Amino acid dipepetide frequency for Rhizobium sp. PDO1-076

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.057AlaAla: 15.057 ± 0.143	0.951AlaCys: 0.951 ± 0.028	6.931AlaAsp: 6.931 ± 0.084	7.425AlaGlu: 7.425 ± 0.086	4.48AlaPhe: 4.48 ± 0.052	9.99AlaGly: 9.99 ± 0.081	2.105AlaHis: 2.105 ± 0.04	6.891AlaIle: 6.891 ± 0.077	4.242AlaLys: 4.242 ± 0.06	12.541AlaLeu: 12.541 ± 0.152	3.542AlaMet: 3.542 ± 0.055	3.091AlaAsn: 3.091 ± 0.048	4.675AlaPro: 4.675 ± 0.064	3.573AlaGln: 3.573 ± 0.055	7.649AlaArg: 7.649 ± 0.083	6.702AlaSer: 6.702 ± 0.067	5.944AlaThr: 5.944 ± 0.077	8.452AlaVal: 8.452 ± 0.082	1.279AlaTrp: 1.279 ± 0.027	2.561AlaTyr: 2.561 ± 0.041	0.001AlaXaa: 0.001 ± 0.001
Cys	0.824CysAla: 0.824 ± 0.022	0.115CysCys: 0.115 ± 0.009	0.495CysAsp: 0.495 ± 0.02	0.419CysGlu: 0.419 ± 0.019	0.315CysPhe: 0.315 ± 0.015	0.854CysGly: 0.854 ± 0.03	0.233CysHis: 0.233 ± 0.011	0.389CysIle: 0.389 ± 0.016	0.208CysLys: 0.208 ± 0.012	0.826CysLeu: 0.826 ± 0.024	0.179CysMet: 0.179 ± 0.011	0.216CysAsn: 0.216 ± 0.011	0.387CysPro: 0.387 ± 0.018	0.245CysGln: 0.245 ± 0.012	0.6CysArg: 0.6 ± 0.021	0.451CysSer: 0.451 ± 0.017	0.382CysThr: 0.382 ± 0.016	0.551CysVal: 0.551 ± 0.02	0.115CysTrp: 0.115 ± 0.008	0.208CysTyr: 0.208 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.575AspAla: 6.575 ± 0.075	0.513AspCys: 0.513 ± 0.021	3.264AspAsp: 3.264 ± 0.059	3.455AspGlu: 3.455 ± 0.051	2.39AspPhe: 2.39 ± 0.04	5.246AspGly: 5.246 ± 0.087	1.298AspHis: 1.298 ± 0.029	3.558AspIle: 3.558 ± 0.046	1.95AspLys: 1.95 ± 0.038	6.009AspLeu: 6.009 ± 0.062	1.54AspMet: 1.54 ± 0.029	1.58AspAsn: 1.58 ± 0.039	3.263AspPro: 3.263 ± 0.051	1.932AspGln: 1.932 ± 0.051	4.209AspArg: 4.209 ± 0.057	2.319AspSer: 2.319 ± 0.041	2.684AspThr: 2.684 ± 0.053	4.137AspVal: 4.137 ± 0.056	0.95AspTrp: 0.95 ± 0.024	1.546AspTyr: 1.546 ± 0.033	0.001AspXaa: 0.001 ± 0.001
Glu	7.163GluAla: 7.163 ± 0.081	0.353GluCys: 0.353 ± 0.015	2.928GluAsp: 2.928 ± 0.047	3.185GluGlu: 3.185 ± 0.049	1.895GluPhe: 1.895 ± 0.039	4.147GluGly: 4.147 ± 0.053	1.192GluHis: 1.192 ± 0.03	3.942GluIle: 3.942 ± 0.048	2.646GluLys: 2.646 ± 0.046	5.273GluLeu: 5.273 ± 0.07	1.553GluMet: 1.553 ± 0.031	1.836GluAsn: 1.836 ± 0.032	2.615GluPro: 2.615 ± 0.049	2.185GluGln: 2.185 ± 0.038	4.528GluArg: 4.528 ± 0.064	2.311GluSer: 2.311 ± 0.044	3.812GluThr: 3.812 ± 0.051	3.783GluVal: 3.783 ± 0.045	0.674GluTrp: 0.674 ± 0.021	0.979GluTyr: 0.979 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.594PheAla: 4.594 ± 0.056	0.429PheCys: 0.429 ± 0.019	2.826PheAsp: 2.826 ± 0.045	2.239PheGlu: 2.239 ± 0.039	1.521PhePhe: 1.521 ± 0.035	3.735PheGly: 3.735 ± 0.047	0.814PheHis: 0.814 ± 0.022	1.901PheIle: 1.901 ± 0.032	1.176PheLys: 1.176 ± 0.026	3.455PheLeu: 3.455 ± 0.054	0.86PheMet: 0.86 ± 0.026	1.152PheAsn: 1.152 ± 0.03	1.52PhePro: 1.52 ± 0.03	1.102PheGln: 1.102 ± 0.027	2.268PheArg: 2.268 ± 0.042	2.584PheSer: 2.584 ± 0.041	2.016PheThr: 2.016 ± 0.038	2.938PheVal: 2.938 ± 0.042	0.544PheTrp: 0.544 ± 0.018	0.984PheTyr: 0.984 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.31GlyAla: 8.31 ± 0.088	0.782GlyCys: 0.782 ± 0.024	4.424GlyAsp: 4.424 ± 0.066	4.713GlyGlu: 4.713 ± 0.063	3.705GlyPhe: 3.705 ± 0.051	6.714GlyGly: 6.714 ± 0.101	1.908GlyHis: 1.908 ± 0.04	4.975GlyIle: 4.975 ± 0.059	3.561GlyLys: 3.561 ± 0.051	8.799GlyLeu: 8.799 ± 0.094	2.348GlyMet: 2.348 ± 0.035	2.411GlyAsn: 2.411 ± 0.052	3.095GlyPro: 3.095 ± 0.049	2.825GlyGln: 2.825 ± 0.051	5.557GlyArg: 5.557 ± 0.063	4.797GlySer: 4.797 ± 0.057	4.482GlyThr: 4.482 ± 0.059	5.628GlyVal: 5.628 ± 0.068	1.181GlyTrp: 1.181 ± 0.03	2.369GlyTyr: 2.369 ± 0.041	0.001GlyXaa: 0.001 ± 0.001
His	2.214HisAla: 2.214 ± 0.039	0.235HisCys: 0.235 ± 0.012	1.282HisAsp: 1.282 ± 0.032	1.059HisGlu: 1.059 ± 0.027	0.934HisPhe: 0.934 ± 0.027	1.934HisGly: 1.934 ± 0.034	0.615HisHis: 0.615 ± 0.021	1.066HisIle: 1.066 ± 0.028	0.544HisLys: 0.544 ± 0.021	2.105HisLeu: 2.105 ± 0.036	0.545HisMet: 0.545 ± 0.02	0.472HisAsn: 0.472 ± 0.017	1.206HisPro: 1.206 ± 0.035	0.665HisGln: 0.665 ± 0.021	1.369HisArg: 1.369 ± 0.032	1.03HisSer: 1.03 ± 0.026	0.827HisThr: 0.827 ± 0.022	1.504HisVal: 1.504 ± 0.03	0.314HisTrp: 0.314 ± 0.015	0.545HisTyr: 0.545 ± 0.017	0.001HisXaa: 0.001 ± 0.001
Ile	7.909IleAla: 7.909 ± 0.091	0.557IleCys: 0.557 ± 0.02	4.074IleAsp: 4.074 ± 0.05	3.961IleGlu: 3.961 ± 0.047	1.974IlePhe: 1.974 ± 0.035	5.437IleGly: 5.437 ± 0.077	0.962IleHis: 0.962 ± 0.025	2.816IleIle: 2.816 ± 0.042	1.733IleLys: 1.733 ± 0.032	5.069IleLeu: 5.069 ± 0.062	1.15IleMet: 1.15 ± 0.029	1.692IleAsn: 1.692 ± 0.03	2.428IlePro: 2.428 ± 0.041	1.343IleGln: 1.343 ± 0.032	3.512IleArg: 3.512 ± 0.046	3.554IleSer: 3.554 ± 0.053	2.96IleThr: 2.96 ± 0.041	4.518IleVal: 4.518 ± 0.054	0.662IleTrp: 0.662 ± 0.021	1.255IleTyr: 1.255 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.855LysAla: 4.855 ± 0.063	0.16LysCys: 0.16 ± 0.009	1.937LysAsp: 1.937 ± 0.039	1.682LysGlu: 1.682 ± 0.038	0.994LysPhe: 0.994 ± 0.023	2.818LysGly: 2.818 ± 0.05	0.692LysHis: 0.692 ± 0.02	2.172LysIle: 2.172 ± 0.04	1.438LysLys: 1.438 ± 0.037	3.651LysLeu: 3.651 ± 0.05	0.903LysMet: 0.903 ± 0.023	1.031LysAsn: 1.031 ± 0.029	2.213LysPro: 2.213 ± 0.04	1.148LysGln: 1.148 ± 0.028	2.445LysArg: 2.445 ± 0.042	2.229LysSer: 2.229 ± 0.042	2.407LysThr: 2.407 ± 0.038	2.64LysVal: 2.64 ± 0.045	0.39LysTrp: 0.39 ± 0.017	0.66LysTyr: 0.66 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.692LeuAla: 12.692 ± 0.114	0.871LeuCys: 0.871 ± 0.025	5.917LeuAsp: 5.917 ± 0.064	5.366LeuGlu: 5.366 ± 0.065	3.681LeuPhe: 3.681 ± 0.056	7.953LeuGly: 7.953 ± 0.088	1.783LeuHis: 1.783 ± 0.038	5.393LeuIle: 5.393 ± 0.065	4.224LeuLys: 4.224 ± 0.06	9.4LeuLeu: 9.4 ± 0.106	2.49LeuMet: 2.49 ± 0.043	2.779LeuAsn: 2.779 ± 0.045	5.252LeuPro: 5.252 ± 0.065	2.862LeuGln: 2.862 ± 0.041	6.123LeuArg: 6.123 ± 0.068	7.295LeuSer: 7.295 ± 0.092	5.831LeuThr: 5.831 ± 0.081	7.496LeuVal: 7.496 ± 0.074	1.096LeuTrp: 1.096 ± 0.028	2.145LeuTyr: 2.145 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.236MetAla: 3.236 ± 0.045	0.147MetCys: 0.147 ± 0.01	1.209MetAsp: 1.209 ± 0.028	1.188MetGlu: 1.188 ± 0.027	0.721MetPhe: 0.721 ± 0.023	1.72MetGly: 1.72 ± 0.034	0.473MetHis: 0.473 ± 0.017	1.591MetIle: 1.591 ± 0.033	1.111MetLys: 1.111 ± 0.027	2.647MetLeu: 2.647 ± 0.045	0.744MetMet: 0.744 ± 0.022	0.885MetAsn: 0.885 ± 0.025	1.544MetPro: 1.544 ± 0.032	0.912MetGln: 0.912 ± 0.024	1.714MetArg: 1.714 ± 0.031	1.828MetSer: 1.828 ± 0.04	2.023MetThr: 2.023 ± 0.039	1.903MetVal: 1.903 ± 0.033	0.196MetTrp: 0.196 ± 0.011	0.303MetTyr: 0.303 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.368AsnAla: 3.368 ± 0.049	0.232AsnCys: 0.232 ± 0.012	1.59AsnAsp: 1.59 ± 0.042	1.423AsnGlu: 1.423 ± 0.033	1.075AsnPhe: 1.075 ± 0.025	2.641AsnGly: 2.641 ± 0.06	0.569AsnHis: 0.569 ± 0.02	1.512AsnIle: 1.512 ± 0.035	0.831AsnLys: 0.831 ± 0.022	2.793AsnLeu: 2.793 ± 0.044	0.719AsnMet: 0.719 ± 0.019	0.832AsnAsn: 0.832 ± 0.027	1.867AsnPro: 1.867 ± 0.039	0.87AsnGln: 0.87 ± 0.024	2.036AsnArg: 2.036 ± 0.037	1.481AsnSer: 1.481 ± 0.036	1.393AsnThr: 1.393 ± 0.031	2.039AsnVal: 2.039 ± 0.039	0.48AsnTrp: 0.48 ± 0.019	0.709AsnTyr: 0.709 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.519ProAla: 5.519 ± 0.075	0.285ProCys: 0.285 ± 0.014	3.4ProAsp: 3.4 ± 0.052	3.332ProGlu: 3.332 ± 0.05	1.943ProPhe: 1.943 ± 0.035	3.898ProGly: 3.898 ± 0.058	1.014ProHis: 1.014 ± 0.026	2.461ProIle: 2.461 ± 0.041	1.73ProLys: 1.73 ± 0.039	4.529ProLeu: 4.529 ± 0.064	1.161ProMet: 1.161 ± 0.025	1.296ProAsn: 1.296 ± 0.03	2.027ProPro: 2.027 ± 0.046	1.632ProGln: 1.632 ± 0.037	2.404ProArg: 2.404 ± 0.041	2.802ProSer: 2.802 ± 0.043	2.396ProThr: 2.396 ± 0.041	4.109ProVal: 4.109 ± 0.051	0.578ProTrp: 0.578 ± 0.019	1.158ProTyr: 1.158 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.005GlnAla: 4.005 ± 0.05	0.187GlnCys: 0.187 ± 0.011	1.469GlnAsp: 1.469 ± 0.031	1.546GlnGlu: 1.546 ± 0.031	1.119GlnPhe: 1.119 ± 0.026	2.215GlnGly: 2.215 ± 0.038	0.642GlnHis: 0.642 ± 0.022	2.099GlnIle: 2.099 ± 0.066	1.228GlnLys: 1.228 ± 0.031	3.037GlnLeu: 3.037 ± 0.052	0.962GlnMet: 0.962 ± 0.025	0.958GlnAsn: 0.958 ± 0.026	1.738GlnPro: 1.738 ± 0.033	1.331GlnGln: 1.331 ± 0.033	2.265GlnArg: 2.265 ± 0.048	2.01GlnSer: 2.01 ± 0.037	1.946GlnThr: 1.946 ± 0.041	2.305GlnVal: 2.305 ± 0.062	0.363GlnTrp: 0.363 ± 0.016	0.605GlnTyr: 0.605 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	6.625ArgAla: 6.625 ± 0.081	0.456ArgCys: 0.456 ± 0.017	3.974ArgAsp: 3.974 ± 0.049	3.764ArgGlu: 3.764 ± 0.054	2.859ArgPhe: 2.859 ± 0.047	4.15ArgGly: 4.15 ± 0.056	1.722ArgHis: 1.722 ± 0.039	4.073ArgIle: 4.073 ± 0.048	2.43ArgLys: 2.43 ± 0.047	7.452ArgLeu: 7.452 ± 0.085	1.863ArgMet: 1.863 ± 0.035	2.001ArgAsn: 2.001 ± 0.031	3.028ArgPro: 3.028 ± 0.047	2.643ArgGln: 2.643 ± 0.048	4.876ArgArg: 4.876 ± 0.069	3.784ArgSer: 3.784 ± 0.054	3.15ArgThr: 3.15 ± 0.041	4.136ArgVal: 4.136 ± 0.054	0.848ArgTrp: 0.848 ± 0.029	1.705ArgTyr: 1.705 ± 0.039	0.001ArgXaa: 0.001 ± 0.001
Ser	6.535SerAla: 6.535 ± 0.075	0.404SerCys: 0.404 ± 0.018	3.384SerAsp: 3.384 ± 0.056	3.073SerGlu: 3.073 ± 0.054	2.512SerPhe: 2.512 ± 0.042	5.893SerGly: 5.893 ± 0.056	1.24SerHis: 1.24 ± 0.027	3.312SerIle: 3.312 ± 0.049	1.924SerLys: 1.924 ± 0.035	6.041SerLeu: 6.041 ± 0.067	1.513SerMet: 1.513 ± 0.029	1.661SerAsn: 1.661 ± 0.039	2.761SerPro: 2.761 ± 0.044	1.905SerGln: 1.905 ± 0.038	3.696SerArg: 3.696 ± 0.056	3.568SerSer: 3.568 ± 0.07	3.15SerThr: 3.15 ± 0.076	4.368SerVal: 4.368 ± 0.057	0.718SerTrp: 0.718 ± 0.023	1.366SerTyr: 1.366 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.391ThrAla: 6.391 ± 0.081	0.409ThrCys: 0.409 ± 0.017	3.077ThrAsp: 3.077 ± 0.057	2.876ThrGlu: 2.876 ± 0.045	2.144ThrPhe: 2.144 ± 0.039	5.005ThrGly: 5.005 ± 0.066	1.046ThrHis: 1.046 ± 0.025	3.277ThrIle: 3.277 ± 0.062	1.716ThrLys: 1.716 ± 0.035	5.893ThrLeu: 5.893 ± 0.077	1.301ThrMet: 1.301 ± 0.031	1.448ThrAsn: 1.448 ± 0.031	2.916ThrPro: 2.916 ± 0.042	1.501ThrGln: 1.501 ± 0.038	3.17ThrArg: 3.17 ± 0.044	3.221ThrSer: 3.221 ± 0.058	3.09ThrThr: 3.09 ± 0.076	4.558ThrVal: 4.558 ± 0.062	0.643ThrTrp: 0.643 ± 0.02	1.26ThrTyr: 1.26 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.747ValAla: 8.747 ± 0.093	0.58ValCys: 0.58 ± 0.021	4.17ValAsp: 4.17 ± 0.054	4.576ValGlu: 4.576 ± 0.061	2.911ValPhe: 2.911 ± 0.043	5.337ValGly: 5.337 ± 0.058	1.368ValHis: 1.368 ± 0.032	4.377ValIle: 4.377 ± 0.059	2.555ValLys: 2.555 ± 0.045	7.194ValLeu: 7.194 ± 0.078	1.919ValMet: 1.919 ± 0.037	2.053ValAsn: 2.053 ± 0.039	3.414ValPro: 3.414 ± 0.057	1.975ValGln: 1.975 ± 0.035	4.439ValArg: 4.439 ± 0.059	4.937ValSer: 4.937 ± 0.058	4.639ValThr: 4.639 ± 0.063	5.804ValVal: 5.804 ± 0.079	0.802ValTrp: 0.802 ± 0.022	1.474ValTyr: 1.474 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.086TrpAla: 1.086 ± 0.031	0.12TrpCys: 0.12 ± 0.009	0.608TrpAsp: 0.608 ± 0.019	0.508TrpGlu: 0.508 ± 0.016	0.523TrpPhe: 0.523 ± 0.018	0.786TrpGly: 0.786 ± 0.021	0.3TrpHis: 0.3 ± 0.013	0.697TrpIle: 0.697 ± 0.022	0.508TrpLys: 0.508 ± 0.017	1.57TrpLeu: 1.57 ± 0.039	0.327TrpMet: 0.327 ± 0.014	0.446TrpAsn: 0.446 ± 0.018	0.626TrpPro: 0.626 ± 0.02	0.587TrpGln: 0.587 ± 0.02	0.95TrpArg: 0.95 ± 0.026	0.813TrpSer: 0.813 ± 0.026	0.711TrpThr: 0.711 ± 0.022	0.739TrpVal: 0.739 ± 0.021	0.196TrpTrp: 0.196 ± 0.012	0.266TrpTyr: 0.266 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.377TyrAla: 2.377 ± 0.043	0.227TyrCys: 0.227 ± 0.011	1.461TyrAsp: 1.461 ± 0.037	1.209TyrGlu: 1.209 ± 0.028	0.963TyrPhe: 0.963 ± 0.023	2.111TyrGly: 2.111 ± 0.037	0.489TyrHis: 0.489 ± 0.018	1.066TyrIle: 1.066 ± 0.026	0.707TyrLys: 0.707 ± 0.026	2.363TyrLeu: 2.363 ± 0.041	0.475TyrMet: 0.475 ± 0.018	0.62TyrAsn: 0.62 ± 0.022	1.101TyrPro: 1.101 ± 0.029	0.792TyrGln: 0.792 ± 0.021	1.729TyrArg: 1.729 ± 0.035	1.309TyrSer: 1.309 ± 0.031	1.096TyrThr: 1.096 ± 0.025	1.666TyrVal: 1.666 ± 0.033	0.338TyrTrp: 0.338 ± 0.015	0.601TyrTyr: 0.601 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5347 proteins (1610893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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