Amino acid dipepetide frequency for Marinobacter sp. X15-166B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.648AlaAla: 12.648 ± 0.145	1.11AlaCys: 1.11 ± 0.034	6.295AlaAsp: 6.295 ± 0.086	6.73AlaGlu: 6.73 ± 0.092	3.628AlaPhe: 3.628 ± 0.057	9.547AlaGly: 9.547 ± 0.096	2.244AlaHis: 2.244 ± 0.051	5.528AlaIle: 5.528 ± 0.08	2.987AlaLys: 2.987 ± 0.058	12.485AlaLeu: 12.485 ± 0.143	2.989AlaMet: 2.989 ± 0.055	2.98AlaAsn: 2.98 ± 0.062	4.429AlaPro: 4.429 ± 0.077	4.3AlaGln: 4.3 ± 0.065	7.463AlaArg: 7.463 ± 0.089	5.886AlaSer: 5.886 ± 0.074	5.594AlaThr: 5.594 ± 0.083	8.032AlaVal: 8.032 ± 0.102	1.316AlaTrp: 1.316 ± 0.035	2.435AlaTyr: 2.435 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.97CysAla: 0.97 ± 0.031	0.107CysCys: 0.107 ± 0.01	0.555CysAsp: 0.555 ± 0.026	0.526CysGlu: 0.526 ± 0.021	0.368CysPhe: 0.368 ± 0.02	0.904CysGly: 0.904 ± 0.035	0.306CysHis: 0.306 ± 0.018	0.42CysIle: 0.42 ± 0.02	0.27CysLys: 0.27 ± 0.018	0.918CysLeu: 0.918 ± 0.033	0.196CysMet: 0.196 ± 0.014	0.256CysAsn: 0.256 ± 0.016	0.525CysPro: 0.525 ± 0.024	0.432CysGln: 0.432 ± 0.021	0.618CysArg: 0.618 ± 0.024	0.502CysSer: 0.502 ± 0.024	0.456CysThr: 0.456 ± 0.021	0.67CysVal: 0.67 ± 0.024	0.133CysTrp: 0.133 ± 0.011	0.279CysTyr: 0.279 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.653AspAla: 5.653 ± 0.087	0.474AspCys: 0.474 ± 0.023	3.223AspAsp: 3.223 ± 0.059	3.664AspGlu: 3.664 ± 0.067	2.011AspPhe: 2.011 ± 0.042	4.369AspGly: 4.369 ± 0.086	1.329AspHis: 1.329 ± 0.039	3.166AspIle: 3.166 ± 0.062	1.827AspLys: 1.827 ± 0.045	5.651AspLeu: 5.651 ± 0.077	1.388AspMet: 1.388 ± 0.038	1.709AspAsn: 1.709 ± 0.04	2.826AspPro: 2.826 ± 0.052	2.398AspGln: 2.398 ± 0.05	3.731AspArg: 3.731 ± 0.066	2.813AspSer: 2.813 ± 0.056	3.093AspThr: 3.093 ± 0.059	3.714AspVal: 3.714 ± 0.053	0.97AspTrp: 0.97 ± 0.028	1.753AspTyr: 1.753 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.47GluAla: 6.47 ± 0.098	0.48GluCys: 0.48 ± 0.021	2.83GluAsp: 2.83 ± 0.059	3.322GluGlu: 3.322 ± 0.068	2.123GluPhe: 2.123 ± 0.05	3.961GluGly: 3.961 ± 0.07	1.584GluHis: 1.584 ± 0.046	3.093GluIle: 3.093 ± 0.067	1.984GluLys: 1.984 ± 0.048	6.914GluLeu: 6.914 ± 0.081	1.381GluMet: 1.381 ± 0.039	1.601GluAsn: 1.601 ± 0.04	2.666GluPro: 2.666 ± 0.074	3.623GluGln: 3.623 ± 0.066	4.55GluArg: 4.55 ± 0.075	2.869GluSer: 2.869 ± 0.061	3.078GluThr: 3.078 ± 0.061	4.452GluVal: 4.452 ± 0.078	0.681GluTrp: 0.681 ± 0.025	1.428GluTyr: 1.428 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.744PheAla: 3.744 ± 0.061	0.393PheCys: 0.393 ± 0.021	2.349PheAsp: 2.349 ± 0.05	2.15PheGlu: 2.15 ± 0.051	1.44PhePhe: 1.44 ± 0.044	3.174PheGly: 3.174 ± 0.063	0.788PheHis: 0.788 ± 0.027	1.927PheIle: 1.927 ± 0.048	1.038PheLys: 1.038 ± 0.029	3.24PheLeu: 3.24 ± 0.061	0.932PheMet: 0.932 ± 0.033	1.361PheAsn: 1.361 ± 0.036	1.533PhePro: 1.533 ± 0.043	1.178PheGln: 1.178 ± 0.034	2.203PheArg: 2.203 ± 0.047	2.501PheSer: 2.501 ± 0.056	2.107PheThr: 2.107 ± 0.048	2.671PheVal: 2.671 ± 0.062	0.509PheTrp: 0.509 ± 0.025	1.062PheTyr: 1.062 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.627GlyAla: 7.627 ± 0.096	0.897GlyCys: 0.897 ± 0.028	4.265GlyAsp: 4.265 ± 0.078	4.704GlyGlu: 4.704 ± 0.083	3.404GlyPhe: 3.404 ± 0.065	6.27GlyGly: 6.27 ± 0.114	1.934GlyHis: 1.934 ± 0.045	4.434GlyIle: 4.434 ± 0.067	3.011GlyLys: 3.011 ± 0.063	8.735GlyLeu: 8.735 ± 0.105	2.317GlyMet: 2.317 ± 0.053	2.348GlyAsn: 2.348 ± 0.052	2.712GlyPro: 2.712 ± 0.065	3.431GlyGln: 3.431 ± 0.05	4.993GlyArg: 4.993 ± 0.071	4.323GlySer: 4.323 ± 0.071	4.15GlyThr: 4.15 ± 0.076	6.423GlyVal: 6.423 ± 0.09	1.257GlyTrp: 1.257 ± 0.039	2.491GlyTyr: 2.491 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.128HisAla: 2.128 ± 0.047	0.315HisCys: 0.315 ± 0.019	1.107HisAsp: 1.107 ± 0.03	1.207HisGlu: 1.207 ± 0.035	0.926HisPhe: 0.926 ± 0.028	1.92HisGly: 1.92 ± 0.042	0.753HisHis: 0.753 ± 0.032	1.153HisIle: 1.153 ± 0.034	0.679HisLys: 0.679 ± 0.024	2.422HisLeu: 2.422 ± 0.052	0.52HisMet: 0.52 ± 0.023	0.747HisAsn: 0.747 ± 0.028	1.515HisPro: 1.515 ± 0.038	1.148HisGln: 1.148 ± 0.039	1.679HisArg: 1.679 ± 0.045	1.273HisSer: 1.273 ± 0.036	1.323HisThr: 1.323 ± 0.039	1.292HisVal: 1.292 ± 0.043	0.447HisTrp: 0.447 ± 0.02	0.815HisTyr: 0.815 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.86IleAla: 5.86 ± 0.091	0.519IleCys: 0.519 ± 0.024	3.303IleAsp: 3.303 ± 0.055	3.425IleGlu: 3.425 ± 0.07	1.519IlePhe: 1.519 ± 0.041	4.204IleGly: 4.204 ± 0.069	1.099IleHis: 1.099 ± 0.032	2.454IleIle: 2.454 ± 0.047	1.7IleLys: 1.7 ± 0.045	4.421IleLeu: 4.421 ± 0.083	1.102IleMet: 1.102 ± 0.035	2.018IleAsn: 2.018 ± 0.046	2.523IlePro: 2.523 ± 0.057	1.752IleGln: 1.752 ± 0.043	3.414IleArg: 3.414 ± 0.058	3.026IleSer: 3.026 ± 0.059	3.072IleThr: 3.072 ± 0.05	3.49IleVal: 3.49 ± 0.062	0.531IleTrp: 0.531 ± 0.027	1.175IleTyr: 1.175 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.562LysAla: 3.562 ± 0.066	0.182LysCys: 0.182 ± 0.014	1.68LysAsp: 1.68 ± 0.049	1.691LysGlu: 1.691 ± 0.047	0.834LysPhe: 0.834 ± 0.028	2.345LysGly: 2.345 ± 0.053	0.77LysHis: 0.77 ± 0.025	1.606LysIle: 1.606 ± 0.038	1.312LysLys: 1.312 ± 0.045	3.213LysLeu: 3.213 ± 0.06	0.753LysMet: 0.753 ± 0.03	1.03LysAsn: 1.03 ± 0.035	1.716LysPro: 1.716 ± 0.041	1.424LysGln: 1.424 ± 0.035	2.132LysArg: 2.132 ± 0.05	1.687LysSer: 1.687 ± 0.043	1.875LysThr: 1.875 ± 0.041	2.476LysVal: 2.476 ± 0.055	0.311LysTrp: 0.311 ± 0.019	0.738LysTyr: 0.738 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	13.244LeuAla: 13.244 ± 0.136	1.022LeuCys: 1.022 ± 0.031	5.977LeuAsp: 5.977 ± 0.08	6.211LeuGlu: 6.211 ± 0.095	3.785LeuPhe: 3.785 ± 0.071	8.408LeuGly: 8.408 ± 0.103	2.316LeuHis: 2.316 ± 0.053	5.418LeuIle: 5.418 ± 0.085	3.523LeuLys: 3.523 ± 0.058	11.492LeuLeu: 11.492 ± 0.173	2.759LeuMet: 2.759 ± 0.061	3.427LeuAsn: 3.427 ± 0.06	5.557LeuPro: 5.557 ± 0.085	4.402LeuGln: 4.402 ± 0.075	6.628LeuArg: 6.628 ± 0.085	6.607LeuSer: 6.607 ± 0.076	6.345LeuThr: 6.345 ± 0.083	7.999LeuVal: 7.999 ± 0.108	1.238LeuTrp: 1.238 ± 0.041	2.317LeuTyr: 2.317 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.121MetAla: 3.121 ± 0.062	0.199MetCys: 0.199 ± 0.013	1.251MetAsp: 1.251 ± 0.038	1.233MetGlu: 1.233 ± 0.036	0.727MetPhe: 0.727 ± 0.029	1.951MetGly: 1.951 ± 0.051	0.503MetHis: 0.503 ± 0.021	1.192MetIle: 1.192 ± 0.039	1.009MetLys: 1.009 ± 0.032	2.68MetLeu: 2.68 ± 0.053	0.652MetMet: 0.652 ± 0.025	0.939MetAsn: 0.939 ± 0.033	1.282MetPro: 1.282 ± 0.038	0.958MetGln: 0.958 ± 0.033	1.421MetArg: 1.421 ± 0.039	1.736MetSer: 1.736 ± 0.041	1.73MetThr: 1.73 ± 0.046	1.823MetVal: 1.823 ± 0.042	0.185MetTrp: 0.185 ± 0.013	0.412MetTyr: 0.412 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.027AsnAla: 3.027 ± 0.063	0.299AsnCys: 0.299 ± 0.019	1.653AsnAsp: 1.653 ± 0.044	1.681AsnGlu: 1.681 ± 0.039	1.047AsnPhe: 1.047 ± 0.035	2.458AsnGly: 2.458 ± 0.058	0.753AsnHis: 0.753 ± 0.029	1.605AsnIle: 1.605 ± 0.042	1.025AsnLys: 1.025 ± 0.033	3.288AsnLeu: 3.288 ± 0.059	0.722AsnMet: 0.722 ± 0.03	1.088AsnAsn: 1.088 ± 0.034	2.101AsnPro: 2.101 ± 0.048	1.289AsnGln: 1.289 ± 0.034	2.128AsnArg: 2.128 ± 0.05	1.515AsnSer: 1.515 ± 0.044	1.757AsnThr: 1.757 ± 0.045	1.932AsnVal: 1.932 ± 0.051	0.424AsnTrp: 0.424 ± 0.021	0.896AsnTyr: 0.896 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.574ProAla: 5.574 ± 0.089	0.339ProCys: 0.339 ± 0.024	3.424ProAsp: 3.424 ± 0.057	3.88ProGlu: 3.88 ± 0.074	1.745ProPhe: 1.745 ± 0.042	4.206ProGly: 4.206 ± 0.076	1.051ProHis: 1.051 ± 0.033	1.944ProIle: 1.944 ± 0.053	1.334ProLys: 1.334 ± 0.041	4.93ProLeu: 4.93 ± 0.076	1.16ProMet: 1.16 ± 0.037	1.212ProAsn: 1.212 ± 0.04	2.031ProPro: 2.031 ± 0.059	1.867ProGln: 1.867 ± 0.046	2.409ProArg: 2.409 ± 0.046	2.308ProSer: 2.308 ± 0.052	2.139ProThr: 2.139 ± 0.048	4.454ProVal: 4.454 ± 0.072	0.683ProTrp: 0.683 ± 0.027	1.195ProTyr: 1.195 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.134GlnAla: 5.134 ± 0.076	0.373GlnCys: 0.373 ± 0.022	1.822GlnAsp: 1.822 ± 0.04	2.152GlnGlu: 2.152 ± 0.054	1.429GlnPhe: 1.429 ± 0.037	3.214GlnGly: 3.214 ± 0.053	1.124GlnHis: 1.124 ± 0.036	1.943GlnIle: 1.943 ± 0.045	1.197GlnLys: 1.197 ± 0.036	4.908GlnLeu: 4.908 ± 0.08	1.017GlnMet: 1.017 ± 0.031	1.111GlnAsn: 1.111 ± 0.036	2.283GlnPro: 2.283 ± 0.05	2.786GlnGln: 2.786 ± 0.06	3.394GlnArg: 3.394 ± 0.073	2.148GlnSer: 2.148 ± 0.054	2.151GlnThr: 2.151 ± 0.052	3.347GlnVal: 3.347 ± 0.062	0.635GlnTrp: 0.635 ± 0.026	0.947GlnTyr: 0.947 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.214ArgAla: 6.214 ± 0.088	0.613ArgCys: 0.613 ± 0.027	3.503ArgAsp: 3.503 ± 0.064	4.127ArgGlu: 4.127 ± 0.065	2.747ArgPhe: 2.747 ± 0.05	4.195ArgGly: 4.195 ± 0.069	1.82ArgHis: 1.82 ± 0.051	3.616ArgIle: 3.616 ± 0.059	2.347ArgLys: 2.347 ± 0.05	7.683ArgLeu: 7.683 ± 0.108	1.72ArgMet: 1.72 ± 0.043	2.102ArgAsn: 2.102 ± 0.044	2.847ArgPro: 2.847 ± 0.065	3.449ArgGln: 3.449 ± 0.069	4.605ArgArg: 4.605 ± 0.077	3.305ArgSer: 3.305 ± 0.06	3.146ArgThr: 3.146 ± 0.056	5.149ArgVal: 5.149 ± 0.075	1.071ArgTrp: 1.071 ± 0.04	2.123ArgTyr: 2.123 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.917SerAla: 5.917 ± 0.083	0.415SerCys: 0.415 ± 0.022	2.939SerAsp: 2.939 ± 0.058	3.102SerGlu: 3.102 ± 0.05	2.158SerPhe: 2.158 ± 0.046	5.373SerGly: 5.373 ± 0.087	1.254SerHis: 1.254 ± 0.036	2.672SerIle: 2.672 ± 0.055	1.636SerLys: 1.636 ± 0.042	5.955SerLeu: 5.955 ± 0.08	1.406SerMet: 1.406 ± 0.037	1.587SerAsn: 1.587 ± 0.039	2.662SerPro: 2.662 ± 0.058	2.207SerGln: 2.207 ± 0.05	3.733SerArg: 3.733 ± 0.063	2.934SerSer: 2.934 ± 0.06	2.763SerThr: 2.763 ± 0.045	4.229SerVal: 4.229 ± 0.067	0.795SerTrp: 0.795 ± 0.033	1.361SerTyr: 1.361 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.937ThrAla: 5.937 ± 0.081	0.455ThrCys: 0.455 ± 0.023	3.177ThrAsp: 3.177 ± 0.059	3.024ThrGlu: 3.024 ± 0.06	1.801ThrPhe: 1.801 ± 0.047	5.071ThrGly: 5.071 ± 0.067	1.153ThrHis: 1.153 ± 0.035	2.524ThrIle: 2.524 ± 0.054	1.144ThrLys: 1.144 ± 0.035	7.0ThrLeu: 7.0 ± 0.096	1.063ThrMet: 1.063 ± 0.029	1.481ThrAsn: 1.481 ± 0.043	3.213ThrPro: 3.213 ± 0.063	1.83ThrGln: 1.83 ± 0.041	3.551ThrArg: 3.551 ± 0.064	2.767ThrSer: 2.767 ± 0.053	2.9ThrThr: 2.9 ± 0.059	4.403ThrVal: 4.403 ± 0.07	0.65ThrTrp: 0.65 ± 0.026	1.225ThrTyr: 1.225 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.403ValAla: 8.403 ± 0.105	0.768ValCys: 0.768 ± 0.027	4.313ValAsp: 4.313 ± 0.072	4.294ValGlu: 4.294 ± 0.062	3.026ValPhe: 3.026 ± 0.06	5.163ValGly: 5.163 ± 0.077	1.524ValHis: 1.524 ± 0.034	4.257ValIle: 4.257 ± 0.065	2.264ValLys: 2.264 ± 0.055	7.755ValLeu: 7.755 ± 0.101	2.072ValMet: 2.072 ± 0.05	2.533ValAsn: 2.533 ± 0.049	3.494ValPro: 3.494 ± 0.065	2.456ValGln: 2.456 ± 0.05	4.667ValArg: 4.667 ± 0.069	4.75ValSer: 4.75 ± 0.085	4.693ValThr: 4.693 ± 0.071	6.334ValVal: 6.334 ± 0.106	0.91ValTrp: 0.91 ± 0.028	1.88ValTyr: 1.88 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.106TrpAla: 1.106 ± 0.033	0.161TrpCys: 0.161 ± 0.014	0.61TrpAsp: 0.61 ± 0.024	0.571TrpGlu: 0.571 ± 0.023	0.569TrpPhe: 0.569 ± 0.022	0.858TrpGly: 0.858 ± 0.031	0.387TrpHis: 0.387 ± 0.022	0.545TrpIle: 0.545 ± 0.025	0.335TrpLys: 0.335 ± 0.017	2.014TrpLeu: 2.014 ± 0.051	0.359TrpMet: 0.359 ± 0.018	0.366TrpAsn: 0.366 ± 0.017	0.652TrpPro: 0.652 ± 0.023	0.906TrpGln: 0.906 ± 0.028	0.967TrpArg: 0.967 ± 0.035	0.725TrpSer: 0.725 ± 0.027	0.633TrpThr: 0.633 ± 0.025	1.034TrpVal: 1.034 ± 0.037	0.213TrpTrp: 0.213 ± 0.015	0.331TrpTyr: 0.331 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.288TyrAla: 2.288 ± 0.051	0.29TyrCys: 0.29 ± 0.017	1.486TyrAsp: 1.486 ± 0.039	1.396TyrGlu: 1.396 ± 0.033	1.015TyrPhe: 1.015 ± 0.036	2.136TyrGly: 2.136 ± 0.05	0.677TyrHis: 0.677 ± 0.028	1.108TyrIle: 1.108 ± 0.038	0.716TyrLys: 0.716 ± 0.028	2.971TyrLeu: 2.971 ± 0.061	0.496TyrMet: 0.496 ± 0.024	0.792TyrAsn: 0.792 ± 0.032	1.318TyrPro: 1.318 ± 0.035	1.279TyrGln: 1.279 ± 0.035	2.094TyrArg: 2.094 ± 0.043	1.424TyrSer: 1.424 ± 0.033	1.364TyrThr: 1.364 ± 0.039	1.631TyrVal: 1.631 ± 0.038	0.383TyrTrp: 0.383 ± 0.021	0.759TyrTyr: 0.759 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3115 proteins (999817 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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