Amino acid dipepetide frequency for Polaribacter sp. ZY113

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.777AlaAla: 3.777 ± 0.092	0.469AlaCys: 0.469 ± 0.021	3.165AlaAsp: 3.165 ± 0.066	3.295AlaGlu: 3.295 ± 0.067	3.113AlaPhe: 3.113 ± 0.06	3.638AlaGly: 3.638 ± 0.073	0.951AlaHis: 0.951 ± 0.032	5.348AlaIle: 5.348 ± 0.075	4.961AlaLys: 4.961 ± 0.084	5.137AlaLeu: 5.137 ± 0.082	1.26AlaMet: 1.26 ± 0.043	3.521AlaAsn: 3.521 ± 0.057	1.67AlaPro: 1.67 ± 0.052	2.019AlaGln: 2.019 ± 0.047	1.75AlaArg: 1.75 ± 0.045	3.932AlaSer: 3.932 ± 0.068	3.534AlaThr: 3.534 ± 0.072	3.579AlaVal: 3.579 ± 0.062	0.544AlaTrp: 0.544 ± 0.023	2.13AlaTyr: 2.13 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.404CysAla: 0.404 ± 0.02	0.087CysCys: 0.087 ± 0.01	0.414CysAsp: 0.414 ± 0.024	0.419CysGlu: 0.419 ± 0.022	0.412CysPhe: 0.412 ± 0.02	0.554CysGly: 0.554 ± 0.027	0.194CysHis: 0.194 ± 0.018	0.551CysIle: 0.551 ± 0.022	0.567CysLys: 0.567 ± 0.025	0.573CysLeu: 0.573 ± 0.022	0.125CysMet: 0.125 ± 0.01	0.415CysAsn: 0.415 ± 0.022	0.277CysPro: 0.277 ± 0.021	0.2CysGln: 0.2 ± 0.013	0.17CysArg: 0.17 ± 0.013	0.494CysSer: 0.494 ± 0.025	0.385CysThr: 0.385 ± 0.018	0.415CysVal: 0.415 ± 0.021	0.059CysTrp: 0.059 ± 0.008	0.262CysTyr: 0.262 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.511AspAla: 3.511 ± 0.059	0.368AspCys: 0.368 ± 0.019	2.924AspAsp: 2.924 ± 0.064	3.677AspGlu: 3.677 ± 0.065	3.864AspPhe: 3.864 ± 0.069	3.72AspGly: 3.72 ± 0.128	0.695AspHis: 0.695 ± 0.027	4.542AspIle: 4.542 ± 0.077	4.754AspLys: 4.754 ± 0.08	5.037AspLeu: 5.037 ± 0.074	0.927AspMet: 0.927 ± 0.031	3.573AspAsn: 3.573 ± 0.101	1.316AspPro: 1.316 ± 0.038	1.077AspGln: 1.077 ± 0.033	1.673AspArg: 1.673 ± 0.042	3.036AspSer: 3.036 ± 0.065	2.576AspThr: 2.576 ± 0.065	3.729AspVal: 3.729 ± 0.071	0.734AspTrp: 0.734 ± 0.029	2.585AspTyr: 2.585 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	3.628GluAla: 3.628 ± 0.075	0.316GluCys: 0.316 ± 0.017	3.24GluAsp: 3.24 ± 0.052	4.426GluGlu: 4.426 ± 0.09	3.06GluPhe: 3.06 ± 0.053	3.236GluGly: 3.236 ± 0.067	0.985GluHis: 0.985 ± 0.03	5.959GluIle: 5.959 ± 0.083	6.444GluLys: 6.444 ± 0.096	5.696GluLeu: 5.696 ± 0.081	1.447GluMet: 1.447 ± 0.039	5.13GluAsn: 5.13 ± 0.079	1.324GluPro: 1.324 ± 0.033	1.828GluGln: 1.828 ± 0.039	2.227GluArg: 2.227 ± 0.058	3.216GluSer: 3.216 ± 0.057	3.514GluThr: 3.514 ± 0.065	4.138GluVal: 4.138 ± 0.074	0.578GluTrp: 0.578 ± 0.021	2.369GluTyr: 2.369 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.837PheAla: 2.837 ± 0.055	0.456PheCys: 0.456 ± 0.021	3.372PheAsp: 3.372 ± 0.056	3.265PheGlu: 3.265 ± 0.062	3.187PhePhe: 3.187 ± 0.077	3.771PheGly: 3.771 ± 0.084	0.843PheHis: 0.843 ± 0.032	4.466PheIle: 4.466 ± 0.076	4.563PheLys: 4.563 ± 0.082	5.207PheLeu: 5.207 ± 0.097	1.065PheMet: 1.065 ± 0.037	3.717PheAsn: 3.717 ± 0.074	1.689PhePro: 1.689 ± 0.046	1.538PheGln: 1.538 ± 0.041	1.694PheArg: 1.694 ± 0.037	4.551PheSer: 4.551 ± 0.084	3.205PheThr: 3.205 ± 0.067	3.189PheVal: 3.189 ± 0.064	0.66PheTrp: 0.66 ± 0.029	2.436PheTyr: 2.436 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.884GlyAla: 3.884 ± 0.077	0.498GlyCys: 0.498 ± 0.025	3.363GlyAsp: 3.363 ± 0.073	3.359GlyGlu: 3.359 ± 0.069	3.895GlyPhe: 3.895 ± 0.061	4.515GlyGly: 4.515 ± 0.1	0.961GlyHis: 0.961 ± 0.03	5.477GlyIle: 5.477 ± 0.085	5.508GlyLys: 5.508 ± 0.084	5.36GlyLeu: 5.36 ± 0.081	1.45GlyMet: 1.45 ± 0.042	3.926GlyAsn: 3.926 ± 0.083	1.178GlyPro: 1.178 ± 0.034	1.606GlyGln: 1.606 ± 0.044	2.02GlyArg: 2.02 ± 0.041	3.725GlySer: 3.725 ± 0.069	3.928GlyThr: 3.928 ± 0.099	4.382GlyVal: 4.382 ± 0.079	0.752GlyTrp: 0.752 ± 0.03	2.621GlyTyr: 2.621 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.859HisAla: 0.859 ± 0.032	0.149HisCys: 0.149 ± 0.011	0.655HisAsp: 0.655 ± 0.024	0.73HisGlu: 0.73 ± 0.029	1.141HisPhe: 1.141 ± 0.036	0.926HisGly: 0.926 ± 0.032	0.499HisHis: 0.499 ± 0.024	1.425HisIle: 1.425 ± 0.036	1.437HisLys: 1.437 ± 0.035	1.699HisLeu: 1.699 ± 0.043	0.277HisMet: 0.277 ± 0.017	1.033HisAsn: 1.033 ± 0.034	0.869HisPro: 0.869 ± 0.03	0.84HisGln: 0.84 ± 0.029	0.633HisArg: 0.633 ± 0.022	1.028HisSer: 1.028 ± 0.034	0.876HisThr: 0.876 ± 0.03	0.77HisVal: 0.77 ± 0.03	0.209HisTrp: 0.209 ± 0.015	0.776HisTyr: 0.776 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.439IleAla: 5.439 ± 0.076	0.653IleCys: 0.653 ± 0.027	5.213IleAsp: 5.213 ± 0.078	5.477IleGlu: 5.477 ± 0.079	4.092IlePhe: 4.092 ± 0.085	5.173IleGly: 5.173 ± 0.086	1.485IleHis: 1.485 ± 0.041	6.938IleIle: 6.938 ± 0.1	7.159IleLys: 7.159 ± 0.096	7.462IleLeu: 7.462 ± 0.094	1.266IleMet: 1.266 ± 0.038	5.444IleAsn: 5.444 ± 0.071	3.249IlePro: 3.249 ± 0.057	2.733IleGln: 2.733 ± 0.05	2.546IleArg: 2.546 ± 0.054	6.297IleSer: 6.297 ± 0.094	5.102IleThr: 5.102 ± 0.087	4.879IleVal: 4.879 ± 0.07	0.739IleTrp: 0.739 ± 0.028	3.067IleTyr: 3.067 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	4.811LysAla: 4.811 ± 0.086	0.354LysCys: 0.354 ± 0.017	4.902LysAsp: 4.902 ± 0.066	7.396LysGlu: 7.396 ± 0.098	3.518LysPhe: 3.518 ± 0.064	5.205LysGly: 5.205 ± 0.081	1.493LysHis: 1.493 ± 0.042	7.749LysIle: 7.749 ± 0.111	9.453LysLys: 9.453 ± 0.133	7.244LysLeu: 7.244 ± 0.092	2.187LysMet: 2.187 ± 0.051	6.874LysAsn: 6.874 ± 0.104	2.647LysPro: 2.647 ± 0.061	2.863LysGln: 2.863 ± 0.058	3.236LysArg: 3.236 ± 0.066	5.539LysSer: 5.539 ± 0.085	5.431LysThr: 5.431 ± 0.088	5.375LysVal: 5.375 ± 0.082	0.954LysTrp: 0.954 ± 0.032	3.594LysTyr: 3.594 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.088LeuAla: 5.088 ± 0.081	0.603LeuCys: 0.603 ± 0.026	4.826LeuAsp: 4.826 ± 0.077	6.061LeuGlu: 6.061 ± 0.091	5.189LeuPhe: 5.189 ± 0.09	5.65LeuGly: 5.65 ± 0.092	1.469LeuHis: 1.469 ± 0.039	7.029LeuIle: 7.029 ± 0.1	8.6LeuLys: 8.6 ± 0.121	8.096LeuLeu: 8.096 ± 0.114	1.837LeuMet: 1.837 ± 0.052	5.726LeuAsn: 5.726 ± 0.078	3.217LeuPro: 3.217 ± 0.054	3.076LeuGln: 3.076 ± 0.065	2.827LeuArg: 2.827 ± 0.055	6.438LeuSer: 6.438 ± 0.081	4.763LeuThr: 4.763 ± 0.065	5.099LeuVal: 5.099 ± 0.076	0.786LeuTrp: 0.786 ± 0.034	3.051LeuTyr: 3.051 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.307MetAla: 1.307 ± 0.047	0.137MetCys: 0.137 ± 0.013	1.009MetAsp: 1.009 ± 0.034	1.088MetGlu: 1.088 ± 0.034	0.868MetPhe: 0.868 ± 0.034	1.195MetGly: 1.195 ± 0.035	0.364MetHis: 0.364 ± 0.019	1.603MetIle: 1.603 ± 0.042	2.251MetLys: 2.251 ± 0.045	1.748MetLeu: 1.748 ± 0.051	0.563MetMet: 0.563 ± 0.023	1.367MetAsn: 1.367 ± 0.035	0.715MetPro: 0.715 ± 0.03	0.732MetGln: 0.732 ± 0.029	0.758MetArg: 0.758 ± 0.028	1.363MetSer: 1.363 ± 0.041	0.946MetThr: 0.946 ± 0.034	1.155MetVal: 1.155 ± 0.035	0.136MetTrp: 0.136 ± 0.011	0.687MetTyr: 0.687 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.841AsnAla: 3.841 ± 0.064	0.494AsnCys: 0.494 ± 0.026	3.456AsnAsp: 3.456 ± 0.077	3.527AsnGlu: 3.527 ± 0.064	3.653AsnPhe: 3.653 ± 0.069	4.301AsnGly: 4.301 ± 0.092	1.253AsnHis: 1.253 ± 0.033	5.605AsnIle: 5.605 ± 0.093	5.641AsnLys: 5.641 ± 0.081	6.071AsnLeu: 6.071 ± 0.104	1.172AsnMet: 1.172 ± 0.032	4.922AsnAsn: 4.922 ± 0.11	2.852AsnPro: 2.852 ± 0.056	2.576AsnGln: 2.576 ± 0.052	2.239AsnArg: 2.239 ± 0.047	4.689AsnSer: 4.689 ± 0.096	3.979AsnThr: 3.979 ± 0.082	3.835AsnVal: 3.835 ± 0.076	0.915AsnTrp: 0.915 ± 0.034	3.177AsnTyr: 3.177 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.605ProAla: 1.605 ± 0.044	0.187ProCys: 0.187 ± 0.015	1.756ProAsp: 1.756 ± 0.05	2.374ProGlu: 2.374 ± 0.049	1.914ProPhe: 1.914 ± 0.047	1.653ProGly: 1.653 ± 0.042	0.614ProHis: 0.614 ± 0.027	2.729ProIle: 2.729 ± 0.055	2.984ProLys: 2.984 ± 0.057	2.635ProLeu: 2.635 ± 0.057	0.58ProMet: 0.58 ± 0.023	2.459ProAsn: 2.459 ± 0.051	0.797ProPro: 0.797 ± 0.041	0.934ProGln: 0.934 ± 0.033	0.909ProArg: 0.909 ± 0.029	2.047ProSer: 2.047 ± 0.048	1.932ProThr: 1.932 ± 0.048	1.879ProVal: 1.879 ± 0.043	0.34ProTrp: 0.34 ± 0.02	1.203ProTyr: 1.203 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.517GlnAla: 1.517 ± 0.04	0.182GlnCys: 0.182 ± 0.014	1.469GlnAsp: 1.469 ± 0.039	2.217GlnGlu: 2.217 ± 0.05	1.743GlnPhe: 1.743 ± 0.04	1.604GlnGly: 1.604 ± 0.04	0.52GlnHis: 0.52 ± 0.023	2.712GlnIle: 2.712 ± 0.055	3.28GlnLys: 3.28 ± 0.059	3.065GlnLeu: 3.065 ± 0.061	0.724GlnMet: 0.724 ± 0.028	2.284GlnAsn: 2.284 ± 0.051	0.99GlnPro: 0.99 ± 0.033	1.375GlnGln: 1.375 ± 0.041	1.111GlnArg: 1.111 ± 0.031	1.796GlnSer: 1.796 ± 0.045	1.794GlnThr: 1.794 ± 0.042	1.816GlnVal: 1.816 ± 0.047	0.289GlnTrp: 0.289 ± 0.016	1.207GlnTyr: 1.207 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.884ArgAla: 1.884 ± 0.044	0.184ArgCys: 0.184 ± 0.014	1.568ArgAsp: 1.568 ± 0.044	2.007ArgGlu: 2.007 ± 0.048	1.933ArgPhe: 1.933 ± 0.046	1.923ArgGly: 1.923 ± 0.051	0.562ArgHis: 0.562 ± 0.026	2.901ArgIle: 2.901 ± 0.047	3.126ArgLys: 3.126 ± 0.062	2.891ArgLeu: 2.891 ± 0.055	0.813ArgMet: 0.813 ± 0.03	2.178ArgAsn: 2.178 ± 0.05	0.952ArgPro: 0.952 ± 0.031	0.942ArgGln: 0.942 ± 0.032	1.275ArgArg: 1.275 ± 0.046	1.719ArgSer: 1.719 ± 0.045	1.85ArgThr: 1.85 ± 0.04	1.965ArgVal: 1.965 ± 0.05	0.376ArgTrp: 0.376 ± 0.02	1.363ArgTyr: 1.363 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.433SerAla: 3.433 ± 0.06	0.613SerCys: 0.613 ± 0.025	3.603SerAsp: 3.603 ± 0.063	4.024SerGlu: 4.024 ± 0.064	4.196SerPhe: 4.196 ± 0.065	4.624SerGly: 4.624 ± 0.094	0.975SerHis: 0.975 ± 0.032	5.694SerIle: 5.694 ± 0.081	5.926SerLys: 5.926 ± 0.081	6.057SerLeu: 6.057 ± 0.091	1.193SerMet: 1.193 ± 0.034	4.329SerAsn: 4.329 ± 0.089	1.93SerPro: 1.93 ± 0.054	1.969SerGln: 1.969 ± 0.045	1.972SerArg: 1.972 ± 0.045	4.619SerSer: 4.619 ± 0.101	3.567SerThr: 3.567 ± 0.078	3.936SerVal: 3.936 ± 0.063	0.794SerTrp: 0.794 ± 0.031	2.822SerTyr: 2.822 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.374ThrAla: 3.374 ± 0.07	0.38ThrCys: 0.38 ± 0.021	3.14ThrAsp: 3.14 ± 0.081	3.261ThrGlu: 3.261 ± 0.051	3.229ThrPhe: 3.229 ± 0.06	3.765ThrGly: 3.765 ± 0.074	0.994ThrHis: 0.994 ± 0.032	5.261ThrIle: 5.261 ± 0.078	4.661ThrLys: 4.661 ± 0.072	5.037ThrLeu: 5.037 ± 0.078	0.901ThrMet: 0.901 ± 0.03	3.746ThrAsn: 3.746 ± 0.079	2.302ThrPro: 2.302 ± 0.053	1.759ThrGln: 1.759 ± 0.037	1.56ThrArg: 1.56 ± 0.038	4.08ThrSer: 4.08 ± 0.087	3.555ThrThr: 3.555 ± 0.081	3.47ThrVal: 3.47 ± 0.072	0.612ThrTrp: 0.612 ± 0.025	2.204ThrTyr: 2.204 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	3.806ValAla: 3.806 ± 0.071	0.459ValCys: 0.459 ± 0.024	3.555ValAsp: 3.555 ± 0.065	3.552ValGlu: 3.552 ± 0.059	3.552ValPhe: 3.552 ± 0.063	3.825ValGly: 3.825 ± 0.06	0.94ValHis: 0.94 ± 0.036	4.819ValIle: 4.819 ± 0.079	4.856ValLys: 4.856 ± 0.074	5.848ValLeu: 5.848 ± 0.07	1.188ValMet: 1.188 ± 0.034	3.905ValAsn: 3.905 ± 0.062	1.934ValPro: 1.934 ± 0.047	1.557ValGln: 1.557 ± 0.036	1.888ValArg: 1.888 ± 0.042	4.415ValSer: 4.415 ± 0.068	3.411ValThr: 3.411 ± 0.066	4.026ValVal: 4.026 ± 0.074	0.582ValTrp: 0.582 ± 0.027	2.266ValTyr: 2.266 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.563TrpAla: 0.563 ± 0.024	0.092TrpCys: 0.092 ± 0.01	0.561TrpAsp: 0.561 ± 0.023	0.647TrpGlu: 0.647 ± 0.025	0.637TrpPhe: 0.637 ± 0.025	0.672TrpGly: 0.672 ± 0.028	0.239TrpHis: 0.239 ± 0.016	0.768TrpIle: 0.768 ± 0.03	0.979TrpLys: 0.979 ± 0.037	0.904TrpLeu: 0.904 ± 0.032	0.324TrpMet: 0.324 ± 0.019	0.797TrpAsn: 0.797 ± 0.031	0.197TrpPro: 0.197 ± 0.015	0.393TrpGln: 0.393 ± 0.023	0.401TrpArg: 0.401 ± 0.022	0.69TrpSer: 0.69 ± 0.025	0.611TrpThr: 0.611 ± 0.033	0.657TrpVal: 0.657 ± 0.028	0.146TrpTrp: 0.146 ± 0.013	0.438TrpTyr: 0.438 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.227TyrAla: 2.227 ± 0.045	0.298TyrCys: 0.298 ± 0.018	2.126TyrAsp: 2.126 ± 0.052	1.958TyrGlu: 1.958 ± 0.052	2.512TyrPhe: 2.512 ± 0.054	2.459TyrGly: 2.459 ± 0.059	0.793TyrHis: 0.793 ± 0.029	2.839TyrIle: 2.839 ± 0.052	3.672TyrLys: 3.672 ± 0.073	3.668TyrLeu: 3.668 ± 0.075	0.692TyrMet: 0.692 ± 0.029	2.849TyrAsn: 2.849 ± 0.055	1.426TyrPro: 1.426 ± 0.04	1.679TyrGln: 1.679 ± 0.049	1.525TyrArg: 1.525 ± 0.038	2.604TyrSer: 2.604 ± 0.056	2.33TyrThr: 2.33 ± 0.05	2.09TyrVal: 2.09 ± 0.043	0.512TyrTrp: 0.512 ± 0.023	1.776TyrTyr: 1.776 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2936 proteins (1035397 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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