Amino acid dipepetide frequency for Streptococcus phage Javan628

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.948AlaAla: 3.948 ± 1.1
0.175AlaCys: 0.175 ± 0.118
5.001AlaAsp: 5.001 ± 0.972
5.264AlaGlu: 5.264 ± 0.682
3.246AlaPhe: 3.246 ± 0.614
4.65AlaGly: 4.65 ± 1.222
0.439AlaHis: 0.439 ± 0.164
6.668AlaIle: 6.668 ± 1.155
5.615AlaLys: 5.615 ± 0.553
6.756AlaLeu: 6.756 ± 0.729
2.544AlaMet: 2.544 ± 0.738
4.124AlaAsn: 4.124 ± 0.601
1.579AlaPro: 1.579 ± 0.358
3.158AlaGln: 3.158 ± 0.777
2.895AlaArg: 2.895 ± 0.37
4.825AlaSer: 4.825 ± 0.917
5.352AlaThr: 5.352 ± 1.126
4.387AlaVal: 4.387 ± 0.94
0.526AlaTrp: 0.526 ± 0.225
3.071AlaTyr: 3.071 ± 0.474
0.0AlaXaa: 0.0 ± 0.0
Cys
0.088CysAla: 0.088 ± 0.074
0.0CysCys: 0.0 ± 0.0
0.175CysAsp: 0.175 ± 0.122
0.79CysGlu: 0.79 ± 0.288
0.088CysPhe: 0.088 ± 0.08
0.614CysGly: 0.614 ± 0.237
0.263CysHis: 0.263 ± 0.155
0.439CysIle: 0.439 ± 0.175
0.702CysLys: 0.702 ± 0.283
0.526CysLeu: 0.526 ± 0.233
0.175CysMet: 0.175 ± 0.121
0.175CysAsn: 0.175 ± 0.121
0.088CysPro: 0.088 ± 0.112
0.0CysGln: 0.0 ± 0.0
0.263CysArg: 0.263 ± 0.142
0.439CysSer: 0.439 ± 0.207
0.088CysThr: 0.088 ± 0.074
0.351CysVal: 0.351 ± 0.159
0.0CysTrp: 0.0 ± 0.0
0.263CysTyr: 0.263 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
5.264AspAla: 5.264 ± 0.641
0.175AspCys: 0.175 ± 0.125
4.65AspAsp: 4.65 ± 0.803
5.79AspGlu: 5.79 ± 0.814
4.474AspPhe: 4.474 ± 0.639
4.65AspGly: 4.65 ± 0.869
0.877AspHis: 0.877 ± 0.234
4.299AspIle: 4.299 ± 0.624
5.352AspLys: 5.352 ± 0.72
4.474AspLeu: 4.474 ± 0.724
2.018AspMet: 2.018 ± 0.446
2.544AspAsn: 2.544 ± 0.65
1.579AspPro: 1.579 ± 0.348
1.579AspGln: 1.579 ± 0.35
2.281AspArg: 2.281 ± 0.536
4.036AspSer: 4.036 ± 0.526
3.773AspThr: 3.773 ± 0.61
3.773AspVal: 3.773 ± 0.654
1.053AspTrp: 1.053 ± 0.279
3.948AspTyr: 3.948 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
5.089GluAla: 5.089 ± 0.751
0.439GluCys: 0.439 ± 0.191
3.86GluAsp: 3.86 ± 0.514
5.966GluGlu: 5.966 ± 1.057
3.509GluPhe: 3.509 ± 0.651
3.246GluGly: 3.246 ± 0.473
1.141GluHis: 1.141 ± 0.245
7.019GluIle: 7.019 ± 1.058
7.37GluLys: 7.37 ± 0.989
7.721GluLeu: 7.721 ± 0.889
3.246GluMet: 3.246 ± 0.656
3.86GluAsn: 3.86 ± 0.561
1.93GluPro: 1.93 ± 0.39
2.808GluGln: 2.808 ± 0.633
4.474GluArg: 4.474 ± 0.791
3.334GluSer: 3.334 ± 0.45
2.895GluThr: 2.895 ± 0.499
5.001GluVal: 5.001 ± 0.776
0.965GluTrp: 0.965 ± 0.255
2.72GluTyr: 2.72 ± 0.595
0.0GluXaa: 0.0 ± 0.0
Phe
2.808PheAla: 2.808 ± 0.559
0.702PheCys: 0.702 ± 0.281
4.036PheAsp: 4.036 ± 0.727
3.86PheGlu: 3.86 ± 0.7
1.141PhePhe: 1.141 ± 0.306
3.334PheGly: 3.334 ± 0.521
0.877PheHis: 0.877 ± 0.268
2.018PheIle: 2.018 ± 0.359
3.422PheLys: 3.422 ± 0.61
2.72PheLeu: 2.72 ± 0.479
1.141PheMet: 1.141 ± 0.292
2.281PheAsn: 2.281 ± 0.379
0.965PhePro: 0.965 ± 0.292
1.316PheGln: 1.316 ± 0.324
1.842PheArg: 1.842 ± 0.372
2.72PheSer: 2.72 ± 0.557
2.369PheThr: 2.369 ± 0.478
1.755PheVal: 1.755 ± 0.326
0.526PheTrp: 0.526 ± 0.201
1.667PheTyr: 1.667 ± 0.352
0.0PheXaa: 0.0 ± 0.0
Gly
4.562GlyAla: 4.562 ± 0.948
0.351GlyCys: 0.351 ± 0.218
3.158GlyAsp: 3.158 ± 0.396
2.895GlyGlu: 2.895 ± 0.48
2.632GlyPhe: 2.632 ± 0.476
4.65GlyGly: 4.65 ± 0.821
1.316GlyHis: 1.316 ± 0.349
6.054GlyIle: 6.054 ± 0.796
6.054GlyLys: 6.054 ± 0.676
5.79GlyLeu: 5.79 ± 0.979
2.106GlyMet: 2.106 ± 0.759
3.246GlyAsn: 3.246 ± 0.589
1.053GlyPro: 1.053 ± 0.245
2.193GlyGln: 2.193 ± 0.368
2.632GlyArg: 2.632 ± 0.49
2.808GlySer: 2.808 ± 0.733
3.597GlyThr: 3.597 ± 0.651
3.685GlyVal: 3.685 ± 0.569
0.439GlyTrp: 0.439 ± 0.168
2.72GlyTyr: 2.72 ± 0.391
0.0GlyXaa: 0.0 ± 0.0
His
1.053HisAla: 1.053 ± 0.304
0.175HisCys: 0.175 ± 0.105
1.228HisAsp: 1.228 ± 0.4
0.965HisGlu: 0.965 ± 0.294
0.439HisPhe: 0.439 ± 0.189
1.053HisGly: 1.053 ± 0.251
0.175HisHis: 0.175 ± 0.116
1.053HisIle: 1.053 ± 0.315
1.491HisLys: 1.491 ± 0.373
1.316HisLeu: 1.316 ± 0.336
0.175HisMet: 0.175 ± 0.158
0.79HisAsn: 0.79 ± 0.256
0.79HisPro: 0.79 ± 0.269
0.351HisGln: 0.351 ± 0.197
0.263HisArg: 0.263 ± 0.156
0.877HisSer: 0.877 ± 0.27
0.965HisThr: 0.965 ± 0.289
0.439HisVal: 0.439 ± 0.158
0.0HisTrp: 0.0 ± 0.0
0.79HisTyr: 0.79 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
6.317IleAla: 6.317 ± 1.318
0.175IleCys: 0.175 ± 0.126
5.615IleAsp: 5.615 ± 0.934
6.405IleGlu: 6.405 ± 0.889
3.158IlePhe: 3.158 ± 0.534
3.86IleGly: 3.86 ± 0.724
1.228IleHis: 1.228 ± 0.383
4.387IleIle: 4.387 ± 0.563
5.79IleLys: 5.79 ± 0.774
6.229IleLeu: 6.229 ± 0.607
1.141IleMet: 1.141 ± 0.326
4.913IleAsn: 4.913 ± 0.643
1.579IlePro: 1.579 ± 0.34
2.106IleGln: 2.106 ± 0.468
2.895IleArg: 2.895 ± 0.465
5.878IleSer: 5.878 ± 0.743
3.509IleThr: 3.509 ± 0.505
4.124IleVal: 4.124 ± 0.773
0.702IleTrp: 0.702 ± 0.208
3.246IleTyr: 3.246 ± 0.519
0.0IleXaa: 0.0 ± 0.0
Lys
6.317LysAla: 6.317 ± 0.674
0.526LysCys: 0.526 ± 0.267
5.176LysAsp: 5.176 ± 0.689
7.107LysGlu: 7.107 ± 1.084
2.808LysPhe: 2.808 ± 0.381
5.089LysGly: 5.089 ± 0.603
0.702LysHis: 0.702 ± 0.277
6.229LysIle: 6.229 ± 0.752
6.756LysLys: 6.756 ± 1.046
6.756LysLeu: 6.756 ± 0.805
2.106LysMet: 2.106 ± 0.415
4.738LysAsn: 4.738 ± 0.836
3.158LysPro: 3.158 ± 0.399
3.509LysGln: 3.509 ± 0.5
3.158LysArg: 3.158 ± 0.589
3.948LysSer: 3.948 ± 0.786
4.65LysThr: 4.65 ± 0.746
5.264LysVal: 5.264 ± 0.776
1.316LysTrp: 1.316 ± 0.304
2.895LysTyr: 2.895 ± 0.579
0.0LysXaa: 0.0 ± 0.0
Leu
5.615LeuAla: 5.615 ± 0.709
0.614LeuCys: 0.614 ± 0.227
5.79LeuAsp: 5.79 ± 0.575
7.282LeuGlu: 7.282 ± 0.915
2.193LeuPhe: 2.193 ± 0.385
5.44LeuGly: 5.44 ± 0.765
1.053LeuHis: 1.053 ± 0.359
5.527LeuIle: 5.527 ± 0.932
7.984LeuLys: 7.984 ± 1.126
5.264LeuLeu: 5.264 ± 0.804
2.018LeuMet: 2.018 ± 0.342
5.176LeuAsn: 5.176 ± 0.573
2.808LeuPro: 2.808 ± 0.534
2.983LeuGln: 2.983 ± 0.453
3.422LeuArg: 3.422 ± 0.604
5.264LeuSer: 5.264 ± 0.757
6.931LeuThr: 6.931 ± 0.965
4.65LeuVal: 4.65 ± 0.574
0.263LeuTrp: 0.263 ± 0.151
2.808LeuTyr: 2.808 ± 0.475
0.0LeuXaa: 0.0 ± 0.0
Met
3.158MetAla: 3.158 ± 0.813
0.088MetCys: 0.088 ± 0.074
1.842MetAsp: 1.842 ± 0.472
1.316MetGlu: 1.316 ± 0.36
0.965MetPhe: 0.965 ± 0.282
1.579MetGly: 1.579 ± 0.441
0.439MetHis: 0.439 ± 0.179
2.106MetIle: 2.106 ± 0.467
2.193MetLys: 2.193 ± 0.494
1.667MetLeu: 1.667 ± 0.301
0.877MetMet: 0.877 ± 0.291
1.491MetAsn: 1.491 ± 0.335
0.79MetPro: 0.79 ± 0.29
1.667MetGln: 1.667 ± 0.425
1.316MetArg: 1.316 ± 0.36
1.93MetSer: 1.93 ± 0.379
2.193MetThr: 2.193 ± 0.473
1.579MetVal: 1.579 ± 0.49
0.175MetTrp: 0.175 ± 0.121
0.439MetTyr: 0.439 ± 0.185
0.0MetXaa: 0.0 ± 0.0
Asn
4.036AsnAla: 4.036 ± 0.632
0.263AsnCys: 0.263 ± 0.164
3.509AsnAsp: 3.509 ± 0.675
3.334AsnGlu: 3.334 ± 0.669
1.579AsnPhe: 1.579 ± 0.354
4.036AsnGly: 4.036 ± 0.58
0.614AsnHis: 0.614 ± 0.22
4.65AsnIle: 4.65 ± 0.757
3.773AsnLys: 3.773 ± 0.681
4.562AsnLeu: 4.562 ± 0.778
1.491AsnMet: 1.491 ± 0.327
2.544AsnAsn: 2.544 ± 0.608
2.281AsnPro: 2.281 ± 0.453
2.193AsnGln: 2.193 ± 0.521
2.457AsnArg: 2.457 ± 0.521
3.246AsnSer: 3.246 ± 0.432
2.281AsnThr: 2.281 ± 0.519
3.071AsnVal: 3.071 ± 0.476
0.79AsnTrp: 0.79 ± 0.257
2.808AsnTyr: 2.808 ± 0.614
0.0AsnXaa: 0.0 ± 0.0
Pro
1.667ProAla: 1.667 ± 0.405
0.175ProCys: 0.175 ± 0.111
1.491ProAsp: 1.491 ± 0.413
1.667ProGlu: 1.667 ± 0.533
1.228ProPhe: 1.228 ± 0.355
1.228ProGly: 1.228 ± 0.283
0.439ProHis: 0.439 ± 0.176
2.369ProIle: 2.369 ± 0.318
2.281ProLys: 2.281 ± 0.523
1.842ProLeu: 1.842 ± 0.295
0.526ProMet: 0.526 ± 0.192
1.667ProAsn: 1.667 ± 0.378
0.351ProPro: 0.351 ± 0.139
1.404ProGln: 1.404 ± 0.473
1.141ProArg: 1.141 ± 0.442
1.667ProSer: 1.667 ± 0.369
1.755ProThr: 1.755 ± 0.31
2.457ProVal: 2.457 ± 0.488
0.175ProTrp: 0.175 ± 0.108
1.141ProTyr: 1.141 ± 0.387
0.0ProXaa: 0.0 ± 0.0
Gln
3.685GlnAla: 3.685 ± 0.679
0.088GlnCys: 0.088 ± 0.074
1.491GlnAsp: 1.491 ± 0.385
3.422GlnGlu: 3.422 ± 0.6
2.018GlnPhe: 2.018 ± 0.44
2.808GlnGly: 2.808 ± 0.433
0.263GlnHis: 0.263 ± 0.155
3.334GlnIle: 3.334 ± 0.604
2.983GlnLys: 2.983 ± 0.555
3.246GlnLeu: 3.246 ± 0.52
1.93GlnMet: 1.93 ± 0.514
1.667GlnAsn: 1.667 ± 0.526
0.79GlnPro: 0.79 ± 0.212
1.755GlnGln: 1.755 ± 0.645
1.053GlnArg: 1.053 ± 0.279
2.983GlnSer: 2.983 ± 0.696
1.579GlnThr: 1.579 ± 0.399
1.667GlnVal: 1.667 ± 0.379
0.439GlnTrp: 0.439 ± 0.206
1.141GlnTyr: 1.141 ± 0.319
0.0GlnXaa: 0.0 ± 0.0
Arg
2.72ArgAla: 2.72 ± 0.48
0.439ArgCys: 0.439 ± 0.289
3.071ArgAsp: 3.071 ± 0.482
2.72ArgGlu: 2.72 ± 0.492
2.193ArgPhe: 2.193 ± 0.474
1.404ArgGly: 1.404 ± 0.294
0.965ArgHis: 0.965 ± 0.284
3.334ArgIle: 3.334 ± 0.59
3.246ArgLys: 3.246 ± 0.414
5.089ArgLeu: 5.089 ± 0.529
1.141ArgMet: 1.141 ± 0.322
2.457ArgAsn: 2.457 ± 0.497
0.877ArgPro: 0.877 ± 0.263
1.404ArgGln: 1.404 ± 0.321
2.106ArgArg: 2.106 ± 0.499
1.141ArgSer: 1.141 ± 0.332
1.842ArgThr: 1.842 ± 0.427
2.544ArgVal: 2.544 ± 0.546
0.614ArgTrp: 0.614 ± 0.238
1.228ArgTyr: 1.228 ± 0.325
0.0ArgXaa: 0.0 ± 0.0
Ser
5.44SerAla: 5.44 ± 1.135
0.263SerCys: 0.263 ± 0.148
3.948SerAsp: 3.948 ± 0.569
4.036SerGlu: 4.036 ± 0.528
2.457SerPhe: 2.457 ± 0.406
4.65SerGly: 4.65 ± 0.512
0.965SerHis: 0.965 ± 0.378
3.071SerIle: 3.071 ± 0.678
5.176SerLys: 5.176 ± 0.673
4.211SerLeu: 4.211 ± 0.57
1.667SerMet: 1.667 ± 0.486
3.071SerAsn: 3.071 ± 0.457
1.316SerPro: 1.316 ± 0.296
2.808SerGln: 2.808 ± 0.522
2.369SerArg: 2.369 ± 0.399
5.001SerSer: 5.001 ± 0.845
3.509SerThr: 3.509 ± 0.9
4.299SerVal: 4.299 ± 0.873
0.526SerTrp: 0.526 ± 0.174
2.457SerTyr: 2.457 ± 0.498
0.0SerXaa: 0.0 ± 0.0
Thr
4.211ThrAla: 4.211 ± 1.133
0.088ThrCys: 0.088 ± 0.077
3.685ThrAsp: 3.685 ± 0.582
3.685ThrGlu: 3.685 ± 0.598
2.808ThrPhe: 2.808 ± 0.392
3.86ThrGly: 3.86 ± 0.684
0.877ThrHis: 0.877 ± 0.263
4.211ThrIle: 4.211 ± 0.708
3.509ThrLys: 3.509 ± 0.572
5.527ThrLeu: 5.527 ± 0.702
1.053ThrMet: 1.053 ± 0.347
2.281ThrAsn: 2.281 ± 0.513
1.491ThrPro: 1.491 ± 0.455
2.018ThrGln: 2.018 ± 0.424
1.228ThrArg: 1.228 ± 0.26
3.86ThrSer: 3.86 ± 0.78
4.387ThrThr: 4.387 ± 0.812
5.878ThrVal: 5.878 ± 0.844
1.053ThrTrp: 1.053 ± 0.37
2.632ThrTyr: 2.632 ± 0.46
0.0ThrXaa: 0.0 ± 0.0
Val
4.65ValAla: 4.65 ± 1.073
0.263ValCys: 0.263 ± 0.14
4.562ValAsp: 4.562 ± 0.608
5.966ValGlu: 5.966 ± 0.917
2.193ValPhe: 2.193 ± 0.377
3.246ValGly: 3.246 ± 0.71
1.141ValHis: 1.141 ± 0.314
4.299ValIle: 4.299 ± 0.523
4.387ValLys: 4.387 ± 0.581
5.001ValLeu: 5.001 ± 0.582
1.316ValMet: 1.316 ± 0.368
3.773ValAsn: 3.773 ± 0.474
2.457ValPro: 2.457 ± 0.468
2.193ValGln: 2.193 ± 0.548
2.369ValArg: 2.369 ± 0.397
3.948ValSer: 3.948 ± 0.517
3.773ValThr: 3.773 ± 0.562
3.948ValVal: 3.948 ± 0.524
0.526ValTrp: 0.526 ± 0.249
2.632ValTyr: 2.632 ± 0.493
0.0ValXaa: 0.0 ± 0.0
Trp
0.79TrpAla: 0.79 ± 0.327
0.088TrpCys: 0.088 ± 0.112
0.965TrpAsp: 0.965 ± 0.215
0.79TrpGlu: 0.79 ± 0.229
0.614TrpPhe: 0.614 ± 0.195
0.526TrpGly: 0.526 ± 0.235
0.175TrpHis: 0.175 ± 0.133
0.175TrpIle: 0.175 ± 0.117
0.614TrpLys: 0.614 ± 0.204
0.877TrpLeu: 0.877 ± 0.295
0.263TrpMet: 0.263 ± 0.157
0.263TrpAsn: 0.263 ± 0.15
0.263TrpPro: 0.263 ± 0.196
0.79TrpGln: 0.79 ± 0.228
0.439TrpArg: 0.439 ± 0.261
0.965TrpSer: 0.965 ± 0.245
0.614TrpThr: 0.614 ± 0.245
0.965TrpVal: 0.965 ± 0.357
0.088TrpTrp: 0.088 ± 0.084
0.263TrpTyr: 0.263 ± 0.158
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.808TyrAla: 2.808 ± 0.531
0.439TyrCys: 0.439 ± 0.184
3.334TyrAsp: 3.334 ± 0.629
3.334TyrGlu: 3.334 ± 0.542
1.755TyrPhe: 1.755 ± 0.427
2.018TyrGly: 2.018 ± 0.493
0.439TyrHis: 0.439 ± 0.194
2.018TyrIle: 2.018 ± 0.364
3.597TyrLys: 3.597 ± 0.611
3.509TyrLeu: 3.509 ± 0.57
0.79TyrMet: 0.79 ± 0.195
2.457TyrAsn: 2.457 ± 0.484
0.526TyrPro: 0.526 ± 0.194
2.106TyrGln: 2.106 ± 0.629
1.93TyrArg: 1.93 ± 0.396
2.369TyrSer: 2.369 ± 0.378
2.281TyrThr: 2.281 ± 0.437
2.808TyrVal: 2.808 ± 0.564
0.351TyrTrp: 0.351 ± 0.168
2.193TyrTyr: 2.193 ± 0.454
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski