Amino acid dipepetide frequency for Leuconostoc lactis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.801AlaAla: 9.801 ± 0.192
0.128AlaCys: 0.128 ± 0.018
6.278AlaAsp: 6.278 ± 0.135
5.379AlaGlu: 5.379 ± 0.137
3.773AlaPhe: 3.773 ± 0.081
7.09AlaGly: 7.09 ± 0.14
1.974AlaHis: 1.974 ± 0.061
6.93AlaIle: 6.93 ± 0.115
5.443AlaLys: 5.443 ± 0.115
9.671AlaLeu: 9.671 ± 0.175
2.697AlaMet: 2.697 ± 0.084
4.106AlaAsn: 4.106 ± 0.113
3.056AlaPro: 3.056 ± 0.098
5.589AlaGln: 5.589 ± 0.123
3.852AlaArg: 3.852 ± 0.091
4.407AlaSer: 4.407 ± 0.092
6.499AlaThr: 6.499 ± 0.134
7.469AlaVal: 7.469 ± 0.139
0.862AlaTrp: 0.862 ± 0.049
3.032AlaTyr: 3.032 ± 0.088
0.0AlaXaa: 0.0 ± 0.0
Cys
0.126CysAla: 0.126 ± 0.017
0.01CysCys: 0.01 ± 0.005
0.062CysAsp: 0.062 ± 0.013
0.056CysGlu: 0.056 ± 0.011
0.09CysPhe: 0.09 ± 0.015
0.184CysGly: 0.184 ± 0.021
0.046CysHis: 0.046 ± 0.014
0.06CysIle: 0.06 ± 0.012
0.02CysLys: 0.02 ± 0.007
0.212CysLeu: 0.212 ± 0.022
0.026CysMet: 0.026 ± 0.007
0.054CysAsn: 0.054 ± 0.01
0.068CysPro: 0.068 ± 0.014
0.088CysGln: 0.088 ± 0.016
0.082CysArg: 0.082 ± 0.014
0.068CysSer: 0.068 ± 0.012
0.074CysThr: 0.074 ± 0.014
0.094CysVal: 0.094 ± 0.014
0.014CysTrp: 0.014 ± 0.005
0.046CysTyr: 0.046 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
5.32AspAla: 5.32 ± 0.103
0.068AspCys: 0.068 ± 0.014
3.838AspAsp: 3.838 ± 0.112
3.759AspGlu: 3.759 ± 0.102
2.95AspPhe: 2.95 ± 0.08
3.789AspGly: 3.789 ± 0.097
1.206AspHis: 1.206 ± 0.049
3.934AspIle: 3.934 ± 0.085
3.232AspLys: 3.232 ± 0.088
5.793AspLeu: 5.793 ± 0.116
1.727AspMet: 1.727 ± 0.057
2.621AspAsn: 2.621 ± 0.084
2.16AspPro: 2.16 ± 0.065
3.026AspGln: 3.026 ± 0.081
2.391AspArg: 2.391 ± 0.071
2.291AspSer: 2.291 ± 0.074
3.413AspThr: 3.413 ± 0.087
4.565AspVal: 4.565 ± 0.1
0.804AspTrp: 0.804 ± 0.042
2.407AspTyr: 2.407 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.274GluAla: 5.274 ± 0.121
0.032GluCys: 0.032 ± 0.008
2.461GluAsp: 2.461 ± 0.087
2.559GluGlu: 2.559 ± 0.095
1.908GluPhe: 1.908 ± 0.066
2.397GluGly: 2.397 ± 0.085
0.982GluHis: 0.982 ± 0.045
3.627GluIle: 3.627 ± 0.103
3.581GluLys: 3.581 ± 0.102
5.184GluLeu: 5.184 ± 0.125
1.609GluMet: 1.609 ± 0.055
2.812GluAsn: 2.812 ± 0.064
1.727GluPro: 1.727 ± 0.067
2.699GluGln: 2.699 ± 0.076
2.393GluArg: 2.393 ± 0.077
2.299GluSer: 2.299 ± 0.072
3.501GluThr: 3.501 ± 0.098
3.459GluVal: 3.459 ± 0.095
0.435GluTrp: 0.435 ± 0.03
1.419GluTyr: 1.419 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.765PheAla: 3.765 ± 0.096
0.074PheCys: 0.074 ± 0.012
3.09PheAsp: 3.09 ± 0.08
2.457PheGlu: 2.457 ± 0.08
1.934PhePhe: 1.934 ± 0.076
3.715PheGly: 3.715 ± 0.098
0.739PheHis: 0.739 ± 0.04
2.798PheIle: 2.798 ± 0.087
2.204PheLys: 2.204 ± 0.073
3.679PheLeu: 3.679 ± 0.104
1.204PheMet: 1.204 ± 0.038
2.116PheAsn: 2.116 ± 0.053
1.445PhePro: 1.445 ± 0.058
1.609PheGln: 1.609 ± 0.059
1.293PheArg: 1.293 ± 0.058
2.599PheSer: 2.599 ± 0.078
2.449PheThr: 2.449 ± 0.071
3.353PheVal: 3.353 ± 0.086
0.571PheTrp: 0.571 ± 0.036
1.493PheTyr: 1.493 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
5.791GlyAla: 5.791 ± 0.142
0.108GlyCys: 0.108 ± 0.015
3.934GlyAsp: 3.934 ± 0.087
3.535GlyGlu: 3.535 ± 0.089
3.244GlyPhe: 3.244 ± 0.092
4.517GlyGly: 4.517 ± 0.123
1.615GlyHis: 1.615 ± 0.072
5.034GlyIle: 5.034 ± 0.116
3.469GlyLys: 3.469 ± 0.105
7.076GlyLeu: 7.076 ± 0.123
1.95GlyMet: 1.95 ± 0.063
2.357GlyAsn: 2.357 ± 0.07
1.685GlyPro: 1.685 ± 0.062
3.85GlyGln: 3.85 ± 0.101
2.836GlyArg: 2.836 ± 0.073
3.417GlySer: 3.417 ± 0.079
4.222GlyThr: 4.222 ± 0.102
5.547GlyVal: 5.547 ± 0.108
0.886GlyTrp: 0.886 ± 0.057
2.629GlyTyr: 2.629 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.735HisAla: 1.735 ± 0.064
0.038HisCys: 0.038 ± 0.01
1.545HisAsp: 1.545 ± 0.06
1.206HisGlu: 1.206 ± 0.053
1.092HisPhe: 1.092 ± 0.041
1.451HisGly: 1.451 ± 0.057
0.615HisHis: 0.615 ± 0.039
1.455HisIle: 1.455 ± 0.061
0.757HisLys: 0.757 ± 0.042
2.124HisLeu: 2.124 ± 0.061
0.495HisMet: 0.495 ± 0.034
0.818HisAsn: 0.818 ± 0.044
0.978HisPro: 0.978 ± 0.049
1.228HisGln: 1.228 ± 0.047
0.898HisArg: 0.898 ± 0.048
0.83HisSer: 0.83 ± 0.044
1.118HisThr: 1.118 ± 0.051
1.683HisVal: 1.683 ± 0.054
0.287HisTrp: 0.287 ± 0.024
0.834HisTyr: 0.834 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
7.236IleAla: 7.236 ± 0.123
0.138IleCys: 0.138 ± 0.017
4.124IleAsp: 4.124 ± 0.093
3.491IleGlu: 3.491 ± 0.089
2.91IlePhe: 2.91 ± 0.087
5.407IleGly: 5.407 ± 0.122
1.196IleHis: 1.196 ± 0.05
4.469IleIle: 4.469 ± 0.121
3.537IleLys: 3.537 ± 0.106
6.527IleLeu: 6.527 ± 0.152
1.657IleMet: 1.657 ± 0.061
2.964IleAsn: 2.964 ± 0.083
2.495IlePro: 2.495 ± 0.071
2.787IleGln: 2.787 ± 0.078
2.447IleArg: 2.447 ± 0.067
3.685IleSer: 3.685 ± 0.09
4.296IleThr: 4.296 ± 0.104
5.533IleVal: 5.533 ± 0.116
0.699IleTrp: 0.699 ± 0.042
1.916IleTyr: 1.916 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.791LysAla: 4.791 ± 0.107
0.038LysCys: 0.038 ± 0.009
2.629LysAsp: 2.629 ± 0.083
2.266LysGlu: 2.266 ± 0.073
1.804LysPhe: 1.804 ± 0.061
2.567LysGly: 2.567 ± 0.071
1.068LysHis: 1.068 ± 0.049
3.703LysIle: 3.703 ± 0.08
3.465LysLys: 3.465 ± 0.109
4.789LysLeu: 4.789 ± 0.097
1.856LysMet: 1.856 ± 0.062
2.715LysAsn: 2.715 ± 0.085
2.048LysPro: 2.048 ± 0.069
3.162LysGln: 3.162 ± 0.09
2.649LysArg: 2.649 ± 0.082
2.886LysSer: 2.886 ± 0.094
3.561LysThr: 3.561 ± 0.092
3.515LysVal: 3.515 ± 0.095
0.509LysTrp: 0.509 ± 0.037
1.83LysTyr: 1.83 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
11.232LeuAla: 11.232 ± 0.176
0.138LeuCys: 0.138 ± 0.017
5.549LeuAsp: 5.549 ± 0.112
4.158LeuGlu: 4.158 ± 0.118
3.898LeuPhe: 3.898 ± 0.111
6.653LeuGly: 6.653 ± 0.119
1.832LeuHis: 1.832 ± 0.066
6.469LeuIle: 6.469 ± 0.167
5.222LeuLys: 5.222 ± 0.114
9.729LeuLeu: 9.729 ± 0.205
2.615LeuMet: 2.615 ± 0.077
4.144LeuAsn: 4.144 ± 0.106
4.515LeuPro: 4.515 ± 0.099
4.433LeuGln: 4.433 ± 0.101
4.122LeuArg: 4.122 ± 0.089
6.234LeuSer: 6.234 ± 0.138
7.603LeuThr: 7.603 ± 0.127
7.357LeuVal: 7.357 ± 0.158
0.892LeuTrp: 0.892 ± 0.051
2.613LeuTyr: 2.613 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
3.146MetAla: 3.146 ± 0.07
0.042MetCys: 0.042 ± 0.01
1.07MetAsp: 1.07 ± 0.046
0.737MetGlu: 0.737 ± 0.04
0.908MetPhe: 0.908 ± 0.05
1.858MetGly: 1.858 ± 0.063
0.443MetHis: 0.443 ± 0.027
1.94MetIle: 1.94 ± 0.067
1.317MetLys: 1.317 ± 0.044
2.497MetLeu: 2.497 ± 0.083
0.86MetMet: 0.86 ± 0.047
1.168MetAsn: 1.168 ± 0.047
1.309MetPro: 1.309 ± 0.051
1.359MetGln: 1.359 ± 0.053
1.18MetArg: 1.18 ± 0.052
1.848MetSer: 1.848 ± 0.056
2.619MetThr: 2.619 ± 0.069
1.838MetVal: 1.838 ± 0.078
0.222MetTrp: 0.222 ± 0.023
0.555MetTyr: 0.555 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.781AsnAla: 3.781 ± 0.089
0.066AsnCys: 0.066 ± 0.012
2.679AsnAsp: 2.679 ± 0.077
2.024AsnGlu: 2.024 ± 0.073
1.914AsnPhe: 1.914 ± 0.063
3.214AsnGly: 3.214 ± 0.079
1.072AsnHis: 1.072 ± 0.046
2.888AsnIle: 2.888 ± 0.095
2.042AsnLys: 2.042 ± 0.078
3.862AsnLeu: 3.862 ± 0.1
1.074AsnMet: 1.074 ± 0.049
1.942AsnAsn: 1.942 ± 0.073
2.058AsnPro: 2.058 ± 0.062
2.399AsnGln: 2.399 ± 0.075
1.771AsnArg: 1.771 ± 0.062
1.928AsnSer: 1.928 ± 0.074
2.475AsnThr: 2.475 ± 0.075
3.12AsnVal: 3.12 ± 0.089
0.617AsnTrp: 0.617 ± 0.034
1.629AsnTyr: 1.629 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
3.635ProAla: 3.635 ± 0.087
0.05ProCys: 0.05 ± 0.009
2.631ProAsp: 2.631 ± 0.075
3.056ProGlu: 3.056 ± 0.089
1.767ProPhe: 1.767 ± 0.063
2.222ProGly: 2.222 ± 0.071
0.766ProHis: 0.766 ± 0.044
2.559ProIle: 2.559 ± 0.075
2.313ProLys: 2.313 ± 0.064
3.357ProLeu: 3.357 ± 0.088
0.87ProMet: 0.87 ± 0.045
1.784ProAsn: 1.784 ± 0.058
0.619ProPro: 0.619 ± 0.038
1.709ProGln: 1.709 ± 0.055
1.256ProArg: 1.256 ± 0.048
1.932ProSer: 1.932 ± 0.061
2.824ProThr: 2.824 ± 0.077
3.268ProVal: 3.268 ± 0.088
0.387ProTrp: 0.387 ± 0.033
1.309ProTyr: 1.309 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
5.693GlnAla: 5.693 ± 0.143
0.07GlnCys: 0.07 ± 0.014
2.485GlnAsp: 2.485 ± 0.066
2.172GlnGlu: 2.172 ± 0.075
2.09GlnPhe: 2.09 ± 0.066
2.653GlnGly: 2.653 ± 0.088
1.283GlnHis: 1.283 ± 0.053
3.188GlnIle: 3.188 ± 0.08
2.755GlnLys: 2.755 ± 0.076
5.956GlnLeu: 5.956 ± 0.131
1.349GlnMet: 1.349 ± 0.059
2.17GlnAsn: 2.17 ± 0.075
2.262GlnPro: 2.262 ± 0.078
3.647GlnGln: 3.647 ± 0.125
2.597GlnArg: 2.597 ± 0.089
2.435GlnSer: 2.435 ± 0.078
3.627GlnThr: 3.627 ± 0.1
3.844GlnVal: 3.844 ± 0.093
0.523GlnTrp: 0.523 ± 0.031
1.713GlnTyr: 1.713 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
3.515ArgAla: 3.515 ± 0.091
0.06ArgCys: 0.06 ± 0.009
2.675ArgAsp: 2.675 ± 0.081
2.643ArgGlu: 2.643 ± 0.084
1.894ArgPhe: 1.894 ± 0.064
2.655ArgGly: 2.655 ± 0.079
1.042ArgHis: 1.042 ± 0.046
2.625ArgIle: 2.625 ± 0.071
1.802ArgLys: 1.802 ± 0.066
4.529ArgLeu: 4.529 ± 0.101
1.09ArgMet: 1.09 ± 0.055
1.441ArgAsn: 1.441 ± 0.059
1.577ArgPro: 1.577 ± 0.06
2.814ArgGln: 2.814 ± 0.076
2.156ArgArg: 2.156 ± 0.079
1.735ArgSer: 1.735 ± 0.061
2.16ArgThr: 2.16 ± 0.064
3.246ArgVal: 3.246 ± 0.085
0.441ArgTrp: 0.441 ± 0.03
1.705ArgTyr: 1.705 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.755SerAla: 4.755 ± 0.109
0.082SerCys: 0.082 ± 0.014
3.365SerAsp: 3.365 ± 0.077
2.828SerGlu: 2.828 ± 0.081
2.367SerPhe: 2.367 ± 0.085
4.236SerGly: 4.236 ± 0.096
1.186SerHis: 1.186 ± 0.046
2.958SerIle: 2.958 ± 0.08
2.405SerLys: 2.405 ± 0.069
5.026SerLeu: 5.026 ± 0.114
1.178SerMet: 1.178 ± 0.045
2.06SerAsn: 2.06 ± 0.072
1.866SerPro: 1.866 ± 0.064
2.665SerGln: 2.665 ± 0.082
2.295SerArg: 2.295 ± 0.071
2.85SerSer: 2.85 ± 0.145
2.956SerThr: 2.956 ± 0.087
3.862SerVal: 3.862 ± 0.101
0.593SerTrp: 0.593 ± 0.036
1.778SerTyr: 1.778 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
6.479ThrAla: 6.479 ± 0.122
0.102ThrCys: 0.102 ± 0.018
3.687ThrAsp: 3.687 ± 0.092
2.715ThrGlu: 2.715 ± 0.077
2.747ThrPhe: 2.747 ± 0.081
4.727ThrGly: 4.727 ± 0.1
1.513ThrHis: 1.513 ± 0.061
4.803ThrIle: 4.803 ± 0.111
3.124ThrLys: 3.124 ± 0.089
6.982ThrLeu: 6.982 ± 0.117
1.403ThrMet: 1.403 ± 0.047
2.643ThrAsn: 2.643 ± 0.072
3.551ThrPro: 3.551 ± 0.092
3.403ThrGln: 3.403 ± 0.095
2.453ThrArg: 2.453 ± 0.076
3.198ThrSer: 3.198 ± 0.085
5.082ThrThr: 5.082 ± 0.132
5.365ThrVal: 5.365 ± 0.123
0.675ThrTrp: 0.675 ± 0.04
2.319ThrTyr: 2.319 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
8.202ValAla: 8.202 ± 0.142
0.132ValCys: 0.132 ± 0.017
4.483ValAsp: 4.483 ± 0.102
3.305ValGlu: 3.305 ± 0.099
2.956ValPhe: 2.956 ± 0.081
5.312ValGly: 5.312 ± 0.11
1.293ValHis: 1.293 ± 0.054
5.601ValIle: 5.601 ± 0.122
3.699ValLys: 3.699 ± 0.08
7.298ValLeu: 7.298 ± 0.131
2.274ValMet: 2.274 ± 0.068
3.072ValAsn: 3.072 ± 0.09
3.214ValPro: 3.214 ± 0.084
2.974ValGln: 2.974 ± 0.083
2.804ValArg: 2.804 ± 0.086
4.573ValSer: 4.573 ± 0.11
5.932ValThr: 5.932 ± 0.106
6.383ValVal: 6.383 ± 0.136
0.745ValTrp: 0.745 ± 0.042
2.17ValTyr: 2.17 ± 0.064
0.0ValXaa: 0.0 ± 0.0
Trp
0.828TrpAla: 0.828 ± 0.042
0.034TrpCys: 0.034 ± 0.009
0.499TrpAsp: 0.499 ± 0.037
0.443TrpGlu: 0.443 ± 0.033
0.607TrpPhe: 0.607 ± 0.04
0.661TrpGly: 0.661 ± 0.036
0.373TrpHis: 0.373 ± 0.025
0.565TrpIle: 0.565 ± 0.033
0.228TrpLys: 0.228 ± 0.023
1.611TrpLeu: 1.611 ± 0.069
0.22TrpMet: 0.22 ± 0.021
0.275TrpAsn: 0.275 ± 0.023
0.363TrpPro: 0.363 ± 0.029
0.976TrpGln: 0.976 ± 0.049
0.641TrpArg: 0.641 ± 0.041
0.573TrpSer: 0.573 ± 0.035
0.605TrpThr: 0.605 ± 0.04
0.683TrpVal: 0.683 ± 0.034
0.218TrpTrp: 0.218 ± 0.024
0.399TrpTyr: 0.399 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.926TyrAla: 2.926 ± 0.082
0.07TyrCys: 0.07 ± 0.013
2.21TyrAsp: 2.21 ± 0.066
1.567TyrGlu: 1.567 ± 0.061
1.735TyrPhe: 1.735 ± 0.07
2.391TyrGly: 2.391 ± 0.067
0.944TyrHis: 0.944 ± 0.044
1.91TyrIle: 1.91 ± 0.061
1.236TyrLys: 1.236 ± 0.054
3.507TyrLeu: 3.507 ± 0.091
0.757TyrMet: 0.757 ± 0.033
1.295TyrAsn: 1.295 ± 0.054
1.317TyrPro: 1.317 ± 0.056
2.096TyrGln: 2.096 ± 0.067
1.691TyrArg: 1.691 ± 0.059
1.523TyrSer: 1.523 ± 0.054
1.956TyrThr: 1.956 ± 0.065
2.24TyrVal: 2.24 ± 0.07
0.423TyrTrp: 0.423 ± 0.03
1.17TyrTyr: 1.17 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1614 proteins (499015 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski