Amino acid dipepetide frequency for Caldithrix abyssi DSM 13497

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.612AlaAla: 5.612 ± 0.082
0.575AlaCys: 0.575 ± 0.027
3.745AlaAsp: 3.745 ± 0.06
4.598AlaGlu: 4.598 ± 0.071
3.552AlaPhe: 3.552 ± 0.053
5.232AlaGly: 5.232 ± 0.064
1.535AlaHis: 1.535 ± 0.038
5.097AlaIle: 5.097 ± 0.068
3.374AlaLys: 3.374 ± 0.058
8.159AlaLeu: 8.159 ± 0.087
1.616AlaMet: 1.616 ± 0.035
2.678AlaAsn: 2.678 ± 0.05
2.556AlaPro: 2.556 ± 0.047
3.276AlaGln: 3.276 ± 0.053
4.385AlaArg: 4.385 ± 0.062
3.688AlaSer: 3.688 ± 0.057
3.144AlaThr: 3.144 ± 0.059
4.813AlaVal: 4.813 ± 0.064
0.766AlaTrp: 0.766 ± 0.026
2.628AlaTyr: 2.628 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.517CysAla: 0.517 ± 0.021
0.064CysCys: 0.064 ± 0.006
0.364CysAsp: 0.364 ± 0.017
0.432CysGlu: 0.432 ± 0.018
0.306CysPhe: 0.306 ± 0.016
0.582CysGly: 0.582 ± 0.023
0.334CysHis: 0.334 ± 0.042
0.396CysIle: 0.396 ± 0.019
0.378CysLys: 0.378 ± 0.017
0.57CysLeu: 0.57 ± 0.02
0.122CysMet: 0.122 ± 0.009
0.276CysAsn: 0.276 ± 0.013
0.413CysPro: 0.413 ± 0.02
0.32CysGln: 0.32 ± 0.015
0.324CysArg: 0.324 ± 0.017
0.358CysSer: 0.358 ± 0.018
0.348CysThr: 0.348 ± 0.017
0.418CysVal: 0.418 ± 0.021
0.087CysTrp: 0.087 ± 0.008
0.252CysTyr: 0.252 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.557AspAla: 3.557 ± 0.056
0.397AspCys: 0.397 ± 0.021
2.747AspAsp: 2.747 ± 0.052
3.882AspGlu: 3.882 ± 0.058
3.26AspPhe: 3.26 ± 0.049
3.843AspGly: 3.843 ± 0.068
1.067AspHis: 1.067 ± 0.03
3.416AspIle: 3.416 ± 0.064
2.529AspLys: 2.529 ± 0.047
5.627AspLeu: 5.627 ± 0.078
1.049AspMet: 1.049 ± 0.031
1.945AspAsn: 1.945 ± 0.05
2.506AspPro: 2.506 ± 0.056
2.165AspGln: 2.165 ± 0.043
2.826AspArg: 2.826 ± 0.043
3.13AspSer: 3.13 ± 0.084
2.208AspThr: 2.208 ± 0.054
3.525AspVal: 3.525 ± 0.051
0.767AspTrp: 0.767 ± 0.028
2.494AspTyr: 2.494 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
4.782GluAla: 4.782 ± 0.069
0.335GluCys: 0.335 ± 0.018
3.094GluAsp: 3.094 ± 0.052
5.056GluGlu: 5.056 ± 0.091
2.798GluPhe: 2.798 ± 0.044
3.512GluGly: 3.512 ± 0.051
1.282GluHis: 1.282 ± 0.03
5.609GluIle: 5.609 ± 0.084
5.889GluLys: 5.889 ± 0.09
6.571GluLeu: 6.571 ± 0.082
1.831GluMet: 1.831 ± 0.035
3.53GluAsn: 3.53 ± 0.056
2.086GluPro: 2.086 ± 0.041
3.104GluGln: 3.104 ± 0.06
3.789GluArg: 3.789 ± 0.074
2.917GluSer: 2.917 ± 0.051
3.045GluThr: 3.045 ± 0.048
3.941GluVal: 3.941 ± 0.065
0.808GluTrp: 0.808 ± 0.026
2.239GluTyr: 2.239 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.411PheAla: 3.411 ± 0.056
0.403PheCys: 0.403 ± 0.019
3.027PheAsp: 3.027 ± 0.054
3.344PheGlu: 3.344 ± 0.052
2.891PhePhe: 2.891 ± 0.054
3.223PheGly: 3.223 ± 0.058
0.964PheHis: 0.964 ± 0.03
3.499PheIle: 3.499 ± 0.054
3.628PheLys: 3.628 ± 0.056
5.37PheLeu: 5.37 ± 0.086
1.06PheMet: 1.06 ± 0.031
2.864PheAsn: 2.864 ± 0.058
2.026PhePro: 2.026 ± 0.038
1.691PheGln: 1.691 ± 0.035
2.211PheArg: 2.211 ± 0.044
3.736PheSer: 3.736 ± 0.057
2.731PheThr: 2.731 ± 0.047
3.391PheVal: 3.391 ± 0.051
0.722PheTrp: 0.722 ± 0.024
2.312PheTyr: 2.312 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.593GlyAla: 4.593 ± 0.069
0.496GlyCys: 0.496 ± 0.023
3.325GlyAsp: 3.325 ± 0.057
3.768GlyGlu: 3.768 ± 0.057
3.353GlyPhe: 3.353 ± 0.051
4.505GlyGly: 4.505 ± 0.08
1.337GlyHis: 1.337 ± 0.031
4.804GlyIle: 4.804 ± 0.06
4.666GlyLys: 4.666 ± 0.065
6.625GlyLeu: 6.625 ± 0.082
1.682GlyMet: 1.682 ± 0.041
2.773GlyAsn: 2.773 ± 0.054
1.814GlyPro: 1.814 ± 0.039
2.814GlyGln: 2.814 ± 0.05
3.314GlyArg: 3.314 ± 0.05
3.55GlySer: 3.55 ± 0.056
3.154GlyThr: 3.154 ± 0.062
4.508GlyVal: 4.508 ± 0.061
0.957GlyTrp: 0.957 ± 0.029
2.814GlyTyr: 2.814 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.269HisAla: 1.269 ± 0.033
0.184HisCys: 0.184 ± 0.012
0.981HisAsp: 0.981 ± 0.028
1.049HisGlu: 1.049 ± 0.032
1.294HisPhe: 1.294 ± 0.031
1.296HisGly: 1.296 ± 0.034
0.577HisHis: 0.577 ± 0.021
1.378HisIle: 1.378 ± 0.031
1.074HisLys: 1.074 ± 0.03
2.295HisLeu: 2.295 ± 0.051
0.319HisMet: 0.319 ± 0.016
0.853HisAsn: 0.853 ± 0.026
1.266HisPro: 1.266 ± 0.03
0.93HisGln: 0.93 ± 0.03
1.015HisArg: 1.015 ± 0.029
1.143HisSer: 1.143 ± 0.03
0.843HisThr: 0.843 ± 0.026
1.218HisVal: 1.218 ± 0.031
0.279HisTrp: 0.279 ± 0.014
0.901HisTyr: 0.901 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.132IleAla: 5.132 ± 0.058
0.522IleCys: 0.522 ± 0.022
4.505IleAsp: 4.505 ± 0.055
5.214IleGlu: 5.214 ± 0.066
3.819IlePhe: 3.819 ± 0.046
4.652IleGly: 4.652 ± 0.063
1.492IleHis: 1.492 ± 0.036
5.189IleIle: 5.189 ± 0.08
5.181IleLys: 5.181 ± 0.07
7.403IleLeu: 7.403 ± 0.088
1.283IleMet: 1.283 ± 0.034
3.521IleAsn: 3.521 ± 0.061
3.323IlePro: 3.323 ± 0.053
2.484IleGln: 2.484 ± 0.048
3.541IleArg: 3.541 ± 0.053
4.465IleSer: 4.465 ± 0.057
3.648IleThr: 3.648 ± 0.054
4.646IleVal: 4.646 ± 0.067
0.746IleTrp: 0.746 ± 0.023
2.762IleTyr: 2.762 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.592LysAla: 4.592 ± 0.063
0.316LysCys: 0.316 ± 0.015
3.377LysAsp: 3.377 ± 0.061
5.366LysGlu: 5.366 ± 0.082
2.549LysPhe: 2.549 ± 0.042
3.612LysGly: 3.612 ± 0.058
1.163LysHis: 1.163 ± 0.03
6.074LysIle: 6.074 ± 0.083
5.945LysLys: 5.945 ± 0.1
5.716LysLeu: 5.716 ± 0.076
1.876LysMet: 1.876 ± 0.037
3.827LysAsn: 3.827 ± 0.066
2.457LysPro: 2.457 ± 0.049
2.703LysGln: 2.703 ± 0.045
3.477LysArg: 3.477 ± 0.062
3.243LysSer: 3.243 ± 0.055
3.562LysThr: 3.562 ± 0.052
3.991LysVal: 3.991 ± 0.064
0.644LysTrp: 0.644 ± 0.023
2.37LysTyr: 2.37 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
7.544LeuAla: 7.544 ± 0.078
0.627LeuCys: 0.627 ± 0.021
4.939LeuAsp: 4.939 ± 0.063
6.384LeuGlu: 6.384 ± 0.08
5.355LeuPhe: 5.355 ± 0.067
5.967LeuGly: 5.967 ± 0.076
1.875LeuHis: 1.875 ± 0.038
7.76LeuIle: 7.76 ± 0.086
8.681LeuLys: 8.681 ± 0.103
10.453LeuLeu: 10.453 ± 0.124
2.179LeuMet: 2.179 ± 0.043
5.381LeuAsn: 5.381 ± 0.071
4.665LeuPro: 4.665 ± 0.073
4.568LeuGln: 4.568 ± 0.069
4.814LeuArg: 4.814 ± 0.064
6.444LeuSer: 6.444 ± 0.086
5.546LeuThr: 5.546 ± 0.078
5.754LeuVal: 5.754 ± 0.071
1.143LeuTrp: 1.143 ± 0.032
3.231LeuTyr: 3.231 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
1.989MetAla: 1.989 ± 0.041
0.101MetCys: 0.101 ± 0.008
1.204MetAsp: 1.204 ± 0.028
1.529MetGlu: 1.529 ± 0.04
0.831MetPhe: 0.831 ± 0.024
1.591MetGly: 1.591 ± 0.035
0.396MetHis: 0.396 ± 0.018
1.542MetIle: 1.542 ± 0.037
1.676MetLys: 1.676 ± 0.035
1.946MetLeu: 1.946 ± 0.041
0.597MetMet: 0.597 ± 0.025
1.085MetAsn: 1.085 ± 0.029
1.014MetPro: 1.014 ± 0.026
0.871MetGln: 0.871 ± 0.029
1.171MetArg: 1.171 ± 0.028
1.178MetSer: 1.178 ± 0.029
1.034MetThr: 1.034 ± 0.03
1.617MetVal: 1.617 ± 0.038
0.201MetTrp: 0.201 ± 0.012
0.555MetTyr: 0.555 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.067AsnAla: 3.067 ± 0.045
0.321AsnCys: 0.321 ± 0.018
2.556AsnAsp: 2.556 ± 0.056
2.797AsnGlu: 2.797 ± 0.052
2.479AsnPhe: 2.479 ± 0.048
3.337AsnGly: 3.337 ± 0.072
0.931AsnHis: 0.931 ± 0.025
3.32AsnIle: 3.32 ± 0.055
2.768AsnLys: 2.768 ± 0.045
4.889AsnLeu: 4.889 ± 0.063
0.957AsnMet: 0.957 ± 0.026
2.221AsnAsn: 2.221 ± 0.062
2.687AsnPro: 2.687 ± 0.046
1.97AsnGln: 1.97 ± 0.043
2.419AsnArg: 2.419 ± 0.042
2.275AsnSer: 2.275 ± 0.053
1.962AsnThr: 1.962 ± 0.044
2.909AsnVal: 2.909 ± 0.051
0.73AsnTrp: 0.73 ± 0.029
1.961AsnTyr: 1.961 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.11ProAla: 3.11 ± 0.058
0.235ProCys: 0.235 ± 0.016
2.891ProAsp: 2.891 ± 0.054
3.575ProGlu: 3.575 ± 0.048
2.471ProPhe: 2.471 ± 0.046
2.876ProGly: 2.876 ± 0.05
0.869ProHis: 0.869 ± 0.028
2.574ProIle: 2.574 ± 0.044
1.801ProLys: 1.801 ± 0.043
4.097ProLeu: 4.097 ± 0.06
0.776ProMet: 0.776 ± 0.025
1.668ProAsn: 1.668 ± 0.041
1.706ProPro: 1.706 ± 0.04
2.09ProGln: 2.09 ± 0.039
1.671ProArg: 1.671 ± 0.034
1.99ProSer: 1.99 ± 0.042
1.923ProThr: 1.923 ± 0.045
3.057ProVal: 3.057 ± 0.054
0.478ProTrp: 0.478 ± 0.019
1.508ProTyr: 1.508 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.175GlnAla: 3.175 ± 0.059
0.225GlnCys: 0.225 ± 0.015
1.696GlnAsp: 1.696 ± 0.036
2.451GlnGlu: 2.451 ± 0.043
2.055GlnPhe: 2.055 ± 0.042
2.175GlnGly: 2.175 ± 0.041
0.72GlnHis: 0.72 ± 0.021
3.498GlnIle: 3.498 ± 0.054
3.861GlnLys: 3.861 ± 0.064
4.208GlnLeu: 4.208 ± 0.074
1.029GlnMet: 1.029 ± 0.026
2.397GlnAsn: 2.397 ± 0.045
1.64GlnPro: 1.64 ± 0.038
1.948GlnGln: 1.948 ± 0.05
2.123GlnArg: 2.123 ± 0.045
2.197GlnSer: 2.197 ± 0.042
2.349GlnThr: 2.349 ± 0.052
2.56GlnVal: 2.56 ± 0.043
0.554GlnTrp: 0.554 ± 0.021
1.427GlnTyr: 1.427 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.324ArgAla: 3.324 ± 0.051
0.362ArgCys: 0.362 ± 0.016
2.267ArgAsp: 2.267 ± 0.039
3.316ArgGlu: 3.316 ± 0.06
3.13ArgPhe: 3.13 ± 0.052
2.767ArgGly: 2.767 ± 0.042
1.092ArgHis: 1.092 ± 0.03
3.958ArgIle: 3.958 ± 0.055
3.47ArgLys: 3.47 ± 0.059
6.036ArgLeu: 6.036 ± 0.095
1.298ArgMet: 1.298 ± 0.032
1.993ArgAsn: 1.993 ± 0.037
1.958ArgPro: 1.958 ± 0.04
2.516ArgGln: 2.516 ± 0.048
2.6ArgArg: 2.6 ± 0.055
2.65ArgSer: 2.65 ± 0.053
2.149ArgThr: 2.149 ± 0.044
3.145ArgVal: 3.145 ± 0.045
0.788ArgTrp: 0.788 ± 0.025
2.142ArgTyr: 2.142 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.131SerAla: 4.131 ± 0.064
0.427SerCys: 0.427 ± 0.02
2.997SerAsp: 2.997 ± 0.053
3.42SerGlu: 3.42 ± 0.057
3.181SerPhe: 3.181 ± 0.055
4.783SerGly: 4.783 ± 0.085
1.024SerHis: 1.024 ± 0.03
3.721SerIle: 3.721 ± 0.061
2.946SerLys: 2.946 ± 0.054
5.789SerLeu: 5.789 ± 0.085
1.233SerMet: 1.233 ± 0.03
2.273SerAsn: 2.273 ± 0.049
2.302SerPro: 2.302 ± 0.04
2.002SerGln: 2.002 ± 0.04
2.677SerArg: 2.677 ± 0.043
3.18SerSer: 3.18 ± 0.064
2.577SerThr: 2.577 ± 0.05
3.794SerVal: 3.794 ± 0.061
0.751SerTrp: 0.751 ± 0.025
2.008SerTyr: 2.008 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
3.545ThrAla: 3.545 ± 0.058
0.346ThrCys: 0.346 ± 0.019
2.712ThrAsp: 2.712 ± 0.053
2.594ThrGlu: 2.594 ± 0.048
2.604ThrPhe: 2.604 ± 0.048
3.692ThrGly: 3.692 ± 0.054
1.01ThrHis: 1.01 ± 0.025
3.974ThrIle: 3.974 ± 0.062
1.993ThrLys: 1.993 ± 0.042
5.343ThrLeu: 5.343 ± 0.08
0.949ThrMet: 0.949 ± 0.026
1.875ThrAsn: 1.875 ± 0.038
2.4ThrPro: 2.4 ± 0.045
1.636ThrGln: 1.636 ± 0.035
2.289ThrArg: 2.289 ± 0.044
2.565ThrSer: 2.565 ± 0.057
2.571ThrThr: 2.571 ± 0.046
3.618ThrVal: 3.618 ± 0.064
0.55ThrTrp: 0.55 ± 0.02
1.838ThrTyr: 1.838 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
4.503ValAla: 4.503 ± 0.066
0.529ValCys: 0.529 ± 0.021
3.61ValAsp: 3.61 ± 0.053
4.51ValGlu: 4.51 ± 0.063
3.409ValPhe: 3.409 ± 0.054
3.987ValGly: 3.987 ± 0.053
1.276ValHis: 1.276 ± 0.027
4.661ValIle: 4.661 ± 0.065
4.324ValLys: 4.324 ± 0.061
6.483ValLeu: 6.483 ± 0.083
1.333ValMet: 1.333 ± 0.031
3.011ValAsn: 3.011 ± 0.061
2.464ValPro: 2.464 ± 0.044
2.471ValGln: 2.471 ± 0.043
3.226ValArg: 3.226 ± 0.051
3.658ValSer: 3.658 ± 0.064
3.133ValThr: 3.133 ± 0.055
4.607ValVal: 4.607 ± 0.078
0.733ValTrp: 0.733 ± 0.024
2.464ValTyr: 2.464 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.812TrpAla: 0.812 ± 0.026
0.089TrpCys: 0.089 ± 0.008
0.668TrpAsp: 0.668 ± 0.025
0.715TrpGlu: 0.715 ± 0.023
0.598TrpPhe: 0.598 ± 0.021
0.821TrpGly: 0.821 ± 0.025
0.292TrpHis: 0.292 ± 0.015
0.87TrpIle: 0.87 ± 0.031
0.773TrpLys: 0.773 ± 0.023
1.369TrpLeu: 1.369 ± 0.037
0.285TrpMet: 0.285 ± 0.015
0.694TrpAsn: 0.694 ± 0.026
0.452TrpPro: 0.452 ± 0.018
0.862TrpGln: 0.862 ± 0.027
0.655TrpArg: 0.655 ± 0.024
0.66TrpSer: 0.66 ± 0.026
0.541TrpThr: 0.541 ± 0.025
0.655TrpVal: 0.655 ± 0.025
0.21TrpTrp: 0.21 ± 0.013
0.466TrpTyr: 0.466 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.362TyrAla: 2.362 ± 0.045
0.308TyrCys: 0.308 ± 0.016
2.234TyrAsp: 2.234 ± 0.044
2.219TyrGlu: 2.219 ± 0.043
2.572TyrPhe: 2.572 ± 0.049
2.4TyrGly: 2.4 ± 0.04
0.927TyrHis: 0.927 ± 0.025
2.187TyrIle: 2.187 ± 0.042
1.901TyrLys: 1.901 ± 0.038
4.362TyrLeu: 4.362 ± 0.063
0.653TyrMet: 0.653 ± 0.022
1.688TyrAsn: 1.688 ± 0.044
1.625TyrPro: 1.625 ± 0.034
1.869TyrGln: 1.869 ± 0.043
2.435TyrArg: 2.435 ± 0.048
2.19TyrSer: 2.19 ± 0.041
1.637TyrThr: 1.637 ± 0.042
2.227TyrVal: 2.227 ± 0.045
0.576TyrTrp: 0.576 ± 0.021
1.856TyrTyr: 1.856 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3674 proteins (1397650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski