Amino acid dipepetide frequency for Pseudohongiella acticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.44AlaAla: 11.44 ± 0.164	1.087AlaCys: 1.087 ± 0.033	6.622AlaAsp: 6.622 ± 0.096	6.227AlaGlu: 6.227 ± 0.09	3.605AlaPhe: 3.605 ± 0.06	8.629AlaGly: 8.629 ± 0.112	1.806AlaHis: 1.806 ± 0.043	5.425AlaIle: 5.425 ± 0.071	2.427AlaLys: 2.427 ± 0.068	11.809AlaLeu: 11.809 ± 0.127	3.147AlaMet: 3.147 ± 0.051	3.286AlaAsn: 3.286 ± 0.061	3.884AlaPro: 3.884 ± 0.061	4.493AlaGln: 4.493 ± 0.068	6.307AlaArg: 6.307 ± 0.079	6.394AlaSer: 6.394 ± 0.083	5.241AlaThr: 5.241 ± 0.091	7.375AlaVal: 7.375 ± 0.097	1.402AlaTrp: 1.402 ± 0.042	2.416AlaTyr: 2.416 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.83CysAla: 0.83 ± 0.031	0.124CysCys: 0.124 ± 0.011	0.515CysAsp: 0.515 ± 0.024	0.474CysGlu: 0.474 ± 0.023	0.372CysPhe: 0.372 ± 0.019	0.802CysGly: 0.802 ± 0.029	0.333CysHis: 0.333 ± 0.02	0.474CysIle: 0.474 ± 0.021	0.242CysLys: 0.242 ± 0.017	1.029CysLeu: 1.029 ± 0.029	0.18CysMet: 0.18 ± 0.013	0.277CysAsn: 0.277 ± 0.017	0.4CysPro: 0.4 ± 0.022	0.43CysGln: 0.43 ± 0.02	0.632CysArg: 0.632 ± 0.025	0.585CysSer: 0.585 ± 0.022	0.449CysThr: 0.449 ± 0.022	0.647CysVal: 0.647 ± 0.028	0.125CysTrp: 0.125 ± 0.01	0.256CysTyr: 0.256 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.305AspAla: 6.305 ± 0.09	0.544AspCys: 0.544 ± 0.025	3.854AspAsp: 3.854 ± 0.09	3.779AspGlu: 3.779 ± 0.068	2.503AspPhe: 2.503 ± 0.043	4.607AspGly: 4.607 ± 0.077	1.182AspHis: 1.182 ± 0.037	3.831AspIle: 3.831 ± 0.068	1.976AspLys: 1.976 ± 0.054	5.666AspLeu: 5.666 ± 0.071	1.639AspMet: 1.639 ± 0.04	2.44AspAsn: 2.44 ± 0.051	2.854AspPro: 2.854 ± 0.051	2.39AspGln: 2.39 ± 0.049	3.35AspArg: 3.35 ± 0.057	3.707AspSer: 3.707 ± 0.075	3.273AspThr: 3.273 ± 0.056	4.441AspVal: 4.441 ± 0.076	0.974AspTrp: 0.974 ± 0.034	1.921AspTyr: 1.921 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.607GluAla: 5.607 ± 0.078	0.389GluCys: 0.389 ± 0.018	2.804GluAsp: 2.804 ± 0.053	3.203GluGlu: 3.203 ± 0.074	2.215GluPhe: 2.215 ± 0.047	3.517GluGly: 3.517 ± 0.058	1.467GluHis: 1.467 ± 0.039	3.271GluIle: 3.271 ± 0.063	2.068GluLys: 2.068 ± 0.058	6.588GluLeu: 6.588 ± 0.089	1.472GluMet: 1.472 ± 0.037	2.115GluAsn: 2.115 ± 0.046	2.411GluPro: 2.411 ± 0.052	3.502GluGln: 3.502 ± 0.071	4.031GluArg: 4.031 ± 0.079	3.395GluSer: 3.395 ± 0.063	3.143GluThr: 3.143 ± 0.06	3.762GluVal: 3.762 ± 0.057	0.621GluTrp: 0.621 ± 0.025	1.416GluTyr: 1.416 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.852PheAla: 3.852 ± 0.061	0.425PheCys: 0.425 ± 0.021	2.684PheAsp: 2.684 ± 0.062	2.056PheGlu: 2.056 ± 0.045	1.495PhePhe: 1.495 ± 0.049	3.08PheGly: 3.08 ± 0.057	0.725PheHis: 0.725 ± 0.023	2.039PheIle: 2.039 ± 0.051	0.989PheLys: 0.989 ± 0.029	3.306PheLeu: 3.306 ± 0.064	1.046PheMet: 1.046 ± 0.029	1.548PheAsn: 1.548 ± 0.042	1.42PhePro: 1.42 ± 0.038	1.22PheGln: 1.22 ± 0.033	2.091PheArg: 2.091 ± 0.045	3.002PheSer: 3.002 ± 0.053	2.105PheThr: 2.105 ± 0.051	2.844PheVal: 2.844 ± 0.056	0.501PheTrp: 0.501 ± 0.026	1.21PheTyr: 1.21 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.704GlyAla: 6.704 ± 0.092	0.749GlyCys: 0.749 ± 0.027	4.54GlyAsp: 4.54 ± 0.074	4.418GlyGlu: 4.418 ± 0.07	3.384GlyPhe: 3.384 ± 0.063	5.901GlyGly: 5.901 ± 0.162	1.674GlyHis: 1.674 ± 0.047	4.559GlyIle: 4.559 ± 0.069	2.8GlyLys: 2.8 ± 0.056	7.962GlyLeu: 7.962 ± 0.099	2.17GlyMet: 2.17 ± 0.055	2.929GlyAsn: 2.929 ± 0.073	2.425GlyPro: 2.425 ± 0.055	3.151GlyGln: 3.151 ± 0.061	4.459GlyArg: 4.459 ± 0.067	5.002GlySer: 5.002 ± 0.089	4.068GlyThr: 4.068 ± 0.096	5.563GlyVal: 5.563 ± 0.085	1.183GlyTrp: 1.183 ± 0.038	2.264GlyTyr: 2.264 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.945HisAla: 1.945 ± 0.046	0.281HisCys: 0.281 ± 0.017	1.255HisAsp: 1.255 ± 0.034	1.157HisGlu: 1.157 ± 0.031	0.866HisPhe: 0.866 ± 0.03	1.73HisGly: 1.73 ± 0.052	0.622HisHis: 0.622 ± 0.031	1.158HisIle: 1.158 ± 0.033	0.692HisLys: 0.692 ± 0.027	2.044HisLeu: 2.044 ± 0.046	0.514HisMet: 0.514 ± 0.021	0.712HisAsn: 0.712 ± 0.026	1.184HisPro: 1.184 ± 0.035	0.977HisGln: 0.977 ± 0.032	1.302HisArg: 1.302 ± 0.036	1.213HisSer: 1.213 ± 0.036	1.122HisThr: 1.122 ± 0.035	1.311HisVal: 1.311 ± 0.041	0.368HisTrp: 0.368 ± 0.02	0.765HisTyr: 0.765 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.989IleAla: 5.989 ± 0.089	0.549IleCys: 0.549 ± 0.024	3.925IleAsp: 3.925 ± 0.06	3.556IleGlu: 3.556 ± 0.059	1.733IlePhe: 1.733 ± 0.043	4.182IleGly: 4.182 ± 0.061	0.998IleHis: 0.998 ± 0.03	2.746IleIle: 2.746 ± 0.059	1.953IleLys: 1.953 ± 0.046	4.56IleLeu: 4.56 ± 0.082	1.193IleMet: 1.193 ± 0.037	2.486IleAsn: 2.486 ± 0.048	2.447IlePro: 2.447 ± 0.049	1.748IleGln: 1.748 ± 0.044	3.309IleArg: 3.309 ± 0.062	3.837IleSer: 3.837 ± 0.06	3.148IleThr: 3.148 ± 0.06	3.906IleVal: 3.906 ± 0.062	0.616IleTrp: 0.616 ± 0.023	1.359IleTyr: 1.359 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.075LysAla: 3.075 ± 0.08	0.171LysCys: 0.171 ± 0.012	1.606LysAsp: 1.606 ± 0.05	1.472LysGlu: 1.472 ± 0.044	0.832LysPhe: 0.832 ± 0.026	1.954LysGly: 1.954 ± 0.052	0.698LysHis: 0.698 ± 0.027	1.589LysIle: 1.589 ± 0.039	1.397LysLys: 1.397 ± 0.052	3.037LysLeu: 3.037 ± 0.06	0.72LysMet: 0.72 ± 0.025	1.061LysAsn: 1.061 ± 0.031	1.634LysPro: 1.634 ± 0.04	1.527LysGln: 1.527 ± 0.04	2.001LysArg: 2.001 ± 0.052	1.836LysSer: 1.836 ± 0.055	1.889LysThr: 1.889 ± 0.043	2.157LysVal: 2.157 ± 0.048	0.298LysTrp: 0.298 ± 0.017	0.672LysTyr: 0.672 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.92LeuAla: 11.92 ± 0.138	0.998LeuCys: 0.998 ± 0.032	6.121LeuAsp: 6.121 ± 0.092	5.645LeuGlu: 5.645 ± 0.08	3.782LeuPhe: 3.782 ± 0.07	7.508LeuGly: 7.508 ± 0.092	2.129LeuHis: 2.129 ± 0.053	5.572LeuIle: 5.572 ± 0.097	3.08LeuLys: 3.08 ± 0.063	11.47LeuLeu: 11.47 ± 0.159	2.811LeuMet: 2.811 ± 0.067	3.727LeuAsn: 3.727 ± 0.066	5.353LeuPro: 5.353 ± 0.087	4.959LeuGln: 4.959 ± 0.072	6.484LeuArg: 6.484 ± 0.085	7.662LeuSer: 7.662 ± 0.099	6.058LeuThr: 6.058 ± 0.079	7.397LeuVal: 7.397 ± 0.099	1.193LeuTrp: 1.193 ± 0.038	2.429LeuTyr: 2.429 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.913MetAla: 2.913 ± 0.058	0.179MetCys: 0.179 ± 0.013	1.276MetAsp: 1.276 ± 0.039	1.217MetGlu: 1.217 ± 0.037	0.846MetPhe: 0.846 ± 0.034	1.748MetGly: 1.748 ± 0.041	0.539MetHis: 0.539 ± 0.022	1.393MetIle: 1.393 ± 0.038	0.956MetLys: 0.956 ± 0.032	2.993MetLeu: 2.993 ± 0.055	0.682MetMet: 0.682 ± 0.029	0.983MetAsn: 0.983 ± 0.03	1.455MetPro: 1.455 ± 0.045	1.334MetGln: 1.334 ± 0.031	1.553MetArg: 1.553 ± 0.04	1.893MetSer: 1.893 ± 0.04	1.811MetThr: 1.811 ± 0.043	1.735MetVal: 1.735 ± 0.044	0.215MetTrp: 0.215 ± 0.015	0.487MetTyr: 0.487 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.653AsnAla: 3.653 ± 0.064	0.31AsnCys: 0.31 ± 0.018	2.067AsnAsp: 2.067 ± 0.045	1.861AsnGlu: 1.861 ± 0.04	1.313AsnPhe: 1.313 ± 0.039	2.703AsnGly: 2.703 ± 0.069	0.681AsnHis: 0.681 ± 0.028	2.093AsnIle: 2.093 ± 0.043	1.161AsnLys: 1.161 ± 0.03	3.349AsnLeu: 3.349 ± 0.065	0.895AsnMet: 0.895 ± 0.03	1.585AsnAsn: 1.585 ± 0.058	2.089AsnPro: 2.089 ± 0.044	1.514AsnGln: 1.514 ± 0.034	2.182AsnArg: 2.182 ± 0.047	2.19AsnSer: 2.19 ± 0.047	2.095AsnThr: 2.095 ± 0.051	2.356AsnVal: 2.356 ± 0.053	0.541AsnTrp: 0.541 ± 0.023	1.058AsnTyr: 1.058 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.131ProAla: 5.131 ± 0.073	0.316ProCys: 0.316 ± 0.019	3.698ProAsp: 3.698 ± 0.061	3.424ProGlu: 3.424 ± 0.063	1.657ProPhe: 1.657 ± 0.047	4.104ProGly: 4.104 ± 0.077	0.858ProHis: 0.858 ± 0.031	1.909ProIle: 1.909 ± 0.043	0.96ProLys: 0.96 ± 0.031	4.427ProLeu: 4.427 ± 0.069	1.173ProMet: 1.173 ± 0.033	1.215ProAsn: 1.215 ± 0.037	1.787ProPro: 1.787 ± 0.049	1.74ProGln: 1.74 ± 0.047	2.149ProArg: 2.149 ± 0.046	2.348ProSer: 2.348 ± 0.048	2.173ProThr: 2.173 ± 0.047	4.117ProVal: 4.117 ± 0.068	0.686ProTrp: 0.686 ± 0.025	1.05ProTyr: 1.05 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.054GlnAla: 5.054 ± 0.084	0.369GlnCys: 0.369 ± 0.019	2.27GlnAsp: 2.27 ± 0.046	2.297GlnGlu: 2.297 ± 0.051	1.554GlnPhe: 1.554 ± 0.04	3.174GlnGly: 3.174 ± 0.066	1.143GlnHis: 1.143 ± 0.035	2.266GlnIle: 2.266 ± 0.041	1.253GlnLys: 1.253 ± 0.034	4.849GlnLeu: 4.849 ± 0.067	1.129GlnMet: 1.129 ± 0.033	1.415GlnAsn: 1.415 ± 0.042	2.067GlnPro: 2.067 ± 0.048	3.123GlnGln: 3.123 ± 0.089	3.356GlnArg: 3.356 ± 0.054	2.807GlnSer: 2.807 ± 0.049	2.394GlnThr: 2.394 ± 0.047	3.143GlnVal: 3.143 ± 0.056	0.69GlnTrp: 0.69 ± 0.025	1.155GlnTyr: 1.155 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	5.42ArgAla: 5.42 ± 0.068	0.563ArgCys: 0.563 ± 0.025	3.841ArgAsp: 3.841 ± 0.06	3.876ArgGlu: 3.876 ± 0.079	2.652ArgPhe: 2.652 ± 0.051	3.811ArgGly: 3.811 ± 0.065	1.551ArgHis: 1.551 ± 0.043	3.641ArgIle: 3.641 ± 0.067	1.922ArgLys: 1.922 ± 0.049	7.016ArgLeu: 7.016 ± 0.081	1.569ArgMet: 1.569 ± 0.041	2.147ArgAsn: 2.147 ± 0.042	2.545ArgPro: 2.545 ± 0.054	3.337ArgGln: 3.337 ± 0.054	3.954ArgArg: 3.954 ± 0.067	3.567ArgSer: 3.567 ± 0.06	2.81ArgThr: 2.81 ± 0.048	4.221ArgVal: 4.221 ± 0.068	0.918ArgTrp: 0.918 ± 0.035	2.089ArgTyr: 2.089 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.892SerAla: 6.892 ± 0.089	0.551SerCys: 0.551 ± 0.026	3.984SerAsp: 3.984 ± 0.07	3.523SerGlu: 3.523 ± 0.058	2.417SerPhe: 2.417 ± 0.052	5.767SerGly: 5.767 ± 0.115	1.352SerHis: 1.352 ± 0.034	3.353SerIle: 3.353 ± 0.067	1.648SerLys: 1.648 ± 0.042	6.787SerLeu: 6.787 ± 0.095	1.634SerMet: 1.634 ± 0.043	2.167SerAsn: 2.167 ± 0.042	2.834SerPro: 2.834 ± 0.053	2.582SerGln: 2.582 ± 0.052	3.965SerArg: 3.965 ± 0.067	4.044SerSer: 4.044 ± 0.078	3.328SerThr: 3.328 ± 0.065	4.782SerVal: 4.782 ± 0.084	0.849SerTrp: 0.849 ± 0.025	1.766SerTyr: 1.766 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.505ThrAla: 5.505 ± 0.096	0.398ThrCys: 0.398 ± 0.02	3.322ThrAsp: 3.322 ± 0.057	2.988ThrGlu: 2.988 ± 0.055	1.83ThrPhe: 1.83 ± 0.049	5.155ThrGly: 5.155 ± 0.082	1.067ThrHis: 1.067 ± 0.034	2.694ThrIle: 2.694 ± 0.054	1.041ThrLys: 1.041 ± 0.035	6.846ThrLeu: 6.846 ± 0.086	1.223ThrMet: 1.223 ± 0.036	1.599ThrAsn: 1.599 ± 0.049	2.97ThrPro: 2.97 ± 0.061	2.263ThrGln: 2.263 ± 0.05	3.279ThrArg: 3.279 ± 0.052	3.163ThrSer: 3.163 ± 0.056	2.945ThrThr: 2.945 ± 0.067	4.175ThrVal: 4.175 ± 0.073	0.633ThrTrp: 0.633 ± 0.026	1.293ThrTyr: 1.293 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	7.399ValAla: 7.399 ± 0.089	0.748ValCys: 0.748 ± 0.026	4.516ValAsp: 4.516 ± 0.064	3.885ValGlu: 3.885 ± 0.064	2.873ValPhe: 2.873 ± 0.061	4.597ValGly: 4.597 ± 0.073	1.394ValHis: 1.394 ± 0.04	4.309ValIle: 4.309 ± 0.07	2.093ValLys: 2.093 ± 0.054	7.805ValLeu: 7.805 ± 0.106	2.085ValMet: 2.085 ± 0.049	2.695ValAsn: 2.695 ± 0.051	3.267ValPro: 3.267 ± 0.059	2.546ValGln: 2.546 ± 0.053	4.01ValArg: 4.01 ± 0.067	5.189ValSer: 5.189 ± 0.069	4.286ValThr: 4.286 ± 0.062	5.643ValVal: 5.643 ± 0.084	0.867ValTrp: 0.867 ± 0.031	1.944ValTyr: 1.944 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.019TrpAla: 1.019 ± 0.035	0.129TrpCys: 0.129 ± 0.013	0.662TrpAsp: 0.662 ± 0.023	0.506TrpGlu: 0.506 ± 0.022	0.559TrpPhe: 0.559 ± 0.026	0.83TrpGly: 0.83 ± 0.03	0.36TrpHis: 0.36 ± 0.018	0.685TrpIle: 0.685 ± 0.026	0.279TrpLys: 0.279 ± 0.018	1.811TrpLeu: 1.811 ± 0.05	0.353TrpMet: 0.353 ± 0.021	0.392TrpAsn: 0.392 ± 0.022	0.63TrpPro: 0.63 ± 0.024	1.134TrpGln: 1.134 ± 0.035	1.019TrpArg: 1.019 ± 0.034	0.787TrpSer: 0.787 ± 0.03	0.66TrpThr: 0.66 ± 0.027	0.895TrpVal: 0.895 ± 0.028	0.225TrpTrp: 0.225 ± 0.017	0.385TrpTyr: 0.385 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.371TyrAla: 2.371 ± 0.048	0.298TyrCys: 0.298 ± 0.016	1.675TyrAsp: 1.675 ± 0.041	1.434TyrGlu: 1.434 ± 0.037	1.151TyrPhe: 1.151 ± 0.038	2.109TyrGly: 2.109 ± 0.045	0.636TyrHis: 0.636 ± 0.023	1.234TyrIle: 1.234 ± 0.031	0.688TyrLys: 0.688 ± 0.027	2.941TyrLeu: 2.941 ± 0.06	0.571TyrMet: 0.571 ± 0.024	0.918TyrAsn: 0.918 ± 0.031	1.268TyrPro: 1.268 ± 0.033	1.537TyrGln: 1.537 ± 0.035	2.015TyrArg: 2.015 ± 0.045	1.601TyrSer: 1.601 ± 0.044	1.392TyrThr: 1.392 ± 0.042	1.679TyrVal: 1.679 ± 0.043	0.414TyrTrp: 0.414 ± 0.021	0.835TyrTyr: 0.835 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3105 proteins (1076679 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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