Amino acid dipepetide frequency for Lutibacter profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.828AlaAla: 3.828 ± 0.091
0.505AlaCys: 0.505 ± 0.028
2.648AlaAsp: 2.648 ± 0.076
3.318AlaGlu: 3.318 ± 0.067
3.024AlaPhe: 3.024 ± 0.057
3.654AlaGly: 3.654 ± 0.082
0.968AlaHis: 0.968 ± 0.037
5.947AlaIle: 5.947 ± 0.091
4.818AlaLys: 4.818 ± 0.091
5.601AlaLeu: 5.601 ± 0.102
1.363AlaMet: 1.363 ± 0.047
3.397AlaAsn: 3.397 ± 0.078
1.639AlaPro: 1.639 ± 0.047
2.023AlaGln: 2.023 ± 0.059
1.737AlaArg: 1.737 ± 0.045
3.967AlaSer: 3.967 ± 0.082
3.741AlaThr: 3.741 ± 0.091
3.753AlaVal: 3.753 ± 0.079
0.515AlaTrp: 0.515 ± 0.029
2.21AlaTyr: 2.21 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.391CysAla: 0.391 ± 0.021
0.077CysCys: 0.077 ± 0.01
0.402CysAsp: 0.402 ± 0.026
0.461CysGlu: 0.461 ± 0.039
0.34CysPhe: 0.34 ± 0.022
0.564CysGly: 0.564 ± 0.029
0.232CysHis: 0.232 ± 0.026
0.557CysIle: 0.557 ± 0.03
0.505CysLys: 0.505 ± 0.026
0.535CysLeu: 0.535 ± 0.024
0.131CysMet: 0.131 ± 0.014
0.491CysAsn: 0.491 ± 0.038
0.372CysPro: 0.372 ± 0.033
0.168CysGln: 0.168 ± 0.015
0.172CysArg: 0.172 ± 0.015
0.499CysSer: 0.499 ± 0.035
0.416CysThr: 0.416 ± 0.021
0.378CysVal: 0.378 ± 0.025
0.055CysTrp: 0.055 ± 0.007
0.263CysTyr: 0.263 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.181AspAla: 3.181 ± 0.076
0.357AspCys: 0.357 ± 0.022
2.364AspAsp: 2.364 ± 0.067
3.189AspGlu: 3.189 ± 0.079
3.368AspPhe: 3.368 ± 0.06
3.179AspGly: 3.179 ± 0.083
0.559AspHis: 0.559 ± 0.033
4.436AspIle: 4.436 ± 0.083
4.206AspLys: 4.206 ± 0.083
4.546AspLeu: 4.546 ± 0.087
0.913AspMet: 0.913 ± 0.034
3.029AspAsn: 3.029 ± 0.081
1.234AspPro: 1.234 ± 0.045
0.91AspGln: 0.91 ± 0.035
1.434AspArg: 1.434 ± 0.04
2.815AspSer: 2.815 ± 0.079
2.614AspThr: 2.614 ± 0.067
3.276AspVal: 3.276 ± 0.066
0.591AspTrp: 0.591 ± 0.026
2.351AspTyr: 2.351 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
3.766GluAla: 3.766 ± 0.085
0.308GluCys: 0.308 ± 0.02
3.019GluAsp: 3.019 ± 0.068
4.354GluGlu: 4.354 ± 0.094
3.045GluPhe: 3.045 ± 0.069
3.52GluGly: 3.52 ± 0.074
1.015GluHis: 1.015 ± 0.031
6.424GluIle: 6.424 ± 0.1
6.303GluLys: 6.303 ± 0.112
6.082GluLeu: 6.082 ± 0.096
1.516GluMet: 1.516 ± 0.047
5.189GluAsn: 5.189 ± 0.08
1.442GluPro: 1.442 ± 0.074
2.077GluGln: 2.077 ± 0.05
2.127GluArg: 2.127 ± 0.052
2.912GluSer: 2.912 ± 0.061
3.535GluThr: 3.535 ± 0.071
4.074GluVal: 4.074 ± 0.084
0.526GluTrp: 0.526 ± 0.025
2.286GluTyr: 2.286 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
2.703PheAla: 2.703 ± 0.07
0.37PheCys: 0.37 ± 0.025
2.98PheAsp: 2.98 ± 0.07
3.39PheGlu: 3.39 ± 0.067
2.786PhePhe: 2.786 ± 0.073
3.699PheGly: 3.699 ± 0.07
0.761PheHis: 0.761 ± 0.029
4.611PheIle: 4.611 ± 0.087
4.668PheLys: 4.668 ± 0.087
4.818PheLeu: 4.818 ± 0.093
1.144PheMet: 1.144 ± 0.041
3.857PheAsn: 3.857 ± 0.084
1.677PhePro: 1.677 ± 0.047
1.417PheGln: 1.417 ± 0.035
1.467PheArg: 1.467 ± 0.045
4.232PheSer: 4.232 ± 0.078
3.156PheThr: 3.156 ± 0.061
2.946PheVal: 2.946 ± 0.066
0.521PheTrp: 0.521 ± 0.03
2.253PheTyr: 2.253 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
3.932GlyAla: 3.932 ± 0.077
0.581GlyCys: 0.581 ± 0.048
2.966GlyAsp: 2.966 ± 0.071
3.539GlyGlu: 3.539 ± 0.073
3.541GlyPhe: 3.541 ± 0.075
4.433GlyGly: 4.433 ± 0.113
0.991GlyHis: 0.991 ± 0.037
5.717GlyIle: 5.717 ± 0.095
5.135GlyLys: 5.135 ± 0.081
5.278GlyLeu: 5.278 ± 0.084
1.545GlyMet: 1.545 ± 0.045
3.797GlyAsn: 3.797 ± 0.083
1.202GlyPro: 1.202 ± 0.039
1.441GlyGln: 1.441 ± 0.049
1.954GlyArg: 1.954 ± 0.052
3.8GlySer: 3.8 ± 0.116
3.818GlyThr: 3.818 ± 0.093
4.413GlyVal: 4.413 ± 0.091
0.677GlyTrp: 0.677 ± 0.031
2.683GlyTyr: 2.683 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
0.852HisAla: 0.852 ± 0.032
0.155HisCys: 0.155 ± 0.014
0.616HisAsp: 0.616 ± 0.027
0.808HisGlu: 0.808 ± 0.032
1.068HisPhe: 1.068 ± 0.036
0.93HisGly: 0.93 ± 0.036
0.44HisHis: 0.44 ± 0.023
1.523HisIle: 1.523 ± 0.046
1.426HisLys: 1.426 ± 0.036
1.687HisLeu: 1.687 ± 0.042
0.27HisMet: 0.27 ± 0.016
1.046HisAsn: 1.046 ± 0.041
0.879HisPro: 0.879 ± 0.038
0.664HisGln: 0.664 ± 0.027
0.6HisArg: 0.6 ± 0.028
0.994HisSer: 0.994 ± 0.032
0.926HisThr: 0.926 ± 0.032
0.801HisVal: 0.801 ± 0.042
0.219HisTrp: 0.219 ± 0.015
0.771HisTyr: 0.771 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.97IleAla: 5.97 ± 0.099
0.588IleCys: 0.588 ± 0.029
5.254IleAsp: 5.254 ± 0.087
6.372IleGlu: 6.372 ± 0.096
4.141IlePhe: 4.141 ± 0.076
5.582IleGly: 5.582 ± 0.098
1.458IleHis: 1.458 ± 0.041
8.006IleIle: 8.006 ± 0.112
7.543IleLys: 7.543 ± 0.098
8.212IleLeu: 8.212 ± 0.127
1.448IleMet: 1.448 ± 0.048
5.836IleAsn: 5.836 ± 0.094
3.545IlePro: 3.545 ± 0.065
2.827IleGln: 2.827 ± 0.059
2.579IleArg: 2.579 ± 0.054
6.745IleSer: 6.745 ± 0.092
5.6IleThr: 5.6 ± 0.103
5.377IleVal: 5.377 ± 0.074
0.745IleTrp: 0.745 ± 0.031
3.321IleTyr: 3.321 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
4.765LysAla: 4.765 ± 0.081
0.408LysCys: 0.408 ± 0.023
4.184LysAsp: 4.184 ± 0.086
7.02LysGlu: 7.02 ± 0.117
3.616LysPhe: 3.616 ± 0.062
5.24LysGly: 5.24 ± 0.081
1.534LysHis: 1.534 ± 0.044
8.537LysIle: 8.537 ± 0.119
9.029LysLys: 9.029 ± 0.135
7.885LysLeu: 7.885 ± 0.111
2.032LysMet: 2.032 ± 0.044
7.372LysAsn: 7.372 ± 0.112
2.629LysPro: 2.629 ± 0.053
3.195LysGln: 3.195 ± 0.061
3.005LysArg: 3.005 ± 0.067
5.01LysSer: 5.01 ± 0.081
5.225LysThr: 5.225 ± 0.097
4.986LysVal: 4.986 ± 0.084
0.853LysTrp: 0.853 ± 0.035
3.614LysTyr: 3.614 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
5.407LeuAla: 5.407 ± 0.108
0.562LeuCys: 0.562 ± 0.028
4.46LeuAsp: 4.46 ± 0.082
5.771LeuGlu: 5.771 ± 0.087
5.231LeuPhe: 5.231 ± 0.094
5.483LeuGly: 5.483 ± 0.091
1.507LeuHis: 1.507 ± 0.046
8.156LeuIle: 8.156 ± 0.118
9.249LeuLys: 9.249 ± 0.12
8.739LeuLeu: 8.739 ± 0.142
1.832LeuMet: 1.832 ± 0.05
6.57LeuAsn: 6.57 ± 0.104
3.323LeuPro: 3.323 ± 0.067
3.008LeuGln: 3.008 ± 0.071
2.725LeuArg: 2.725 ± 0.054
6.113LeuSer: 6.113 ± 0.084
5.329LeuThr: 5.329 ± 0.097
5.091LeuVal: 5.091 ± 0.089
0.695LeuTrp: 0.695 ± 0.029
3.112LeuTyr: 3.112 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
1.387MetAla: 1.387 ± 0.039
0.135MetCys: 0.135 ± 0.012
0.988MetAsp: 0.988 ± 0.032
1.158MetGlu: 1.158 ± 0.038
0.848MetPhe: 0.848 ± 0.036
1.352MetGly: 1.352 ± 0.044
0.381MetHis: 0.381 ± 0.023
1.449MetIle: 1.449 ± 0.041
2.218MetLys: 2.218 ± 0.049
1.899MetLeu: 1.899 ± 0.051
0.541MetMet: 0.541 ± 0.033
1.367MetAsn: 1.367 ± 0.04
0.8MetPro: 0.8 ± 0.026
0.721MetGln: 0.721 ± 0.025
0.743MetArg: 0.743 ± 0.028
1.316MetSer: 1.316 ± 0.04
0.992MetThr: 0.992 ± 0.037
1.248MetVal: 1.248 ± 0.036
0.145MetTrp: 0.145 ± 0.012
0.691MetTyr: 0.691 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.735AsnAla: 3.735 ± 0.068
0.543AsnCys: 0.543 ± 0.027
3.101AsnAsp: 3.101 ± 0.076
4.355AsnGlu: 4.355 ± 0.077
3.839AsnPhe: 3.839 ± 0.077
4.012AsnGly: 4.012 ± 0.1
1.134AsnHis: 1.134 ± 0.037
5.958AsnIle: 5.958 ± 0.103
6.141AsnLys: 6.141 ± 0.099
6.41AsnLeu: 6.41 ± 0.115
1.318AsnMet: 1.318 ± 0.036
5.259AsnAsn: 5.259 ± 0.099
2.801AsnPro: 2.801 ± 0.065
2.085AsnGln: 2.085 ± 0.06
2.028AsnArg: 2.028 ± 0.049
4.658AsnSer: 4.658 ± 0.097
4.214AsnThr: 4.214 ± 0.087
3.696AsnVal: 3.696 ± 0.068
0.849AsnTrp: 0.849 ± 0.035
3.644AsnTyr: 3.644 ± 0.079
0.0AsnXaa: 0.0 ± 0.0
Pro
1.619ProAla: 1.619 ± 0.049
0.199ProCys: 0.199 ± 0.016
1.576ProAsp: 1.576 ± 0.05
2.257ProGlu: 2.257 ± 0.046
1.924ProPhe: 1.924 ± 0.051
1.59ProGly: 1.59 ± 0.046
0.589ProHis: 0.589 ± 0.028
3.107ProIle: 3.107 ± 0.065
2.791ProLys: 2.791 ± 0.053
2.752ProLeu: 2.752 ± 0.059
0.678ProMet: 0.678 ± 0.026
2.401ProAsn: 2.401 ± 0.05
0.774ProPro: 0.774 ± 0.037
1.006ProGln: 1.006 ± 0.036
0.784ProArg: 0.784 ± 0.03
2.066ProSer: 2.066 ± 0.048
2.112ProThr: 2.112 ± 0.055
2.04ProVal: 2.04 ± 0.054
0.324ProTrp: 0.324 ± 0.021
1.372ProTyr: 1.372 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
1.64GlnAla: 1.64 ± 0.054
0.166GlnCys: 0.166 ± 0.015
1.133GlnAsp: 1.133 ± 0.041
2.02GlnGlu: 2.02 ± 0.049
1.647GlnPhe: 1.647 ± 0.043
1.524GlnGly: 1.524 ± 0.049
0.646GlnHis: 0.646 ± 0.025
2.724GlnIle: 2.724 ± 0.062
2.992GlnLys: 2.992 ± 0.058
3.544GlnLeu: 3.544 ± 0.07
0.669GlnMet: 0.669 ± 0.029
2.175GlnAsn: 2.175 ± 0.049
0.915GlnPro: 0.915 ± 0.032
1.49GlnGln: 1.49 ± 0.049
1.073GlnArg: 1.073 ± 0.04
1.665GlnSer: 1.665 ± 0.048
1.775GlnThr: 1.775 ± 0.047
1.627GlnVal: 1.627 ± 0.038
0.292GlnTrp: 0.292 ± 0.017
1.208GlnTyr: 1.208 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
1.887ArgAla: 1.887 ± 0.05
0.173ArgCys: 0.173 ± 0.015
1.503ArgAsp: 1.503 ± 0.044
1.941ArgGlu: 1.941 ± 0.055
1.617ArgPhe: 1.617 ± 0.045
1.864ArgGly: 1.864 ± 0.048
0.502ArgHis: 0.502 ± 0.026
2.814ArgIle: 2.814 ± 0.056
2.846ArgLys: 2.846 ± 0.064
2.827ArgLeu: 2.827 ± 0.062
0.736ArgMet: 0.736 ± 0.029
2.031ArgAsn: 2.031 ± 0.054
0.928ArgPro: 0.928 ± 0.035
0.828ArgGln: 0.828 ± 0.032
1.185ArgArg: 1.185 ± 0.046
1.627ArgSer: 1.627 ± 0.05
1.643ArgThr: 1.643 ± 0.043
1.901ArgVal: 1.901 ± 0.049
0.317ArgTrp: 0.317 ± 0.019
1.318ArgTyr: 1.318 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
3.273SerAla: 3.273 ± 0.069
0.649SerCys: 0.649 ± 0.031
3.005SerAsp: 3.005 ± 0.085
3.941SerGlu: 3.941 ± 0.066
3.832SerPhe: 3.832 ± 0.075
3.99SerGly: 3.99 ± 0.068
1.062SerHis: 1.062 ± 0.04
5.913SerIle: 5.913 ± 0.091
6.005SerLys: 6.005 ± 0.096
5.708SerLeu: 5.708 ± 0.092
1.133SerMet: 1.133 ± 0.04
4.475SerAsn: 4.475 ± 0.099
1.883SerPro: 1.883 ± 0.045
1.883SerGln: 1.883 ± 0.057
1.859SerArg: 1.859 ± 0.05
4.179SerSer: 4.179 ± 0.082
3.871SerThr: 3.871 ± 0.088
3.7SerVal: 3.7 ± 0.077
0.707SerTrp: 0.707 ± 0.033
2.884SerTyr: 2.884 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
3.625ThrAla: 3.625 ± 0.11
0.416ThrCys: 0.416 ± 0.044
2.761ThrAsp: 2.761 ± 0.061
3.251ThrGlu: 3.251 ± 0.079
3.075ThrPhe: 3.075 ± 0.066
3.892ThrGly: 3.892 ± 0.107
1.038ThrHis: 1.038 ± 0.036
6.037ThrIle: 6.037 ± 0.09
4.798ThrLys: 4.798 ± 0.075
5.355ThrLeu: 5.355 ± 0.077
0.934ThrMet: 0.934 ± 0.033
4.01ThrAsn: 4.01 ± 0.075
2.38ThrPro: 2.38 ± 0.05
1.813ThrGln: 1.813 ± 0.044
1.52ThrArg: 1.52 ± 0.05
3.975ThrSer: 3.975 ± 0.074
3.858ThrThr: 3.858 ± 0.087
3.749ThrVal: 3.749 ± 0.102
0.54ThrTrp: 0.54 ± 0.03
2.304ThrTyr: 2.304 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
3.842ValAla: 3.842 ± 0.077
0.466ValCys: 0.466 ± 0.024
3.179ValAsp: 3.179 ± 0.071
3.75ValGlu: 3.75 ± 0.107
3.246ValPhe: 3.246 ± 0.066
3.741ValGly: 3.741 ± 0.071
0.94ValHis: 0.94 ± 0.036
5.341ValIle: 5.341 ± 0.084
4.898ValLys: 4.898 ± 0.084
5.632ValLeu: 5.632 ± 0.097
1.159ValMet: 1.159 ± 0.035
3.777ValAsn: 3.777 ± 0.069
1.877ValPro: 1.877 ± 0.053
1.612ValGln: 1.612 ± 0.044
1.762ValArg: 1.762 ± 0.053
4.097ValSer: 4.097 ± 0.068
3.559ValThr: 3.559 ± 0.131
3.909ValVal: 3.909 ± 0.094
0.569ValTrp: 0.569 ± 0.027
2.247ValTyr: 2.247 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.572TrpAla: 0.572 ± 0.027
0.07TrpCys: 0.07 ± 0.008
0.513TrpAsp: 0.513 ± 0.024
0.597TrpGlu: 0.597 ± 0.027
0.572TrpPhe: 0.572 ± 0.032
0.638TrpGly: 0.638 ± 0.03
0.177TrpHis: 0.177 ± 0.015
0.81TrpIle: 0.81 ± 0.029
0.79TrpLys: 0.79 ± 0.031
0.938TrpLeu: 0.938 ± 0.033
0.295TrpMet: 0.295 ± 0.019
0.748TrpAsn: 0.748 ± 0.03
0.224TrpPro: 0.224 ± 0.017
0.354TrpGln: 0.354 ± 0.021
0.381TrpArg: 0.381 ± 0.024
0.559TrpSer: 0.559 ± 0.033
0.443TrpThr: 0.443 ± 0.027
0.553TrpVal: 0.553 ± 0.028
0.15TrpTrp: 0.15 ± 0.013
0.402TrpTyr: 0.402 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.279TyrAla: 2.279 ± 0.057
0.281TyrCys: 0.281 ± 0.018
1.899TyrAsp: 1.899 ± 0.055
2.026TyrGlu: 2.026 ± 0.053
2.695TyrPhe: 2.695 ± 0.062
2.555TyrGly: 2.555 ± 0.06
0.744TyrHis: 0.744 ± 0.03
3.082TyrIle: 3.082 ± 0.064
3.778TyrLys: 3.778 ± 0.074
3.914TyrLeu: 3.914 ± 0.086
0.72TyrMet: 0.72 ± 0.027
2.954TyrAsn: 2.954 ± 0.068
1.437TyrPro: 1.437 ± 0.048
1.409TyrGln: 1.409 ± 0.042
1.35TyrArg: 1.35 ± 0.042
2.721TyrSer: 2.721 ± 0.071
2.505TyrThr: 2.505 ± 0.068
2.087TyrVal: 2.087 ± 0.05
0.496TyrTrp: 0.496 ± 0.025
1.91TyrTyr: 1.91 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2525 proteins (871124 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski