Amino acid dipepetide frequency for Lake Sarah-associated circular virus-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.672AlaAla: 3.672 ± 1.164
0.0AlaCys: 0.0 ± 0.0
4.896AlaAsp: 4.896 ± 4.006
1.224AlaGlu: 1.224 ± 0.839
3.672AlaPhe: 3.672 ± 1.164
3.672AlaGly: 3.672 ± 0.677
1.224AlaHis: 1.224 ± 0.839
3.672AlaIle: 3.672 ± 0.677
3.672AlaLys: 3.672 ± 1.164
0.0AlaLeu: 0.0 ± 0.0
1.224AlaMet: 1.224 ± 0.839
2.448AlaAsn: 2.448 ± 0.162
2.448AlaPro: 2.448 ± 0.162
11.016AlaGln: 11.016 ± 1.651
2.448AlaArg: 2.448 ± 0.162
6.12AlaSer: 6.12 ± 2.356
6.12AlaThr: 6.12 ± 4.197
4.896AlaVal: 4.896 ± 2.165
1.224AlaTrp: 1.224 ± 0.839
3.672AlaTyr: 3.672 ± 2.518
0.0AlaXaa: 0.0 ± 0.0
Cys
1.224CysAla: 1.224 ± 0.839
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.224CysPhe: 1.224 ± 1.002
1.224CysGly: 1.224 ± 1.002
1.224CysHis: 1.224 ± 1.002
0.0CysIle: 0.0 ± 0.0
1.224CysLys: 1.224 ± 1.002
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
2.448CysAsn: 2.448 ± 0.162
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
2.448CysArg: 2.448 ± 1.679
0.0CysSer: 0.0 ± 0.0
2.448CysThr: 2.448 ± 0.162
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.568AspAla: 8.568 ± 1.488
0.0AspCys: 0.0 ± 0.0
9.792AspAsp: 9.792 ± 4.331
3.672AspGlu: 3.672 ± 3.005
4.896AspPhe: 4.896 ± 2.165
3.672AspGly: 3.672 ± 1.164
0.0AspHis: 0.0 ± 0.0
3.672AspIle: 3.672 ± 1.164
3.672AspLys: 3.672 ± 0.677
7.344AspLeu: 7.344 ± 2.328
1.224AspMet: 1.224 ± 0.839
3.672AspAsn: 3.672 ± 0.677
1.224AspPro: 1.224 ± 0.839
3.672AspGln: 3.672 ± 0.677
3.672AspArg: 3.672 ± 3.005
1.224AspSer: 1.224 ± 1.002
3.672AspThr: 3.672 ± 0.677
2.448AspVal: 2.448 ± 1.679
0.0AspTrp: 0.0 ± 0.0
1.224AspTyr: 1.224 ± 1.002
0.0AspXaa: 0.0 ± 0.0
Glu
4.896GluAla: 4.896 ± 2.165
1.224GluCys: 1.224 ± 1.002
2.448GluAsp: 2.448 ± 2.003
4.896GluGlu: 4.896 ± 4.006
8.568GluPhe: 8.568 ± 0.353
2.448GluGly: 2.448 ± 0.162
3.672GluHis: 3.672 ± 0.677
2.448GluIle: 2.448 ± 1.679
2.448GluLys: 2.448 ± 2.003
1.224GluLeu: 1.224 ± 1.002
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
1.224GluPro: 1.224 ± 1.002
1.224GluGln: 1.224 ± 1.002
3.672GluArg: 3.672 ± 1.164
1.224GluSer: 1.224 ± 0.839
3.672GluThr: 3.672 ± 3.005
2.448GluVal: 2.448 ± 2.003
0.0GluTrp: 0.0 ± 0.0
3.672GluTyr: 3.672 ± 1.164
0.0GluXaa: 0.0 ± 0.0
Phe
2.448PheAla: 2.448 ± 2.003
1.224PheCys: 1.224 ± 1.002
4.896PheAsp: 4.896 ± 0.324
4.896PheGlu: 4.896 ± 0.324
1.224PhePhe: 1.224 ± 0.839
0.0PheGly: 0.0 ± 0.0
2.448PheHis: 2.448 ± 0.162
3.672PheIle: 3.672 ± 1.164
4.896PheLys: 4.896 ± 0.324
3.672PheLeu: 3.672 ± 1.164
2.448PheMet: 2.448 ± 0.534
2.448PheAsn: 2.448 ± 1.679
1.224PhePro: 1.224 ± 0.839
2.448PheGln: 2.448 ± 0.162
1.224PheArg: 1.224 ± 1.002
1.224PheSer: 1.224 ± 1.002
9.792PheThr: 9.792 ± 2.49
1.224PheVal: 1.224 ± 0.839
2.448PheTrp: 2.448 ± 2.003
3.672PheTyr: 3.672 ± 0.677
0.0PheXaa: 0.0 ± 0.0
Gly
6.12GlyAla: 6.12 ± 1.326
0.0GlyCys: 0.0 ± 0.0
6.12GlyAsp: 6.12 ± 1.326
3.672GlyGlu: 3.672 ± 1.164
2.448GlyPhe: 2.448 ± 0.162
7.344GlyGly: 7.344 ± 3.195
1.224GlyHis: 1.224 ± 0.839
1.224GlyIle: 1.224 ± 0.839
3.672GlyLys: 3.672 ± 0.677
2.448GlyLeu: 2.448 ± 0.162
1.224GlyMet: 1.224 ± 0.839
3.672GlyAsn: 3.672 ± 0.677
1.224GlyPro: 1.224 ± 1.002
0.0GlyGln: 0.0 ± 0.0
6.12GlyArg: 6.12 ± 0.515
9.792GlySer: 9.792 ± 1.192
4.896GlyThr: 4.896 ± 2.165
4.896GlyVal: 4.896 ± 1.517
1.224GlyTrp: 1.224 ± 0.839
6.12GlyTyr: 6.12 ± 0.515
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
1.224HisAsp: 1.224 ± 1.002
1.224HisGlu: 1.224 ± 1.002
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
1.224HisHis: 1.224 ± 0.839
1.224HisIle: 1.224 ± 1.002
2.448HisLys: 2.448 ± 0.162
3.672HisLeu: 3.672 ± 1.164
0.0HisMet: 0.0 ± 0.0
1.224HisAsn: 1.224 ± 0.839
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.224HisArg: 1.224 ± 1.002
2.448HisSer: 2.448 ± 1.679
1.224HisThr: 1.224 ± 0.839
1.224HisVal: 1.224 ± 0.839
0.0HisTrp: 0.0 ± 0.0
1.224HisTyr: 1.224 ± 0.839
0.0HisXaa: 0.0 ± 0.0
Ile
1.224IleAla: 1.224 ± 0.839
0.0IleCys: 0.0 ± 0.0
2.448IleAsp: 2.448 ± 0.162
2.448IleGlu: 2.448 ± 0.162
3.672IlePhe: 3.672 ± 3.005
4.896IleGly: 4.896 ± 1.517
0.0IleHis: 0.0 ± 0.0
1.224IleIle: 1.224 ± 0.839
2.448IleLys: 2.448 ± 0.162
0.0IleLeu: 0.0 ± 0.0
0.0IleMet: 0.0 ± 0.0
3.672IleAsn: 3.672 ± 2.518
1.224IlePro: 1.224 ± 1.002
1.224IleGln: 1.224 ± 1.002
1.224IleArg: 1.224 ± 1.002
3.672IleSer: 3.672 ± 0.677
1.224IleThr: 1.224 ± 0.839
3.672IleVal: 3.672 ± 1.164
0.0IleTrp: 0.0 ± 0.0
4.896IleTyr: 4.896 ± 3.357
0.0IleXaa: 0.0 ± 0.0
Lys
3.672LysAla: 3.672 ± 2.518
0.0LysCys: 0.0 ± 0.0
4.896LysAsp: 4.896 ± 2.165
1.224LysGlu: 1.224 ± 0.839
4.896LysPhe: 4.896 ± 1.517
8.568LysGly: 8.568 ± 3.329
1.224LysHis: 1.224 ± 0.839
2.448LysIle: 2.448 ± 1.679
0.0LysLys: 0.0 ± 0.0
2.448LysLeu: 2.448 ± 0.162
0.0LysMet: 0.0 ± 0.0
1.224LysAsn: 1.224 ± 0.839
2.448LysPro: 2.448 ± 1.679
2.448LysGln: 2.448 ± 2.003
4.896LysArg: 4.896 ± 2.165
4.896LysSer: 4.896 ± 1.517
3.672LysThr: 3.672 ± 1.164
3.672LysVal: 3.672 ± 1.164
1.224LysTrp: 1.224 ± 0.839
1.224LysTyr: 1.224 ± 1.002
0.0LysXaa: 0.0 ± 0.0
Leu
2.448LeuAla: 2.448 ± 2.003
1.224LeuCys: 1.224 ± 0.839
1.224LeuAsp: 1.224 ± 0.839
2.448LeuGlu: 2.448 ± 2.003
3.672LeuPhe: 3.672 ± 0.677
4.896LeuGly: 4.896 ± 2.165
0.0LeuHis: 0.0 ± 0.0
0.0LeuIle: 0.0 ± 0.0
0.0LeuLys: 0.0 ± 0.0
3.672LeuLeu: 3.672 ± 1.164
0.0LeuMet: 0.0 ± 0.0
6.12LeuAsn: 6.12 ± 1.326
2.448LeuPro: 2.448 ± 0.162
2.448LeuGln: 2.448 ± 0.162
2.448LeuArg: 2.448 ± 2.003
1.224LeuSer: 1.224 ± 0.839
4.896LeuThr: 4.896 ± 0.324
8.568LeuVal: 8.568 ± 0.353
0.0LeuTrp: 0.0 ± 0.0
1.224LeuTyr: 1.224 ± 1.002
0.0LeuXaa: 0.0 ± 0.0
Met
1.224MetAla: 1.224 ± 0.839
0.0MetCys: 0.0 ± 0.0
1.224MetAsp: 1.224 ± 0.839
1.224MetGlu: 1.224 ± 0.839
0.0MetPhe: 0.0 ± 0.0
1.224MetGly: 1.224 ± 0.839
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
2.448MetMet: 2.448 ± 1.679
1.224MetAsn: 1.224 ± 0.839
3.672MetPro: 3.672 ± 2.518
1.224MetGln: 1.224 ± 0.839
0.0MetArg: 0.0 ± 0.0
3.672MetSer: 3.672 ± 0.677
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
1.224MetTyr: 1.224 ± 0.839
0.0MetXaa: 0.0 ± 0.0
Asn
3.672AsnAla: 3.672 ± 0.677
1.224AsnCys: 1.224 ± 0.839
4.896AsnAsp: 4.896 ± 0.324
2.448AsnGlu: 2.448 ± 2.003
1.224AsnPhe: 1.224 ± 1.002
3.672AsnGly: 3.672 ± 1.164
0.0AsnHis: 0.0 ± 0.0
1.224AsnIle: 1.224 ± 0.839
4.896AsnLys: 4.896 ± 1.517
1.224AsnLeu: 1.224 ± 0.839
1.224AsnMet: 1.224 ± 0.839
3.672AsnAsn: 3.672 ± 0.677
1.224AsnPro: 1.224 ± 0.839
1.224AsnGln: 1.224 ± 0.839
4.896AsnArg: 4.896 ± 0.324
6.12AsnSer: 6.12 ± 2.356
3.672AsnThr: 3.672 ± 2.518
4.896AsnVal: 4.896 ± 1.517
0.0AsnTrp: 0.0 ± 0.0
4.896AsnTyr: 4.896 ± 1.517
0.0AsnXaa: 0.0 ± 0.0
Pro
2.448ProAla: 2.448 ± 0.162
0.0ProCys: 0.0 ± 0.0
1.224ProAsp: 1.224 ± 1.002
1.224ProGlu: 1.224 ± 1.002
2.448ProPhe: 2.448 ± 0.162
3.672ProGly: 3.672 ± 0.677
1.224ProHis: 1.224 ± 1.002
1.224ProIle: 1.224 ± 0.839
1.224ProLys: 1.224 ± 0.839
1.224ProLeu: 1.224 ± 1.002
1.224ProMet: 1.224 ± 0.839
2.448ProAsn: 2.448 ± 2.003
2.448ProPro: 2.448 ± 0.162
0.0ProGln: 0.0 ± 0.0
7.344ProArg: 7.344 ± 2.328
3.672ProSer: 3.672 ± 0.677
4.896ProThr: 4.896 ± 0.324
4.896ProVal: 4.896 ± 0.324
1.224ProTrp: 1.224 ± 1.002
2.448ProTyr: 2.448 ± 1.679
0.0ProXaa: 0.0 ± 0.0
Gln
1.224GlnAla: 1.224 ± 0.839
1.224GlnCys: 1.224 ± 0.839
3.672GlnAsp: 3.672 ± 0.677
2.448GlnGlu: 2.448 ± 2.003
1.224GlnPhe: 1.224 ± 1.002
3.672GlnGly: 3.672 ± 1.164
1.224GlnHis: 1.224 ± 1.002
0.0GlnIle: 0.0 ± 0.0
1.224GlnLys: 1.224 ± 0.839
3.672GlnLeu: 3.672 ± 1.164
0.0GlnMet: 0.0 ± 0.0
2.448GlnAsn: 2.448 ± 0.162
3.672GlnPro: 3.672 ± 1.164
2.448GlnGln: 2.448 ± 2.003
6.12GlnArg: 6.12 ± 1.326
1.224GlnSer: 1.224 ± 0.839
4.896GlnThr: 4.896 ± 3.357
0.0GlnVal: 0.0 ± 0.0
1.224GlnTrp: 1.224 ± 0.839
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.672ArgAla: 3.672 ± 3.005
1.224ArgCys: 1.224 ± 1.002
2.448ArgAsp: 2.448 ± 0.162
3.672ArgGlu: 3.672 ± 1.164
3.672ArgPhe: 3.672 ± 0.677
2.448ArgGly: 2.448 ± 0.162
2.448ArgHis: 2.448 ± 0.162
3.672ArgIle: 3.672 ± 3.005
1.224ArgLys: 1.224 ± 1.002
4.896ArgLeu: 4.896 ± 0.324
0.0ArgMet: 0.0 ± 0.0
3.672ArgAsn: 3.672 ± 1.164
1.224ArgPro: 1.224 ± 1.002
4.896ArgGln: 4.896 ± 0.324
2.448ArgArg: 2.448 ± 2.003
7.344ArgSer: 7.344 ± 4.169
4.896ArgThr: 4.896 ± 1.517
3.672ArgVal: 3.672 ± 1.164
0.0ArgTrp: 0.0 ± 0.0
1.224ArgTyr: 1.224 ± 1.002
0.0ArgXaa: 0.0 ± 0.0
Ser
6.12SerAla: 6.12 ± 4.197
0.0SerCys: 0.0 ± 0.0
2.448SerAsp: 2.448 ± 2.003
2.448SerGlu: 2.448 ± 0.162
4.896SerPhe: 4.896 ± 1.517
7.344SerGly: 7.344 ± 5.036
1.224SerHis: 1.224 ± 1.002
6.12SerIle: 6.12 ± 2.356
7.344SerLys: 7.344 ± 3.195
0.0SerLeu: 0.0 ± 0.0
2.448SerMet: 2.448 ± 1.679
1.224SerAsn: 1.224 ± 0.839
7.344SerPro: 7.344 ± 4.169
1.224SerGln: 1.224 ± 0.839
0.0SerArg: 0.0 ± 0.0
6.12SerSer: 6.12 ± 4.197
7.344SerThr: 7.344 ± 0.487
4.896SerVal: 4.896 ± 0.324
0.0SerTrp: 0.0 ± 0.0
3.672SerTyr: 3.672 ± 2.518
0.0SerXaa: 0.0 ± 0.0
Thr
8.568ThrAla: 8.568 ± 2.194
1.224ThrCys: 1.224 ± 0.839
6.12ThrAsp: 6.12 ± 2.356
4.896ThrGlu: 4.896 ± 1.517
1.224ThrPhe: 1.224 ± 1.002
4.896ThrGly: 4.896 ± 1.517
1.224ThrHis: 1.224 ± 0.839
1.224ThrIle: 1.224 ± 0.839
7.344ThrLys: 7.344 ± 2.328
6.12ThrLeu: 6.12 ± 0.515
1.224ThrMet: 1.224 ± 0.839
8.568ThrAsn: 8.568 ± 4.035
7.344ThrPro: 7.344 ± 4.169
0.0ThrGln: 0.0 ± 0.0
2.448ThrArg: 2.448 ± 2.003
2.448ThrSer: 2.448 ± 1.679
13.464ThrThr: 13.464 ± 9.233
7.344ThrVal: 7.344 ± 1.354
2.448ThrTrp: 2.448 ± 2.003
2.448ThrTyr: 2.448 ± 1.679
0.0ThrXaa: 0.0 ± 0.0
Val
4.896ValAla: 4.896 ± 3.357
2.448ValCys: 2.448 ± 0.162
3.672ValAsp: 3.672 ± 1.164
7.344ValGlu: 7.344 ± 4.169
4.896ValPhe: 4.896 ± 2.165
2.448ValGly: 2.448 ± 0.162
0.0ValHis: 0.0 ± 0.0
2.448ValIle: 2.448 ± 0.162
2.448ValLys: 2.448 ± 1.679
4.896ValLeu: 4.896 ± 2.165
1.224ValMet: 1.224 ± 1.305
4.896ValAsn: 4.896 ± 1.517
3.672ValPro: 3.672 ± 0.677
4.896ValGln: 4.896 ± 1.517
3.672ValArg: 3.672 ± 1.164
2.448ValSer: 2.448 ± 0.162
2.448ValThr: 2.448 ± 1.679
3.672ValVal: 3.672 ± 0.677
0.0ValTrp: 0.0 ± 0.0
1.224ValTyr: 1.224 ± 0.839
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
1.224TrpCys: 1.224 ± 1.002
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
2.448TrpPhe: 2.448 ± 0.162
1.224TrpGly: 1.224 ± 0.839
0.0TrpHis: 0.0 ± 0.0
1.224TrpIle: 1.224 ± 1.002
2.448TrpLys: 2.448 ± 2.003
1.224TrpLeu: 1.224 ± 0.839
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.224TrpArg: 1.224 ± 0.839
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
1.224TrpTrp: 1.224 ± 1.002
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.224TyrAla: 1.224 ± 1.002
1.224TyrCys: 1.224 ± 1.002
3.672TyrAsp: 3.672 ± 0.677
0.0TyrGlu: 0.0 ± 0.0
1.224TyrPhe: 1.224 ± 1.002
6.12TyrGly: 6.12 ± 0.515
0.0TyrHis: 0.0 ± 0.0
2.448TyrIle: 2.448 ± 0.162
2.448TyrLys: 2.448 ± 0.162
1.224TyrLeu: 1.224 ± 0.839
1.224TyrMet: 1.224 ± 0.839
1.224TyrAsn: 1.224 ± 0.839
2.448TyrPro: 2.448 ± 1.679
1.224TyrGln: 1.224 ± 0.839
1.224TyrArg: 1.224 ± 1.002
7.344TyrSer: 7.344 ± 5.036
7.344TyrThr: 7.344 ± 3.195
2.448TyrVal: 2.448 ± 1.679
0.0TyrTrp: 0.0 ± 0.0
2.448TyrTyr: 2.448 ± 0.162
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (818 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski