1.476ArgMet: 1.476 ± 0.338
3.32ArgAsn: 3.32 ± 0.406
0.885ArgPro: 0.885 ± 0.279
0.885ArgGln: 0.885 ± 0.23
2.582ArgArg: 2.582 ± 0.534
2.582ArgSer: 2.582 ± 0.374
1.623ArgThr: 1.623 ± 0.381
3.247ArgVal: 3.247 ± 0.497
0.885ArgTrp: 0.885 ± 0.243
3.025ArgTyr: 3.025 ± 0.491
0.0ArgXaa: 0.0 ± 0.0
Ser
3.247SerAla: 3.247 ± 0.592
0.221SerCys: 0.221 ± 0.12
4.058SerAsp: 4.058 ± 0.587
3.689SerGlu: 3.689 ± 0.486
2.214SerPhe: 2.214 ± 0.423
4.279SerGly: 4.279 ± 0.681
1.181SerHis: 1.181 ± 0.359
3.32SerIle: 3.32 ± 0.529
5.46SerLys: 5.46 ± 0.649
4.87SerLeu: 4.87 ± 0.703
1.476SerMet: 1.476 ± 0.274
4.427SerAsn: 4.427 ± 0.778
1.181SerPro: 1.181 ± 0.32
3.025SerGln: 3.025 ± 0.599
2.509SerArg: 2.509 ± 0.53
2.656SerSer: 2.656 ± 0.335
3.099SerThr: 3.099 ± 0.576
3.689SerVal: 3.689 ± 0.413
1.107SerTrp: 1.107 ± 0.346
2.435SerTyr: 2.435 ± 0.499
0.0SerXaa: 0.0 ± 0.0
Thr
3.173ThrAla: 3.173 ± 0.651
0.221ThrCys: 0.221 ± 0.105
3.984ThrAsp: 3.984 ± 0.516
3.025ThrGlu: 3.025 ± 0.552
3.025ThrPhe: 3.025 ± 0.444
3.763ThrGly: 3.763 ± 0.525
0.885ThrHis: 0.885 ± 0.208
5.312ThrIle: 5.312 ± 0.536
6.272ThrLys: 6.272 ± 0.864
3.763ThrLeu: 3.763 ± 0.545
1.107ThrMet: 1.107 ± 0.235
4.206ThrAsn: 4.206 ± 0.548
2.582ThrPro: 2.582 ± 0.528
2.435ThrGln: 2.435 ± 0.391
1.771ThrArg: 1.771 ± 0.453
3.32ThrSer: 3.32 ± 0.535
3.984ThrThr: 3.984 ± 0.69
3.173ThrVal: 3.173 ± 0.759
0.443ThrTrp: 0.443 ± 0.157
2.066ThrTyr: 2.066 ± 0.405
0.0ThrXaa: 0.0 ± 0.0
Val
3.984ValAla: 3.984 ± 0.835
0.221ValCys: 0.221 ± 0.155
4.648ValAsp: 4.648 ± 0.546
5.386ValGlu: 5.386 ± 0.673
2.14ValPhe: 2.14 ± 0.507
3.837ValGly: 3.837 ± 0.487
0.664ValHis: 0.664 ± 0.234
4.132ValIle: 4.132 ± 0.583
5.239ValLys: 5.239 ± 0.597
4.132ValLeu: 4.132 ± 0.548
1.402ValMet: 1.402 ± 0.257
3.394ValAsn: 3.394 ± 0.411
2.066ValPro: 2.066 ± 0.346
1.992ValGln: 1.992 ± 0.336
2.804ValArg: 2.804 ± 0.349
4.648ValSer: 4.648 ± 0.594
3.615ValThr: 3.615 ± 0.525
4.648ValVal: 4.648 ± 0.606
0.443ValTrp: 0.443 ± 0.251
2.509ValTyr: 2.509 ± 0.491
0.0ValXaa: 0.0 ± 0.0
Trp
0.664TrpAla: 0.664 ± 0.251
0.221TrpCys: 0.221 ± 0.122
0.516TrpAsp: 0.516 ± 0.19
1.254TrpGlu: 1.254 ± 0.319
0.295TrpPhe: 0.295 ± 0.174
0.885TrpGly: 0.885 ± 0.271
0.221TrpHis: 0.221 ± 0.12
0.959TrpIle: 0.959 ± 0.296
1.107TrpLys: 1.107 ± 0.297
1.181TrpLeu: 1.181 ± 0.286
0.0TrpMet: 0.0 ± 0.0
0.885TrpAsn: 0.885 ± 0.316
0.148TrpPro: 0.148 ± 0.093
0.443TrpGln: 0.443 ± 0.166
0.443TrpArg: 0.443 ± 0.157
0.664TrpSer: 0.664 ± 0.194
1.402TrpThr: 1.402 ± 0.275
1.181TrpVal: 1.181 ± 0.302
0.295TrpTrp: 0.295 ± 0.177
0.664TrpTyr: 0.664 ± 0.227
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.845TyrAla: 1.845 ± 0.401
0.443TyrCys: 0.443 ± 0.169
2.878TyrAsp: 2.878 ± 0.41
4.132TyrGlu: 4.132 ± 0.678
1.771TyrPhe: 1.771 ± 0.384
3.394TyrGly: 3.394 ± 0.597
0.885TyrHis: 0.885 ± 0.247
3.468TyrIle: 3.468 ± 0.556
4.279TyrLys: 4.279 ± 0.658
3.394TyrLeu: 3.394 ± 0.501
1.476TyrMet: 1.476 ± 0.331
2.804TyrAsn: 2.804 ± 0.461
1.402TyrPro: 1.402 ± 0.347
1.549TyrGln: 1.549 ± 0.301
2.14TyrArg: 2.14 ± 0.453
1.697TyrSer: 1.697 ± 0.321
2.214TyrThr: 2.214 ± 0.345
2.509TyrVal: 2.509 ± 0.284
0.738TyrTrp: 0.738 ± 0.248
1.623TyrTyr: 1.623 ± 0.314
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (13554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski