Amino acid dipepetide frequency for Acetobacter orientalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.863AlaAla: 14.863 ± 0.166
1.45AlaCys: 1.45 ± 0.049
5.452AlaAsp: 5.452 ± 0.075
6.445AlaGlu: 6.445 ± 0.127
3.965AlaPhe: 3.965 ± 0.084
9.683AlaGly: 9.683 ± 0.12
2.94AlaHis: 2.94 ± 0.065
5.352AlaIle: 5.352 ± 0.087
3.841AlaLys: 3.841 ± 0.073
13.606AlaLeu: 13.606 ± 0.162
2.961AlaMet: 2.961 ± 0.072
2.976AlaAsn: 2.976 ± 0.065
6.292AlaPro: 6.292 ± 0.116
6.25AlaGln: 6.25 ± 0.125
7.318AlaArg: 7.318 ± 0.119
6.033AlaSer: 6.033 ± 0.103
6.986AlaThr: 6.986 ± 0.095
7.767AlaVal: 7.767 ± 0.112
1.598AlaTrp: 1.598 ± 0.048
2.557AlaTyr: 2.557 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.317CysAla: 1.317 ± 0.039
0.154CysCys: 0.154 ± 0.012
0.486CysAsp: 0.486 ± 0.024
0.383CysGlu: 0.383 ± 0.023
0.371CysPhe: 0.371 ± 0.021
1.106CysGly: 1.106 ± 0.04
0.289CysHis: 0.289 ± 0.023
0.486CysIle: 0.486 ± 0.022
0.248CysLys: 0.248 ± 0.018
1.118CysLeu: 1.118 ± 0.038
0.211CysMet: 0.211 ± 0.016
0.26CysAsn: 0.26 ± 0.018
0.554CysPro: 0.554 ± 0.023
0.34CysGln: 0.34 ± 0.021
0.545CysArg: 0.545 ± 0.027
0.563CysSer: 0.563 ± 0.028
0.632CysThr: 0.632 ± 0.026
0.888CysVal: 0.888 ± 0.034
0.106CysTrp: 0.106 ± 0.012
0.226CysTyr: 0.226 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.48AspAla: 5.48 ± 0.094
0.436AspCys: 0.436 ± 0.025
2.294AspAsp: 2.294 ± 0.06
2.527AspGlu: 2.527 ± 0.063
1.854AspPhe: 1.854 ± 0.048
4.093AspGly: 4.093 ± 0.097
1.155AspHis: 1.155 ± 0.042
3.025AspIle: 3.025 ± 0.064
1.717AspLys: 1.717 ± 0.047
4.99AspLeu: 4.99 ± 0.093
1.389AspMet: 1.389 ± 0.045
1.394AspAsn: 1.394 ± 0.039
2.807AspPro: 2.807 ± 0.059
1.51AspGln: 1.51 ± 0.045
2.793AspArg: 2.793 ± 0.062
2.275AspSer: 2.275 ± 0.057
3.024AspThr: 3.024 ± 0.064
3.789AspVal: 3.789 ± 0.085
0.781AspTrp: 0.781 ± 0.031
1.385AspTyr: 1.385 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.372GluAla: 6.372 ± 0.125
0.43GluCys: 0.43 ± 0.021
2.35GluAsp: 2.35 ± 0.06
2.923GluGlu: 2.923 ± 0.069
1.395GluPhe: 1.395 ± 0.044
3.93GluGly: 3.93 ± 0.076
1.479GluHis: 1.479 ± 0.047
2.655GluIle: 2.655 ± 0.065
2.513GluLys: 2.513 ± 0.067
4.214GluLeu: 4.214 ± 0.076
1.168GluMet: 1.168 ± 0.039
1.89GluAsn: 1.89 ± 0.045
2.076GluPro: 2.076 ± 0.051
2.685GluGln: 2.685 ± 0.074
3.81GluArg: 3.81 ± 0.077
2.396GluSer: 2.396 ± 0.052
3.284GluThr: 3.284 ± 0.07
3.107GluVal: 3.107 ± 0.065
0.641GluTrp: 0.641 ± 0.029
0.978GluTyr: 0.978 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
4.045PheAla: 4.045 ± 0.076
0.5PheCys: 0.5 ± 0.027
2.039PheAsp: 2.039 ± 0.055
1.773PheGlu: 1.773 ± 0.044
1.417PhePhe: 1.417 ± 0.05
3.322PheGly: 3.322 ± 0.065
0.782PheHis: 0.782 ± 0.031
1.622PheIle: 1.622 ± 0.054
1.137PheLys: 1.137 ± 0.042
3.66PheLeu: 3.66 ± 0.081
0.964PheMet: 0.964 ± 0.033
1.196PheAsn: 1.196 ± 0.038
1.516PhePro: 1.516 ± 0.041
1.048PheGln: 1.048 ± 0.038
1.853PheArg: 1.853 ± 0.051
2.613PheSer: 2.613 ± 0.068
2.299PheThr: 2.299 ± 0.056
2.604PheVal: 2.604 ± 0.068
0.53PheTrp: 0.53 ± 0.03
1.016PheTyr: 1.016 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
8.457GlyAla: 8.457 ± 0.129
0.89GlyCys: 0.89 ± 0.037
3.214GlyAsp: 3.214 ± 0.078
3.483GlyGlu: 3.483 ± 0.077
3.344GlyPhe: 3.344 ± 0.065
7.362GlyGly: 7.362 ± 0.383
2.137GlyHis: 2.137 ± 0.06
4.161GlyIle: 4.161 ± 0.086
3.202GlyLys: 3.202 ± 0.078
8.913GlyLeu: 8.913 ± 0.111
2.249GlyMet: 2.249 ± 0.051
2.501GlyAsn: 2.501 ± 0.107
3.3GlyPro: 3.3 ± 0.064
3.652GlyGln: 3.652 ± 0.067
4.991GlyArg: 4.991 ± 0.09
4.653GlySer: 4.653 ± 0.113
5.182GlyThr: 5.182 ± 0.117
6.222GlyVal: 6.222 ± 0.089
1.394GlyTrp: 1.394 ± 0.045
2.332GlyTyr: 2.332 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.874HisAla: 2.874 ± 0.055
0.267HisCys: 0.267 ± 0.019
1.378HisAsp: 1.378 ± 0.044
1.104HisGlu: 1.104 ± 0.036
1.003HisPhe: 1.003 ± 0.033
2.045HisGly: 2.045 ± 0.051
0.761HisHis: 0.761 ± 0.036
1.344HisIle: 1.344 ± 0.042
0.899HisLys: 0.899 ± 0.035
2.246HisLeu: 2.246 ± 0.053
0.626HisMet: 0.626 ± 0.025
0.94HisAsn: 0.94 ± 0.033
1.47HisPro: 1.47 ± 0.045
0.767HisGln: 0.767 ± 0.029
1.276HisArg: 1.276 ± 0.038
1.302HisSer: 1.302 ± 0.039
1.693HisThr: 1.693 ± 0.051
1.757HisVal: 1.757 ± 0.043
0.383HisTrp: 0.383 ± 0.022
0.74HisTyr: 0.74 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.944IleAla: 5.944 ± 0.083
0.528IleCys: 0.528 ± 0.025
2.711IleAsp: 2.711 ± 0.064
2.827IleGlu: 2.827 ± 0.067
1.617IlePhe: 1.617 ± 0.056
4.304IleGly: 4.304 ± 0.1
0.844IleHis: 0.844 ± 0.028
2.337IleIle: 2.337 ± 0.06
1.599IleLys: 1.599 ± 0.05
4.601IleLeu: 4.601 ± 0.089
1.079IleMet: 1.079 ± 0.037
1.559IleAsn: 1.559 ± 0.05
2.404IlePro: 2.404 ± 0.058
1.489IleGln: 1.489 ± 0.044
2.759IleArg: 2.759 ± 0.06
3.069IleSer: 3.069 ± 0.065
3.271IleThr: 3.271 ± 0.072
3.516IleVal: 3.516 ± 0.071
0.535IleTrp: 0.535 ± 0.028
1.074IleTyr: 1.074 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.619LysAla: 4.619 ± 0.083
0.194LysCys: 0.194 ± 0.015
1.772LysAsp: 1.772 ± 0.05
1.795LysGlu: 1.795 ± 0.055
0.891LysPhe: 0.891 ± 0.036
2.757LysGly: 2.757 ± 0.058
0.798LysHis: 0.798 ± 0.034
1.855LysIle: 1.855 ± 0.053
1.656LysLys: 1.656 ± 0.057
3.522LysLeu: 3.522 ± 0.074
0.771LysMet: 0.771 ± 0.03
1.443LysAsn: 1.443 ± 0.055
2.168LysPro: 2.168 ± 0.049
1.579LysGln: 1.579 ± 0.049
2.23LysArg: 2.23 ± 0.047
1.731LysSer: 1.731 ± 0.05
2.5LysThr: 2.5 ± 0.06
2.195LysVal: 2.195 ± 0.065
0.437LysTrp: 0.437 ± 0.027
0.665LysTyr: 0.665 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
13.128LeuAla: 13.128 ± 0.154
1.254LeuCys: 1.254 ± 0.037
5.357LeuAsp: 5.357 ± 0.094
5.281LeuGlu: 5.281 ± 0.093
3.764LeuPhe: 3.764 ± 0.091
7.715LeuGly: 7.715 ± 0.125
2.672LeuHis: 2.672 ± 0.06
4.405LeuIle: 4.405 ± 0.08
3.766LeuLys: 3.766 ± 0.081
10.319LeuLeu: 10.319 ± 0.183
2.402LeuMet: 2.402 ± 0.06
3.12LeuAsn: 3.12 ± 0.061
6.8LeuPro: 6.8 ± 0.115
3.694LeuGln: 3.694 ± 0.071
6.582LeuArg: 6.582 ± 0.093
7.286LeuSer: 7.286 ± 0.098
6.423LeuThr: 6.423 ± 0.1
7.246LeuVal: 7.246 ± 0.105
1.295LeuTrp: 1.295 ± 0.04
2.277LeuTyr: 2.277 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
3.057MetAla: 3.057 ± 0.059
0.17MetCys: 0.17 ± 0.014
1.035MetAsp: 1.035 ± 0.037
0.944MetGlu: 0.944 ± 0.03
0.643MetPhe: 0.643 ± 0.028
1.903MetGly: 1.903 ± 0.05
0.53MetHis: 0.53 ± 0.023
0.99MetIle: 0.99 ± 0.035
0.805MetLys: 0.805 ± 0.031
2.645MetLeu: 2.645 ± 0.069
0.59MetMet: 0.59 ± 0.031
0.724MetAsn: 0.724 ± 0.031
1.721MetPro: 1.721 ± 0.05
1.162MetGln: 1.162 ± 0.042
1.635MetArg: 1.635 ± 0.054
1.574MetSer: 1.574 ± 0.044
1.718MetThr: 1.718 ± 0.048
1.851MetVal: 1.851 ± 0.048
0.211MetTrp: 0.211 ± 0.015
0.306MetTyr: 0.306 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.772AsnAla: 3.772 ± 0.072
0.274AsnCys: 0.274 ± 0.018
1.367AsnAsp: 1.367 ± 0.041
1.225AsnGlu: 1.225 ± 0.045
1.114AsnPhe: 1.114 ± 0.035
2.977AsnGly: 2.977 ± 0.087
0.661AsnHis: 0.661 ± 0.028
1.719AsnIle: 1.719 ± 0.049
1.087AsnLys: 1.087 ± 0.039
2.929AsnLeu: 2.929 ± 0.056
0.752AsnMet: 0.752 ± 0.032
1.041AsnAsn: 1.041 ± 0.048
2.025AsnPro: 2.025 ± 0.048
1.08AsnGln: 1.08 ± 0.037
1.775AsnArg: 1.775 ± 0.044
1.67AsnSer: 1.67 ± 0.061
2.213AsnThr: 2.213 ± 0.069
2.045AsnVal: 2.045 ± 0.048
0.453AsnTrp: 0.453 ± 0.022
0.818AsnTyr: 0.818 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
6.484ProAla: 6.484 ± 0.106
0.43ProCys: 0.43 ± 0.024
3.523ProAsp: 3.523 ± 0.068
3.847ProGlu: 3.847 ± 0.061
2.067ProPhe: 2.067 ± 0.045
3.959ProGly: 3.959 ± 0.079
1.522ProHis: 1.522 ± 0.049
2.072ProIle: 2.072 ± 0.054
1.664ProLys: 1.664 ± 0.051
5.529ProLeu: 5.529 ± 0.109
1.19ProMet: 1.19 ± 0.035
1.675ProAsn: 1.675 ± 0.051
3.042ProPro: 3.042 ± 0.1
2.494ProGln: 2.494 ± 0.064
2.582ProArg: 2.582 ± 0.059
3.099ProSer: 3.099 ± 0.067
3.554ProThr: 3.554 ± 0.07
4.413ProVal: 4.413 ± 0.081
0.718ProTrp: 0.718 ± 0.031
1.33ProTyr: 1.33 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.879GlnAla: 5.879 ± 0.121
0.299GlnCys: 0.299 ± 0.019
2.22GlnAsp: 2.22 ± 0.053
2.123GlnGlu: 2.123 ± 0.056
1.3GlnPhe: 1.3 ± 0.042
3.088GlnGly: 3.088 ± 0.07
1.095GlnHis: 1.095 ± 0.039
2.111GlnIle: 2.111 ± 0.051
1.878GlnLys: 1.878 ± 0.049
3.163GlnLeu: 3.163 ± 0.057
0.95GlnMet: 0.95 ± 0.032
1.658GlnAsn: 1.658 ± 0.05
2.495GlnPro: 2.495 ± 0.06
2.129GlnGln: 2.129 ± 0.06
2.306GlnArg: 2.306 ± 0.048
2.31GlnSer: 2.31 ± 0.068
2.834GlnThr: 2.834 ± 0.064
2.571GlnVal: 2.571 ± 0.051
0.487GlnTrp: 0.487 ± 0.024
0.874GlnTyr: 0.874 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.288ArgAla: 6.288 ± 0.087
0.505ArgCys: 0.505 ± 0.025
2.869ArgAsp: 2.869 ± 0.07
2.993ArgGlu: 2.993 ± 0.07
2.472ArgPhe: 2.472 ± 0.051
3.894ArgGly: 3.894 ± 0.073
1.685ArgHis: 1.685 ± 0.038
3.368ArgIle: 3.368 ± 0.079
2.479ArgLys: 2.479 ± 0.064
6.924ArgLeu: 6.924 ± 0.126
1.548ArgMet: 1.548 ± 0.04
1.907ArgAsn: 1.907 ± 0.056
2.985ArgPro: 2.985 ± 0.063
2.571ArgGln: 2.571 ± 0.052
4.054ArgArg: 4.054 ± 0.09
3.149ArgSer: 3.149 ± 0.061
3.382ArgThr: 3.382 ± 0.066
4.167ArgVal: 4.167 ± 0.075
0.798ArgTrp: 0.798 ± 0.03
1.763ArgTyr: 1.763 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.494SerAla: 6.494 ± 0.107
0.569SerCys: 0.569 ± 0.026
2.603SerAsp: 2.603 ± 0.066
2.402SerGlu: 2.402 ± 0.061
2.494SerPhe: 2.494 ± 0.063
5.474SerGly: 5.474 ± 0.12
1.267SerHis: 1.267 ± 0.04
2.881SerIle: 2.881 ± 0.082
1.653SerLys: 1.653 ± 0.041
6.463SerLeu: 6.463 ± 0.09
1.392SerMet: 1.392 ± 0.04
1.682SerAsn: 1.682 ± 0.054
2.845SerPro: 2.845 ± 0.06
1.82SerGln: 1.82 ± 0.052
3.156SerArg: 3.156 ± 0.063
3.609SerSer: 3.609 ± 0.087
3.444SerThr: 3.444 ± 0.072
4.589SerVal: 4.589 ± 0.086
0.861SerTrp: 0.861 ± 0.032
1.617SerTyr: 1.617 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
7.074ThrAla: 7.074 ± 0.1
0.575ThrCys: 0.575 ± 0.027
2.941ThrAsp: 2.941 ± 0.069
2.906ThrGlu: 2.906 ± 0.063
2.096ThrPhe: 2.096 ± 0.055
5.268ThrGly: 5.268 ± 0.097
1.674ThrHis: 1.674 ± 0.049
2.767ThrIle: 2.767 ± 0.061
1.679ThrLys: 1.679 ± 0.045
7.945ThrLeu: 7.945 ± 0.112
1.182ThrMet: 1.182 ± 0.04
1.779ThrAsn: 1.779 ± 0.066
4.897ThrPro: 4.897 ± 0.106
2.852ThrGln: 2.852 ± 0.062
3.424ThrArg: 3.424 ± 0.065
3.159ThrSer: 3.159 ± 0.069
3.888ThrThr: 3.888 ± 0.1
4.6ThrVal: 4.6 ± 0.079
0.81ThrTrp: 0.81 ± 0.033
1.468ThrTyr: 1.468 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
8.317ValAla: 8.317 ± 0.101
0.902ValCys: 0.902 ± 0.035
3.151ValAsp: 3.151 ± 0.063
3.719ValGlu: 3.719 ± 0.084
2.715ValPhe: 2.715 ± 0.062
5.431ValGly: 5.431 ± 0.095
1.484ValHis: 1.484 ± 0.041
3.384ValIle: 3.384 ± 0.063
2.388ValLys: 2.388 ± 0.056
7.979ValLeu: 7.979 ± 0.117
1.979ValMet: 1.979 ± 0.047
1.939ValAsn: 1.939 ± 0.049
3.957ValPro: 3.957 ± 0.081
2.734ValGln: 2.734 ± 0.064
4.167ValArg: 4.167 ± 0.07
4.671ValSer: 4.671 ± 0.082
4.5ValThr: 4.5 ± 0.092
5.7ValVal: 5.7 ± 0.086
0.977ValTrp: 0.977 ± 0.035
1.494ValTyr: 1.494 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.207TrpAla: 1.207 ± 0.042
0.187TrpCys: 0.187 ± 0.016
0.584TrpAsp: 0.584 ± 0.028
0.499TrpGlu: 0.499 ± 0.025
0.513TrpPhe: 0.513 ± 0.025
1.034TrpGly: 1.034 ± 0.043
0.51TrpHis: 0.51 ± 0.027
0.511TrpIle: 0.511 ± 0.025
0.518TrpLys: 0.518 ± 0.023
1.762TrpLeu: 1.762 ± 0.052
0.293TrpMet: 0.293 ± 0.017
0.443TrpAsn: 0.443 ± 0.023
0.691TrpPro: 0.691 ± 0.03
0.844TrpGln: 0.844 ± 0.037
1.052TrpArg: 1.052 ± 0.037
0.797TrpSer: 0.797 ± 0.032
0.606TrpThr: 0.606 ± 0.027
0.961TrpVal: 0.961 ± 0.043
0.218TrpTrp: 0.218 ± 0.015
0.338TrpTyr: 0.338 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.666TyrAla: 2.666 ± 0.053
0.268TyrCys: 0.268 ± 0.016
1.373TyrAsp: 1.373 ± 0.043
1.098TyrGlu: 1.098 ± 0.041
0.899TyrPhe: 0.899 ± 0.038
2.295TyrGly: 2.295 ± 0.055
0.586TyrHis: 0.586 ± 0.023
1.019TyrIle: 1.019 ± 0.037
0.852TyrLys: 0.852 ± 0.036
2.257TyrLeu: 2.257 ± 0.055
0.517TyrMet: 0.517 ± 0.024
0.868TyrAsn: 0.868 ± 0.034
1.151TyrPro: 1.151 ± 0.039
1.072TyrGln: 1.072 ± 0.042
1.496TyrArg: 1.496 ± 0.049
1.356TyrSer: 1.356 ± 0.044
1.551TyrThr: 1.551 ± 0.04
1.598TyrVal: 1.598 ± 0.043
0.335TyrTrp: 0.335 ± 0.021
0.804TyrTyr: 0.804 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2561 proteins (843554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski