Amino acid dipepetide frequency for Methanomethylophilus alvus (strain Mx1201)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.155AlaAla: 8.155 ± 0.188	1.214AlaCys: 1.214 ± 0.05	5.852AlaAsp: 5.852 ± 0.113	6.064AlaGlu: 6.064 ± 0.131	3.097AlaPhe: 3.097 ± 0.079	6.523AlaGly: 6.523 ± 0.125	1.206AlaHis: 1.206 ± 0.048	5.408AlaIle: 5.408 ± 0.121	4.756AlaLys: 4.756 ± 0.123	7.028AlaLeu: 7.028 ± 0.144	2.89AlaMet: 2.89 ± 0.073	2.158AlaAsn: 2.158 ± 0.07	2.443AlaPro: 2.443 ± 0.074	1.858AlaGln: 1.858 ± 0.073	3.709AlaArg: 3.709 ± 0.098	4.52AlaSer: 4.52 ± 0.108	3.364AlaThr: 3.364 ± 0.082	7.523AlaVal: 7.523 ± 0.14	0.575AlaTrp: 0.575 ± 0.038	2.716AlaTyr: 2.716 ± 0.074	0.0AlaXaa: 0.0 ± 0.0
Cys	1.247CysAla: 1.247 ± 0.056	0.359CysCys: 0.359 ± 0.034	1.2CysAsp: 1.2 ± 0.05	0.927CysGlu: 0.927 ± 0.039	0.562CysPhe: 0.562 ± 0.032	2.026CysGly: 2.026 ± 0.076	0.342CysHis: 0.342 ± 0.035	1.049CysIle: 1.049 ± 0.051	0.817CysLys: 0.817 ± 0.039	1.172CysLeu: 1.172 ± 0.059	0.518CysMet: 0.518 ± 0.035	0.511CysAsn: 0.511 ± 0.037	1.098CysPro: 1.098 ± 0.057	0.41CysGln: 0.41 ± 0.031	1.09CysArg: 1.09 ± 0.052	1.054CysSer: 1.054 ± 0.046	0.831CysThr: 0.831 ± 0.04	1.043CysVal: 1.043 ± 0.043	0.147CysTrp: 0.147 ± 0.017	0.52CysTyr: 0.52 ± 0.036	0.0CysXaa: 0.0 ± 0.0
Asp	5.469AspAla: 5.469 ± 0.118	0.964AspCys: 0.964 ± 0.05	4.312AspAsp: 4.312 ± 0.105	4.791AspGlu: 4.791 ± 0.101	2.541AspPhe: 2.541 ± 0.073	6.286AspGly: 6.286 ± 0.147	1.135AspHis: 1.135 ± 0.045	5.418AspIle: 5.418 ± 0.095	3.167AspLys: 3.167 ± 0.083	6.24AspLeu: 6.24 ± 0.136	2.72AspMet: 2.72 ± 0.084	2.093AspAsn: 2.093 ± 0.064	3.509AspPro: 3.509 ± 0.081	1.219AspGln: 1.219 ± 0.052	4.402AspArg: 4.402 ± 0.106	3.914AspSer: 3.914 ± 0.089	3.199AspThr: 3.199 ± 0.086	5.636AspVal: 5.636 ± 0.119	0.683AspTrp: 0.683 ± 0.042	2.435AspTyr: 2.435 ± 0.077	0.0AspXaa: 0.0 ± 0.0
Glu	5.453GluAla: 5.453 ± 0.132	1.084GluCys: 1.084 ± 0.053	4.776GluAsp: 4.776 ± 0.111	5.571GluGlu: 5.571 ± 0.131	2.307GluPhe: 2.307 ± 0.072	5.074GluGly: 5.074 ± 0.112	1.166GluHis: 1.166 ± 0.05	4.719GluIle: 4.719 ± 0.109	5.131GluLys: 5.131 ± 0.111	5.013GluLeu: 5.013 ± 0.105	2.441GluMet: 2.441 ± 0.07	2.661GluAsn: 2.661 ± 0.078	2.019GluPro: 2.019 ± 0.058	1.53GluGln: 1.53 ± 0.07	3.798GluArg: 3.798 ± 0.095	3.912GluSer: 3.912 ± 0.096	3.454GluThr: 3.454 ± 0.083	4.75GluVal: 4.75 ± 0.115	0.732GluTrp: 0.732 ± 0.039	2.757GluTyr: 2.757 ± 0.08	0.0GluXaa: 0.0 ± 0.0
Phe	2.523PheAla: 2.523 ± 0.081	0.701PheCys: 0.701 ± 0.04	2.887PheAsp: 2.887 ± 0.085	2.527PheGlu: 2.527 ± 0.082	1.406PhePhe: 1.406 ± 0.063	3.315PheGly: 3.315 ± 0.078	0.617PheHis: 0.617 ± 0.035	2.329PheIle: 2.329 ± 0.072	1.752PheLys: 1.752 ± 0.062	3.022PheLeu: 3.022 ± 0.082	1.3PheMet: 1.3 ± 0.051	1.257PheAsn: 1.257 ± 0.052	1.486PhePro: 1.486 ± 0.054	0.77PheGln: 0.77 ± 0.038	2.07PheArg: 2.07 ± 0.074	2.696PheSer: 2.696 ± 0.08	1.96PheThr: 1.96 ± 0.072	3.163PheVal: 3.163 ± 0.087	0.314PheTrp: 0.314 ± 0.027	1.272PheTyr: 1.272 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	5.793GlyAla: 5.793 ± 0.108	1.697GlyCys: 1.697 ± 0.07	4.982GlyAsp: 4.982 ± 0.105	4.673GlyGlu: 4.673 ± 0.1	3.167GlyPhe: 3.167 ± 0.067	5.832GlyGly: 5.832 ± 0.143	1.589GlyHis: 1.589 ± 0.056	6.142GlyIle: 6.142 ± 0.12	5.848GlyLys: 5.848 ± 0.107	6.238GlyLeu: 6.238 ± 0.135	3.169GlyMet: 3.169 ± 0.08	3.077GlyAsn: 3.077 ± 0.078	2.482GlyPro: 2.482 ± 0.08	1.665GlyGln: 1.665 ± 0.061	4.764GlyArg: 4.764 ± 0.118	5.151GlySer: 5.151 ± 0.132	5.003GlyThr: 5.003 ± 0.124	5.844GlyVal: 5.844 ± 0.113	0.862GlyTrp: 0.862 ± 0.057	3.189GlyTyr: 3.189 ± 0.084	0.0GlyXaa: 0.0 ± 0.0
His	1.119HisAla: 1.119 ± 0.049	0.34HisCys: 0.34 ± 0.031	1.025HisAsp: 1.025 ± 0.052	0.905HisGlu: 0.905 ± 0.044	0.674HisPhe: 0.674 ± 0.039	1.455HisGly: 1.455 ± 0.058	0.385HisHis: 0.385 ± 0.053	1.164HisIle: 1.164 ± 0.057	0.701HisLys: 0.701 ± 0.035	1.357HisLeu: 1.357 ± 0.054	0.607HisMet: 0.607 ± 0.032	0.577HisAsn: 0.577 ± 0.035	0.968HisPro: 0.968 ± 0.045	0.342HisGln: 0.342 ± 0.026	0.982HisArg: 0.982 ± 0.046	0.972HisSer: 0.972 ± 0.045	0.825HisThr: 0.825 ± 0.041	1.357HisVal: 1.357 ± 0.053	0.163HisTrp: 0.163 ± 0.02	0.581HisTyr: 0.581 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.579IleAla: 5.579 ± 0.119	1.223IleCys: 1.223 ± 0.053	4.62IleAsp: 4.62 ± 0.093	4.322IleGlu: 4.322 ± 0.103	2.27IlePhe: 2.27 ± 0.085	5.716IleGly: 5.716 ± 0.11	1.178IleHis: 1.178 ± 0.054	3.957IleIle: 3.957 ± 0.109	3.093IleLys: 3.093 ± 0.09	5.587IleLeu: 5.587 ± 0.142	2.021IleMet: 2.021 ± 0.07	2.076IleAsn: 2.076 ± 0.064	3.338IlePro: 3.338 ± 0.075	1.357IleGln: 1.357 ± 0.058	3.827IleArg: 3.827 ± 0.099	4.799IleSer: 4.799 ± 0.097	3.468IleThr: 3.468 ± 0.086	5.467IleVal: 5.467 ± 0.114	0.524IleTrp: 0.524 ± 0.033	1.948IleTyr: 1.948 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	5.424LysAla: 5.424 ± 0.133	0.817LysCys: 0.817 ± 0.046	4.834LysAsp: 4.834 ± 0.099	4.709LysGlu: 4.709 ± 0.112	1.783LysPhe: 1.783 ± 0.063	4.475LysGly: 4.475 ± 0.116	0.825LysHis: 0.825 ± 0.046	3.745LysIle: 3.745 ± 0.109	4.454LysLys: 4.454 ± 0.131	3.747LysLeu: 3.747 ± 0.105	1.879LysMet: 1.879 ± 0.058	2.274LysAsn: 2.274 ± 0.081	1.594LysPro: 1.594 ± 0.061	1.353LysGln: 1.353 ± 0.058	2.92LysArg: 2.92 ± 0.095	2.91LysSer: 2.91 ± 0.097	3.593LysThr: 3.593 ± 0.088	4.53LysVal: 4.53 ± 0.091	0.579LysTrp: 0.579 ± 0.038	2.062LysTyr: 2.062 ± 0.077	0.0LysXaa: 0.0 ± 0.0
Leu	6.845LeuAla: 6.845 ± 0.144	1.453LeuCys: 1.453 ± 0.057	5.757LeuAsp: 5.757 ± 0.119	5.249LeuGlu: 5.249 ± 0.115	3.13LeuPhe: 3.13 ± 0.1	6.492LeuGly: 6.492 ± 0.111	1.121LeuHis: 1.121 ± 0.05	4.807LeuIle: 4.807 ± 0.132	4.634LeuLys: 4.634 ± 0.1	5.922LeuLeu: 5.922 ± 0.152	3.008LeuMet: 3.008 ± 0.072	2.733LeuAsn: 2.733 ± 0.082	3.065LeuPro: 3.065 ± 0.087	1.628LeuGln: 1.628 ± 0.061	4.615LeuArg: 4.615 ± 0.116	5.905LeuSer: 5.905 ± 0.112	4.124LeuThr: 4.124 ± 0.101	5.73LeuVal: 5.73 ± 0.132	0.652LeuTrp: 0.652 ± 0.041	2.557LeuTyr: 2.557 ± 0.09	0.0LeuXaa: 0.0 ± 0.0
Met	3.13MetAla: 3.13 ± 0.079	0.609MetCys: 0.609 ± 0.04	2.659MetAsp: 2.659 ± 0.07	2.382MetGlu: 2.382 ± 0.069	1.359MetPhe: 1.359 ± 0.062	2.686MetGly: 2.686 ± 0.081	0.556MetHis: 0.556 ± 0.036	2.15MetIle: 2.15 ± 0.067	2.15MetLys: 2.15 ± 0.062	2.598MetLeu: 2.598 ± 0.074	1.43MetMet: 1.43 ± 0.059	1.278MetAsn: 1.278 ± 0.048	1.306MetPro: 1.306 ± 0.052	0.811MetGln: 0.811 ± 0.043	1.81MetArg: 1.81 ± 0.064	2.539MetSer: 2.539 ± 0.074	2.16MetThr: 2.16 ± 0.065	2.614MetVal: 2.614 ± 0.07	0.271MetTrp: 0.271 ± 0.025	1.141MetTyr: 1.141 ± 0.059	0.0MetXaa: 0.0 ± 0.0
Asn	2.773AsnAla: 2.773 ± 0.081	0.52AsnCys: 0.52 ± 0.033	1.952AsnAsp: 1.952 ± 0.075	1.942AsnGlu: 1.942 ± 0.068	1.037AsnPhe: 1.037 ± 0.05	3.167AsnGly: 3.167 ± 0.093	0.518AsnHis: 0.518 ± 0.038	2.659AsnIle: 2.659 ± 0.078	1.665AsnLys: 1.665 ± 0.075	2.722AsnLeu: 2.722 ± 0.084	1.235AsnMet: 1.235 ± 0.058	1.184AsnAsn: 1.184 ± 0.065	1.763AsnPro: 1.763 ± 0.062	0.652AsnGln: 0.652 ± 0.042	1.893AsnArg: 1.893 ± 0.07	2.034AsnSer: 2.034 ± 0.069	1.75AsnThr: 1.75 ± 0.071	2.753AsnVal: 2.753 ± 0.082	0.302AsnTrp: 0.302 ± 0.03	1.204AsnTyr: 1.204 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.973ProAla: 2.973 ± 0.1	0.581ProCys: 0.581 ± 0.035	3.11ProAsp: 3.11 ± 0.085	3.762ProGlu: 3.762 ± 0.101	1.528ProPhe: 1.528 ± 0.053	3.014ProGly: 3.014 ± 0.088	0.695ProHis: 0.695 ± 0.037	2.18ProIle: 2.18 ± 0.067	2.233ProLys: 2.233 ± 0.076	2.979ProLeu: 2.979 ± 0.081	1.162ProMet: 1.162 ± 0.049	1.149ProAsn: 1.149 ± 0.055	1.2ProPro: 1.2 ± 0.053	0.913ProGln: 0.913 ± 0.042	1.761ProArg: 1.761 ± 0.062	2.588ProSer: 2.588 ± 0.072	1.761ProThr: 1.761 ± 0.061	3.417ProVal: 3.417 ± 0.089	0.346ProTrp: 0.346 ± 0.026	1.492ProTyr: 1.492 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	1.805GlnAla: 1.805 ± 0.056	0.346GlnCys: 0.346 ± 0.027	1.214GlnAsp: 1.214 ± 0.055	1.357GlnGlu: 1.357 ± 0.055	0.862GlnPhe: 0.862 ± 0.044	1.402GlnGly: 1.402 ± 0.06	0.357GlnHis: 0.357 ± 0.024	1.594GlnIle: 1.594 ± 0.059	1.555GlnLys: 1.555 ± 0.058	1.683GlnLeu: 1.683 ± 0.062	1.086GlnMet: 1.086 ± 0.045	0.893GlnAsn: 0.893 ± 0.048	0.66GlnPro: 0.66 ± 0.037	0.624GlnGln: 0.624 ± 0.041	1.198GlnArg: 1.198 ± 0.052	1.188GlnSer: 1.188 ± 0.05	1.202GlnThr: 1.202 ± 0.049	1.386GlnVal: 1.386 ± 0.051	0.21GlnTrp: 0.21 ± 0.023	0.958GlnTyr: 0.958 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.709ArgAla: 3.709 ± 0.094	0.935ArgCys: 0.935 ± 0.053	3.641ArgAsp: 3.641 ± 0.105	3.802ArgGlu: 3.802 ± 0.096	2.244ArgPhe: 2.244 ± 0.062	3.69ArgGly: 3.69 ± 0.11	1.037ArgHis: 1.037 ± 0.047	4.057ArgIle: 4.057 ± 0.109	3.684ArgLys: 3.684 ± 0.089	4.344ArgLeu: 4.344 ± 0.088	2.35ArgMet: 2.35 ± 0.074	2.227ArgAsn: 2.227 ± 0.067	2.038ArgPro: 2.038 ± 0.073	1.337ArgGln: 1.337 ± 0.06	3.462ArgArg: 3.462 ± 0.12	3.489ArgSer: 3.489 ± 0.089	2.865ArgThr: 2.865 ± 0.091	3.228ArgVal: 3.228 ± 0.083	0.499ArgTrp: 0.499 ± 0.032	2.321ArgTyr: 2.321 ± 0.071	0.0ArgXaa: 0.0 ± 0.0
Ser	5.076SerAla: 5.076 ± 0.113	0.911SerCys: 0.911 ± 0.053	4.791SerAsp: 4.791 ± 0.098	4.583SerGlu: 4.583 ± 0.1	2.396SerPhe: 2.396 ± 0.069	5.742SerGly: 5.742 ± 0.138	0.921SerHis: 0.921 ± 0.047	4.043SerIle: 4.043 ± 0.09	3.917SerLys: 3.917 ± 0.107	5.033SerLeu: 5.033 ± 0.122	2.254SerMet: 2.254 ± 0.067	1.903SerAsn: 1.903 ± 0.075	2.262SerPro: 2.262 ± 0.074	1.378SerGln: 1.378 ± 0.054	3.24SerArg: 3.24 ± 0.082	4.481SerSer: 4.481 ± 0.124	3.002SerThr: 3.002 ± 0.076	5.461SerVal: 5.461 ± 0.141	0.548SerTrp: 0.548 ± 0.037	2.18SerTyr: 2.18 ± 0.076	0.002SerXaa: 0.002 ± 0.002
Thr	4.338ThrAla: 4.338 ± 0.098	0.768ThrCys: 0.768 ± 0.037	3.772ThrAsp: 3.772 ± 0.078	3.352ThrGlu: 3.352 ± 0.082	2.001ThrPhe: 2.001 ± 0.074	4.734ThrGly: 4.734 ± 0.095	0.827ThrHis: 0.827 ± 0.04	3.252ThrIle: 3.252 ± 0.096	2.378ThrLys: 2.378 ± 0.072	4.092ThrLeu: 4.092 ± 0.103	1.543ThrMet: 1.543 ± 0.056	1.557ThrAsn: 1.557 ± 0.064	2.193ThrPro: 2.193 ± 0.075	1.121ThrGln: 1.121 ± 0.05	2.129ThrArg: 2.129 ± 0.071	3.326ThrSer: 3.326 ± 0.089	2.458ThrThr: 2.458 ± 0.084	5.537ThrVal: 5.537 ± 0.15	0.465ThrTrp: 0.465 ± 0.029	2.032ThrTyr: 2.032 ± 0.078	0.0ThrXaa: 0.0 ± 0.0
Val	6.026ValAla: 6.026 ± 0.122	1.51ValCys: 1.51 ± 0.06	5.339ValAsp: 5.339 ± 0.11	4.884ValGlu: 4.884 ± 0.118	3.23ValPhe: 3.23 ± 0.099	5.608ValGly: 5.608 ± 0.13	1.229ValHis: 1.229 ± 0.05	5.123ValIle: 5.123 ± 0.103	4.501ValLys: 4.501 ± 0.097	6.847ValLeu: 6.847 ± 0.149	2.598ValMet: 2.598 ± 0.071	2.431ValAsn: 2.431 ± 0.074	3.778ValPro: 3.778 ± 0.104	1.634ValGln: 1.634 ± 0.063	4.585ValArg: 4.585 ± 0.115	5.673ValSer: 5.673 ± 0.134	4.397ValThr: 4.397 ± 0.116	5.954ValVal: 5.954 ± 0.135	0.689ValTrp: 0.689 ± 0.048	2.58ValTyr: 2.58 ± 0.081	0.0ValXaa: 0.0 ± 0.0
Trp	0.732TrpAla: 0.732 ± 0.043	0.177TrpCys: 0.177 ± 0.017	0.644TrpAsp: 0.644 ± 0.039	0.569TrpGlu: 0.569 ± 0.03	0.438TrpPhe: 0.438 ± 0.036	0.605TrpGly: 0.605 ± 0.037	0.171TrpHis: 0.171 ± 0.018	0.569TrpIle: 0.569 ± 0.038	0.624TrpLys: 0.624 ± 0.04	0.666TrpLeu: 0.666 ± 0.037	0.367TrpMet: 0.367 ± 0.029	0.469TrpAsn: 0.469 ± 0.042	0.273TrpPro: 0.273 ± 0.02	0.236TrpGln: 0.236 ± 0.022	0.434TrpArg: 0.434 ± 0.03	0.507TrpSer: 0.507 ± 0.032	0.487TrpThr: 0.487 ± 0.03	0.564TrpVal: 0.564 ± 0.037	0.112TrpTrp: 0.112 ± 0.022	0.389TrpTyr: 0.389 ± 0.035	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.885TyrAla: 2.885 ± 0.089	0.713TyrCys: 0.713 ± 0.038	2.769TyrAsp: 2.769 ± 0.073	1.981TyrGlu: 1.981 ± 0.071	1.335TyrPhe: 1.335 ± 0.047	3.319TyrGly: 3.319 ± 0.109	0.624TyrHis: 0.624 ± 0.031	2.007TyrIle: 2.007 ± 0.07	1.447TyrLys: 1.447 ± 0.061	3.132TyrLeu: 3.132 ± 0.089	1.062TyrMet: 1.062 ± 0.048	1.217TyrAsn: 1.217 ± 0.051	1.371TyrPro: 1.371 ± 0.057	0.742TyrGln: 0.742 ± 0.038	2.274TyrArg: 2.274 ± 0.078	2.466TyrSer: 2.466 ± 0.097	1.966TyrThr: 1.966 ± 0.089	2.667TyrVal: 2.667 ± 0.084	0.361TyrTrp: 0.361 ± 0.029	1.38TyrTyr: 1.38 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.002XaaMet: 0.002 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1643 proteins (490742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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