Amino acid dipepetide frequency for Planctomycetes bacterium FF011L

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.785AlaAla: 11.785 ± 0.127	1.165AlaCys: 1.165 ± 0.03	6.201AlaAsp: 6.201 ± 0.067	6.781AlaGlu: 6.781 ± 0.085	3.435AlaPhe: 3.435 ± 0.047	7.908AlaGly: 7.908 ± 0.087	1.543AlaHis: 1.543 ± 0.033	5.953AlaIle: 5.953 ± 0.062	4.213AlaLys: 4.213 ± 0.061	8.125AlaLeu: 8.125 ± 0.069	2.593AlaMet: 2.593 ± 0.041	3.355AlaAsn: 3.355 ± 0.05	4.269AlaPro: 4.269 ± 0.061	3.243AlaGln: 3.243 ± 0.049	4.914AlaArg: 4.914 ± 0.063	6.541AlaSer: 6.541 ± 0.063	5.764AlaThr: 5.764 ± 0.062	6.922AlaVal: 6.922 ± 0.063	1.361AlaTrp: 1.361 ± 0.028	2.094AlaTyr: 2.094 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.71CysAla: 0.71 ± 0.023	0.252CysCys: 0.252 ± 0.017	0.702CysAsp: 0.702 ± 0.019	0.639CysGlu: 0.639 ± 0.021	0.473CysPhe: 0.473 ± 0.018	1.029CysGly: 1.029 ± 0.033	0.438CysHis: 0.438 ± 0.019	0.456CysIle: 0.456 ± 0.015	0.323CysLys: 0.323 ± 0.013	1.167CysLeu: 1.167 ± 0.024	0.2CysMet: 0.2 ± 0.01	0.312CysAsn: 0.312 ± 0.013	0.557CysPro: 0.557 ± 0.019	0.495CysGln: 0.495 ± 0.017	0.75CysArg: 0.75 ± 0.022	0.707CysSer: 0.707 ± 0.019	0.494CysThr: 0.494 ± 0.016	0.798CysVal: 0.798 ± 0.021	0.179CysTrp: 0.179 ± 0.009	0.301CysTyr: 0.301 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.945AspAla: 5.945 ± 0.064	0.603AspCys: 0.603 ± 0.019	3.685AspAsp: 3.685 ± 0.065	3.606AspGlu: 3.606 ± 0.051	2.425AspPhe: 2.425 ± 0.036	5.205AspGly: 5.205 ± 0.09	1.373AspHis: 1.373 ± 0.027	2.546AspIle: 2.546 ± 0.043	1.818AspLys: 1.818 ± 0.035	6.024AspLeu: 6.024 ± 0.055	0.977AspMet: 0.977 ± 0.022	1.728AspAsn: 1.728 ± 0.04	3.833AspPro: 3.833 ± 0.05	2.873AspGln: 2.873 ± 0.038	4.196AspArg: 4.196 ± 0.045	4.151AspSer: 4.151 ± 0.058	2.61AspThr: 2.61 ± 0.054	4.041AspVal: 4.041 ± 0.045	1.104AspTrp: 1.104 ± 0.023	1.552AspTyr: 1.552 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.781GluAla: 5.781 ± 0.07	0.491GluCys: 0.491 ± 0.016	2.979GluAsp: 2.979 ± 0.039	3.671GluGlu: 3.671 ± 0.065	2.138GluPhe: 2.138 ± 0.035	4.01GluGly: 4.01 ± 0.044	1.3GluHis: 1.3 ± 0.035	3.462GluIle: 3.462 ± 0.046	2.698GluLys: 2.698 ± 0.053	6.284GluLeu: 6.284 ± 0.075	1.568GluMet: 1.568 ± 0.03	2.21GluAsn: 2.21 ± 0.031	2.792GluPro: 2.792 ± 0.044	3.088GluGln: 3.088 ± 0.047	4.115GluArg: 4.115 ± 0.063	4.448GluSer: 4.448 ± 0.058	3.817GluThr: 3.817 ± 0.051	3.986GluVal: 3.986 ± 0.052	0.879GluTrp: 0.879 ± 0.024	1.343GluTyr: 1.343 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.899PheAla: 3.899 ± 0.047	0.494PheCys: 0.494 ± 0.017	2.683PheAsp: 2.683 ± 0.04	2.193PheGlu: 2.193 ± 0.034	1.444PhePhe: 1.444 ± 0.029	3.18PheGly: 3.18 ± 0.046	0.82PheHis: 0.82 ± 0.022	1.471PheIle: 1.471 ± 0.031	1.021PheLys: 1.021 ± 0.024	3.598PheLeu: 3.598 ± 0.041	0.643PheMet: 0.643 ± 0.018	1.135PheAsn: 1.135 ± 0.032	1.733PhePro: 1.733 ± 0.034	1.55PheGln: 1.55 ± 0.025	2.327PheArg: 2.327 ± 0.039	2.514PheSer: 2.514 ± 0.035	1.899PheThr: 1.899 ± 0.035	2.737PheVal: 2.737 ± 0.042	0.553PheTrp: 0.553 ± 0.019	0.958PheTyr: 0.958 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.783GlyAla: 5.783 ± 0.074	1.001GlyCys: 1.001 ± 0.032	4.647GlyAsp: 4.647 ± 0.081	4.595GlyGlu: 4.595 ± 0.061	3.034GlyPhe: 3.034 ± 0.047	6.595GlyGly: 6.595 ± 0.112	1.599GlyHis: 1.599 ± 0.031	4.312GlyIle: 4.312 ± 0.062	3.666GlyLys: 3.666 ± 0.055	7.152GlyLeu: 7.152 ± 0.059	2.094GlyMet: 2.094 ± 0.045	2.811GlyAsn: 2.811 ± 0.062	3.224GlyPro: 3.224 ± 0.046	3.138GlyGln: 3.138 ± 0.056	4.701GlyArg: 4.701 ± 0.055	5.066GlySer: 5.066 ± 0.075	4.622GlyThr: 4.622 ± 0.081	5.201GlyVal: 5.201 ± 0.063	1.344GlyTrp: 1.344 ± 0.028	2.136GlyTyr: 2.136 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	1.964HisAla: 1.964 ± 0.036	0.322HisCys: 0.322 ± 0.014	1.291HisAsp: 1.291 ± 0.029	1.152HisGlu: 1.152 ± 0.027	0.939HisPhe: 0.939 ± 0.021	1.717HisGly: 1.717 ± 0.039	0.647HisHis: 0.647 ± 0.017	0.808HisIle: 0.808 ± 0.02	0.566HisLys: 0.566 ± 0.019	2.204HisLeu: 2.204 ± 0.035	0.359HisMet: 0.359 ± 0.014	0.646HisAsn: 0.646 ± 0.019	1.516HisPro: 1.516 ± 0.033	0.962HisGln: 0.962 ± 0.027	1.596HisArg: 1.596 ± 0.038	1.377HisSer: 1.377 ± 0.03	0.917HisThr: 0.917 ± 0.022	1.418HisVal: 1.418 ± 0.028	0.448HisTrp: 0.448 ± 0.015	0.596HisTyr: 0.596 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.012IleAla: 6.012 ± 0.057	0.632IleCys: 0.632 ± 0.017	4.024IleAsp: 4.024 ± 0.058	3.79IleGlu: 3.79 ± 0.05	1.515IlePhe: 1.515 ± 0.032	4.238IleGly: 4.238 ± 0.051	1.118IleHis: 1.118 ± 0.026	1.822IleIle: 1.822 ± 0.039	1.46IleLys: 1.46 ± 0.031	4.429IleLeu: 4.429 ± 0.057	0.73IleMet: 0.73 ± 0.022	1.47IleAsn: 1.47 ± 0.036	2.74IlePro: 2.74 ± 0.035	2.153IleGln: 2.153 ± 0.035	3.556IleArg: 3.556 ± 0.043	3.058IleSer: 3.058 ± 0.042	2.573IleThr: 2.573 ± 0.043	3.915IleVal: 3.915 ± 0.046	0.653IleTrp: 0.653 ± 0.021	1.177IleTyr: 1.177 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.246LysAla: 3.246 ± 0.064	0.301LysCys: 0.301 ± 0.011	1.862LysAsp: 1.862 ± 0.036	2.189LysGlu: 2.189 ± 0.048	1.14LysPhe: 1.14 ± 0.025	2.198LysGly: 2.198 ± 0.041	0.835LysHis: 0.835 ± 0.023	1.991LysIle: 1.991 ± 0.031	1.826LysLys: 1.826 ± 0.042	3.519LysLeu: 3.519 ± 0.046	0.967LysMet: 0.967 ± 0.023	1.24LysAsn: 1.24 ± 0.029	2.355LysPro: 2.355 ± 0.04	1.916LysGln: 1.916 ± 0.038	2.656LysArg: 2.656 ± 0.043	2.423LysSer: 2.423 ± 0.04	2.366LysThr: 2.366 ± 0.041	2.388LysVal: 2.388 ± 0.04	0.534LysTrp: 0.534 ± 0.019	0.879LysTyr: 0.879 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	10.905LeuAla: 10.905 ± 0.094	1.076LeuCys: 1.076 ± 0.025	5.658LeuAsp: 5.658 ± 0.06	5.733LeuGlu: 5.733 ± 0.068	3.567LeuPhe: 3.567 ± 0.047	7.014LeuGly: 7.014 ± 0.065	1.994LeuHis: 1.994 ± 0.034	4.641LeuIle: 4.641 ± 0.054	3.71LeuLys: 3.71 ± 0.053	10.236LeuLeu: 10.236 ± 0.103	2.062LeuMet: 2.062 ± 0.034	3.039LeuAsn: 3.039 ± 0.04	5.735LeuPro: 5.735 ± 0.057	4.548LeuGln: 4.548 ± 0.055	6.27LeuArg: 6.27 ± 0.068	6.421LeuSer: 6.421 ± 0.056	5.724LeuThr: 5.724 ± 0.057	6.893LeuVal: 6.893 ± 0.086	1.233LeuTrp: 1.233 ± 0.031	2.029LeuTyr: 2.029 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.074MetAla: 2.074 ± 0.033	0.176MetCys: 0.176 ± 0.011	1.133MetAsp: 1.133 ± 0.029	1.202MetGlu: 1.202 ± 0.026	0.725MetPhe: 0.725 ± 0.018	1.547MetGly: 1.547 ± 0.04	0.533MetHis: 0.533 ± 0.017	1.231MetIle: 1.231 ± 0.029	0.943MetLys: 0.943 ± 0.022	2.44MetLeu: 2.44 ± 0.04	0.54MetMet: 0.54 ± 0.019	0.879MetAsn: 0.879 ± 0.022	1.429MetPro: 1.429 ± 0.029	1.054MetGln: 1.054 ± 0.023	1.427MetArg: 1.427 ± 0.028	1.441MetSer: 1.441 ± 0.027	1.391MetThr: 1.391 ± 0.027	1.584MetVal: 1.584 ± 0.029	0.247MetTrp: 0.247 ± 0.013	0.391MetTyr: 0.391 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.087AsnAla: 3.087 ± 0.051	0.343AsnCys: 0.343 ± 0.013	1.974AsnAsp: 1.974 ± 0.048	1.869AsnGlu: 1.869 ± 0.034	1.132AsnPhe: 1.132 ± 0.028	2.809AsnGly: 2.809 ± 0.062	0.811AsnHis: 0.811 ± 0.021	1.397AsnIle: 1.397 ± 0.031	0.907AsnLys: 0.907 ± 0.02	3.124AsnLeu: 3.124 ± 0.045	0.612AsnMet: 0.612 ± 0.016	1.047AsnAsn: 1.047 ± 0.029	2.164AsnPro: 2.164 ± 0.037	1.636AsnGln: 1.636 ± 0.028	2.487AsnArg: 2.487 ± 0.035	2.0AsnSer: 2.0 ± 0.043	1.516AsnThr: 1.516 ± 0.036	2.324AsnVal: 2.324 ± 0.041	0.565AsnTrp: 0.565 ± 0.018	0.844AsnTyr: 0.844 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.78ProAla: 5.78 ± 0.081	0.397ProCys: 0.397 ± 0.014	3.403ProAsp: 3.403 ± 0.048	3.932ProGlu: 3.932 ± 0.056	1.95ProPhe: 1.95 ± 0.034	3.889ProGly: 3.889 ± 0.069	1.095ProHis: 1.095 ± 0.023	2.76ProIle: 2.76 ± 0.039	2.026ProLys: 2.026 ± 0.036	5.078ProLeu: 5.078 ± 0.051	1.139ProMet: 1.139 ± 0.026	1.912ProAsn: 1.912 ± 0.038	3.034ProPro: 3.034 ± 0.057	2.211ProGln: 2.211 ± 0.036	2.686ProArg: 2.686 ± 0.04	3.714ProSer: 3.714 ± 0.046	3.222ProThr: 3.222 ± 0.045	3.85ProVal: 3.85 ± 0.051	0.724ProTrp: 0.724 ± 0.02	1.188ProTyr: 1.188 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.541GlnAla: 4.541 ± 0.051	0.347GlnCys: 0.347 ± 0.015	1.877GlnAsp: 1.877 ± 0.034	2.162GlnGlu: 2.162 ± 0.037	1.6GlnPhe: 1.6 ± 0.028	2.564GlnGly: 2.564 ± 0.045	1.03GlnHis: 1.03 ± 0.024	2.577GlnIle: 2.577 ± 0.035	1.494GlnLys: 1.494 ± 0.03	4.645GlnLeu: 4.645 ± 0.054	1.129GlnMet: 1.129 ± 0.026	1.36GlnAsn: 1.36 ± 0.026	2.607GlnPro: 2.607 ± 0.047	2.642GlnGln: 2.642 ± 0.058	3.123GlnArg: 3.123 ± 0.051	2.842GlnSer: 2.842 ± 0.041	2.82GlnThr: 2.82 ± 0.035	2.978GlnVal: 2.978 ± 0.041	0.726GlnTrp: 0.726 ± 0.018	0.988GlnTyr: 0.988 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.516ArgAla: 4.516 ± 0.063	0.747ArgCys: 0.747 ± 0.022	3.585ArgAsp: 3.585 ± 0.043	3.752ArgGlu: 3.752 ± 0.059	2.952ArgPhe: 2.952 ± 0.038	4.101ArgGly: 4.101 ± 0.052	1.375ArgHis: 1.375 ± 0.028	3.695ArgIle: 3.695 ± 0.043	2.437ArgLys: 2.437 ± 0.039	7.143ArgLeu: 7.143 ± 0.08	1.775ArgMet: 1.775 ± 0.035	2.123ArgAsn: 2.123 ± 0.03	3.239ArgPro: 3.239 ± 0.053	2.938ArgGln: 2.938 ± 0.044	5.021ArgArg: 5.021 ± 0.064	4.284ArgSer: 4.284 ± 0.052	3.18ArgThr: 3.18 ± 0.041	4.203ArgVal: 4.203 ± 0.04	1.206ArgTrp: 1.206 ± 0.027	1.902ArgTyr: 1.902 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.796SerAla: 5.796 ± 0.062	0.664SerCys: 0.664 ± 0.021	4.206SerAsp: 4.206 ± 0.049	4.164SerGlu: 4.164 ± 0.05	2.285SerPhe: 2.285 ± 0.035	5.827SerGly: 5.827 ± 0.083	1.43SerHis: 1.43 ± 0.029	3.395SerIle: 3.395 ± 0.049	2.359SerLys: 2.359 ± 0.037	6.747SerLeu: 6.747 ± 0.061	1.473SerMet: 1.473 ± 0.03	2.194SerAsn: 2.194 ± 0.041	3.861SerPro: 3.861 ± 0.044	2.77SerGln: 2.77 ± 0.036	3.939SerArg: 3.939 ± 0.048	4.293SerSer: 4.293 ± 0.057	3.542SerThr: 3.542 ± 0.057	4.662SerVal: 4.662 ± 0.054	0.923SerTrp: 0.923 ± 0.022	1.434SerTyr: 1.434 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	5.671ThrAla: 5.671 ± 0.066	0.57ThrCys: 0.57 ± 0.017	3.462ThrAsp: 3.462 ± 0.053	3.287ThrGlu: 3.287 ± 0.043	2.076ThrPhe: 2.076 ± 0.039	4.639ThrGly: 4.639 ± 0.065	1.087ThrHis: 1.087 ± 0.027	3.212ThrIle: 3.212 ± 0.054	1.913ThrLys: 1.913 ± 0.035	5.529ThrLeu: 5.529 ± 0.058	1.163ThrMet: 1.163 ± 0.025	1.798ThrAsn: 1.798 ± 0.039	3.427ThrPro: 3.427 ± 0.051	1.892ThrGln: 1.892 ± 0.033	2.862ThrArg: 2.862 ± 0.04	3.549ThrSer: 3.549 ± 0.048	3.169ThrThr: 3.169 ± 0.05	4.198ThrVal: 4.198 ± 0.066	0.793ThrTrp: 0.793 ± 0.019	1.358ThrTyr: 1.358 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.402ValAla: 7.402 ± 0.075	0.899ValCys: 0.899 ± 0.024	4.593ValAsp: 4.593 ± 0.068	4.127ValGlu: 4.127 ± 0.049	2.382ValPhe: 2.382 ± 0.039	5.248ValGly: 5.248 ± 0.076	1.421ValHis: 1.421 ± 0.025	3.638ValIle: 3.638 ± 0.046	2.106ValLys: 2.106 ± 0.037	6.849ValLeu: 6.849 ± 0.081	1.486ValMet: 1.486 ± 0.029	2.095ValAsn: 2.095 ± 0.046	3.606ValPro: 3.606 ± 0.057	2.869ValGln: 2.869 ± 0.038	4.6ValArg: 4.6 ± 0.054	4.664ValSer: 4.664 ± 0.05	4.068ValThr: 4.068 ± 0.055	5.604ValVal: 5.604 ± 0.073	1.007ValTrp: 1.007 ± 0.026	1.578ValTyr: 1.578 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.131TrpAla: 1.131 ± 0.025	0.168TrpCys: 0.168 ± 0.007	0.804TrpAsp: 0.804 ± 0.02	0.787TrpGlu: 0.787 ± 0.027	0.618TrpPhe: 0.618 ± 0.017	1.008TrpGly: 1.008 ± 0.026	0.412TrpHis: 0.412 ± 0.016	0.881TrpIle: 0.881 ± 0.022	0.681TrpLys: 0.681 ± 0.02	1.771TrpLeu: 1.771 ± 0.027	0.476TrpMet: 0.476 ± 0.015	0.574TrpAsn: 0.574 ± 0.015	0.681TrpPro: 0.681 ± 0.02	0.856TrpGln: 0.856 ± 0.019	0.938TrpArg: 0.938 ± 0.022	0.995TrpSer: 0.995 ± 0.023	0.847TrpThr: 0.847 ± 0.023	0.946TrpVal: 0.946 ± 0.021	0.284TrpTrp: 0.284 ± 0.012	0.347TrpTyr: 0.347 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.138TyrAla: 2.138 ± 0.036	0.332TyrCys: 0.332 ± 0.013	1.528TyrAsp: 1.528 ± 0.032	1.427TyrGlu: 1.427 ± 0.028	1.021TyrPhe: 1.021 ± 0.025	1.995TyrGly: 1.995 ± 0.033	0.587TyrHis: 0.587 ± 0.019	0.816TyrIle: 0.816 ± 0.02	0.668TyrLys: 0.668 ± 0.02	2.426TyrLeu: 2.426 ± 0.038	0.401TyrMet: 0.401 ± 0.013	0.721TyrAsn: 0.721 ± 0.02	1.185TyrPro: 1.185 ± 0.026	1.219TyrGln: 1.219 ± 0.025	2.009TyrArg: 2.009 ± 0.033	1.473TyrSer: 1.473 ± 0.029	1.114TyrThr: 1.114 ± 0.027	1.595TyrVal: 1.595 ± 0.027	0.441TyrTrp: 0.441 ± 0.014	0.691TyrTyr: 0.691 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5455 proteins (2043855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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