Amino acid dipepetide frequency for Human papillomavirus type 61

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.402AlaAla: 6.402 ± 1.614
1.707AlaCys: 1.707 ± 0.887
3.841AlaAsp: 3.841 ± 1.289
3.841AlaGlu: 3.841 ± 1.35
2.134AlaPhe: 2.134 ± 1.041
4.695AlaGly: 4.695 ± 1.716
2.134AlaHis: 2.134 ± 0.793
2.988AlaIle: 2.988 ± 1.054
1.707AlaLys: 1.707 ± 0.929
5.548AlaLeu: 5.548 ± 1.62
1.707AlaMet: 1.707 ± 0.756
1.707AlaAsn: 1.707 ± 0.916
4.268AlaPro: 4.268 ± 1.641
4.695AlaGln: 4.695 ± 1.19
3.414AlaArg: 3.414 ± 0.929
4.695AlaSer: 4.695 ± 1.636
5.975AlaThr: 5.975 ± 1.615
3.841AlaVal: 3.841 ± 1.214
0.854AlaTrp: 0.854 ± 0.658
2.988AlaTyr: 2.988 ± 0.582
0.0AlaXaa: 0.0 ± 0.0
Cys
2.561CysAla: 2.561 ± 0.752
0.427CysCys: 0.427 ± 0.549
0.427CysAsp: 0.427 ± 0.474
0.427CysGlu: 0.427 ± 0.551
0.427CysPhe: 0.427 ± 0.474
2.134CysGly: 2.134 ± 1.201
0.427CysHis: 0.427 ± 0.549
0.427CysIle: 0.427 ± 0.474
3.414CysLys: 3.414 ± 1.268
0.854CysLeu: 0.854 ± 0.613
1.28CysMet: 1.28 ± 0.624
0.854CysAsn: 0.854 ± 0.754
2.561CysPro: 2.561 ± 0.868
2.134CysGln: 2.134 ± 0.647
1.28CysArg: 1.28 ± 0.818
1.28CysSer: 1.28 ± 0.604
1.28CysThr: 1.28 ± 0.857
2.134CysVal: 2.134 ± 1.024
1.28CysTrp: 1.28 ± 0.42
0.427CysTyr: 0.427 ± 0.549
0.0CysXaa: 0.0 ± 0.0
Asp
3.841AspAla: 3.841 ± 1.451
0.854AspCys: 0.854 ± 0.754
1.707AspAsp: 1.707 ± 0.772
1.28AspGlu: 1.28 ± 1.025
2.561AspPhe: 2.561 ± 0.981
4.695AspGly: 4.695 ± 1.311
0.854AspHis: 0.854 ± 0.686
3.841AspIle: 3.841 ± 1.628
1.707AspLys: 1.707 ± 0.66
5.975AspLeu: 5.975 ± 1.328
0.427AspMet: 0.427 ± 0.377
2.988AspAsn: 2.988 ± 1.037
4.695AspPro: 4.695 ± 1.784
1.707AspGln: 1.707 ± 0.808
3.414AspArg: 3.414 ± 0.642
5.548AspSer: 5.548 ± 1.569
5.975AspThr: 5.975 ± 1.376
0.854AspVal: 0.854 ± 0.728
1.28AspTrp: 1.28 ± 0.624
1.28AspTyr: 1.28 ± 0.857
0.0AspXaa: 0.0 ± 0.0
Glu
4.268GluAla: 4.268 ± 1.94
0.0GluCys: 0.0 ± 0.0
5.122GluAsp: 5.122 ± 1.528
6.829GluGlu: 6.829 ± 2.554
1.28GluPhe: 1.28 ± 0.682
2.561GluGly: 2.561 ± 0.886
1.707GluHis: 1.707 ± 0.641
1.707GluIle: 1.707 ± 0.558
1.707GluLys: 1.707 ± 1.097
4.695GluLeu: 4.695 ± 2.639
0.854GluMet: 0.854 ± 0.947
1.707GluAsn: 1.707 ± 0.66
2.561GluPro: 2.561 ± 0.759
4.268GluGln: 4.268 ± 1.591
2.134GluArg: 2.134 ± 0.92
3.841GluSer: 3.841 ± 0.986
4.268GluThr: 4.268 ± 1.365
5.122GluVal: 5.122 ± 1.212
0.427GluTrp: 0.427 ± 0.342
1.707GluTyr: 1.707 ± 0.66
0.0GluXaa: 0.0 ± 0.0
Phe
2.988PheAla: 2.988 ± 1.108
1.28PheCys: 1.28 ± 0.604
1.707PheAsp: 1.707 ± 0.909
1.707PheGlu: 1.707 ± 0.814
2.134PhePhe: 2.134 ± 0.769
2.561PheGly: 2.561 ± 0.911
0.427PheHis: 0.427 ± 0.549
1.707PheIle: 1.707 ± 0.558
2.134PheLys: 2.134 ± 1.24
4.268PheLeu: 4.268 ± 1.147
0.854PheMet: 0.854 ± 0.658
1.707PheAsn: 1.707 ± 1.103
0.854PhePro: 0.854 ± 0.458
0.854PheGln: 0.854 ± 0.386
2.134PheArg: 2.134 ± 0.653
2.134PheSer: 2.134 ± 0.964
0.854PheThr: 0.854 ± 0.458
2.134PheVal: 2.134 ± 0.342
0.854PheTrp: 0.854 ± 0.386
1.707PheTyr: 1.707 ± 0.635
0.0PheXaa: 0.0 ± 0.0
Gly
3.414GlyAla: 3.414 ± 1.122
0.854GlyCys: 0.854 ± 0.507
6.829GlyAsp: 6.829 ± 1.396
4.268GlyGlu: 4.268 ± 1.567
0.854GlyPhe: 0.854 ± 0.728
5.122GlyGly: 5.122 ± 1.672
3.841GlyHis: 3.841 ± 1.139
2.561GlyIle: 2.561 ± 0.925
3.414GlyLys: 3.414 ± 1.176
3.414GlyLeu: 3.414 ± 1.007
0.427GlyMet: 0.427 ± 0.342
2.134GlyAsn: 2.134 ± 1.24
4.268GlyPro: 4.268 ± 1.725
3.414GlyGln: 3.414 ± 0.767
3.414GlyArg: 3.414 ± 0.969
4.695GlySer: 4.695 ± 2.103
5.122GlyThr: 5.122 ± 1.904
3.414GlyVal: 3.414 ± 1.02
0.854GlyTrp: 0.854 ± 0.624
2.988GlyTyr: 2.988 ± 0.631
0.0GlyXaa: 0.0 ± 0.0
His
1.707HisAla: 1.707 ± 0.811
0.427HisCys: 0.427 ± 0.446
0.427HisAsp: 0.427 ± 0.364
1.28HisGlu: 1.28 ± 0.639
1.707HisPhe: 1.707 ± 0.546
0.427HisGly: 0.427 ± 0.446
0.0HisHis: 0.0 ± 0.0
0.427HisIle: 0.427 ± 0.342
2.561HisLys: 2.561 ± 1.74
2.134HisLeu: 2.134 ± 1.405
0.427HisMet: 0.427 ± 0.474
1.707HisAsn: 1.707 ± 0.823
2.134HisPro: 2.134 ± 1.045
0.854HisGln: 0.854 ± 0.686
2.988HisArg: 2.988 ± 0.933
2.561HisSer: 2.561 ± 0.756
1.707HisThr: 1.707 ± 0.635
0.427HisVal: 0.427 ± 0.364
1.707HisTrp: 1.707 ± 1.023
1.707HisTyr: 1.707 ± 0.953
0.0HisXaa: 0.0 ± 0.0
Ile
0.427IleAla: 0.427 ± 0.549
3.414IleCys: 3.414 ± 1.318
2.561IleAsp: 2.561 ± 1.161
2.561IleGlu: 2.561 ± 0.47
1.707IlePhe: 1.707 ± 0.805
2.561IleGly: 2.561 ± 1.311
1.707IleHis: 1.707 ± 0.58
0.854IleIle: 0.854 ± 0.728
1.28IleLys: 1.28 ± 0.571
1.707IleLeu: 1.707 ± 0.563
0.854IleMet: 0.854 ± 0.538
1.28IleAsn: 1.28 ± 0.423
2.134IlePro: 2.134 ± 0.515
2.988IleGln: 2.988 ± 0.664
1.707IleArg: 1.707 ± 0.811
2.988IleSer: 2.988 ± 1.004
3.841IleThr: 3.841 ± 1.554
3.841IleVal: 3.841 ± 1.167
0.0IleTrp: 0.0 ± 0.0
2.561IleTyr: 2.561 ± 1.194
0.0IleXaa: 0.0 ± 0.0
Lys
4.695LysAla: 4.695 ± 1.955
2.134LysCys: 2.134 ± 0.988
2.561LysAsp: 2.561 ± 1.115
1.28LysGlu: 1.28 ± 1.102
2.134LysPhe: 2.134 ± 0.989
3.841LysGly: 3.841 ± 2.262
0.854LysHis: 0.854 ± 0.684
0.854LysIle: 0.854 ± 0.386
2.561LysLys: 2.561 ± 0.941
3.414LysLeu: 3.414 ± 1.162
0.427LysMet: 0.427 ± 0.342
0.854LysAsn: 0.854 ± 0.613
1.28LysPro: 1.28 ± 0.857
2.134LysGln: 2.134 ± 0.869
4.268LysArg: 4.268 ± 1.315
2.988LysSer: 2.988 ± 1.921
0.854LysThr: 0.854 ± 0.624
5.548LysVal: 5.548 ± 0.484
0.854LysTrp: 0.854 ± 0.523
2.988LysTyr: 2.988 ± 1.114
0.0LysXaa: 0.0 ± 0.0
Leu
5.548LeuAla: 5.548 ± 2.077
0.854LeuCys: 0.854 ± 0.613
6.829LeuAsp: 6.829 ± 1.186
3.414LeuGlu: 3.414 ± 1.238
4.695LeuPhe: 4.695 ± 1.052
3.414LeuGly: 3.414 ± 0.944
3.414LeuHis: 3.414 ± 1.009
2.134LeuIle: 2.134 ± 0.726
5.548LeuLys: 5.548 ± 1.093
8.109LeuLeu: 8.109 ± 1.93
1.707LeuMet: 1.707 ± 0.974
2.561LeuAsn: 2.561 ± 1.138
2.988LeuPro: 2.988 ± 1.64
5.548LeuGln: 5.548 ± 3.181
3.841LeuArg: 3.841 ± 1.03
4.268LeuSer: 4.268 ± 1.151
4.695LeuThr: 4.695 ± 1.151
5.122LeuVal: 5.122 ± 1.869
1.28LeuTrp: 1.28 ± 0.961
4.268LeuTyr: 4.268 ± 0.504
0.0LeuXaa: 0.0 ± 0.0
Met
2.561MetAla: 2.561 ± 0.937
0.854MetCys: 0.854 ± 0.45
0.0MetAsp: 0.0 ± 0.0
0.854MetGlu: 0.854 ± 0.947
0.854MetPhe: 0.854 ± 0.754
2.134MetGly: 2.134 ± 0.647
0.854MetHis: 0.854 ± 0.571
0.427MetIle: 0.427 ± 0.342
0.0MetLys: 0.0 ± 0.0
1.707MetLeu: 1.707 ± 0.927
0.0MetMet: 0.0 ± 0.0
0.854MetAsn: 0.854 ± 0.651
0.0MetPro: 0.0 ± 0.0
0.427MetGln: 0.427 ± 0.342
0.427MetArg: 0.427 ± 0.474
1.28MetSer: 1.28 ± 0.423
0.427MetThr: 0.427 ± 0.342
2.561MetVal: 2.561 ± 0.927
0.427MetTrp: 0.427 ± 0.474
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.134AsnAla: 2.134 ± 1.24
0.854AsnCys: 0.854 ± 0.45
0.854AsnAsp: 0.854 ± 0.386
2.134AsnGlu: 2.134 ± 0.825
1.28AsnPhe: 1.28 ± 0.624
1.28AsnGly: 1.28 ± 0.42
0.427AsnHis: 0.427 ± 0.474
1.28AsnIle: 1.28 ± 0.855
2.561AsnLys: 2.561 ± 1.646
2.134AsnLeu: 2.134 ± 0.673
0.427AsnMet: 0.427 ± 0.377
0.854AsnAsn: 0.854 ± 0.386
3.414AsnPro: 3.414 ± 1.116
0.854AsnGln: 0.854 ± 0.42
1.28AsnArg: 1.28 ± 0.823
1.707AsnSer: 1.707 ± 0.927
2.561AsnThr: 2.561 ± 1.667
1.707AsnVal: 1.707 ± 0.738
0.854AsnTrp: 0.854 ± 0.632
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.122ProAla: 5.122 ± 2.745
2.561ProCys: 2.561 ± 1.703
4.268ProAsp: 4.268 ± 1.996
2.988ProGlu: 2.988 ± 0.538
1.28ProPhe: 1.28 ± 0.89
3.841ProGly: 3.841 ± 0.51
1.28ProHis: 1.28 ± 0.69
2.134ProIle: 2.134 ± 0.964
2.988ProLys: 2.988 ± 0.49
7.682ProLeu: 7.682 ± 1.938
0.854ProMet: 0.854 ± 0.6
1.28ProAsn: 1.28 ± 0.42
9.39ProPro: 9.39 ± 3.959
0.854ProGln: 0.854 ± 0.523
3.414ProArg: 3.414 ± 2.222
5.122ProSer: 5.122 ± 2.723
6.829ProThr: 6.829 ± 1.688
4.268ProVal: 4.268 ± 1.529
0.427ProTrp: 0.427 ± 0.474
2.134ProTyr: 2.134 ± 1.192
0.0ProXaa: 0.0 ± 0.0
Gln
5.122GlnAla: 5.122 ± 1.388
1.28GlnCys: 1.28 ± 0.789
2.134GlnAsp: 2.134 ± 0.783
4.695GlnGlu: 4.695 ± 1.729
2.561GlnPhe: 2.561 ± 0.725
3.414GlnGly: 3.414 ± 1.35
1.707GlnHis: 1.707 ± 0.591
1.28GlnIle: 1.28 ± 0.423
1.707GlnLys: 1.707 ± 1.004
3.414GlnLeu: 3.414 ± 1.729
1.707GlnMet: 1.707 ± 0.886
0.427GlnAsn: 0.427 ± 0.342
2.988GlnPro: 2.988 ± 0.747
2.561GlnGln: 2.561 ± 0.895
2.561GlnArg: 2.561 ± 1.413
1.707GlnSer: 1.707 ± 0.909
3.841GlnThr: 3.841 ± 2.059
2.988GlnVal: 2.988 ± 1.4
2.134GlnTrp: 2.134 ± 1.024
0.854GlnTyr: 0.854 ± 0.386
0.0GlnXaa: 0.0 ± 0.0
Arg
4.268ArgAla: 4.268 ± 0.743
2.134ArgCys: 2.134 ± 1.206
1.707ArgAsp: 1.707 ± 1.111
3.414ArgGlu: 3.414 ± 1.325
0.854ArgPhe: 0.854 ± 0.458
2.561ArgGly: 2.561 ± 1.035
2.134ArgHis: 2.134 ± 1.336
2.134ArgIle: 2.134 ± 1.069
4.268ArgLys: 4.268 ± 0.995
6.402ArgLeu: 6.402 ± 1.745
0.854ArgMet: 0.854 ± 0.556
1.28ArgAsn: 1.28 ± 0.643
4.695ArgPro: 4.695 ± 1.333
2.561ArgGln: 2.561 ± 0.61
5.548ArgArg: 5.548 ± 1.639
2.561ArgSer: 2.561 ± 0.722
3.414ArgThr: 3.414 ± 1.176
3.414ArgVal: 3.414 ± 1.48
0.427ArgTrp: 0.427 ± 0.549
2.134ArgTyr: 2.134 ± 0.653
0.0ArgXaa: 0.0 ± 0.0
Ser
2.561SerAla: 2.561 ± 0.959
0.854SerCys: 0.854 ± 0.632
5.122SerAsp: 5.122 ± 1.686
3.841SerGlu: 3.841 ± 1.169
2.561SerPhe: 2.561 ± 1.025
5.975SerGly: 5.975 ± 2.472
0.854SerHis: 0.854 ± 0.42
4.695SerIle: 4.695 ± 1.983
1.28SerLys: 1.28 ± 0.619
5.975SerLeu: 5.975 ± 0.827
1.707SerMet: 1.707 ± 0.528
1.707SerAsn: 1.707 ± 0.927
4.268SerPro: 4.268 ± 0.743
0.854SerGln: 0.854 ± 0.386
4.268SerArg: 4.268 ± 1.328
9.816SerSer: 9.816 ± 2.052
8.963SerThr: 8.963 ± 3.376
5.122SerVal: 5.122 ± 1.454
0.854SerTrp: 0.854 ± 0.45
2.134SerTyr: 2.134 ± 0.924
0.0SerXaa: 0.0 ± 0.0
Thr
3.841ThrAla: 3.841 ± 1.123
4.268ThrCys: 4.268 ± 0.808
2.988ThrAsp: 2.988 ± 1.019
4.695ThrGlu: 4.695 ± 1.084
2.134ThrPhe: 2.134 ± 0.963
5.975ThrGly: 5.975 ± 1.348
0.854ThrHis: 0.854 ± 0.42
2.988ThrIle: 2.988 ± 1.403
2.134ThrLys: 2.134 ± 0.532
4.695ThrLeu: 4.695 ± 1.208
0.854ThrMet: 0.854 ± 0.684
2.134ThrAsn: 2.134 ± 1.07
6.402ThrPro: 6.402 ± 2.106
4.695ThrGln: 4.695 ± 1.796
2.988ThrArg: 2.988 ± 0.627
7.256ThrSer: 7.256 ± 2.187
9.39ThrThr: 9.39 ± 3.076
8.963ThrVal: 8.963 ± 3.081
0.427ThrTrp: 0.427 ± 0.474
2.134ThrTyr: 2.134 ± 0.706
0.0ThrXaa: 0.0 ± 0.0
Val
2.988ValAla: 2.988 ± 0.894
0.854ValCys: 0.854 ± 0.754
4.695ValAsp: 4.695 ± 0.55
4.695ValGlu: 4.695 ± 0.823
2.988ValPhe: 2.988 ± 0.939
3.841ValGly: 3.841 ± 1.142
2.134ValHis: 2.134 ± 1.093
3.841ValIle: 3.841 ± 0.81
1.707ValLys: 1.707 ± 0.789
2.988ValLeu: 2.988 ± 1.286
0.427ValMet: 0.427 ± 0.377
0.854ValAsn: 0.854 ± 0.45
8.536ValPro: 8.536 ± 2.408
5.122ValGln: 5.122 ± 0.585
3.841ValArg: 3.841 ± 1.341
7.256ValSer: 7.256 ± 2.048
6.402ValThr: 6.402 ± 2.587
4.695ValVal: 4.695 ± 1.398
0.854ValTrp: 0.854 ± 0.613
2.134ValTyr: 2.134 ± 1.254
0.0ValXaa: 0.0 ± 0.0
Trp
2.561TrpAla: 2.561 ± 0.484
0.0TrpCys: 0.0 ± 0.0
0.427TrpAsp: 0.427 ± 0.549
0.427TrpGlu: 0.427 ± 0.474
0.854TrpPhe: 0.854 ± 0.406
0.854TrpGly: 0.854 ± 0.45
0.854TrpHis: 0.854 ± 0.947
1.28TrpIle: 1.28 ± 0.643
1.28TrpLys: 1.28 ± 0.643
0.854TrpLeu: 0.854 ± 0.386
0.0TrpMet: 0.0 ± 0.349
0.854TrpAsn: 0.854 ± 0.556
0.427TrpPro: 0.427 ± 0.549
0.854TrpGln: 0.854 ± 0.632
0.854TrpArg: 0.854 ± 0.613
0.0TrpSer: 0.0 ± 0.0
2.134TrpThr: 2.134 ± 0.98
0.427TrpVal: 0.427 ± 0.342
0.0TrpTrp: 0.0 ± 0.0
1.28TrpTyr: 1.28 ± 0.858
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.134TyrAla: 2.134 ± 0.342
0.427TyrCys: 0.427 ± 0.377
1.28TyrAsp: 1.28 ± 0.708
2.134TyrGlu: 2.134 ± 1.355
0.0TyrPhe: 0.0 ± 0.0
3.414TyrGly: 3.414 ± 0.981
0.854TyrHis: 0.854 ± 0.42
3.414TyrIle: 3.414 ± 1.472
2.561TyrLys: 2.561 ± 0.841
4.268TyrLeu: 4.268 ± 1.625
0.427TyrMet: 0.427 ± 0.474
0.854TyrAsn: 0.854 ± 0.754
0.854TyrPro: 0.854 ± 0.651
1.707TyrGln: 1.707 ± 0.929
2.988TyrArg: 2.988 ± 0.437
1.707TyrSer: 1.707 ± 0.738
1.28TyrThr: 1.28 ± 0.674
4.268TyrVal: 4.268 ± 2.077
0.854TyrTrp: 0.854 ± 0.386
1.707TyrTyr: 1.707 ± 1.111
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2344 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski