Amino acid dipepetide frequency for Halococcus saccharolyticus DSM 5350

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.252AlaAla: 14.252 ± 0.163	0.747AlaCys: 0.747 ± 0.03	9.754AlaAsp: 9.754 ± 0.122	8.301AlaGlu: 8.301 ± 0.109	4.185AlaPhe: 4.185 ± 0.068	10.118AlaGly: 10.118 ± 0.127	1.947AlaHis: 1.947 ± 0.041	5.726AlaIle: 5.726 ± 0.084	1.806AlaLys: 1.806 ± 0.047	10.703AlaLeu: 10.703 ± 0.137	2.102AlaMet: 2.102 ± 0.045	2.827AlaAsn: 2.827 ± 0.059	3.881AlaPro: 3.881 ± 0.065	2.149AlaGln: 2.149 ± 0.049	6.511AlaArg: 6.511 ± 0.095	5.59AlaSer: 5.59 ± 0.086	7.782AlaThr: 7.782 ± 0.111	10.181AlaVal: 10.181 ± 0.135	1.234AlaTrp: 1.234 ± 0.037	2.637AlaTyr: 2.637 ± 0.055	0.002AlaXaa: 0.002 ± 0.001
Cys	0.685CysAla: 0.685 ± 0.03	0.099CysCys: 0.099 ± 0.01	0.604CysAsp: 0.604 ± 0.025	0.703CysGlu: 0.703 ± 0.03	0.217CysPhe: 0.217 ± 0.015	0.892CysGly: 0.892 ± 0.038	0.185CysHis: 0.185 ± 0.014	0.272CysIle: 0.272 ± 0.017	0.104CysLys: 0.104 ± 0.01	0.578CysLeu: 0.578 ± 0.022	0.096CysMet: 0.096 ± 0.01	0.18CysAsn: 0.18 ± 0.014	0.53CysPro: 0.53 ± 0.029	0.147CysGln: 0.147 ± 0.013	0.503CysArg: 0.503 ± 0.025	0.426CysSer: 0.426 ± 0.022	0.413CysThr: 0.413 ± 0.023	0.578CysVal: 0.578 ± 0.026	0.087CysTrp: 0.087 ± 0.01	0.223CysTyr: 0.223 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.598AspAla: 9.598 ± 0.126	0.687AspCys: 0.687 ± 0.027	7.755AspAsp: 7.755 ± 0.123	8.094AspGlu: 8.094 ± 0.118	1.887AspPhe: 1.887 ± 0.049	7.892AspGly: 7.892 ± 0.128	2.082AspHis: 2.082 ± 0.049	3.012AspIle: 3.012 ± 0.068	0.863AspLys: 0.863 ± 0.033	7.118AspLeu: 7.118 ± 0.096	1.264AspMet: 1.264 ± 0.039	1.298AspAsn: 1.298 ± 0.038	4.481AspPro: 4.481 ± 0.074	1.701AspGln: 1.701 ± 0.047	6.652AspArg: 6.652 ± 0.103	3.662AspSer: 3.662 ± 0.062	4.605AspThr: 4.605 ± 0.07	6.927AspVal: 6.927 ± 0.091	1.0AspTrp: 1.0 ± 0.039	1.621AspTyr: 1.621 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.181GluAla: 8.181 ± 0.113	0.63GluCys: 0.63 ± 0.027	4.927GluAsp: 4.927 ± 0.078	6.163GluGlu: 6.163 ± 0.111	3.015GluPhe: 3.015 ± 0.051	5.492GluGly: 5.492 ± 0.082	2.177GluHis: 2.177 ± 0.055	3.995GluIle: 3.995 ± 0.071	1.742GluLys: 1.742 ± 0.044	6.684GluLeu: 6.684 ± 0.101	1.787GluMet: 1.787 ± 0.05	2.532GluAsn: 2.532 ± 0.048	3.877GluPro: 3.877 ± 0.07	2.378GluGln: 2.378 ± 0.058	8.062GluArg: 8.062 ± 0.117	5.121GluSer: 5.121 ± 0.077	6.418GluThr: 6.418 ± 0.103	5.047GluVal: 5.047 ± 0.083	1.163GluTrp: 1.163 ± 0.04	2.658GluTyr: 2.658 ± 0.061	0.002GluXaa: 0.002 ± 0.001
Phe	4.047PheAla: 4.047 ± 0.077	0.288PheCys: 0.288 ± 0.016	3.28PheAsp: 3.28 ± 0.054	3.015PheGlu: 3.015 ± 0.064	1.087PhePhe: 1.087 ± 0.039	3.492PheGly: 3.492 ± 0.067	0.619PheHis: 0.619 ± 0.027	1.048PheIle: 1.048 ± 0.039	0.434PheLys: 0.434 ± 0.02	2.774PheLeu: 2.774 ± 0.077	0.529PheMet: 0.529 ± 0.026	0.666PheAsn: 0.666 ± 0.029	1.37PhePro: 1.37 ± 0.037	0.726PheGln: 0.726 ± 0.027	1.741PheArg: 1.741 ± 0.038	1.687PheSer: 1.687 ± 0.043	1.95PheThr: 1.95 ± 0.047	3.585PheVal: 3.585 ± 0.073	0.408PheTrp: 0.408 ± 0.025	0.843PheTyr: 0.843 ± 0.03	0.003PheXaa: 0.003 ± 0.002
Gly	8.593GlyAla: 8.593 ± 0.109	0.728GlyCys: 0.728 ± 0.029	6.183GlyAsp: 6.183 ± 0.096	7.259GlyGlu: 7.259 ± 0.106	3.47GlyPhe: 3.47 ± 0.076	8.251GlyGly: 8.251 ± 0.14	1.702GlyHis: 1.702 ± 0.048	4.4GlyIle: 4.4 ± 0.071	1.837GlyLys: 1.837 ± 0.044	7.856GlyLeu: 7.856 ± 0.133	1.963GlyMet: 1.963 ± 0.044	2.238GlyAsn: 2.238 ± 0.061	3.351GlyPro: 3.351 ± 0.057	2.021GlyGln: 2.021 ± 0.047	5.062GlyArg: 5.062 ± 0.086	5.62GlySer: 5.62 ± 0.083	6.162GlyThr: 6.162 ± 0.098	8.021GlyVal: 8.021 ± 0.122	1.213GlyTrp: 1.213 ± 0.034	2.694GlyTyr: 2.694 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.243HisAla: 2.243 ± 0.046	0.209HisCys: 0.209 ± 0.015	2.13HisAsp: 2.13 ± 0.054	1.828HisGlu: 1.828 ± 0.042	0.498HisPhe: 0.498 ± 0.025	1.992HisGly: 1.992 ± 0.046	0.557HisHis: 0.557 ± 0.028	0.697HisIle: 0.697 ± 0.031	0.284HisLys: 0.284 ± 0.018	1.749HisLeu: 1.749 ± 0.048	0.286HisMet: 0.286 ± 0.017	0.461HisAsn: 0.461 ± 0.024	1.286HisPro: 1.286 ± 0.033	0.464HisGln: 0.464 ± 0.021	1.327HisArg: 1.327 ± 0.038	0.847HisSer: 0.847 ± 0.029	1.188HisThr: 1.188 ± 0.036	1.832HisVal: 1.832 ± 0.036	0.226HisTrp: 0.226 ± 0.017	0.574HisTyr: 0.574 ± 0.024	0.002HisXaa: 0.002 ± 0.002
Ile	5.604IleAla: 5.604 ± 0.073	0.267IleCys: 0.267 ± 0.017	4.314IleAsp: 4.314 ± 0.063	4.874IleGlu: 4.874 ± 0.074	0.909IlePhe: 0.909 ± 0.034	4.254IleGly: 4.254 ± 0.089	0.9IleHis: 0.9 ± 0.034	1.248IleIle: 1.248 ± 0.037	0.645IleLys: 0.645 ± 0.027	2.678IleLeu: 2.678 ± 0.057	0.489IleMet: 0.489 ± 0.021	0.997IleAsn: 0.997 ± 0.036	2.117IlePro: 2.117 ± 0.046	1.048IleGln: 1.048 ± 0.032	2.469IleArg: 2.469 ± 0.05	1.917IleSer: 1.917 ± 0.049	2.588IleThr: 2.588 ± 0.057	4.138IleVal: 4.138 ± 0.077	0.344IleTrp: 0.344 ± 0.019	0.92IleTyr: 0.92 ± 0.032	0.003IleXaa: 0.003 ± 0.002
Lys	1.602LysAla: 1.602 ± 0.045	0.106LysCys: 0.106 ± 0.011	0.896LysAsp: 0.896 ± 0.034	1.183LysGlu: 1.183 ± 0.034	0.511LysPhe: 0.511 ± 0.024	1.287LysGly: 1.287 ± 0.04	0.453LysHis: 0.453 ± 0.021	0.755LysIle: 0.755 ± 0.03	0.437LysLys: 0.437 ± 0.023	1.586LysLeu: 1.586 ± 0.042	0.324LysMet: 0.324 ± 0.019	0.539LysAsn: 0.539 ± 0.025	0.91LysPro: 0.91 ± 0.029	0.66LysGln: 0.66 ± 0.027	1.563LysArg: 1.563 ± 0.045	1.069LysSer: 1.069 ± 0.039	1.228LysThr: 1.228 ± 0.041	1.041LysVal: 1.041 ± 0.034	0.213LysTrp: 0.213 ± 0.014	0.545LysTyr: 0.545 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	11.651LeuAla: 11.651 ± 0.137	0.679LeuCys: 0.679 ± 0.026	8.616LeuAsp: 8.616 ± 0.122	5.414LeuGlu: 5.414 ± 0.087	3.158LeuPhe: 3.158 ± 0.078	7.965LeuGly: 7.965 ± 0.123	1.533LeuHis: 1.533 ± 0.041	3.069LeuIle: 3.069 ± 0.071	1.345LeuLys: 1.345 ± 0.039	8.118LeuLeu: 8.118 ± 0.124	1.294LeuMet: 1.294 ± 0.041	1.794LeuAsn: 1.794 ± 0.039	4.104LeuPro: 4.104 ± 0.073	1.884LeuGln: 1.884 ± 0.048	5.384LeuArg: 5.384 ± 0.077	5.199LeuSer: 5.199 ± 0.077	5.218LeuThr: 5.218 ± 0.076	8.437LeuVal: 8.437 ± 0.118	0.877LeuTrp: 0.877 ± 0.032	2.159LeuTyr: 2.159 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.042MetAla: 2.042 ± 0.047	0.127MetCys: 0.127 ± 0.013	1.31MetAsp: 1.31 ± 0.042	1.132MetGlu: 1.132 ± 0.04	0.541MetPhe: 0.541 ± 0.026	1.523MetGly: 1.523 ± 0.044	0.319MetHis: 0.319 ± 0.02	0.764MetIle: 0.764 ± 0.031	0.394MetLys: 0.394 ± 0.021	1.455MetLeu: 1.455 ± 0.044	0.321MetMet: 0.321 ± 0.02	0.674MetAsn: 0.674 ± 0.028	0.762MetPro: 0.762 ± 0.026	0.457MetGln: 0.457 ± 0.021	0.989MetArg: 0.989 ± 0.034	1.573MetSer: 1.573 ± 0.036	1.563MetThr: 1.563 ± 0.041	1.309MetVal: 1.309 ± 0.037	0.159MetTrp: 0.159 ± 0.014	0.369MetTyr: 0.369 ± 0.023	0.001MetXaa: 0.001 ± 0.001
Asn	2.927AsnAla: 2.927 ± 0.064	0.223AsnCys: 0.223 ± 0.016	1.878AsnAsp: 1.878 ± 0.048	1.965AsnGlu: 1.965 ± 0.051	0.727AsnPhe: 0.727 ± 0.029	2.42AsnGly: 2.42 ± 0.065	0.558AsnHis: 0.558 ± 0.026	0.884AsnIle: 0.884 ± 0.033	0.394AsnLys: 0.394 ± 0.019	1.94AsnLeu: 1.94 ± 0.052	0.383AsnMet: 0.383 ± 0.019	0.601AsnAsn: 0.601 ± 0.028	1.596AsnPro: 1.596 ± 0.043	0.747AsnGln: 0.747 ± 0.03	1.638AsnArg: 1.638 ± 0.043	1.055AsnSer: 1.055 ± 0.039	1.463AsnThr: 1.463 ± 0.039	2.337AsnVal: 2.337 ± 0.049	0.288AsnTrp: 0.288 ± 0.018	0.693AsnTyr: 0.693 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.742ProAla: 4.742 ± 0.071	0.228ProCys: 0.228 ± 0.016	4.696ProAsp: 4.696 ± 0.077	4.381ProGlu: 4.381 ± 0.076	1.568ProPhe: 1.568 ± 0.041	3.875ProGly: 3.875 ± 0.063	0.957ProHis: 0.957 ± 0.035	2.087ProIle: 2.087 ± 0.043	0.815ProLys: 0.815 ± 0.027	3.783ProLeu: 3.783 ± 0.069	0.845ProMet: 0.845 ± 0.031	1.252ProAsn: 1.252 ± 0.041	2.128ProPro: 2.128 ± 0.046	1.048ProGln: 1.048 ± 0.031	2.276ProArg: 2.276 ± 0.058	2.56ProSer: 2.56 ± 0.052	3.446ProThr: 3.446 ± 0.08	3.914ProVal: 3.914 ± 0.065	0.534ProTrp: 0.534 ± 0.022	1.123ProTyr: 1.123 ± 0.032	0.001ProXaa: 0.001 ± 0.001
Gln	2.395GlnAla: 2.395 ± 0.05	0.177GlnCys: 0.177 ± 0.011	1.275GlnAsp: 1.275 ± 0.04	1.51GlnGlu: 1.51 ± 0.039	0.941GlnPhe: 0.941 ± 0.03	1.669GlnGly: 1.669 ± 0.04	0.59GlnHis: 0.59 ± 0.028	1.027GlnIle: 1.027 ± 0.035	0.52GlnLys: 0.52 ± 0.022	2.229GlnLeu: 2.229 ± 0.045	0.487GlnMet: 0.487 ± 0.023	0.779GlnAsn: 0.779 ± 0.028	1.255GlnPro: 1.255 ± 0.037	1.03GlnGln: 1.03 ± 0.034	1.979GlnArg: 1.979 ± 0.05	1.52GlnSer: 1.52 ± 0.051	1.581GlnThr: 1.581 ± 0.048	1.796GlnVal: 1.796 ± 0.039	0.352GlnTrp: 0.352 ± 0.021	0.837GlnTyr: 0.837 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.708ArgAla: 6.708 ± 0.096	0.497ArgCys: 0.497 ± 0.026	4.917ArgAsp: 4.917 ± 0.074	6.881ArgGlu: 6.881 ± 0.106	2.36ArgPhe: 2.36 ± 0.049	4.604ArgGly: 4.604 ± 0.08	1.289ArgHis: 1.289 ± 0.041	3.02ArgIle: 3.02 ± 0.06	1.31ArgLys: 1.31 ± 0.041	6.08ArgLeu: 6.08 ± 0.097	1.304ArgMet: 1.304 ± 0.036	1.708ArgAsn: 1.708 ± 0.05	2.55ArgPro: 2.55 ± 0.058	1.762ArgGln: 1.762 ± 0.049	4.712ArgArg: 4.712 ± 0.088	3.732ArgSer: 3.732 ± 0.068	4.269ArgThr: 4.269 ± 0.084	5.215ArgVal: 5.215 ± 0.078	0.759ArgTrp: 0.759 ± 0.026	1.908ArgTyr: 1.908 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.565SerAla: 5.565 ± 0.096	0.341SerCys: 0.341 ± 0.02	4.035SerAsp: 4.035 ± 0.059	4.153SerGlu: 4.153 ± 0.09	1.86SerPhe: 1.86 ± 0.047	5.713SerGly: 5.713 ± 0.091	1.074SerHis: 1.074 ± 0.035	2.548SerIle: 2.548 ± 0.057	1.007SerLys: 1.007 ± 0.033	4.674SerLeu: 4.674 ± 0.073	1.138SerMet: 1.138 ± 0.029	1.426SerAsn: 1.426 ± 0.037	2.558SerPro: 2.558 ± 0.056	1.469SerGln: 1.469 ± 0.045	3.077SerArg: 3.077 ± 0.056	3.244SerSer: 3.244 ± 0.081	3.769SerThr: 3.769 ± 0.073	4.879SerVal: 4.879 ± 0.066	0.621SerTrp: 0.621 ± 0.026	1.515SerTyr: 1.515 ± 0.043	0.002SerXaa: 0.002 ± 0.002
Thr	7.639ThrAla: 7.639 ± 0.104	0.415ThrCys: 0.415 ± 0.023	5.988ThrAsp: 5.988 ± 0.091	4.912ThrGlu: 4.912 ± 0.07	2.128ThrPhe: 2.128 ± 0.048	5.995ThrGly: 5.995 ± 0.089	1.272ThrHis: 1.272 ± 0.033	3.271ThrIle: 3.271 ± 0.061	1.046ThrLys: 1.046 ± 0.031	5.692ThrLeu: 5.692 ± 0.071	1.188ThrMet: 1.188 ± 0.034	1.734ThrAsn: 1.734 ± 0.05	3.58ThrPro: 3.58 ± 0.082	1.51ThrGln: 1.51 ± 0.042	3.358ThrArg: 3.358 ± 0.056	3.193ThrSer: 3.193 ± 0.073	5.208ThrThr: 5.208 ± 0.127	6.647ThrVal: 6.647 ± 0.095	0.62ThrTrp: 0.62 ± 0.024	1.667ThrTyr: 1.667 ± 0.042	0.004ThrXaa: 0.004 ± 0.002
Val	10.249ValAla: 10.249 ± 0.13	0.726ValCys: 0.726 ± 0.026	6.446ValAsp: 6.446 ± 0.077	7.257ValGlu: 7.257 ± 0.088	3.174ValPhe: 3.174 ± 0.063	8.006ValGly: 8.006 ± 0.138	1.643ValHis: 1.643 ± 0.038	3.59ValIle: 3.59 ± 0.062	1.223ValLys: 1.223 ± 0.037	8.552ValLeu: 8.552 ± 0.124	1.387ValMet: 1.387 ± 0.042	1.985ValAsn: 1.985 ± 0.052	4.171ValPro: 4.171 ± 0.07	1.666ValGln: 1.666 ± 0.045	5.386ValArg: 5.386 ± 0.08	4.813ValSer: 4.813 ± 0.073	5.783ValThr: 5.783 ± 0.082	8.744ValVal: 8.744 ± 0.119	0.853ValTrp: 0.853 ± 0.031	1.987ValTyr: 1.987 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.921TrpAla: 0.921 ± 0.036	0.104TrpCys: 0.104 ± 0.011	0.715TrpAsp: 0.715 ± 0.028	0.773TrpGlu: 0.773 ± 0.031	0.483TrpPhe: 0.483 ± 0.026	0.889TrpGly: 0.889 ± 0.032	0.238TrpHis: 0.238 ± 0.016	0.524TrpIle: 0.524 ± 0.022	0.291TrpLys: 0.291 ± 0.018	1.289TrpLeu: 1.289 ± 0.04	0.244TrpMet: 0.244 ± 0.016	0.392TrpAsn: 0.392 ± 0.02	0.468TrpPro: 0.468 ± 0.023	0.409TrpGln: 0.409 ± 0.021	0.887TrpArg: 0.887 ± 0.028	0.622TrpSer: 0.622 ± 0.029	0.854TrpThr: 0.854 ± 0.033	0.807TrpVal: 0.807 ± 0.029	0.199TrpTrp: 0.199 ± 0.016	0.39TrpTyr: 0.39 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.787TyrAla: 2.787 ± 0.056	0.244TyrCys: 0.244 ± 0.017	2.48TyrAsp: 2.48 ± 0.055	2.253TyrGlu: 2.253 ± 0.044	0.871TyrPhe: 0.871 ± 0.03	2.293TyrGly: 2.293 ± 0.051	0.584TyrHis: 0.584 ± 0.024	0.785TyrIle: 0.785 ± 0.032	0.411TyrLys: 0.411 ± 0.024	2.359TyrLeu: 2.359 ± 0.056	0.355TyrMet: 0.355 ± 0.021	0.634TyrAsn: 0.634 ± 0.022	1.286TyrPro: 1.286 ± 0.04	0.673TyrGln: 0.673 ± 0.029	2.01TyrArg: 2.01 ± 0.054	1.215TyrSer: 1.215 ± 0.037	1.575TyrThr: 1.575 ± 0.045	2.201TyrVal: 2.201 ± 0.047	0.351TyrTrp: 0.351 ± 0.018	0.812TyrTyr: 0.812 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.008XaaAla: 0.008 ± 0.004	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.004XaaSer: 0.004 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3441 proteins (981310 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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