Amino acid dipepetide frequency for Actinomyces ruminicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.112AlaAla: 23.112 ± 0.29
1.267AlaCys: 1.267 ± 0.041
9.405AlaAsp: 9.405 ± 0.117
8.07AlaGlu: 8.07 ± 0.122
3.234AlaPhe: 3.234 ± 0.068
13.007AlaGly: 13.007 ± 0.154
2.547AlaHis: 2.547 ± 0.059
4.681AlaIle: 4.681 ± 0.079
2.197AlaLys: 2.197 ± 0.063
14.484AlaLeu: 14.484 ± 0.16
2.773AlaMet: 2.773 ± 0.053
2.199AlaAsn: 2.199 ± 0.053
7.291AlaPro: 7.291 ± 0.11
4.361AlaGln: 4.361 ± 0.081
10.185AlaArg: 10.185 ± 0.149
7.114AlaSer: 7.114 ± 0.092
7.65AlaThr: 7.65 ± 0.107
12.353AlaVal: 12.353 ± 0.143
2.24AlaTrp: 2.24 ± 0.056
2.656AlaTyr: 2.656 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.028CysAla: 1.028 ± 0.031
0.093CysCys: 0.093 ± 0.011
0.408CysAsp: 0.408 ± 0.024
0.409CysGlu: 0.409 ± 0.022
0.225CysPhe: 0.225 ± 0.016
0.818CysGly: 0.818 ± 0.034
0.145CysHis: 0.145 ± 0.015
0.258CysIle: 0.258 ± 0.015
0.096CysLys: 0.096 ± 0.011
0.761CysLeu: 0.761 ± 0.027
0.128CysMet: 0.128 ± 0.012
0.137CysAsn: 0.137 ± 0.014
0.454CysPro: 0.454 ± 0.025
0.222CysGln: 0.222 ± 0.016
0.532CysArg: 0.532 ± 0.025
0.458CysSer: 0.458 ± 0.021
0.553CysThr: 0.553 ± 0.034
0.648CysVal: 0.648 ± 0.025
0.125CysTrp: 0.125 ± 0.012
0.187CysTyr: 0.187 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
9.614AspAla: 9.614 ± 0.115
0.414AspCys: 0.414 ± 0.022
4.05AspAsp: 4.05 ± 0.08
3.594AspGlu: 3.594 ± 0.066
1.631AspPhe: 1.631 ± 0.042
6.275AspGly: 6.275 ± 0.098
1.183AspHis: 1.183 ± 0.035
2.019AspIle: 2.019 ± 0.057
0.974AspLys: 0.974 ± 0.038
6.145AspLeu: 6.145 ± 0.089
1.002AspMet: 1.002 ± 0.033
1.05AspAsn: 1.05 ± 0.038
4.159AspPro: 4.159 ± 0.067
1.496AspGln: 1.496 ± 0.043
3.982AspArg: 3.982 ± 0.077
3.062AspSer: 3.062 ± 0.07
3.181AspThr: 3.181 ± 0.07
5.366AspVal: 5.366 ± 0.078
1.01AspTrp: 1.01 ± 0.038
1.467AspTyr: 1.467 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
7.706GluAla: 7.706 ± 0.111
0.354GluCys: 0.354 ± 0.018
3.211GluAsp: 3.211 ± 0.069
3.415GluGlu: 3.415 ± 0.073
1.249GluPhe: 1.249 ± 0.036
3.847GluGly: 3.847 ± 0.077
1.428GluHis: 1.428 ± 0.042
2.43GluIle: 2.43 ± 0.054
1.0GluLys: 1.0 ± 0.043
6.441GluLeu: 6.441 ± 0.096
1.05GluMet: 1.05 ± 0.033
1.066GluAsn: 1.066 ± 0.036
3.076GluPro: 3.076 ± 0.06
2.395GluGln: 2.395 ± 0.057
4.957GluArg: 4.957 ± 0.084
2.593GluSer: 2.593 ± 0.054
2.714GluThr: 2.714 ± 0.057
4.688GluVal: 4.688 ± 0.078
0.682GluTrp: 0.682 ± 0.029
1.104GluTyr: 1.104 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.081PheAla: 3.081 ± 0.063
0.218PheCys: 0.218 ± 0.016
1.817PheAsp: 1.817 ± 0.043
1.338PheGlu: 1.338 ± 0.04
0.913PhePhe: 0.913 ± 0.035
2.537PheGly: 2.537 ± 0.068
0.53PheHis: 0.53 ± 0.028
1.172PheIle: 1.172 ± 0.042
0.516PheLys: 0.516 ± 0.028
2.459PheLeu: 2.459 ± 0.063
0.516PheMet: 0.516 ± 0.024
0.728PheAsn: 0.728 ± 0.027
1.296PhePro: 1.296 ± 0.037
0.677PheGln: 0.677 ± 0.029
1.496PheArg: 1.496 ± 0.045
1.604PheSer: 1.604 ± 0.052
1.976PheThr: 1.976 ± 0.052
2.096PheVal: 2.096 ± 0.058
0.41PheTrp: 0.41 ± 0.022
0.631PheTyr: 0.631 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
11.793GlyAla: 11.793 ± 0.153
0.71GlyCys: 0.71 ± 0.026
4.723GlyAsp: 4.723 ± 0.082
4.814GlyGlu: 4.814 ± 0.079
2.589GlyPhe: 2.589 ± 0.051
7.765GlyGly: 7.765 ± 0.117
1.813GlyHis: 1.813 ± 0.04
3.762GlyIle: 3.762 ± 0.069
1.959GlyLys: 1.959 ± 0.061
8.898GlyLeu: 8.898 ± 0.117
2.113GlyMet: 2.113 ± 0.049
1.791GlyAsn: 1.791 ± 0.045
4.133GlyPro: 4.133 ± 0.07
2.761GlyGln: 2.761 ± 0.058
7.215GlyArg: 7.215 ± 0.112
5.244GlySer: 5.244 ± 0.089
6.015GlyThr: 6.015 ± 0.098
7.913GlyVal: 7.913 ± 0.097
1.54GlyTrp: 1.54 ± 0.044
2.259GlyTyr: 2.259 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.431HisAla: 2.431 ± 0.055
0.169HisCys: 0.169 ± 0.013
1.257HisAsp: 1.257 ± 0.041
1.101HisGlu: 1.101 ± 0.034
0.469HisPhe: 0.469 ± 0.024
1.896HisGly: 1.896 ± 0.049
0.512HisHis: 0.512 ± 0.022
0.608HisIle: 0.608 ± 0.024
0.302HisLys: 0.302 ± 0.018
2.192HisLeu: 2.192 ± 0.054
0.364HisMet: 0.364 ± 0.021
0.419HisAsn: 0.419 ± 0.022
1.444HisPro: 1.444 ± 0.05
0.52HisGln: 0.52 ± 0.026
1.674HisArg: 1.674 ± 0.044
0.929HisSer: 0.929 ± 0.031
1.086HisThr: 1.086 ± 0.03
1.662HisVal: 1.662 ± 0.044
0.309HisTrp: 0.309 ± 0.018
0.466HisTyr: 0.466 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.349IleAla: 5.349 ± 0.082
0.351IleCys: 0.351 ± 0.02
3.009IleAsp: 3.009 ± 0.05
2.215IleGlu: 2.215 ± 0.052
0.923IlePhe: 0.923 ± 0.038
3.919IleGly: 3.919 ± 0.073
0.685IleHis: 0.685 ± 0.025
1.711IleIle: 1.711 ± 0.056
0.777IleLys: 0.777 ± 0.03
3.31IleLeu: 3.31 ± 0.075
0.762IleMet: 0.762 ± 0.032
0.998IleAsn: 0.998 ± 0.04
2.178IlePro: 2.178 ± 0.049
0.927IleGln: 0.927 ± 0.032
2.255IleArg: 2.255 ± 0.045
2.094IleSer: 2.094 ± 0.053
2.81IleThr: 2.81 ± 0.067
3.535IleVal: 3.535 ± 0.073
0.456IleTrp: 0.456 ± 0.022
0.74IleTyr: 0.74 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
2.212LysAla: 2.212 ± 0.062
0.095LysCys: 0.095 ± 0.011
1.146LysAsp: 1.146 ± 0.042
1.025LysGlu: 1.025 ± 0.039
0.345LysPhe: 0.345 ± 0.02
1.362LysGly: 1.362 ± 0.046
0.388LysHis: 0.388 ± 0.02
0.736LysIle: 0.736 ± 0.033
0.496LysLys: 0.496 ± 0.03
1.429LysLeu: 1.429 ± 0.042
0.347LysMet: 0.347 ± 0.018
0.489LysAsn: 0.489 ± 0.027
0.938LysPro: 0.938 ± 0.04
0.7LysGln: 0.7 ± 0.033
1.441LysArg: 1.441 ± 0.048
0.947LysSer: 0.947 ± 0.034
1.157LysThr: 1.157 ± 0.035
1.477LysVal: 1.477 ± 0.045
0.223LysTrp: 0.223 ± 0.016
0.451LysTyr: 0.451 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.337LeuAla: 15.337 ± 0.172
0.748LeuCys: 0.748 ± 0.031
6.489LeuAsp: 6.489 ± 0.088
5.265LeuGlu: 5.265 ± 0.092
2.359LeuPhe: 2.359 ± 0.057
9.087LeuGly: 9.087 ± 0.126
1.895LeuHis: 1.895 ± 0.048
3.91LeuIle: 3.91 ± 0.086
1.674LeuLys: 1.674 ± 0.047
10.555LeuLeu: 10.555 ± 0.155
1.917LeuMet: 1.917 ± 0.047
1.933LeuAsn: 1.933 ± 0.053
6.021LeuPro: 6.021 ± 0.082
2.109LeuGln: 2.109 ± 0.049
7.556LeuArg: 7.556 ± 0.107
5.655LeuSer: 5.655 ± 0.081
6.842LeuThr: 6.842 ± 0.102
8.831LeuVal: 8.831 ± 0.116
1.204LeuTrp: 1.204 ± 0.035
1.619LeuTyr: 1.619 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.343MetAla: 2.343 ± 0.057
0.142MetCys: 0.142 ± 0.011
1.012MetAsp: 1.012 ± 0.034
0.86MetGlu: 0.86 ± 0.03
0.526MetPhe: 0.526 ± 0.026
1.55MetGly: 1.55 ± 0.045
0.371MetHis: 0.371 ± 0.019
0.8MetIle: 0.8 ± 0.033
0.369MetLys: 0.369 ± 0.023
1.953MetLeu: 1.953 ± 0.049
0.332MetMet: 0.332 ± 0.022
0.506MetAsn: 0.506 ± 0.021
1.208MetPro: 1.208 ± 0.034
0.509MetGln: 0.509 ± 0.023
1.606MetArg: 1.606 ± 0.039
1.704MetSer: 1.704 ± 0.042
1.701MetThr: 1.701 ± 0.034
1.549MetVal: 1.549 ± 0.04
0.204MetTrp: 0.204 ± 0.015
0.338MetTyr: 0.338 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.411AsnAla: 2.411 ± 0.056
0.144AsnCys: 0.144 ± 0.011
1.158AsnAsp: 1.158 ± 0.04
0.94AsnGlu: 0.94 ± 0.032
0.528AsnPhe: 0.528 ± 0.027
1.786AsnGly: 1.786 ± 0.052
0.473AsnHis: 0.473 ± 0.025
0.839AsnIle: 0.839 ± 0.034
0.39AsnLys: 0.39 ± 0.025
1.999AsnLeu: 1.999 ± 0.057
0.378AsnMet: 0.378 ± 0.017
0.538AsnAsn: 0.538 ± 0.029
1.487AsnPro: 1.487 ± 0.038
0.647AsnGln: 0.647 ± 0.028
1.411AsnArg: 1.411 ± 0.041
1.033AsnSer: 1.033 ± 0.035
1.294AsnThr: 1.294 ± 0.045
1.516AsnVal: 1.516 ± 0.043
0.322AsnTrp: 0.322 ± 0.021
0.532AsnTyr: 0.532 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
8.442ProAla: 8.442 ± 0.115
0.269ProCys: 0.269 ± 0.019
4.129ProAsp: 4.129 ± 0.077
4.08ProGlu: 4.08 ± 0.073
1.395ProPhe: 1.395 ± 0.045
5.729ProGly: 5.729 ± 0.088
1.068ProHis: 1.068 ± 0.034
1.735ProIle: 1.735 ± 0.047
0.859ProLys: 0.859 ± 0.032
4.97ProLeu: 4.97 ± 0.073
0.97ProMet: 0.97 ± 0.031
1.024ProAsn: 1.024 ± 0.035
2.568ProPro: 2.568 ± 0.077
1.765ProGln: 1.765 ± 0.042
3.527ProArg: 3.527 ± 0.074
3.118ProSer: 3.118 ± 0.058
3.862ProThr: 3.862 ± 0.074
5.024ProVal: 5.024 ± 0.087
0.915ProTrp: 0.915 ± 0.036
1.137ProTyr: 1.137 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.468GlnAla: 4.468 ± 0.074
0.17GlnCys: 0.17 ± 0.015
1.47GlnAsp: 1.47 ± 0.039
1.699GlnGlu: 1.699 ± 0.041
0.654GlnPhe: 0.654 ± 0.029
2.148GlnGly: 2.148 ± 0.054
0.544GlnHis: 0.544 ± 0.023
1.282GlnIle: 1.282 ± 0.039
0.445GlnLys: 0.445 ± 0.023
2.895GlnLeu: 2.895 ± 0.061
0.608GlnMet: 0.608 ± 0.024
0.521GlnAsn: 0.521 ± 0.024
1.585GlnPro: 1.585 ± 0.05
1.15GlnGln: 1.15 ± 0.037
2.337GlnArg: 2.337 ± 0.06
1.311GlnSer: 1.311 ± 0.041
1.558GlnThr: 1.558 ± 0.04
2.882GlnVal: 2.882 ± 0.053
0.477GlnTrp: 0.477 ± 0.026
0.601GlnTyr: 0.601 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.643ArgAla: 9.643 ± 0.116
0.528ArgCys: 0.528 ± 0.025
3.82ArgAsp: 3.82 ± 0.078
4.526ArgGlu: 4.526 ± 0.077
2.025ArgPhe: 2.025 ± 0.05
5.51ArgGly: 5.51 ± 0.097
1.755ArgHis: 1.755 ± 0.049
3.287ArgIle: 3.287 ± 0.064
1.309ArgLys: 1.309 ± 0.048
8.141ArgLeu: 8.141 ± 0.12
1.715ArgMet: 1.715 ± 0.045
1.364ArgAsn: 1.364 ± 0.036
4.39ArgPro: 4.39 ± 0.085
2.075ArgGln: 2.075 ± 0.051
7.752ArgArg: 7.752 ± 0.118
4.102ArgSer: 4.102 ± 0.071
4.493ArgThr: 4.493 ± 0.071
5.861ArgVal: 5.861 ± 0.1
1.188ArgTrp: 1.188 ± 0.038
1.601ArgTyr: 1.601 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
7.589SerAla: 7.589 ± 0.107
0.387SerCys: 0.387 ± 0.022
2.851SerAsp: 2.851 ± 0.059
2.495SerGlu: 2.495 ± 0.064
1.738SerPhe: 1.738 ± 0.049
5.92SerGly: 5.92 ± 0.079
0.926SerHis: 0.926 ± 0.034
2.002SerIle: 2.002 ± 0.052
0.971SerLys: 0.971 ± 0.034
5.356SerLeu: 5.356 ± 0.09
1.158SerMet: 1.158 ± 0.039
1.064SerAsn: 1.064 ± 0.037
3.319SerPro: 3.319 ± 0.067
1.611SerGln: 1.611 ± 0.041
4.1SerArg: 4.1 ± 0.076
3.472SerSer: 3.472 ± 0.075
3.788SerThr: 3.788 ± 0.079
4.284SerVal: 4.284 ± 0.081
0.908SerTrp: 0.908 ± 0.03
1.242SerTyr: 1.242 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
8.849ThrAla: 8.849 ± 0.126
0.536ThrCys: 0.536 ± 0.032
3.821ThrAsp: 3.821 ± 0.075
2.92ThrGlu: 2.92 ± 0.051
1.644ThrPhe: 1.644 ± 0.055
6.329ThrGly: 6.329 ± 0.092
1.149ThrHis: 1.149 ± 0.038
2.647ThrIle: 2.647 ± 0.064
0.966ThrLys: 0.966 ± 0.037
5.685ThrLeu: 5.685 ± 0.094
1.082ThrMet: 1.082 ± 0.033
1.293ThrAsn: 1.293 ± 0.048
4.164ThrPro: 4.164 ± 0.07
1.612ThrGln: 1.612 ± 0.046
4.022ThrArg: 4.022 ± 0.072
3.501ThrSer: 3.501 ± 0.069
4.443ThrThr: 4.443 ± 0.081
5.91ThrVal: 5.91 ± 0.1
1.093ThrTrp: 1.093 ± 0.046
1.425ThrTyr: 1.425 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
11.195ValAla: 11.195 ± 0.123
0.761ValCys: 0.761 ± 0.03
5.608ValAsp: 5.608 ± 0.09
4.6ValGlu: 4.6 ± 0.078
2.448ValPhe: 2.448 ± 0.053
7.279ValGly: 7.279 ± 0.11
1.677ValHis: 1.677 ± 0.048
3.789ValIle: 3.789 ± 0.066
1.454ValLys: 1.454 ± 0.043
9.404ValLeu: 9.404 ± 0.136
1.676ValMet: 1.676 ± 0.038
1.775ValAsn: 1.775 ± 0.046
5.071ValPro: 5.071 ± 0.082
2.038ValGln: 2.038 ± 0.038
6.055ValArg: 6.055 ± 0.091
5.208ValSer: 5.208 ± 0.081
5.68ValThr: 5.68 ± 0.111
8.894ValVal: 8.894 ± 0.12
1.03ValTrp: 1.03 ± 0.033
1.588ValTyr: 1.588 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.692TrpAla: 1.692 ± 0.046
0.162TrpCys: 0.162 ± 0.012
0.938TrpAsp: 0.938 ± 0.031
0.867TrpGlu: 0.867 ± 0.033
0.441TrpPhe: 0.441 ± 0.022
1.072TrpGly: 1.072 ± 0.04
0.322TrpHis: 0.322 ± 0.018
0.629TrpIle: 0.629 ± 0.027
0.275TrpLys: 0.275 ± 0.017
1.687TrpLeu: 1.687 ± 0.052
0.343TrpMet: 0.343 ± 0.021
0.433TrpAsn: 0.433 ± 0.02
0.662TrpPro: 0.662 ± 0.033
0.537TrpGln: 0.537 ± 0.024
1.334TrpArg: 1.334 ± 0.041
0.88TrpSer: 0.88 ± 0.032
0.961TrpThr: 0.961 ± 0.036
1.114TrpVal: 1.114 ± 0.036
0.354TrpTrp: 0.354 ± 0.023
0.327TrpTyr: 0.327 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.53TyrAla: 2.53 ± 0.06
0.166TyrCys: 0.166 ± 0.014
1.353TyrAsp: 1.353 ± 0.041
1.172TyrGlu: 1.172 ± 0.04
0.676TyrPhe: 0.676 ± 0.031
1.973TyrGly: 1.973 ± 0.047
0.4TyrHis: 0.4 ± 0.02
0.708TyrIle: 0.708 ± 0.028
0.373TyrLys: 0.373 ± 0.021
2.237TyrLeu: 2.237 ± 0.05
0.348TyrMet: 0.348 ± 0.019
0.497TyrAsn: 0.497 ± 0.025
1.143TyrPro: 1.143 ± 0.034
0.695TyrGln: 0.695 ± 0.032
1.649TyrArg: 1.649 ± 0.046
1.151TyrSer: 1.151 ± 0.038
1.33TyrThr: 1.33 ± 0.043
1.629TyrVal: 1.629 ± 0.044
0.34TyrTrp: 0.34 ± 0.021
0.569TyrTyr: 0.569 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2725 proteins (958828 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski