Amino acid dipepetide frequency for Aspergillus pseudotamarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.979AlaAla: 7.979 ± 0.057	1.154AlaCys: 1.154 ± 0.014	3.967AlaAsp: 3.967 ± 0.026	4.725AlaGlu: 4.725 ± 0.035	3.195AlaPhe: 3.195 ± 0.021	5.523AlaGly: 5.523 ± 0.033	1.782AlaHis: 1.782 ± 0.018	4.433AlaIle: 4.433 ± 0.028	3.648AlaLys: 3.648 ± 0.029	7.79AlaLeu: 7.79 ± 0.046	1.963AlaMet: 1.963 ± 0.019	2.863AlaAsn: 2.863 ± 0.021	4.275AlaPro: 4.275 ± 0.038	3.228AlaGln: 3.228 ± 0.028	4.605AlaArg: 4.605 ± 0.035	6.866AlaSer: 6.866 ± 0.038	5.092AlaThr: 5.092 ± 0.032	5.387AlaVal: 5.387 ± 0.034	1.182AlaTrp: 1.182 ± 0.015	2.28AlaTyr: 2.28 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.014	0.28CysCys: 0.28 ± 0.007	0.741CysAsp: 0.741 ± 0.014	0.636CysGlu: 0.636 ± 0.011	0.605CysPhe: 0.605 ± 0.011	0.988CysGly: 0.988 ± 0.014	0.376CysHis: 0.376 ± 0.008	0.809CysIle: 0.809 ± 0.01	0.513CysLys: 0.513 ± 0.011	1.468CysLeu: 1.468 ± 0.016	0.317CysMet: 0.317 ± 0.007	0.483CysAsn: 0.483 ± 0.009	0.714CysPro: 0.714 ± 0.012	0.524CysGln: 0.524 ± 0.01	0.849CysArg: 0.849 ± 0.012	1.062CysSer: 1.062 ± 0.014	0.768CysThr: 0.768 ± 0.012	0.874CysVal: 0.874 ± 0.014	0.231CysTrp: 0.231 ± 0.007	0.407CysTyr: 0.407 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.377AspAla: 4.377 ± 0.029	0.664AspCys: 0.664 ± 0.012	3.69AspAsp: 3.69 ± 0.036	3.988AspGlu: 3.988 ± 0.033	2.136AspPhe: 2.136 ± 0.016	3.892AspGly: 3.892 ± 0.029	1.284AspHis: 1.284 ± 0.014	3.268AspIle: 3.268 ± 0.023	2.23AspLys: 2.23 ± 0.022	5.105AspLeu: 5.105 ± 0.033	1.269AspMet: 1.269 ± 0.014	1.936AspAsn: 1.936 ± 0.019	3.289AspPro: 3.289 ± 0.023	1.933AspGln: 1.933 ± 0.019	3.063AspArg: 3.063 ± 0.027	4.09AspSer: 4.09 ± 0.032	3.008AspThr: 3.008 ± 0.023	3.591AspVal: 3.591 ± 0.026	0.894AspTrp: 0.894 ± 0.012	1.669AspTyr: 1.669 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	4.966GluAla: 4.966 ± 0.032	0.687GluCys: 0.687 ± 0.012	3.854GluAsp: 3.854 ± 0.034	5.01GluGlu: 5.01 ± 0.055	1.943GluPhe: 1.943 ± 0.02	3.609GluGly: 3.609 ± 0.028	1.384GluHis: 1.384 ± 0.015	3.063GluIle: 3.063 ± 0.024	3.494GluLys: 3.494 ± 0.029	5.17GluLeu: 5.17 ± 0.034	1.393GluMet: 1.393 ± 0.015	2.34GluAsn: 2.34 ± 0.02	2.694GluPro: 2.694 ± 0.027	2.436GluGln: 2.436 ± 0.022	3.768GluArg: 3.768 ± 0.029	4.321GluSer: 4.321 ± 0.031	3.483GluThr: 3.483 ± 0.025	3.505GluVal: 3.505 ± 0.024	0.887GluTrp: 0.887 ± 0.013	1.767GluTyr: 1.767 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.044PheAla: 3.044 ± 0.025	0.627PheCys: 0.627 ± 0.011	2.252PheAsp: 2.252 ± 0.019	2.069PheGlu: 2.069 ± 0.019	1.79PhePhe: 1.79 ± 0.021	2.872PheGly: 2.872 ± 0.029	1.01PheHis: 1.01 ± 0.013	1.989PheIle: 1.989 ± 0.019	1.453PheLys: 1.453 ± 0.018	3.81PheLeu: 3.81 ± 0.03	0.83PheMet: 0.83 ± 0.011	1.493PheAsn: 1.493 ± 0.017	2.08PhePro: 2.08 ± 0.019	1.493PheGln: 1.493 ± 0.017	2.036PheArg: 2.036 ± 0.016	3.11PheSer: 3.11 ± 0.023	2.28PheThr: 2.28 ± 0.02	2.495PheVal: 2.495 ± 0.021	0.699PheTrp: 0.699 ± 0.011	1.235PheTyr: 1.235 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.087GlyAla: 5.087 ± 0.035	0.984GlyCys: 0.984 ± 0.014	3.532GlyAsp: 3.532 ± 0.027	3.516GlyGlu: 3.516 ± 0.025	2.903GlyPhe: 2.903 ± 0.025	5.313GlyGly: 5.313 ± 0.042	1.714GlyHis: 1.714 ± 0.018	3.806GlyIle: 3.806 ± 0.028	3.293GlyLys: 3.293 ± 0.024	6.335GlyLeu: 6.335 ± 0.03	1.559GlyMet: 1.559 ± 0.017	2.583GlyAsn: 2.583 ± 0.024	3.29GlyPro: 3.29 ± 0.027	2.584GlyGln: 2.584 ± 0.024	3.974GlyArg: 3.974 ± 0.027	5.643GlySer: 5.643 ± 0.039	4.003GlyThr: 4.003 ± 0.026	4.535GlyVal: 4.535 ± 0.029	1.233GlyTrp: 1.233 ± 0.015	2.299GlyTyr: 2.299 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.841HisAla: 1.841 ± 0.016	0.38HisCys: 0.38 ± 0.008	1.345HisAsp: 1.345 ± 0.015	1.324HisGlu: 1.324 ± 0.016	0.943HisPhe: 0.943 ± 0.012	1.777HisGly: 1.777 ± 0.019	0.863HisHis: 0.863 ± 0.014	1.349HisIle: 1.349 ± 0.014	0.885HisLys: 0.885 ± 0.012	2.346HisLeu: 2.346 ± 0.02	0.526HisMet: 0.526 ± 0.009	0.878HisAsn: 0.878 ± 0.013	1.698HisPro: 1.698 ± 0.017	0.975HisGln: 0.975 ± 0.014	1.586HisArg: 1.586 ± 0.018	1.952HisSer: 1.952 ± 0.022	1.33HisThr: 1.33 ± 0.016	1.473HisVal: 1.473 ± 0.018	0.384HisTrp: 0.384 ± 0.007	0.758HisTyr: 0.758 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.342IleAla: 4.342 ± 0.033	0.869IleCys: 0.869 ± 0.012	2.898IleAsp: 2.898 ± 0.025	2.862IleGlu: 2.862 ± 0.026	2.186IlePhe: 2.186 ± 0.023	3.451IleGly: 3.451 ± 0.027	1.322IleHis: 1.322 ± 0.016	2.769IleIle: 2.769 ± 0.025	2.054IleLys: 2.054 ± 0.019	5.007IleLeu: 5.007 ± 0.034	1.087IleMet: 1.087 ± 0.014	1.882IleAsn: 1.882 ± 0.018	3.28IlePro: 3.28 ± 0.022	2.07IleGln: 2.07 ± 0.019	2.891IleArg: 2.891 ± 0.022	4.162IleSer: 4.162 ± 0.028	3.01IleThr: 3.01 ± 0.022	3.41IleVal: 3.41 ± 0.027	0.772IleTrp: 0.772 ± 0.012	1.625IleTyr: 1.625 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.929LysAla: 3.929 ± 0.03	0.554LysCys: 0.554 ± 0.011	2.667LysAsp: 2.667 ± 0.022	3.181LysGlu: 3.181 ± 0.034	1.39LysPhe: 1.39 ± 0.014	2.883LysGly: 2.883 ± 0.026	1.077LysHis: 1.077 ± 0.012	2.154LysIle: 2.154 ± 0.02	2.807LysLys: 2.807 ± 0.034	3.931LysLeu: 3.931 ± 0.029	0.926LysMet: 0.926 ± 0.012	1.68LysAsn: 1.68 ± 0.018	2.545LysPro: 2.545 ± 0.026	1.798LysGln: 1.798 ± 0.02	3.117LysArg: 3.117 ± 0.028	3.288LysSer: 3.288 ± 0.029	2.583LysThr: 2.583 ± 0.021	2.766LysVal: 2.766 ± 0.02	0.666LysTrp: 0.666 ± 0.011	1.385LysTyr: 1.385 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.77LeuAla: 7.77 ± 0.04	1.371LeuCys: 1.371 ± 0.017	5.182LeuAsp: 5.182 ± 0.032	5.518LeuGlu: 5.518 ± 0.034	3.631LeuPhe: 3.631 ± 0.027	6.231LeuGly: 6.231 ± 0.034	2.387LeuHis: 2.387 ± 0.021	4.286LeuIle: 4.286 ± 0.031	4.026LeuLys: 4.026 ± 0.03	8.909LeuLeu: 8.909 ± 0.052	1.905LeuMet: 1.905 ± 0.017	3.319LeuAsn: 3.319 ± 0.023	5.549LeuPro: 5.549 ± 0.033	3.99LeuGln: 3.99 ± 0.031	5.843LeuArg: 5.843 ± 0.036	7.796LeuSer: 7.796 ± 0.036	5.023LeuThr: 5.023 ± 0.033	5.762LeuVal: 5.762 ± 0.03	1.297LeuTrp: 1.297 ± 0.016	2.644LeuTyr: 2.644 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.156MetAla: 2.156 ± 0.02	0.288MetCys: 0.288 ± 0.007	1.233MetAsp: 1.233 ± 0.012	1.299MetGlu: 1.299 ± 0.016	0.767MetPhe: 0.767 ± 0.012	1.517MetGly: 1.517 ± 0.015	0.489MetHis: 0.489 ± 0.008	1.087MetIle: 1.087 ± 0.014	1.005MetLys: 1.005 ± 0.013	1.908MetLeu: 1.908 ± 0.019	0.554MetMet: 0.554 ± 0.01	0.832MetAsn: 0.832 ± 0.01	1.196MetPro: 1.196 ± 0.014	0.852MetGln: 0.852 ± 0.012	1.243MetArg: 1.243 ± 0.014	1.883MetSer: 1.883 ± 0.019	1.349MetThr: 1.349 ± 0.015	1.43MetVal: 1.43 ± 0.014	0.278MetTrp: 0.278 ± 0.007	0.562MetTyr: 0.562 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.07AsnAla: 3.07 ± 0.023	0.499AsnCys: 0.499 ± 0.009	1.975AsnAsp: 1.975 ± 0.019	2.058AsnGlu: 2.058 ± 0.02	1.391AsnPhe: 1.391 ± 0.014	2.937AsnGly: 2.937 ± 0.024	0.903AsnHis: 0.903 ± 0.013	2.203AsnIle: 2.203 ± 0.02	1.507AsnLys: 1.507 ± 0.017	3.315AsnLeu: 3.315 ± 0.029	0.878AsnMet: 0.878 ± 0.013	1.48AsnAsn: 1.48 ± 0.017	2.487AsnPro: 2.487 ± 0.024	1.36AsnGln: 1.36 ± 0.014	1.98AsnArg: 1.98 ± 0.019	2.737AsnSer: 2.737 ± 0.022	2.25AsnThr: 2.25 ± 0.021	2.448AsnVal: 2.448 ± 0.022	0.611AsnTrp: 0.611 ± 0.01	1.129AsnTyr: 1.129 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.622ProAla: 4.622 ± 0.035	0.607ProCys: 0.607 ± 0.011	3.162ProAsp: 3.162 ± 0.023	3.815ProGlu: 3.815 ± 0.023	2.163ProPhe: 2.163 ± 0.021	3.873ProGly: 3.873 ± 0.031	1.315ProHis: 1.315 ± 0.014	2.605ProIle: 2.605 ± 0.022	2.482ProLys: 2.482 ± 0.023	4.779ProLeu: 4.779 ± 0.031	1.092ProMet: 1.092 ± 0.015	2.201ProAsn: 2.201 ± 0.021	4.4ProPro: 4.4 ± 0.055	2.375ProGln: 2.375 ± 0.029	3.291ProArg: 3.291 ± 0.027	5.849ProSer: 5.849 ± 0.041	3.903ProThr: 3.903 ± 0.029	3.627ProVal: 3.627 ± 0.027	0.806ProTrp: 0.806 ± 0.012	1.577ProTyr: 1.577 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.258GlnAla: 3.258 ± 0.025	0.511GlnCys: 0.511 ± 0.01	2.058GlnAsp: 2.058 ± 0.017	2.451GlnGlu: 2.451 ± 0.02	1.35GlnPhe: 1.35 ± 0.017	2.512GlnGly: 2.512 ± 0.023	1.058GlnHis: 1.058 ± 0.015	1.961GlnIle: 1.961 ± 0.018	1.965GlnLys: 1.965 ± 0.019	3.605GlnLeu: 3.605 ± 0.028	0.884GlnMet: 0.884 ± 0.013	1.591GlnAsn: 1.591 ± 0.017	2.469GlnPro: 2.469 ± 0.026	2.193GlnGln: 2.193 ± 0.036	2.587GlnArg: 2.587 ± 0.024	3.198GlnSer: 3.198 ± 0.025	2.356GlnThr: 2.356 ± 0.022	2.245GlnVal: 2.245 ± 0.022	0.627GlnTrp: 0.627 ± 0.01	1.234GlnTyr: 1.234 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.432ArgAla: 4.432 ± 0.031	0.794ArgCys: 0.794 ± 0.012	3.26ArgAsp: 3.26 ± 0.028	3.682ArgGlu: 3.682 ± 0.027	2.234ArgPhe: 2.234 ± 0.019	3.569ArgGly: 3.569 ± 0.03	1.57ArgHis: 1.57 ± 0.018	2.953ArgIle: 2.953 ± 0.024	3.243ArgLys: 3.243 ± 0.027	5.637ArgLeu: 5.637 ± 0.035	1.304ArgMet: 1.304 ± 0.017	2.257ArgAsn: 2.257 ± 0.019	3.342ArgPro: 3.342 ± 0.026	2.577ArgGln: 2.577 ± 0.022	4.825ArgArg: 4.825 ± 0.044	4.722ArgSer: 4.722 ± 0.032	3.228ArgThr: 3.228 ± 0.023	3.463ArgVal: 3.463 ± 0.023	0.996ArgTrp: 0.996 ± 0.013	1.792ArgTyr: 1.792 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.386SerAla: 6.386 ± 0.042	1.002SerCys: 1.002 ± 0.012	4.245SerAsp: 4.245 ± 0.027	4.201SerGlu: 4.201 ± 0.032	3.224SerPhe: 3.224 ± 0.025	5.54SerGly: 5.54 ± 0.036	2.049SerHis: 2.049 ± 0.019	4.245SerIle: 4.245 ± 0.03	3.536SerLys: 3.536 ± 0.029	7.664SerLeu: 7.664 ± 0.043	1.743SerMet: 1.743 ± 0.017	3.045SerAsn: 3.045 ± 0.023	5.239SerPro: 5.239 ± 0.04	3.368SerGln: 3.368 ± 0.026	4.945SerArg: 4.945 ± 0.035	8.53SerSer: 8.53 ± 0.057	5.497SerThr: 5.497 ± 0.035	4.801SerVal: 4.801 ± 0.031	1.216SerTrp: 1.216 ± 0.016	2.226SerTyr: 2.226 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.039ThrAla: 5.039 ± 0.033	0.814ThrCys: 0.814 ± 0.012	2.919ThrAsp: 2.919 ± 0.024	3.193ThrGlu: 3.193 ± 0.026	2.327ThrPhe: 2.327 ± 0.018	4.302ThrGly: 4.302 ± 0.031	1.321ThrHis: 1.321 ± 0.018	3.261ThrIle: 3.261 ± 0.026	2.488ThrLys: 2.488 ± 0.021	5.421ThrLeu: 5.421 ± 0.031	1.241ThrMet: 1.241 ± 0.014	2.123ThrAsn: 2.123 ± 0.016	4.084ThrPro: 4.084 ± 0.031	2.098ThrGln: 2.098 ± 0.02	3.053ThrArg: 3.053 ± 0.023	5.197ThrSer: 5.197 ± 0.035	4.082ThrThr: 4.082 ± 0.036	3.977ThrVal: 3.977 ± 0.031	0.923ThrTrp: 0.923 ± 0.012	1.736ThrTyr: 1.736 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.2ValAla: 5.2 ± 0.032	0.911ValCys: 0.911 ± 0.013	3.751ValAsp: 3.751 ± 0.026	3.771ValGlu: 3.771 ± 0.024	2.608ValPhe: 2.608 ± 0.022	4.168ValGly: 4.168 ± 0.026	1.494ValHis: 1.494 ± 0.017	3.236ValIle: 3.236 ± 0.028	2.755ValLys: 2.755 ± 0.024	5.83ValLeu: 5.83 ± 0.037	1.385ValMet: 1.385 ± 0.014	2.356ValAsn: 2.356 ± 0.019	3.644ValPro: 3.644 ± 0.023	2.457ValGln: 2.457 ± 0.022	3.48ValArg: 3.48 ± 0.024	4.979ValSer: 4.979 ± 0.035	3.643ValThr: 3.643 ± 0.028	4.378ValVal: 4.378 ± 0.032	0.918ValTrp: 0.918 ± 0.013	1.924ValTyr: 1.924 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.162TrpAla: 1.162 ± 0.014	0.216TrpCys: 0.216 ± 0.006	0.944TrpAsp: 0.944 ± 0.013	0.879TrpGlu: 0.879 ± 0.012	0.576TrpPhe: 0.576 ± 0.008	1.005TrpGly: 1.005 ± 0.014	0.381TrpHis: 0.381 ± 0.009	0.849TrpIle: 0.849 ± 0.011	0.849TrpLys: 0.849 ± 0.013	1.476TrpLeu: 1.476 ± 0.017	0.396TrpMet: 0.396 ± 0.009	0.678TrpAsn: 0.678 ± 0.012	0.639TrpPro: 0.639 ± 0.01	0.595TrpGln: 0.595 ± 0.011	0.975TrpArg: 0.975 ± 0.013	1.115TrpSer: 1.115 ± 0.014	0.96TrpThr: 0.96 ± 0.014	0.959TrpVal: 0.959 ± 0.012	0.301TrpTrp: 0.301 ± 0.007	0.468TrpTyr: 0.468 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.254TyrAla: 2.254 ± 0.019	0.458TyrCys: 0.458 ± 0.009	1.7TyrAsp: 1.7 ± 0.017	1.595TyrGlu: 1.595 ± 0.019	1.306TyrPhe: 1.306 ± 0.016	2.225TyrGly: 2.225 ± 0.021	0.836TyrHis: 0.836 ± 0.011	1.626TyrIle: 1.626 ± 0.016	1.092TyrLys: 1.092 ± 0.014	2.934TyrLeu: 2.934 ± 0.021	0.671TyrMet: 0.671 ± 0.01	1.199TyrAsn: 1.199 ± 0.016	1.633TyrPro: 1.633 ± 0.016	1.207TyrGln: 1.207 ± 0.013	1.769TyrArg: 1.769 ± 0.016	2.202TyrSer: 2.202 ± 0.021	1.752TyrThr: 1.752 ± 0.018	1.761TyrVal: 1.761 ± 0.018	0.499TyrTrp: 0.499 ± 0.008	1.041TyrTyr: 1.041 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 13426 proteins (6204971 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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