Amino acid dipepetide frequency for Salmonella phage SeSz-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.143AlaAla: 8.143 ± 1.602
0.47AlaCys: 0.47 ± 0.187
4.385AlaAsp: 4.385 ± 0.605
7.516AlaGlu: 7.516 ± 0.946
1.723AlaPhe: 1.723 ± 0.401
6.968AlaGly: 6.968 ± 0.744
0.783AlaHis: 0.783 ± 0.229
6.107AlaIle: 6.107 ± 0.66
6.029AlaLys: 6.029 ± 0.753
6.968AlaLeu: 6.968 ± 0.765
3.367AlaMet: 3.367 ± 0.506
3.758AlaAsn: 3.758 ± 0.667
2.036AlaPro: 2.036 ± 0.366
3.21AlaGln: 3.21 ± 0.724
5.637AlaArg: 5.637 ± 0.773
5.089AlaSer: 5.089 ± 0.828
4.776AlaThr: 4.776 ± 1.106
6.42AlaVal: 6.42 ± 0.819
1.174AlaTrp: 1.174 ± 0.259
2.975AlaTyr: 2.975 ± 0.475
0.0AlaXaa: 0.0 ± 0.0
Cys
1.018CysAla: 1.018 ± 0.25
0.313CysCys: 0.313 ± 0.163
1.096CysAsp: 1.096 ± 0.28
1.253CysGlu: 1.253 ± 0.331
0.47CysPhe: 0.47 ± 0.233
1.644CysGly: 1.644 ± 0.448
0.626CysHis: 0.626 ± 0.203
1.018CysIle: 1.018 ± 0.326
1.018CysLys: 1.018 ± 0.264
1.174CysLeu: 1.174 ± 0.306
0.235CysMet: 0.235 ± 0.146
1.018CysAsn: 1.018 ± 0.335
0.313CysPro: 0.313 ± 0.142
0.235CysGln: 0.235 ± 0.115
0.705CysArg: 0.705 ± 0.205
0.783CysSer: 0.783 ± 0.261
0.548CysThr: 0.548 ± 0.167
0.391CysVal: 0.391 ± 0.168
0.391CysTrp: 0.391 ± 0.166
0.157CysTyr: 0.157 ± 0.11
0.0CysXaa: 0.0 ± 0.0
Asp
6.185AspAla: 6.185 ± 0.674
0.626AspCys: 0.626 ± 0.274
5.559AspAsp: 5.559 ± 0.813
5.402AspGlu: 5.402 ± 0.856
3.054AspPhe: 3.054 ± 0.459
5.794AspGly: 5.794 ± 0.822
0.861AspHis: 0.861 ± 0.225
4.933AspIle: 4.933 ± 0.567
3.837AspLys: 3.837 ± 0.604
2.819AspLeu: 2.819 ± 0.533
2.505AspMet: 2.505 ± 0.415
2.897AspAsn: 2.897 ± 0.495
1.566AspPro: 1.566 ± 0.311
1.096AspGln: 1.096 ± 0.379
3.21AspArg: 3.21 ± 0.489
3.21AspSer: 3.21 ± 0.519
2.819AspThr: 2.819 ± 0.486
3.758AspVal: 3.758 ± 0.538
0.705AspTrp: 0.705 ± 0.211
2.975AspTyr: 2.975 ± 0.505
0.0AspXaa: 0.0 ± 0.0
Glu
5.481GluAla: 5.481 ± 0.6
1.566GluCys: 1.566 ± 0.341
3.758GluAsp: 3.758 ± 0.718
4.776GluGlu: 4.776 ± 0.63
1.957GluPhe: 1.957 ± 0.504
3.523GluGly: 3.523 ± 0.536
0.626GluHis: 0.626 ± 0.226
5.246GluIle: 5.246 ± 0.526
3.758GluLys: 3.758 ± 0.557
6.185GluLeu: 6.185 ± 0.615
3.054GluMet: 3.054 ± 0.41
2.584GluAsn: 2.584 ± 0.4
2.662GluPro: 2.662 ± 0.395
4.698GluGln: 4.698 ± 0.654
3.68GluArg: 3.68 ± 0.541
3.915GluSer: 3.915 ± 0.469
2.897GluThr: 2.897 ± 0.482
4.698GluVal: 4.698 ± 0.739
1.723GluTrp: 1.723 ± 0.309
2.505GluTyr: 2.505 ± 0.447
0.0GluXaa: 0.0 ± 0.0
Phe
1.723PheAla: 1.723 ± 0.327
0.861PheCys: 0.861 ± 0.22
2.897PheAsp: 2.897 ± 0.481
2.271PheGlu: 2.271 ± 0.419
1.096PhePhe: 1.096 ± 0.261
2.819PheGly: 2.819 ± 0.411
0.47PheHis: 0.47 ± 0.189
2.505PheIle: 2.505 ± 0.542
1.331PheLys: 1.331 ± 0.3
1.409PheLeu: 1.409 ± 0.285
1.566PheMet: 1.566 ± 0.395
3.132PheAsn: 3.132 ± 0.451
1.174PhePro: 1.174 ± 0.31
1.096PheGln: 1.096 ± 0.277
1.488PheArg: 1.488 ± 0.351
2.427PheSer: 2.427 ± 0.477
2.192PheThr: 2.192 ± 0.402
1.566PheVal: 1.566 ± 0.325
0.391PheTrp: 0.391 ± 0.186
1.018PheTyr: 1.018 ± 0.323
0.0PheXaa: 0.0 ± 0.0
Gly
5.402GlyAla: 5.402 ± 0.781
1.174GlyCys: 1.174 ± 0.273
4.228GlyAsp: 4.228 ± 0.617
4.933GlyGlu: 4.933 ± 0.517
2.427GlyPhe: 2.427 ± 0.431
4.306GlyGly: 4.306 ± 0.708
1.096GlyHis: 1.096 ± 0.294
4.854GlyIle: 4.854 ± 0.439
5.794GlyLys: 5.794 ± 0.661
4.541GlyLeu: 4.541 ± 0.591
2.584GlyMet: 2.584 ± 0.476
2.74GlyAsn: 2.74 ± 0.447
0.626GlyPro: 0.626 ± 0.241
2.271GlyGln: 2.271 ± 0.439
3.758GlyArg: 3.758 ± 0.535
5.324GlySer: 5.324 ± 0.778
3.837GlyThr: 3.837 ± 0.671
4.854GlyVal: 4.854 ± 0.654
1.096GlyTrp: 1.096 ± 0.264
3.68GlyTyr: 3.68 ± 0.638
0.0GlyXaa: 0.0 ± 0.0
His
1.174HisAla: 1.174 ± 0.358
0.313HisCys: 0.313 ± 0.156
1.488HisAsp: 1.488 ± 0.278
0.861HisGlu: 0.861 ± 0.238
0.626HisPhe: 0.626 ± 0.222
1.723HisGly: 1.723 ± 0.344
0.313HisHis: 0.313 ± 0.14
0.783HisIle: 0.783 ± 0.311
1.409HisLys: 1.409 ± 0.304
1.253HisLeu: 1.253 ± 0.266
0.391HisMet: 0.391 ± 0.185
0.705HisAsn: 0.705 ± 0.2
0.626HisPro: 0.626 ± 0.26
0.47HisGln: 0.47 ± 0.19
1.018HisArg: 1.018 ± 0.27
0.391HisSer: 0.391 ± 0.137
0.548HisThr: 0.548 ± 0.268
1.096HisVal: 1.096 ± 0.357
0.078HisTrp: 0.078 ± 0.079
0.548HisTyr: 0.548 ± 0.179
0.0HisXaa: 0.0 ± 0.0
Ile
6.264IleAla: 6.264 ± 0.72
1.096IleCys: 1.096 ± 0.28
5.089IleAsp: 5.089 ± 0.506
4.933IleGlu: 4.933 ± 0.546
2.114IlePhe: 2.114 ± 0.344
5.246IleGly: 5.246 ± 0.683
1.409IleHis: 1.409 ± 0.352
4.385IleIle: 4.385 ± 0.665
4.541IleLys: 4.541 ± 0.456
4.306IleLeu: 4.306 ± 0.484
1.879IleMet: 1.879 ± 0.425
3.68IleAsn: 3.68 ± 0.522
2.505IlePro: 2.505 ± 0.386
1.879IleGln: 1.879 ± 0.345
3.602IleArg: 3.602 ± 0.574
5.168IleSer: 5.168 ± 0.685
4.071IleThr: 4.071 ± 0.46
4.776IleVal: 4.776 ± 0.441
0.548IleTrp: 0.548 ± 0.191
1.488IleTyr: 1.488 ± 0.433
0.0IleXaa: 0.0 ± 0.0
Lys
5.637LysAla: 5.637 ± 0.733
1.253LysCys: 1.253 ± 0.353
3.837LysAsp: 3.837 ± 0.597
4.306LysGlu: 4.306 ± 0.515
2.271LysPhe: 2.271 ± 0.471
3.445LysGly: 3.445 ± 0.581
1.096LysHis: 1.096 ± 0.327
5.168LysIle: 5.168 ± 0.621
4.15LysLys: 4.15 ± 0.622
5.637LysLeu: 5.637 ± 0.723
2.897LysMet: 2.897 ± 0.464
3.21LysAsn: 3.21 ± 0.525
2.74LysPro: 2.74 ± 0.473
2.114LysGln: 2.114 ± 0.462
3.367LysArg: 3.367 ± 0.609
4.228LysSer: 4.228 ± 0.612
3.445LysThr: 3.445 ± 0.537
3.837LysVal: 3.837 ± 0.531
1.018LysTrp: 1.018 ± 0.3
2.349LysTyr: 2.349 ± 0.395
0.0LysXaa: 0.0 ± 0.0
Leu
5.481LeuAla: 5.481 ± 0.865
0.861LeuCys: 0.861 ± 0.245
3.758LeuAsp: 3.758 ± 0.512
3.758LeuGlu: 3.758 ± 0.531
1.644LeuPhe: 1.644 ± 0.282
4.071LeuGly: 4.071 ± 0.489
1.331LeuHis: 1.331 ± 0.277
4.698LeuIle: 4.698 ± 0.611
5.089LeuLys: 5.089 ± 0.753
4.463LeuLeu: 4.463 ± 0.685
1.488LeuMet: 1.488 ± 0.345
3.445LeuAsn: 3.445 ± 0.445
3.445LeuPro: 3.445 ± 0.572
2.505LeuGln: 2.505 ± 0.481
4.541LeuArg: 4.541 ± 0.576
4.854LeuSer: 4.854 ± 0.533
4.933LeuThr: 4.933 ± 0.714
5.168LeuVal: 5.168 ± 0.677
1.409LeuTrp: 1.409 ± 0.276
2.427LeuTyr: 2.427 ± 0.445
0.0LeuXaa: 0.0 ± 0.0
Met
3.445MetAla: 3.445 ± 0.496
0.47MetCys: 0.47 ± 0.206
1.723MetAsp: 1.723 ± 0.407
1.253MetGlu: 1.253 ± 0.248
1.488MetPhe: 1.488 ± 0.412
1.096MetGly: 1.096 ± 0.308
0.626MetHis: 0.626 ± 0.235
2.192MetIle: 2.192 ± 0.441
2.819MetLys: 2.819 ± 0.459
2.271MetLeu: 2.271 ± 0.349
1.253MetMet: 1.253 ± 0.328
1.723MetAsn: 1.723 ± 0.366
1.957MetPro: 1.957 ± 0.487
1.253MetGln: 1.253 ± 0.284
1.801MetArg: 1.801 ± 0.356
2.349MetSer: 2.349 ± 0.428
2.192MetThr: 2.192 ± 0.414
1.644MetVal: 1.644 ± 0.362
0.705MetTrp: 0.705 ± 0.217
1.096MetTyr: 1.096 ± 0.215
0.0MetXaa: 0.0 ± 0.0
Asn
4.541AsnAla: 4.541 ± 0.694
0.548AsnCys: 0.548 ± 0.171
3.132AsnAsp: 3.132 ± 0.438
2.271AsnGlu: 2.271 ± 0.4
1.096AsnPhe: 1.096 ± 0.35
5.794AsnGly: 5.794 ± 0.564
1.174AsnHis: 1.174 ± 0.312
2.819AsnIle: 2.819 ± 0.44
3.21AsnLys: 3.21 ± 0.523
2.584AsnLeu: 2.584 ± 0.438
1.253AsnMet: 1.253 ± 0.289
1.957AsnAsn: 1.957 ± 0.44
1.409AsnPro: 1.409 ± 0.314
1.801AsnGln: 1.801 ± 0.311
2.897AsnArg: 2.897 ± 0.506
2.819AsnSer: 2.819 ± 0.592
2.192AsnThr: 2.192 ± 0.437
3.68AsnVal: 3.68 ± 0.832
0.548AsnTrp: 0.548 ± 0.193
1.488AsnTyr: 1.488 ± 0.35
0.0AsnXaa: 0.0 ± 0.0
Pro
3.445ProAla: 3.445 ± 0.582
0.626ProCys: 0.626 ± 0.252
2.662ProAsp: 2.662 ± 0.464
3.132ProGlu: 3.132 ± 0.422
1.018ProPhe: 1.018 ± 0.283
1.801ProGly: 1.801 ± 0.378
0.47ProHis: 0.47 ± 0.209
1.488ProIle: 1.488 ± 0.275
2.114ProLys: 2.114 ± 0.371
1.957ProLeu: 1.957 ± 0.455
0.861ProMet: 0.861 ± 0.279
0.861ProAsn: 0.861 ± 0.22
1.174ProPro: 1.174 ± 0.313
1.644ProGln: 1.644 ± 0.53
1.174ProArg: 1.174 ± 0.335
2.036ProSer: 2.036 ± 0.426
2.036ProThr: 2.036 ± 0.428
3.68ProVal: 3.68 ± 0.569
0.47ProTrp: 0.47 ± 0.244
1.174ProTyr: 1.174 ± 0.315
0.0ProXaa: 0.0 ± 0.0
Gln
3.445GlnAla: 3.445 ± 0.739
0.548GlnCys: 0.548 ± 0.221
1.253GlnAsp: 1.253 ± 0.336
2.584GlnGlu: 2.584 ± 0.425
1.566GlnPhe: 1.566 ± 0.336
1.018GlnGly: 1.018 ± 0.293
1.018GlnHis: 1.018 ± 0.289
2.505GlnIle: 2.505 ± 0.437
2.505GlnLys: 2.505 ± 0.409
3.132GlnLeu: 3.132 ± 0.467
1.331GlnMet: 1.331 ± 0.334
1.331GlnAsn: 1.331 ± 0.341
1.644GlnPro: 1.644 ± 0.331
2.819GlnGln: 2.819 ± 0.804
2.114GlnArg: 2.114 ± 0.524
2.819GlnSer: 2.819 ± 0.531
2.114GlnThr: 2.114 ± 0.468
2.192GlnVal: 2.192 ± 0.421
0.861GlnTrp: 0.861 ± 0.216
1.096GlnTyr: 1.096 ± 0.329
0.0GlnXaa: 0.0 ± 0.0
Arg
4.306ArgAla: 4.306 ± 0.546
1.331ArgCys: 1.331 ± 0.374
2.74ArgAsp: 2.74 ± 0.569
4.228ArgGlu: 4.228 ± 0.63
1.644ArgPhe: 1.644 ± 0.361
3.445ArgGly: 3.445 ± 0.551
0.548ArgHis: 0.548 ± 0.143
3.758ArgIle: 3.758 ± 0.539
3.523ArgLys: 3.523 ± 0.583
4.228ArgLeu: 4.228 ± 0.479
1.644ArgMet: 1.644 ± 0.37
4.071ArgAsn: 4.071 ± 0.536
1.018ArgPro: 1.018 ± 0.297
2.192ArgGln: 2.192 ± 0.535
3.054ArgArg: 3.054 ± 0.481
3.054ArgSer: 3.054 ± 0.426
2.036ArgThr: 2.036 ± 0.552
2.975ArgVal: 2.975 ± 0.568
0.626ArgTrp: 0.626 ± 0.231
2.897ArgTyr: 2.897 ± 0.406
0.0ArgXaa: 0.0 ± 0.0
Ser
6.499SerAla: 6.499 ± 0.819
0.705SerCys: 0.705 ± 0.242
4.854SerAsp: 4.854 ± 0.672
3.837SerGlu: 3.837 ± 0.442
2.74SerPhe: 2.74 ± 0.409
5.794SerGly: 5.794 ± 0.659
0.94SerHis: 0.94 ± 0.238
3.915SerIle: 3.915 ± 0.537
3.602SerLys: 3.602 ± 0.509
5.481SerLeu: 5.481 ± 0.702
2.114SerMet: 2.114 ± 0.42
2.349SerAsn: 2.349 ± 0.425
2.036SerPro: 2.036 ± 0.465
2.505SerGln: 2.505 ± 0.483
2.74SerArg: 2.74 ± 0.415
3.445SerSer: 3.445 ± 0.621
3.68SerThr: 3.68 ± 0.767
3.21SerVal: 3.21 ± 0.539
1.096SerTrp: 1.096 ± 0.283
2.662SerTyr: 2.662 ± 0.439
0.0SerXaa: 0.0 ± 0.0
Thr
5.168ThrAla: 5.168 ± 0.98
0.47ThrCys: 0.47 ± 0.187
3.288ThrAsp: 3.288 ± 0.638
4.228ThrGlu: 4.228 ± 0.507
2.271ThrPhe: 2.271 ± 0.513
5.011ThrGly: 5.011 ± 0.796
0.783ThrHis: 0.783 ± 0.24
3.367ThrIle: 3.367 ± 0.604
3.837ThrLys: 3.837 ± 0.602
3.21ThrLeu: 3.21 ± 0.581
1.174ThrMet: 1.174 ± 0.29
2.662ThrAsn: 2.662 ± 0.577
3.367ThrPro: 3.367 ± 0.478
1.723ThrGln: 1.723 ± 0.384
2.427ThrArg: 2.427 ± 0.459
3.21ThrSer: 3.21 ± 0.845
3.758ThrThr: 3.758 ± 0.906
3.054ThrVal: 3.054 ± 0.592
0.783ThrTrp: 0.783 ± 0.335
1.488ThrTyr: 1.488 ± 0.34
0.0ThrXaa: 0.0 ± 0.0
Val
5.481ValAla: 5.481 ± 0.768
0.47ValCys: 0.47 ± 0.227
4.541ValAsp: 4.541 ± 0.591
4.306ValGlu: 4.306 ± 0.601
2.271ValPhe: 2.271 ± 0.447
3.367ValGly: 3.367 ± 0.607
0.47ValHis: 0.47 ± 0.257
6.342ValIle: 6.342 ± 0.69
4.15ValLys: 4.15 ± 0.46
3.837ValLeu: 3.837 ± 0.511
2.74ValMet: 2.74 ± 0.485
3.288ValAsn: 3.288 ± 0.531
1.174ValPro: 1.174 ± 0.369
2.114ValGln: 2.114 ± 0.341
3.21ValArg: 3.21 ± 0.546
5.089ValSer: 5.089 ± 0.538
4.541ValThr: 4.541 ± 1.018
3.993ValVal: 3.993 ± 0.734
1.018ValTrp: 1.018 ± 0.302
2.662ValTyr: 2.662 ± 0.317
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.259
0.078TrpCys: 0.078 ± 0.082
0.783TrpAsp: 0.783 ± 0.22
1.096TrpGlu: 1.096 ± 0.31
0.626TrpPhe: 0.626 ± 0.257
0.235TrpGly: 0.235 ± 0.119
0.47TrpHis: 0.47 ± 0.222
0.783TrpIle: 0.783 ± 0.224
1.174TrpLys: 1.174 ± 0.3
1.488TrpLeu: 1.488 ± 0.404
0.235TrpMet: 0.235 ± 0.191
0.626TrpAsn: 0.626 ± 0.229
0.705TrpPro: 0.705 ± 0.228
0.861TrpGln: 0.861 ± 0.217
1.331TrpArg: 1.331 ± 0.321
0.861TrpSer: 0.861 ± 0.247
1.018TrpThr: 1.018 ± 0.274
1.723TrpVal: 1.723 ± 0.287
0.235TrpTrp: 0.235 ± 0.138
0.391TrpTyr: 0.391 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.758TyrAla: 3.758 ± 0.512
0.626TyrCys: 0.626 ± 0.201
2.74TyrAsp: 2.74 ± 0.491
2.349TyrGlu: 2.349 ± 0.386
1.331TyrPhe: 1.331 ± 0.363
2.427TyrGly: 2.427 ± 0.522
0.705TyrHis: 0.705 ± 0.222
2.114TyrIle: 2.114 ± 0.394
2.114TyrLys: 2.114 ± 0.433
2.427TyrLeu: 2.427 ± 0.552
0.705TyrMet: 0.705 ± 0.215
1.174TyrAsn: 1.174 ± 0.233
1.644TyrPro: 1.644 ± 0.357
1.409TyrGln: 1.409 ± 0.309
1.566TyrArg: 1.566 ± 0.28
3.21TyrSer: 3.21 ± 0.508
1.644TyrThr: 1.644 ± 0.43
2.349TyrVal: 2.349 ± 0.441
0.783TyrTrp: 0.783 ± 0.234
0.94TyrTyr: 0.94 ± 0.308
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (12773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski