Amino acid dipepetide frequency for Torque teno virus 13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.563AlaAla: 3.563 ± 1.44
0.0AlaCys: 0.0 ± 0.0
2.375AlaAsp: 2.375 ± 1.159
2.375AlaGlu: 2.375 ± 1.159
1.188AlaPhe: 1.188 ± 2.599
5.938AlaGly: 5.938 ± 6.639
1.188AlaHis: 1.188 ± 0.58
1.188AlaIle: 1.188 ± 0.58
4.751AlaLys: 4.751 ± 2.318
3.563AlaLeu: 3.563 ± 1.739
0.0AlaMet: 0.0 ± 0.0
1.188AlaAsn: 1.188 ± 0.58
4.751AlaPro: 4.751 ± 4.04
3.563AlaGln: 3.563 ± 1.739
8.314AlaArg: 8.314 ± 11.838
2.375AlaSer: 2.375 ± 2.02
3.563AlaThr: 3.563 ± 1.44
3.563AlaVal: 3.563 ± 1.44
0.0AlaTrp: 0.0 ± 0.0
1.188AlaTyr: 1.188 ± 0.58
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
3.563CysGly: 3.563 ± 1.44
1.188CysHis: 1.188 ± 0.58
0.0CysIle: 0.0 ± 0.0
2.375CysLys: 2.375 ± 1.159
1.188CysLeu: 1.188 ± 0.58
0.0CysMet: 0.0 ± 0.0
1.188CysAsn: 1.188 ± 0.58
2.375CysPro: 2.375 ± 1.159
0.0CysGln: 0.0 ± 0.0
1.188CysArg: 1.188 ± 2.599
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.188CysVal: 1.188 ± 0.58
1.188CysTrp: 1.188 ± 2.599
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.751AspAla: 4.751 ± 4.04
0.0AspCys: 0.0 ± 0.0
3.563AspAsp: 3.563 ± 1.739
2.375AspGlu: 2.375 ± 5.199
3.563AspPhe: 3.563 ± 1.739
3.563AspGly: 3.563 ± 4.619
0.0AspHis: 0.0 ± 0.0
2.375AspIle: 2.375 ± 1.159
4.751AspLys: 4.751 ± 2.318
10.689AspLeu: 10.689 ± 2.037
1.188AspMet: 1.188 ± 0.58
4.751AspAsn: 4.751 ± 2.318
5.938AspPro: 5.938 ± 0.281
2.375AspGln: 2.375 ± 1.159
1.188AspArg: 1.188 ± 0.58
3.563AspSer: 3.563 ± 1.739
3.563AspThr: 3.563 ± 1.739
2.375AspVal: 2.375 ± 2.02
0.0AspTrp: 0.0 ± 0.0
2.375AspTyr: 2.375 ± 1.159
0.0AspXaa: 0.0 ± 0.0
Glu
0.0GluAla: 0.0 ± 0.0
1.188GluCys: 1.188 ± 0.58
3.563GluAsp: 3.563 ± 1.44
4.751GluGlu: 4.751 ± 4.04
2.375GluPhe: 2.375 ± 1.159
7.126GluGly: 7.126 ± 2.881
0.0GluHis: 0.0 ± 0.0
2.375GluIle: 2.375 ± 1.159
0.0GluLys: 0.0 ± 0.0
4.751GluLeu: 4.751 ± 4.04
0.0GluMet: 0.0 ± 0.0
1.188GluAsn: 1.188 ± 0.58
0.0GluPro: 0.0 ± 0.0
4.751GluGln: 4.751 ± 4.04
2.375GluArg: 2.375 ± 2.02
3.563GluSer: 3.563 ± 1.44
5.938GluThr: 5.938 ± 2.898
0.0GluVal: 0.0 ± 0.0
0.0GluTrp: 0.0 ± 0.0
3.563GluTyr: 3.563 ± 1.44
0.0GluXaa: 0.0 ± 0.0
Phe
4.751PheAla: 4.751 ± 2.318
1.188PheCys: 1.188 ± 2.599
2.375PheAsp: 2.375 ± 1.159
1.188PheGlu: 1.188 ± 0.58
1.188PhePhe: 1.188 ± 0.58
4.751PheGly: 4.751 ± 0.861
1.188PheHis: 1.188 ± 2.599
1.188PheIle: 1.188 ± 0.58
2.375PheLys: 2.375 ± 1.159
3.563PheLeu: 3.563 ± 1.44
1.188PheMet: 1.188 ± 0.58
1.188PheAsn: 1.188 ± 0.58
2.375PhePro: 2.375 ± 1.159
4.751PheGln: 4.751 ± 2.318
1.188PheArg: 1.188 ± 0.58
1.188PheSer: 1.188 ± 0.58
7.126PheThr: 7.126 ± 3.477
2.375PheVal: 2.375 ± 1.159
0.0PheTrp: 0.0 ± 0.0
3.563PheTyr: 3.563 ± 1.739
0.0PheXaa: 0.0 ± 0.0
Gly
5.938GlyAla: 5.938 ± 9.818
3.563GlyCys: 3.563 ± 1.44
8.314GlyAsp: 8.314 ± 8.659
5.938GlyGlu: 5.938 ± 6.639
3.563GlyPhe: 3.563 ± 1.739
7.126GlyGly: 7.126 ± 6.06
1.188GlyHis: 1.188 ± 0.58
0.0GlyIle: 0.0 ± 0.0
7.126GlyLys: 7.126 ± 0.298
1.188GlyLeu: 1.188 ± 0.58
3.563GlyMet: 3.563 ± 1.739
2.375GlyAsn: 2.375 ± 1.159
7.126GlyPro: 7.126 ± 2.881
2.375GlyGln: 2.375 ± 1.159
1.188GlyArg: 1.188 ± 0.58
1.188GlySer: 1.188 ± 0.58
3.563GlyThr: 3.563 ± 1.739
0.0GlyVal: 0.0 ± 0.0
0.0GlyTrp: 0.0 ± 0.0
3.563GlyTyr: 3.563 ± 1.739
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
2.375HisAsp: 2.375 ± 2.02
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
2.375HisIle: 2.375 ± 1.159
0.0HisLys: 0.0 ± 0.0
2.375HisLeu: 2.375 ± 2.02
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
3.563HisPro: 3.563 ± 1.739
3.563HisGln: 3.563 ± 1.44
1.188HisArg: 1.188 ± 0.58
2.375HisSer: 2.375 ± 1.159
2.375HisThr: 2.375 ± 1.159
0.0HisVal: 0.0 ± 0.0
1.188HisTrp: 1.188 ± 0.58
1.188HisTyr: 1.188 ± 0.58
0.0HisXaa: 0.0 ± 0.0
Ile
1.188IleAla: 1.188 ± 0.58
0.0IleCys: 0.0 ± 0.0
3.563IleAsp: 3.563 ± 1.739
0.0IleGlu: 0.0 ± 0.0
2.375IlePhe: 2.375 ± 1.159
0.0IleGly: 0.0 ± 0.0
0.0IleHis: 0.0 ± 0.0
1.188IleIle: 1.188 ± 0.58
2.375IleLys: 2.375 ± 1.159
3.563IleLeu: 3.563 ± 1.739
0.0IleMet: 0.0 ± 0.0
1.188IleAsn: 1.188 ± 0.58
2.375IlePro: 2.375 ± 1.159
2.375IleGln: 2.375 ± 1.159
3.563IleArg: 3.563 ± 1.739
2.375IleSer: 2.375 ± 1.159
2.375IleThr: 2.375 ± 1.159
1.188IleVal: 1.188 ± 0.58
2.375IleTrp: 2.375 ± 1.159
1.188IleTyr: 1.188 ± 0.58
0.0IleXaa: 0.0 ± 0.0
Lys
1.188LysAla: 1.188 ± 0.58
0.0LysCys: 0.0 ± 0.0
2.375LysAsp: 2.375 ± 1.159
1.188LysGlu: 1.188 ± 0.58
1.188LysPhe: 1.188 ± 0.58
7.126LysGly: 7.126 ± 3.477
0.0LysHis: 0.0 ± 0.0
1.188LysIle: 1.188 ± 0.58
4.751LysLys: 4.751 ± 0.861
4.751LysLeu: 4.751 ± 4.04
0.0LysMet: 0.0 ± 0.0
3.563LysAsn: 3.563 ± 1.739
4.751LysPro: 4.751 ± 2.318
1.188LysGln: 1.188 ± 0.58
2.375LysArg: 2.375 ± 2.02
0.0LysSer: 0.0 ± 0.0
8.314LysThr: 8.314 ± 4.057
1.188LysVal: 1.188 ± 0.58
4.751LysTrp: 4.751 ± 2.318
3.563LysTyr: 3.563 ± 1.739
0.0LysXaa: 0.0 ± 0.0
Leu
5.938LeuAla: 5.938 ± 0.281
3.563LeuCys: 3.563 ± 1.44
5.938LeuAsp: 5.938 ± 0.281
4.751LeuGlu: 4.751 ± 2.318
5.938LeuPhe: 5.938 ± 0.281
3.563LeuGly: 3.563 ± 1.44
3.563LeuHis: 3.563 ± 1.739
5.938LeuIle: 5.938 ± 2.898
0.0LeuLys: 0.0 ± 0.0
10.689LeuLeu: 10.689 ± 4.321
2.375LeuMet: 2.375 ± 1.159
3.563LeuAsn: 3.563 ± 1.739
5.938LeuPro: 5.938 ± 3.46
3.563LeuGln: 3.563 ± 1.44
5.938LeuArg: 5.938 ± 2.898
3.563LeuSer: 3.563 ± 1.44
3.563LeuThr: 3.563 ± 1.739
2.375LeuVal: 2.375 ± 1.159
2.375LeuTrp: 2.375 ± 1.159
7.126LeuTyr: 7.126 ± 0.298
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
2.375MetPhe: 2.375 ± 2.02
1.188MetGly: 1.188 ± 0.58
0.0MetHis: 0.0 ± 0.0
1.188MetIle: 1.188 ± 0.58
1.188MetLys: 1.188 ± 0.58
2.375MetLeu: 2.375 ± 1.159
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.375MetPro: 2.375 ± 1.159
0.0MetGln: 0.0 ± 0.0
2.375MetArg: 2.375 ± 1.159
1.188MetSer: 1.188 ± 2.599
1.188MetThr: 1.188 ± 0.58
2.375MetVal: 2.375 ± 1.159
0.0MetTrp: 0.0 ± 0.0
1.188MetTyr: 1.188 ± 0.58
0.0MetXaa: 0.0 ± 0.0
Asn
0.0AsnAla: 0.0 ± 0.0
1.188AsnCys: 1.188 ± 0.58
1.188AsnAsp: 1.188 ± 0.58
1.188AsnGlu: 1.188 ± 0.58
3.563AsnPhe: 3.563 ± 1.739
1.188AsnGly: 1.188 ± 0.58
2.375AsnHis: 2.375 ± 2.02
3.563AsnIle: 3.563 ± 1.739
3.563AsnLys: 3.563 ± 1.739
3.563AsnLeu: 3.563 ± 1.739
2.375AsnMet: 2.375 ± 1.159
4.751AsnAsn: 4.751 ± 2.318
4.751AsnPro: 4.751 ± 2.318
2.375AsnGln: 2.375 ± 1.159
1.188AsnArg: 1.188 ± 0.58
3.563AsnSer: 3.563 ± 1.739
3.563AsnThr: 3.563 ± 1.739
0.0AsnVal: 0.0 ± 0.0
0.0AsnTrp: 0.0 ± 0.0
1.188AsnTyr: 1.188 ± 0.58
0.0AsnXaa: 0.0 ± 0.0
Pro
3.563ProAla: 3.563 ± 1.739
2.375ProCys: 2.375 ± 1.159
2.375ProAsp: 2.375 ± 1.159
3.563ProGlu: 3.563 ± 1.44
2.375ProPhe: 2.375 ± 1.159
4.751ProGly: 4.751 ± 4.04
0.0ProHis: 0.0 ± 0.0
1.188ProIle: 1.188 ± 0.58
2.375ProLys: 2.375 ± 1.159
13.064ProLeu: 13.064 ± 3.196
1.188ProMet: 1.188 ± 0.58
1.188ProAsn: 1.188 ± 0.58
8.314ProPro: 8.314 ± 2.301
5.938ProGln: 5.938 ± 3.46
5.938ProArg: 5.938 ± 0.281
5.938ProSer: 5.938 ± 6.639
3.563ProThr: 3.563 ± 4.619
4.751ProVal: 4.751 ± 4.04
2.375ProTrp: 2.375 ± 1.159
1.188ProTyr: 1.188 ± 0.58
0.0ProXaa: 0.0 ± 0.0
Gln
7.126GlnAla: 7.126 ± 6.06
0.0GlnCys: 0.0 ± 0.0
3.563GlnAsp: 3.563 ± 1.739
2.375GlnGlu: 2.375 ± 2.02
3.563GlnPhe: 3.563 ± 1.739
2.375GlnGly: 2.375 ± 2.02
1.188GlnHis: 1.188 ± 0.58
1.188GlnIle: 1.188 ± 0.58
0.0GlnLys: 0.0 ± 0.0
7.126GlnLeu: 7.126 ± 3.477
1.188GlnMet: 1.188 ± 1.01
2.375GlnAsn: 2.375 ± 1.159
2.375GlnPro: 2.375 ± 1.159
5.938GlnGln: 5.938 ± 2.898
4.751GlnArg: 4.751 ± 2.318
2.375GlnSer: 2.375 ± 1.159
4.751GlnThr: 4.751 ± 2.318
4.751GlnVal: 4.751 ± 2.318
1.188GlnTrp: 1.188 ± 0.58
4.751GlnTyr: 4.751 ± 2.318
0.0GlnXaa: 0.0 ± 0.0
Arg
3.563ArgAla: 3.563 ± 4.619
1.188ArgCys: 1.188 ± 0.58
7.126ArgAsp: 7.126 ± 0.298
7.126ArgGlu: 7.126 ± 2.881
2.375ArgPhe: 2.375 ± 1.159
5.938ArgGly: 5.938 ± 3.46
2.375ArgHis: 2.375 ± 1.159
0.0ArgIle: 0.0 ± 0.0
3.563ArgLys: 3.563 ± 4.619
4.751ArgLeu: 4.751 ± 4.04
0.0ArgMet: 0.0 ± 0.0
3.563ArgAsn: 3.563 ± 1.739
4.751ArgPro: 4.751 ± 4.04
2.375ArgGln: 2.375 ± 1.159
4.751ArgArg: 4.751 ± 0.861
7.126ArgSer: 7.126 ± 2.881
0.0ArgThr: 0.0 ± 0.0
4.751ArgVal: 4.751 ± 0.861
2.375ArgTrp: 2.375 ± 2.02
1.188ArgTyr: 1.188 ± 0.58
0.0ArgXaa: 0.0 ± 0.0
Ser
3.563SerAla: 3.563 ± 4.619
0.0SerCys: 0.0 ± 0.0
3.563SerAsp: 3.563 ± 1.739
3.563SerGlu: 3.563 ± 1.739
4.751SerPhe: 4.751 ± 2.318
3.563SerGly: 3.563 ± 1.739
2.375SerHis: 2.375 ± 2.02
0.0SerIle: 0.0 ± 0.0
2.375SerLys: 2.375 ± 1.159
2.375SerLeu: 2.375 ± 1.159
2.375SerMet: 2.375 ± 2.02
3.563SerAsn: 3.563 ± 1.44
3.563SerPro: 3.563 ± 1.739
4.751SerGln: 4.751 ± 2.318
2.375SerArg: 2.375 ± 2.02
9.501SerSer: 9.501 ± 4.901
1.188SerThr: 1.188 ± 2.599
1.188SerVal: 1.188 ± 2.599
1.188SerTrp: 1.188 ± 2.599
2.375SerTyr: 2.375 ± 2.02
0.0SerXaa: 0.0 ± 0.0
Thr
4.751ThrAla: 4.751 ± 2.318
1.188ThrCys: 1.188 ± 0.58
7.126ThrAsp: 7.126 ± 0.298
4.751ThrGlu: 4.751 ± 0.861
4.751ThrPhe: 4.751 ± 2.318
3.563ThrGly: 3.563 ± 1.739
2.375ThrHis: 2.375 ± 1.159
3.563ThrIle: 3.563 ± 1.739
4.751ThrLys: 4.751 ± 2.318
1.188ThrLeu: 1.188 ± 0.58
1.188ThrMet: 1.188 ± 0.58
5.938ThrAsn: 5.938 ± 2.898
4.751ThrPro: 4.751 ± 4.04
7.126ThrGln: 7.126 ± 3.477
2.375ThrArg: 2.375 ± 1.159
1.188ThrSer: 1.188 ± 0.58
2.375ThrThr: 2.375 ± 1.159
0.0ThrVal: 0.0 ± 0.0
0.0ThrTrp: 0.0 ± 0.0
1.188ThrTyr: 1.188 ± 0.58
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.0ValCys: 0.0 ± 0.0
2.375ValAsp: 2.375 ± 1.159
1.188ValGlu: 1.188 ± 0.58
1.188ValPhe: 1.188 ± 2.599
0.0ValGly: 0.0 ± 0.0
1.188ValHis: 1.188 ± 0.58
2.375ValIle: 2.375 ± 1.159
2.375ValLys: 2.375 ± 1.159
7.126ValLeu: 7.126 ± 3.477
1.188ValMet: 1.188 ± 0.58
0.0ValAsn: 0.0 ± 0.0
3.563ValPro: 3.563 ± 1.44
1.188ValGln: 1.188 ± 0.58
5.938ValArg: 5.938 ± 6.639
2.375ValSer: 2.375 ± 2.02
1.188ValThr: 1.188 ± 0.58
3.563ValVal: 3.563 ± 1.739
0.0ValTrp: 0.0 ± 0.0
2.375ValTyr: 2.375 ± 1.159
0.0ValXaa: 0.0 ± 0.0
Trp
2.375TrpAla: 2.375 ± 1.159
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.188TrpGlu: 1.188 ± 0.58
1.188TrpPhe: 1.188 ± 0.58
1.188TrpGly: 1.188 ± 0.58
0.0TrpHis: 0.0 ± 0.0
1.188TrpIle: 1.188 ± 0.58
1.188TrpLys: 1.188 ± 0.58
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.188TrpPro: 1.188 ± 2.599
3.563TrpGln: 3.563 ± 1.739
1.188TrpArg: 1.188 ± 2.599
1.188TrpSer: 1.188 ± 0.58
1.188TrpThr: 1.188 ± 0.58
1.188TrpVal: 1.188 ± 0.58
0.0TrpTrp: 0.0 ± 0.0
3.563TrpTyr: 3.563 ± 1.44
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.375TyrAla: 2.375 ± 1.159
0.0TyrCys: 0.0 ± 0.0
1.188TyrAsp: 1.188 ± 0.58
0.0TyrGlu: 0.0 ± 0.0
1.188TyrPhe: 1.188 ± 0.58
2.375TyrGly: 2.375 ± 1.159
2.375TyrHis: 2.375 ± 1.159
1.188TyrIle: 1.188 ± 0.58
3.563TyrLys: 3.563 ± 1.739
2.375TyrLeu: 2.375 ± 1.159
0.0TyrMet: 0.0 ± 0.0
3.563TyrAsn: 3.563 ± 1.739
1.188TyrPro: 1.188 ± 2.599
2.375TyrGln: 2.375 ± 1.159
9.501TyrArg: 9.501 ± 4.901
3.563TyrSer: 3.563 ± 1.739
4.751TyrThr: 4.751 ± 2.318
2.375TyrVal: 2.375 ± 1.159
2.375TyrTrp: 2.375 ± 1.159
1.188TyrTyr: 1.188 ± 0.58
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski