Amino acid dipepetide frequency for Granulicatella sp. zg-ZJ

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.779AlaAla: 3.779 ± 0.131
0.555AlaCys: 0.555 ± 0.033
3.124AlaAsp: 3.124 ± 0.088
3.351AlaGlu: 3.351 ± 0.097
2.9AlaPhe: 2.9 ± 0.082
4.11AlaGly: 4.11 ± 0.106
1.258AlaHis: 1.258 ± 0.053
5.813AlaIle: 5.813 ± 0.137
4.967AlaLys: 4.967 ± 0.139
7.234AlaLeu: 7.234 ± 0.149
1.857AlaMet: 1.857 ± 0.066
2.907AlaAsn: 2.907 ± 0.077
1.805AlaPro: 1.805 ± 0.067
2.492AlaGln: 2.492 ± 0.077
2.375AlaArg: 2.375 ± 0.071
3.703AlaSer: 3.703 ± 0.081
4.264AlaThr: 4.264 ± 0.116
4.364AlaVal: 4.364 ± 0.1
0.414AlaTrp: 0.414 ± 0.03
2.713AlaTyr: 2.713 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.519CysAla: 0.519 ± 0.03
0.145CysCys: 0.145 ± 0.017
0.453CysAsp: 0.453 ± 0.033
0.41CysGlu: 0.41 ± 0.035
0.455CysPhe: 0.455 ± 0.029
0.573CysGly: 0.573 ± 0.031
0.312CysHis: 0.312 ± 0.029
0.631CysIle: 0.631 ± 0.037
0.302CysLys: 0.302 ± 0.024
0.87CysLeu: 0.87 ± 0.053
0.212CysMet: 0.212 ± 0.022
0.21CysAsn: 0.21 ± 0.018
0.297CysPro: 0.297 ± 0.026
0.46CysGln: 0.46 ± 0.027
0.299CysArg: 0.299 ± 0.022
0.451CysSer: 0.451 ± 0.028
0.343CysThr: 0.343 ± 0.024
0.635CysVal: 0.635 ± 0.039
0.065CysTrp: 0.065 ± 0.011
0.295CysTyr: 0.295 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.759AspAla: 3.759 ± 0.092
0.414AspCys: 0.414 ± 0.027
2.972AspAsp: 2.972 ± 0.085
4.265AspGlu: 4.265 ± 0.138
2.551AspPhe: 2.551 ± 0.075
3.566AspGly: 3.566 ± 0.485
0.776AspHis: 0.776 ± 0.036
5.471AspIle: 5.471 ± 0.111
4.651AspLys: 4.651 ± 0.117
4.744AspLeu: 4.744 ± 0.102
1.701AspMet: 1.701 ± 0.06
2.623AspAsn: 2.623 ± 0.08
1.325AspPro: 1.325 ± 0.079
0.965AspGln: 0.965 ± 0.043
1.811AspArg: 1.811 ± 0.058
2.777AspSer: 2.777 ± 0.154
4.18AspThr: 4.18 ± 0.105
5.071AspVal: 5.071 ± 0.098
0.508AspTrp: 0.508 ± 0.031
2.575AspTyr: 2.575 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
4.334GluAla: 4.334 ± 0.108
0.486GluCys: 0.486 ± 0.033
3.568GluAsp: 3.568 ± 0.093
5.655GluGlu: 5.655 ± 0.147
2.11GluPhe: 2.11 ± 0.059
3.184GluGly: 3.184 ± 0.082
1.879GluHis: 1.879 ± 0.067
4.653GluIle: 4.653 ± 0.097
7.46GluLys: 7.46 ± 0.162
6.093GluLeu: 6.093 ± 0.128
1.915GluMet: 1.915 ± 0.056
4.225GluAsn: 4.225 ± 0.112
1.761GluPro: 1.761 ± 0.063
3.718GluGln: 3.718 ± 0.099
3.024GluArg: 3.024 ± 0.077
3.364GluSer: 3.364 ± 0.261
4.416GluThr: 4.416 ± 0.122
4.458GluVal: 4.458 ± 0.096
0.668GluTrp: 0.668 ± 0.034
2.46GluTyr: 2.46 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.432PheAla: 2.432 ± 0.076
0.347PheCys: 0.347 ± 0.023
2.829PheAsp: 2.829 ± 0.077
2.865PheGlu: 2.865 ± 0.079
2.037PhePhe: 2.037 ± 0.076
2.82PheGly: 2.82 ± 0.081
0.85PheHis: 0.85 ± 0.04
3.564PheIle: 3.564 ± 0.098
2.792PheLys: 2.792 ± 0.078
4.011PheLeu: 4.011 ± 0.1
1.145PheMet: 1.145 ± 0.048
1.835PheAsn: 1.835 ± 0.063
1.302PhePro: 1.302 ± 0.05
1.354PheGln: 1.354 ± 0.046
1.334PheArg: 1.334 ± 0.044
3.345PheSer: 3.345 ± 0.079
2.443PheThr: 2.443 ± 0.072
3.238PheVal: 3.238 ± 0.09
0.306PheTrp: 0.306 ± 0.024
1.839PheTyr: 1.839 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
4.21GlyAla: 4.21 ± 0.116
0.49GlyCys: 0.49 ± 0.038
3.173GlyAsp: 3.173 ± 0.201
3.64GlyGlu: 3.64 ± 0.08
2.733GlyPhe: 2.733 ± 0.08
3.803GlyGly: 3.803 ± 0.113
1.336GlyHis: 1.336 ± 0.05
5.214GlyIle: 5.214 ± 0.13
4.67GlyLys: 4.67 ± 0.094
5.551GlyLeu: 5.551 ± 0.116
1.705GlyMet: 1.705 ± 0.061
2.64GlyAsn: 2.64 ± 0.091
1.026GlyPro: 1.026 ± 0.05
2.362GlyGln: 2.362 ± 0.069
2.273GlyArg: 2.273 ± 0.067
3.356GlySer: 3.356 ± 0.094
4.239GlyThr: 4.239 ± 0.163
4.926GlyVal: 4.926 ± 0.156
0.49GlyTrp: 0.49 ± 0.035
2.946GlyTyr: 2.946 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.404HisAla: 1.404 ± 0.051
0.184HisCys: 0.184 ± 0.021
1.308HisAsp: 1.308 ± 0.115
1.301HisGlu: 1.301 ± 0.055
1.122HisPhe: 1.122 ± 0.045
1.262HisGly: 1.262 ± 0.054
0.874HisHis: 0.874 ± 0.045
2.1HisIle: 2.1 ± 0.067
1.215HisLys: 1.215 ± 0.053
2.347HisLeu: 2.347 ± 0.066
0.378HisMet: 0.378 ± 0.023
0.755HisAsn: 0.755 ± 0.037
0.87HisPro: 0.87 ± 0.045
1.137HisGln: 1.137 ± 0.053
0.794HisArg: 0.794 ± 0.04
1.028HisSer: 1.028 ± 0.047
1.393HisThr: 1.393 ± 0.054
1.761HisVal: 1.761 ± 0.057
0.154HisTrp: 0.154 ± 0.017
1.095HisTyr: 1.095 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
5.557IleAla: 5.557 ± 0.118
0.79IleCys: 0.79 ± 0.047
5.269IleAsp: 5.269 ± 0.116
5.386IleGlu: 5.386 ± 0.109
3.304IlePhe: 3.304 ± 0.091
5.152IleGly: 5.152 ± 0.123
1.618IleHis: 1.618 ± 0.062
5.521IleIle: 5.521 ± 0.127
4.894IleLys: 4.894 ± 0.098
7.583IleLeu: 7.583 ± 0.152
1.724IleMet: 1.724 ± 0.062
3.03IleAsn: 3.03 ± 0.069
2.998IlePro: 2.998 ± 0.073
3.351IleGln: 3.351 ± 0.081
2.828IleArg: 2.828 ± 0.071
4.967IleSer: 4.967 ± 0.113
4.393IleThr: 4.393 ± 0.093
5.967IleVal: 5.967 ± 0.116
0.538IleTrp: 0.538 ± 0.032
2.917IleTyr: 2.917 ± 0.089
0.0IleXaa: 0.0 ± 0.0
Lys
4.87LysAla: 4.87 ± 0.134
0.38LysCys: 0.38 ± 0.028
4.707LysAsp: 4.707 ± 0.12
7.418LysGlu: 7.418 ± 0.14
1.828LysPhe: 1.828 ± 0.075
4.169LysGly: 4.169 ± 0.097
1.722LysHis: 1.722 ± 0.114
4.85LysIle: 4.85 ± 0.106
6.353LysLys: 6.353 ± 0.153
5.284LysLeu: 5.284 ± 0.112
2.275LysMet: 2.275 ± 0.065
3.772LysAsn: 3.772 ± 0.096
2.252LysPro: 2.252 ± 0.079
4.232LysGln: 4.232 ± 0.12
3.416LysArg: 3.416 ± 0.086
3.607LysSer: 3.607 ± 0.089
4.445LysThr: 4.445 ± 0.113
4.996LysVal: 4.996 ± 0.103
0.701LysTrp: 0.701 ± 0.043
2.623LysTyr: 2.623 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
6.204LeuAla: 6.204 ± 0.106
0.889LeuCys: 0.889 ± 0.043
5.355LeuAsp: 5.355 ± 0.094
6.614LeuGlu: 6.614 ± 0.137
4.371LeuPhe: 4.371 ± 0.117
5.854LeuGly: 5.854 ± 0.148
1.904LeuHis: 1.904 ± 0.066
6.163LeuIle: 6.163 ± 0.125
6.985LeuLys: 6.985 ± 0.138
9.804LeuLeu: 9.804 ± 0.206
2.28LeuMet: 2.28 ± 0.06
4.579LeuAsn: 4.579 ± 0.094
3.724LeuPro: 3.724 ± 0.084
3.379LeuGln: 3.379 ± 0.092
3.145LeuArg: 3.145 ± 0.084
8.023LeuSer: 8.023 ± 0.37
6.201LeuThr: 6.201 ± 0.123
6.464LeuVal: 6.464 ± 0.143
0.657LeuTrp: 0.657 ± 0.038
3.484LeuTyr: 3.484 ± 0.1
0.0LeuXaa: 0.0 ± 0.0
Met
1.737MetAla: 1.737 ± 0.061
0.223MetCys: 0.223 ± 0.02
1.312MetAsp: 1.312 ± 0.055
1.408MetGlu: 1.408 ± 0.05
0.959MetPhe: 0.959 ± 0.038
1.479MetGly: 1.479 ± 0.056
0.477MetHis: 0.477 ± 0.029
2.236MetIle: 2.236 ± 0.067
2.098MetLys: 2.098 ± 0.063
2.384MetLeu: 2.384 ± 0.074
0.844MetMet: 0.844 ± 0.044
1.275MetAsn: 1.275 ± 0.051
0.85MetPro: 0.85 ± 0.037
0.918MetGln: 0.918 ± 0.045
0.913MetArg: 0.913 ± 0.042
1.926MetSer: 1.926 ± 0.061
2.045MetThr: 2.045 ± 0.066
1.662MetVal: 1.662 ± 0.056
0.15MetTrp: 0.15 ± 0.015
0.943MetTyr: 0.943 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.056AsnAla: 3.056 ± 0.081
0.299AsnCys: 0.299 ± 0.024
2.629AsnAsp: 2.629 ± 0.169
2.989AsnGlu: 2.989 ± 0.072
1.425AsnPhe: 1.425 ± 0.058
3.752AsnGly: 3.752 ± 0.102
1.186AsnHis: 1.186 ± 0.051
4.119AsnIle: 4.119 ± 0.1
3.314AsnLys: 3.314 ± 0.082
3.369AsnLeu: 3.369 ± 0.087
1.377AsnMet: 1.377 ± 0.05
1.983AsnAsn: 1.983 ± 0.06
2.121AsnPro: 2.121 ± 0.144
2.063AsnGln: 2.063 ± 0.063
1.961AsnArg: 1.961 ± 0.066
2.078AsnSer: 2.078 ± 0.071
2.828AsnThr: 2.828 ± 0.105
3.343AsnVal: 3.343 ± 0.083
0.419AsnTrp: 0.419 ± 0.032
1.579AsnTyr: 1.579 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
1.798ProAla: 1.798 ± 0.053
0.187ProCys: 0.187 ± 0.021
1.848ProAsp: 1.848 ± 0.15
2.51ProGlu: 2.51 ± 0.082
1.694ProPhe: 1.694 ± 0.058
1.427ProGly: 1.427 ± 0.056
0.798ProHis: 0.798 ± 0.04
2.596ProIle: 2.596 ± 0.075
2.312ProLys: 2.312 ± 0.085
2.928ProLeu: 2.928 ± 0.11
0.768ProMet: 0.768 ± 0.048
1.928ProAsn: 1.928 ± 0.091
0.564ProPro: 0.564 ± 0.035
1.078ProGln: 1.078 ± 0.048
0.831ProArg: 0.831 ± 0.039
1.844ProSer: 1.844 ± 0.064
2.377ProThr: 2.377 ± 0.073
2.551ProVal: 2.551 ± 0.087
0.191ProTrp: 0.191 ± 0.019
1.488ProTyr: 1.488 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
3.02GlnAla: 3.02 ± 0.084
0.234GlnCys: 0.234 ± 0.021
2.126GlnAsp: 2.126 ± 0.071
3.451GlnGlu: 3.451 ± 0.088
1.79GlnPhe: 1.79 ± 0.058
2.058GlnGly: 2.058 ± 0.061
1.007GlnHis: 1.007 ± 0.047
2.603GlnIle: 2.603 ± 0.093
3.375GlnLys: 3.375 ± 0.086
4.21GlnLeu: 4.21 ± 0.098
1.026GlnMet: 1.026 ± 0.05
1.85GlnAsn: 1.85 ± 0.07
1.145GlnPro: 1.145 ± 0.051
2.041GlnGln: 2.041 ± 0.068
1.56GlnArg: 1.56 ± 0.057
2.51GlnSer: 2.51 ± 0.107
2.7GlnThr: 2.7 ± 0.071
2.711GlnVal: 2.711 ± 0.085
0.36GlnTrp: 0.36 ± 0.028
1.755GlnTyr: 1.755 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
2.251ArgAla: 2.251 ± 0.067
0.289ArgCys: 0.289 ± 0.021
1.887ArgAsp: 1.887 ± 0.056
2.664ArgGlu: 2.664 ± 0.073
1.798ArgPhe: 1.798 ± 0.057
1.917ArgGly: 1.917 ± 0.076
0.92ArgHis: 0.92 ± 0.047
2.978ArgIle: 2.978 ± 0.07
2.636ArgLys: 2.636 ± 0.078
4.032ArgLeu: 4.032 ± 0.098
1.041ArgMet: 1.041 ± 0.047
1.462ArgAsn: 1.462 ± 0.062
1.108ArgPro: 1.108 ± 0.053
1.963ArgGln: 1.963 ± 0.063
1.844ArgArg: 1.844 ± 0.064
1.592ArgSer: 1.592 ± 0.06
1.853ArgThr: 1.853 ± 0.06
2.813ArgVal: 2.813 ± 0.074
0.278ArgTrp: 0.278 ± 0.029
1.664ArgTyr: 1.664 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
3.429SerAla: 3.429 ± 0.085
0.462SerCys: 0.462 ± 0.027
3.486SerAsp: 3.486 ± 0.182
4.013SerGlu: 4.013 ± 0.264
2.918SerPhe: 2.918 ± 0.081
4.078SerGly: 4.078 ± 0.103
1.404SerHis: 1.404 ± 0.056
4.872SerIle: 4.872 ± 0.112
3.887SerLys: 3.887 ± 0.085
6.253SerLeu: 6.253 ± 0.332
1.468SerMet: 1.468 ± 0.05
2.638SerAsn: 2.638 ± 0.073
1.718SerPro: 1.718 ± 0.058
2.653SerGln: 2.653 ± 0.107
1.985SerArg: 1.985 ± 0.063
3.503SerSer: 3.503 ± 0.092
3.915SerThr: 3.915 ± 0.352
4.763SerVal: 4.763 ± 0.103
0.404SerTrp: 0.404 ± 0.03
2.167SerTyr: 2.167 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
3.809ThrAla: 3.809 ± 0.085
0.466ThrCys: 0.466 ± 0.029
3.269ThrAsp: 3.269 ± 0.104
3.605ThrGlu: 3.605 ± 0.106
3.011ThrPhe: 3.011 ± 0.086
4.006ThrGly: 4.006 ± 0.102
1.458ThrHis: 1.458 ± 0.057
5.392ThrIle: 5.392 ± 0.11
4.299ThrLys: 4.299 ± 0.102
6.956ThrLeu: 6.956 ± 0.13
1.323ThrMet: 1.323 ± 0.046
2.982ThrAsn: 2.982 ± 0.153
2.694ThrPro: 2.694 ± 0.12
2.51ThrGln: 2.51 ± 0.079
2.026ThrArg: 2.026 ± 0.059
4.145ThrSer: 4.145 ± 0.351
4.303ThrThr: 4.303 ± 0.158
5.223ThrVal: 5.223 ± 0.134
0.512ThrTrp: 0.512 ± 0.036
2.657ThrTyr: 2.657 ± 0.092
0.0ThrXaa: 0.0 ± 0.0
Val
4.824ValAla: 4.824 ± 0.102
0.686ValCys: 0.686 ± 0.04
4.436ValAsp: 4.436 ± 0.108
4.883ValGlu: 4.883 ± 0.117
3.356ValPhe: 3.356 ± 0.094
4.592ValGly: 4.592 ± 0.11
1.353ValHis: 1.353 ± 0.055
5.245ValIle: 5.245 ± 0.119
4.661ValLys: 4.661 ± 0.104
7.794ValLeu: 7.794 ± 0.147
1.675ValMet: 1.675 ± 0.065
3.243ValAsn: 3.243 ± 0.123
2.714ValPro: 2.714 ± 0.122
2.412ValGln: 2.412 ± 0.079
2.46ValArg: 2.46 ± 0.089
5.368ValSer: 5.368 ± 0.113
5.022ValThr: 5.022 ± 0.164
5.54ValVal: 5.54 ± 0.131
0.499ValTrp: 0.499 ± 0.03
2.985ValTyr: 2.985 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.406TrpAla: 0.406 ± 0.028
0.063TrpCys: 0.063 ± 0.011
0.412TrpAsp: 0.412 ± 0.028
0.523TrpGlu: 0.523 ± 0.034
0.408TrpPhe: 0.408 ± 0.028
0.449TrpGly: 0.449 ± 0.033
0.226TrpHis: 0.226 ± 0.023
0.675TrpIle: 0.675 ± 0.034
0.553TrpLys: 0.553 ± 0.034
0.82TrpLeu: 0.82 ± 0.043
0.173TrpMet: 0.173 ± 0.018
0.382TrpAsn: 0.382 ± 0.031
0.132TrpPro: 0.132 ± 0.019
0.406TrpGln: 0.406 ± 0.025
0.314TrpArg: 0.314 ± 0.023
0.412TrpSer: 0.412 ± 0.034
0.495TrpThr: 0.495 ± 0.031
0.442TrpVal: 0.442 ± 0.031
0.067TrpTrp: 0.067 ± 0.011
0.323TrpTyr: 0.323 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.584TyrAla: 2.584 ± 0.075
0.347TyrCys: 0.347 ± 0.028
2.544TyrAsp: 2.544 ± 0.077
2.479TyrGlu: 2.479 ± 0.071
1.918TyrPhe: 1.918 ± 0.066
2.534TyrGly: 2.534 ± 0.068
1.126TyrHis: 1.126 ± 0.05
3.093TyrIle: 3.093 ± 0.089
2.475TyrLys: 2.475 ± 0.074
3.811TyrLeu: 3.811 ± 0.095
0.95TyrMet: 0.95 ± 0.036
1.57TyrAsn: 1.57 ± 0.058
1.312TyrPro: 1.312 ± 0.049
2.037TyrGln: 2.037 ± 0.075
1.798TyrArg: 1.798 ± 0.071
2.019TyrSer: 2.019 ± 0.062
2.789TyrThr: 2.789 ± 0.106
2.824TyrVal: 2.824 ± 0.071
0.299TyrTrp: 0.299 ± 0.024
1.661TyrTyr: 1.661 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1680 proteins (538985 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski