Amino acid dipepetide frequency for Qipengyuania marisflavi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.362AlaAla: 18.362 ± 0.226	1.104AlaCys: 1.104 ± 0.041	7.713AlaAsp: 7.713 ± 0.103	8.11AlaGlu: 8.11 ± 0.124	4.18AlaPhe: 4.18 ± 0.071	11.251AlaGly: 11.251 ± 0.187	2.272AlaHis: 2.272 ± 0.058	6.905AlaIle: 6.905 ± 0.103	4.539AlaLys: 4.539 ± 0.096	14.062AlaLeu: 14.062 ± 0.17	4.01AlaMet: 4.01 ± 0.08	3.249AlaAsn: 3.249 ± 0.067	5.864AlaPro: 5.864 ± 0.103	4.953AlaGln: 4.953 ± 0.096	9.09AlaArg: 9.09 ± 0.131	6.304AlaSer: 6.304 ± 0.121	5.829AlaThr: 5.829 ± 0.119	8.339AlaVal: 8.339 ± 0.106	1.544AlaTrp: 1.544 ± 0.052	2.459AlaTyr: 2.459 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.014CysAla: 1.014 ± 0.038	0.082CysCys: 0.082 ± 0.01	0.626CysAsp: 0.626 ± 0.031	0.529CysGlu: 0.529 ± 0.027	0.29CysPhe: 0.29 ± 0.017	0.883CysGly: 0.883 ± 0.035	0.245CysHis: 0.245 ± 0.025	0.369CysIle: 0.369 ± 0.025	0.195CysLys: 0.195 ± 0.016	0.717CysLeu: 0.717 ± 0.033	0.14CysMet: 0.14 ± 0.012	0.216CysAsn: 0.216 ± 0.015	0.467CysPro: 0.467 ± 0.029	0.245CysGln: 0.245 ± 0.018	0.509CysArg: 0.509 ± 0.029	0.5CysSer: 0.5 ± 0.025	0.414CysThr: 0.414 ± 0.025	0.538CysVal: 0.538 ± 0.03	0.103CysTrp: 0.103 ± 0.01	0.17CysTyr: 0.17 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.762AspAla: 7.762 ± 0.135	0.565AspCys: 0.565 ± 0.031	3.828AspAsp: 3.828 ± 0.097	3.791AspGlu: 3.791 ± 0.073	2.402AspPhe: 2.402 ± 0.059	5.841AspGly: 5.841 ± 0.097	1.376AspHis: 1.376 ± 0.043	3.079AspIle: 3.079 ± 0.083	2.091AspLys: 2.091 ± 0.057	5.779AspLeu: 5.779 ± 0.098	1.637AspMet: 1.637 ± 0.053	1.606AspAsn: 1.606 ± 0.048	3.692AspPro: 3.692 ± 0.073	1.934AspGln: 1.934 ± 0.05	4.635AspArg: 4.635 ± 0.081	2.793AspSer: 2.793 ± 0.066	3.067AspThr: 3.067 ± 0.071	3.847AspVal: 3.847 ± 0.076	1.217AspTrp: 1.217 ± 0.042	1.669AspTyr: 1.669 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.847GluAla: 7.847 ± 0.119	0.425GluCys: 0.425 ± 0.021	3.513GluAsp: 3.513 ± 0.074	3.581GluGlu: 3.581 ± 0.084	1.966GluPhe: 1.966 ± 0.052	4.721GluGly: 4.721 ± 0.088	1.29GluHis: 1.29 ± 0.042	3.194GluIle: 3.194 ± 0.072	2.162GluLys: 2.162 ± 0.062	5.702GluLeu: 5.702 ± 0.095	1.735GluMet: 1.735 ± 0.044	1.652GluAsn: 1.652 ± 0.049	2.805GluPro: 2.805 ± 0.067	2.536GluGln: 2.536 ± 0.068	4.952GluArg: 4.952 ± 0.09	2.403GluSer: 2.403 ± 0.055	3.269GluThr: 3.269 ± 0.066	3.769GluVal: 3.769 ± 0.082	0.877GluTrp: 0.877 ± 0.032	1.169GluTyr: 1.169 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	5.314PheAla: 5.314 ± 0.088	0.347PheCys: 0.347 ± 0.019	2.771PheAsp: 2.771 ± 0.067	2.113PheGlu: 2.113 ± 0.06	1.338PhePhe: 1.338 ± 0.047	3.631PheGly: 3.631 ± 0.064	0.67PheHis: 0.67 ± 0.03	1.548PheIle: 1.548 ± 0.046	0.894PheLys: 0.894 ± 0.039	3.044PheLeu: 3.044 ± 0.063	0.749PheMet: 0.749 ± 0.028	0.985PheAsn: 0.985 ± 0.035	1.528PhePro: 1.528 ± 0.042	0.868PheGln: 0.868 ± 0.033	2.012PheArg: 2.012 ± 0.051	2.132PheSer: 2.132 ± 0.053	2.09PheThr: 2.09 ± 0.059	2.681PheVal: 2.681 ± 0.056	0.546PheTrp: 0.546 ± 0.028	0.913PheTyr: 0.913 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.82GlyAla: 9.82 ± 0.167	0.847GlyCys: 0.847 ± 0.035	5.463GlyAsp: 5.463 ± 0.16	5.65GlyGlu: 5.65 ± 0.092	3.592GlyPhe: 3.592 ± 0.072	8.443GlyGly: 8.443 ± 0.277	1.885GlyHis: 1.885 ± 0.058	4.332GlyIle: 4.332 ± 0.076	3.658GlyLys: 3.658 ± 0.083	8.229GlyLeu: 8.229 ± 0.092	2.44GlyMet: 2.44 ± 0.071	2.44GlyAsn: 2.44 ± 0.076	3.457GlyPro: 3.457 ± 0.071	3.13GlyGln: 3.13 ± 0.074	5.785GlyArg: 5.785 ± 0.093	5.029GlySer: 5.029 ± 0.12	4.877GlyThr: 4.877 ± 0.133	5.924GlyVal: 5.924 ± 0.096	1.598GlyTrp: 1.598 ± 0.052	2.175GlyTyr: 2.175 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.304HisAla: 2.304 ± 0.061	0.259HisCys: 0.259 ± 0.017	1.251HisAsp: 1.251 ± 0.045	1.09HisGlu: 1.09 ± 0.038	0.872HisPhe: 0.872 ± 0.035	1.968HisGly: 1.968 ± 0.057	0.546HisHis: 0.546 ± 0.029	0.961HisIle: 0.961 ± 0.035	0.514HisLys: 0.514 ± 0.025	1.8HisLeu: 1.8 ± 0.051	0.451HisMet: 0.451 ± 0.024	0.484HisAsn: 0.484 ± 0.027	1.232HisPro: 1.232 ± 0.039	0.569HisGln: 0.569 ± 0.028	1.484HisArg: 1.484 ± 0.047	1.07HisSer: 1.07 ± 0.037	0.802HisThr: 0.802 ± 0.031	1.307HisVal: 1.307 ± 0.041	0.386HisTrp: 0.386 ± 0.021	0.581HisTyr: 0.581 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	8.046IleAla: 8.046 ± 0.11	0.418IleCys: 0.418 ± 0.025	3.8IleAsp: 3.8 ± 0.085	3.507IleGlu: 3.507 ± 0.066	1.663IlePhe: 1.663 ± 0.05	4.973IleGly: 4.973 ± 0.095	0.873IleHis: 0.873 ± 0.03	2.137IleIle: 2.137 ± 0.057	1.302IleLys: 1.302 ± 0.046	3.822IleLeu: 3.822 ± 0.065	0.981IleMet: 0.981 ± 0.037	1.341IleAsn: 1.341 ± 0.046	2.339IlePro: 2.339 ± 0.063	1.041IleGln: 1.041 ± 0.034	2.995IleArg: 2.995 ± 0.063	2.657IleSer: 2.657 ± 0.063	2.772IleThr: 2.772 ± 0.08	3.817IleVal: 3.817 ± 0.056	0.585IleTrp: 0.585 ± 0.031	1.024IleTyr: 1.024 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.057LysAla: 4.057 ± 0.083	0.2LysCys: 0.2 ± 0.016	1.784LysAsp: 1.784 ± 0.057	1.387LysGlu: 1.387 ± 0.05	1.017LysPhe: 1.017 ± 0.035	2.643LysGly: 2.643 ± 0.062	0.661LysHis: 0.661 ± 0.026	1.652LysIle: 1.652 ± 0.048	1.303LysLys: 1.303 ± 0.06	3.378LysLeu: 3.378 ± 0.073	0.845LysMet: 0.845 ± 0.031	0.782LysAsn: 0.782 ± 0.037	2.044LysPro: 2.044 ± 0.056	1.11LysGln: 1.11 ± 0.04	2.414LysArg: 2.414 ± 0.058	1.698LysSer: 1.698 ± 0.048	1.855LysThr: 1.855 ± 0.048	2.167LysVal: 2.167 ± 0.06	0.418LysTrp: 0.418 ± 0.025	0.65LysTyr: 0.65 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	14.577LeuAla: 14.577 ± 0.152	0.754LeuCys: 0.754 ± 0.029	6.196LeuAsp: 6.196 ± 0.11	5.359LeuGlu: 5.359 ± 0.102	3.576LeuPhe: 3.576 ± 0.059	8.346LeuGly: 8.346 ± 0.108	1.781LeuHis: 1.781 ± 0.049	4.419LeuIle: 4.419 ± 0.085	2.995LeuLys: 2.995 ± 0.068	9.452LeuLeu: 9.452 ± 0.15	2.288LeuMet: 2.288 ± 0.058	2.245LeuAsn: 2.245 ± 0.054	5.271LeuPro: 5.271 ± 0.099	2.587LeuGln: 2.587 ± 0.063	6.663LeuArg: 6.663 ± 0.113	5.74LeuSer: 5.74 ± 0.085	5.509LeuThr: 5.509 ± 0.096	7.45LeuVal: 7.45 ± 0.101	1.226LeuTrp: 1.226 ± 0.043	1.901LeuTyr: 1.901 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.49MetAla: 3.49 ± 0.073	0.168MetCys: 0.168 ± 0.014	1.315MetAsp: 1.315 ± 0.05	1.226MetGlu: 1.226 ± 0.045	0.707MetPhe: 0.707 ± 0.032	2.144MetGly: 2.144 ± 0.058	0.493MetHis: 0.493 ± 0.023	1.374MetIle: 1.374 ± 0.041	0.947MetLys: 0.947 ± 0.036	2.752MetLeu: 2.752 ± 0.061	0.706MetMet: 0.706 ± 0.033	0.68MetAsn: 0.68 ± 0.033	1.441MetPro: 1.441 ± 0.041	0.881MetGln: 0.881 ± 0.033	1.941MetArg: 1.941 ± 0.049	1.462MetSer: 1.462 ± 0.041	1.837MetThr: 1.837 ± 0.047	1.773MetVal: 1.773 ± 0.056	0.234MetTrp: 0.234 ± 0.018	0.295MetTyr: 0.295 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.205AsnAla: 3.205 ± 0.082	0.266AsnCys: 0.266 ± 0.02	1.532AsnAsp: 1.532 ± 0.055	1.232AsnGlu: 1.232 ± 0.044	0.993AsnPhe: 0.993 ± 0.04	2.387AsnGly: 2.387 ± 0.065	0.498AsnHis: 0.498 ± 0.023	1.333AsnIle: 1.333 ± 0.038	0.654AsnLys: 0.654 ± 0.03	2.39AsnLeu: 2.39 ± 0.06	0.563AsnMet: 0.563 ± 0.026	0.615AsnAsn: 0.615 ± 0.035	1.781AsnPro: 1.781 ± 0.053	0.806AsnGln: 0.806 ± 0.036	1.873AsnArg: 1.873 ± 0.052	1.355AsnSer: 1.355 ± 0.049	1.235AsnThr: 1.235 ± 0.043	1.781AsnVal: 1.781 ± 0.058	0.441AsnTrp: 0.441 ± 0.023	0.688AsnTyr: 0.688 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.44ProAla: 6.44 ± 0.103	0.354ProCys: 0.354 ± 0.02	3.813ProAsp: 3.813 ± 0.073	3.823ProGlu: 3.823 ± 0.076	1.821ProPhe: 1.821 ± 0.043	4.49ProGly: 4.49 ± 0.079	1.019ProHis: 1.019 ± 0.035	2.332ProIle: 2.332 ± 0.054	1.544ProLys: 1.544 ± 0.056	4.828ProLeu: 4.828 ± 0.079	1.192ProMet: 1.192 ± 0.038	1.174ProAsn: 1.174 ± 0.038	2.539ProPro: 2.539 ± 0.088	1.829ProGln: 1.829 ± 0.056	2.917ProArg: 2.917 ± 0.06	2.494ProSer: 2.494 ± 0.063	2.312ProThr: 2.312 ± 0.053	3.933ProVal: 3.933 ± 0.067	0.615ProTrp: 0.615 ± 0.03	1.051ProTyr: 1.051 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.159GlnAla: 4.159 ± 0.073	0.247GlnCys: 0.247 ± 0.017	1.787GlnAsp: 1.787 ± 0.04	1.582GlnGlu: 1.582 ± 0.05	1.197GlnPhe: 1.197 ± 0.039	2.666GlnGly: 2.666 ± 0.058	0.686GlnHis: 0.686 ± 0.028	1.878GlnIle: 1.878 ± 0.049	0.897GlnLys: 0.897 ± 0.038	3.509GlnLeu: 3.509 ± 0.065	0.954GlnMet: 0.954 ± 0.034	0.747GlnAsn: 0.747 ± 0.034	1.829GlnPro: 1.829 ± 0.054	1.365GlnGln: 1.365 ± 0.045	2.578GlnArg: 2.578 ± 0.067	1.801GlnSer: 1.801 ± 0.054	1.694GlnThr: 1.694 ± 0.05	2.352GlnVal: 2.352 ± 0.055	0.451GlnTrp: 0.451 ± 0.026	0.656GlnTyr: 0.656 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.107ArgAla: 8.107 ± 0.131	0.502ArgCys: 0.502 ± 0.026	4.322ArgAsp: 4.322 ± 0.072	4.549ArgGlu: 4.549 ± 0.09	2.884ArgPhe: 2.884 ± 0.064	5.091ArgGly: 5.091 ± 0.08	1.553ArgHis: 1.553 ± 0.047	4.01ArgIle: 4.01 ± 0.076	2.396ArgLys: 2.396 ± 0.057	7.356ArgLeu: 7.356 ± 0.113	2.003ArgMet: 2.003 ± 0.053	1.85ArgAsn: 1.85 ± 0.049	3.104ArgPro: 3.104 ± 0.06	2.369ArgGln: 2.369 ± 0.059	5.112ArgArg: 5.112 ± 0.096	3.741ArgSer: 3.741 ± 0.072	3.218ArgThr: 3.218 ± 0.064	4.519ArgVal: 4.519 ± 0.09	1.11ArgTrp: 1.11 ± 0.046	1.663ArgTyr: 1.663 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	6.481SerAla: 6.481 ± 0.118	0.433SerCys: 0.433 ± 0.023	3.402SerAsp: 3.402 ± 0.056	3.136SerGlu: 3.136 ± 0.061	2.165SerPhe: 2.165 ± 0.056	5.654SerGly: 5.654 ± 0.124	0.931SerHis: 0.931 ± 0.038	2.459SerIle: 2.459 ± 0.064	1.496SerLys: 1.496 ± 0.047	5.069SerLeu: 5.069 ± 0.104	1.215SerMet: 1.215 ± 0.04	1.405SerAsn: 1.405 ± 0.04	2.643SerPro: 2.643 ± 0.06	1.692SerGln: 1.692 ± 0.043	3.42SerArg: 3.42 ± 0.069	2.749SerSer: 2.749 ± 0.08	2.523SerThr: 2.523 ± 0.066	3.575SerVal: 3.575 ± 0.078	0.868SerTrp: 0.868 ± 0.036	1.336SerTyr: 1.336 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.546ThrAla: 6.546 ± 0.128	0.395ThrCys: 0.395 ± 0.026	2.922ThrAsp: 2.922 ± 0.063	2.587ThrGlu: 2.587 ± 0.061	1.72ThrPhe: 1.72 ± 0.046	5.265ThrGly: 5.265 ± 0.138	0.996ThrHis: 0.996 ± 0.04	2.877ThrIle: 2.877 ± 0.081	1.443ThrLys: 1.443 ± 0.04	5.645ThrLeu: 5.645 ± 0.091	1.318ThrMet: 1.318 ± 0.034	1.32ThrAsn: 1.32 ± 0.043	3.109ThrPro: 3.109 ± 0.062	1.649ThrGln: 1.649 ± 0.044	3.434ThrArg: 3.434 ± 0.061	2.748ThrSer: 2.748 ± 0.073	2.547ThrThr: 2.547 ± 0.061	3.969ThrVal: 3.969 ± 0.079	0.524ThrTrp: 0.524 ± 0.026	1.106ThrTyr: 1.106 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	8.763ValAla: 8.763 ± 0.11	0.52ValCys: 0.52 ± 0.023	4.188ValAsp: 4.188 ± 0.08	4.412ValGlu: 4.412 ± 0.089	2.31ValPhe: 2.31 ± 0.058	5.356ValGly: 5.356 ± 0.098	1.282ValHis: 1.282 ± 0.035	3.698ValIle: 3.698 ± 0.072	2.017ValLys: 2.017 ± 0.052	6.909ValLeu: 6.909 ± 0.107	1.867ValMet: 1.867 ± 0.048	1.813ValAsn: 1.813 ± 0.058	3.683ValPro: 3.683 ± 0.066	2.066ValGln: 2.066 ± 0.053	4.512ValArg: 4.512 ± 0.08	3.952ValSer: 3.952 ± 0.076	4.466ValThr: 4.466 ± 0.084	5.029ValVal: 5.029 ± 0.096	0.877ValTrp: 0.877 ± 0.036	1.261ValTyr: 1.261 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.315TrpAla: 1.315 ± 0.045	0.125TrpCys: 0.125 ± 0.013	0.771TrpAsp: 0.771 ± 0.037	0.69TrpGlu: 0.69 ± 0.028	0.609TrpPhe: 0.609 ± 0.029	0.967TrpGly: 0.967 ± 0.031	0.39TrpHis: 0.39 ± 0.022	0.627TrpIle: 0.627 ± 0.03	0.435TrpLys: 0.435 ± 0.024	1.834TrpLeu: 1.834 ± 0.057	0.359TrpMet: 0.359 ± 0.019	0.435TrpAsn: 0.435 ± 0.022	0.658TrpPro: 0.658 ± 0.032	0.738TrpGln: 0.738 ± 0.03	1.307TrpArg: 1.307 ± 0.045	0.872TrpSer: 0.872 ± 0.037	0.725TrpThr: 0.725 ± 0.031	0.82TrpVal: 0.82 ± 0.035	0.269TrpTrp: 0.269 ± 0.021	0.267TrpTyr: 0.267 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.527TyrAla: 2.527 ± 0.057	0.241TyrCys: 0.241 ± 0.018	1.613TyrAsp: 1.613 ± 0.043	1.215TyrGlu: 1.215 ± 0.045	0.873TyrPhe: 0.873 ± 0.033	2.057TyrGly: 2.057 ± 0.056	0.487TyrHis: 0.487 ± 0.022	0.908TyrIle: 0.908 ± 0.037	0.583TyrLys: 0.583 ± 0.028	2.057TyrLeu: 2.057 ± 0.056	0.412TyrMet: 0.412 ± 0.023	0.589TyrAsn: 0.589 ± 0.031	1.034TyrPro: 1.034 ± 0.036	0.67TyrGln: 0.67 ± 0.027	1.827TyrArg: 1.827 ± 0.051	1.151TyrSer: 1.151 ± 0.034	1.077TyrThr: 1.077 ± 0.041	1.393TyrVal: 1.393 ± 0.041	0.325TyrTrp: 0.325 ± 0.023	0.554TyrTyr: 0.554 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2508 proteins (813454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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