Amino acid dipepetide frequency for Anopheles darlingi (Mosquito)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.675AlaAla: 8.675 ± 0.1	1.162AlaCys: 1.162 ± 0.024	3.499AlaAsp: 3.499 ± 0.025	4.17AlaGlu: 4.17 ± 0.036	2.267AlaPhe: 2.267 ± 0.021	5.618AlaGly: 5.618 ± 0.051	1.623AlaHis: 1.623 ± 0.019	3.87AlaIle: 3.87 ± 0.026	3.775AlaLys: 3.775 ± 0.031	6.307AlaLeu: 6.307 ± 0.041	1.691AlaMet: 1.691 ± 0.019	3.212AlaAsn: 3.212 ± 0.027	3.795AlaPro: 3.795 ± 0.037	2.809AlaGln: 2.809 ± 0.027	3.558AlaArg: 3.558 ± 0.03	6.439AlaSer: 6.439 ± 0.043	5.493AlaThr: 5.493 ± 0.046	4.723AlaVal: 4.723 ± 0.032	0.575AlaTrp: 0.575 ± 0.01	1.763AlaTyr: 1.763 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.157CysAla: 1.157 ± 0.021	0.484CysCys: 0.484 ± 0.011	1.099CysAsp: 1.099 ± 0.021	1.102CysGlu: 1.102 ± 0.019	0.702CysPhe: 0.702 ± 0.014	1.322CysGly: 1.322 ± 0.024	0.476CysHis: 0.476 ± 0.011	0.94CysIle: 0.94 ± 0.019	0.837CysLys: 0.837 ± 0.016	1.629CysLeu: 1.629 ± 0.021	0.369CysMet: 0.369 ± 0.01	0.791CysAsn: 0.791 ± 0.015	0.973CysPro: 0.973 ± 0.026	0.697CysGln: 0.697 ± 0.015	1.112CysArg: 1.112 ± 0.026	1.53CysSer: 1.53 ± 0.026	1.044CysThr: 1.044 ± 0.019	1.172CysVal: 1.172 ± 0.022	0.23CysTrp: 0.23 ± 0.007	0.591CysTyr: 0.591 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.511AspAla: 3.511 ± 0.025	1.017AspCys: 1.017 ± 0.02	4.32AspAsp: 4.32 ± 0.053	4.424AspGlu: 4.424 ± 0.042	1.95AspPhe: 1.95 ± 0.024	4.007AspGly: 4.007 ± 0.039	1.243AspHis: 1.243 ± 0.017	2.706AspIle: 2.706 ± 0.023	2.331AspLys: 2.331 ± 0.022	4.464AspLeu: 4.464 ± 0.032	1.124AspMet: 1.124 ± 0.013	2.068AspAsn: 2.068 ± 0.024	2.586AspPro: 2.586 ± 0.031	1.897AspGln: 1.897 ± 0.02	3.204AspArg: 3.204 ± 0.029	3.956AspSer: 3.956 ± 0.032	2.716AspThr: 2.716 ± 0.019	3.286AspVal: 3.286 ± 0.021	0.597AspTrp: 0.597 ± 0.011	1.685AspTyr: 1.685 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.259GluAla: 4.259 ± 0.039	1.178GluCys: 1.178 ± 0.028	3.695GluAsp: 3.695 ± 0.036	5.684GluGlu: 5.684 ± 0.064	1.98GluPhe: 1.98 ± 0.02	3.114GluGly: 3.114 ± 0.025	1.555GluHis: 1.555 ± 0.016	3.127GluIle: 3.127 ± 0.029	3.865GluLys: 3.865 ± 0.042	6.058GluLeu: 6.058 ± 0.043	1.577GluMet: 1.577 ± 0.018	2.666GluAsn: 2.666 ± 0.021	2.84GluPro: 2.84 ± 0.034	3.391GluGln: 3.391 ± 0.03	4.197GluArg: 4.197 ± 0.04	4.208GluSer: 4.208 ± 0.031	3.441GluThr: 3.441 ± 0.029	3.46GluVal: 3.46 ± 0.036	0.607GluTrp: 0.607 ± 0.011	1.838GluTyr: 1.838 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.275PheAla: 2.275 ± 0.022	0.721PheCys: 0.721 ± 0.012	2.034PheAsp: 2.034 ± 0.022	2.062PheGlu: 2.062 ± 0.022	1.381PhePhe: 1.381 ± 0.019	2.453PheGly: 2.453 ± 0.027	0.883PheHis: 0.883 ± 0.012	1.77PheIle: 1.77 ± 0.02	1.585PheLys: 1.585 ± 0.017	3.311PheLeu: 3.311 ± 0.03	0.757PheMet: 0.757 ± 0.01	1.543PheAsn: 1.543 ± 0.016	1.544PhePro: 1.544 ± 0.017	1.329PheGln: 1.329 ± 0.016	2.056PheArg: 2.056 ± 0.022	2.539PheSer: 2.539 ± 0.023	1.861PheThr: 1.861 ± 0.022	2.375PheVal: 2.375 ± 0.024	0.416PheTrp: 0.416 ± 0.01	1.23PheTyr: 1.23 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.198GlyAla: 5.198 ± 0.048	1.103GlyCys: 1.103 ± 0.021	3.291GlyAsp: 3.291 ± 0.03	3.394GlyGlu: 3.394 ± 0.033	2.196GlyPhe: 2.196 ± 0.022	8.487GlyGly: 8.487 ± 0.13	1.676GlyHis: 1.676 ± 0.023	3.023GlyIle: 3.023 ± 0.028	3.216GlyLys: 3.216 ± 0.028	4.881GlyLeu: 4.881 ± 0.035	1.488GlyMet: 1.488 ± 0.018	2.936GlyAsn: 2.936 ± 0.028	3.034GlyPro: 3.034 ± 0.047	2.463GlyGln: 2.463 ± 0.028	3.504GlyArg: 3.504 ± 0.029	6.652GlySer: 6.652 ± 0.065	4.512GlyThr: 4.512 ± 0.041	3.959GlyVal: 3.959 ± 0.03	0.684GlyTrp: 0.684 ± 0.013	2.04GlyTyr: 2.04 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.496HisAla: 1.496 ± 0.018	0.558HisCys: 0.558 ± 0.011	1.207HisAsp: 1.207 ± 0.016	1.347HisGlu: 1.347 ± 0.014	0.947HisPhe: 0.947 ± 0.013	1.73HisGly: 1.73 ± 0.021	2.28HisHis: 2.28 ± 0.051	1.217HisIle: 1.217 ± 0.014	1.064HisLys: 1.064 ± 0.017	2.414HisLeu: 2.414 ± 0.023	0.566HisMet: 0.566 ± 0.012	1.08HisAsn: 1.08 ± 0.016	1.59HisPro: 1.59 ± 0.02	1.869HisGln: 1.869 ± 0.03	1.752HisArg: 1.752 ± 0.021	2.027HisSer: 2.027 ± 0.023	1.352HisThr: 1.352 ± 0.016	1.409HisVal: 1.409 ± 0.017	0.293HisTrp: 0.293 ± 0.007	0.903HisTyr: 0.903 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.769IleAla: 3.769 ± 0.028	1.04IleCys: 1.04 ± 0.016	3.009IleAsp: 3.009 ± 0.024	3.311IleGlu: 3.311 ± 0.033	1.765IlePhe: 1.765 ± 0.021	3.237IleGly: 3.237 ± 0.027	1.136IleHis: 1.136 ± 0.015	2.593IleIle: 2.593 ± 0.027	2.474IleLys: 2.474 ± 0.025	4.197IleLeu: 4.197 ± 0.036	1.048IleMet: 1.048 ± 0.014	2.231IleAsn: 2.231 ± 0.021	2.664IlePro: 2.664 ± 0.021	1.901IleGln: 1.901 ± 0.021	2.844IleArg: 2.844 ± 0.025	3.645IleSer: 3.645 ± 0.027	2.908IleThr: 2.908 ± 0.026	3.713IleVal: 3.713 ± 0.027	0.46IleTrp: 0.46 ± 0.009	1.436IleTyr: 1.436 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.378LysAla: 3.378 ± 0.026	0.959LysCys: 0.959 ± 0.018	2.642LysAsp: 2.642 ± 0.026	3.598LysGlu: 3.598 ± 0.032	1.65LysPhe: 1.65 ± 0.019	2.469LysGly: 2.469 ± 0.029	1.418LysHis: 1.418 ± 0.017	2.611LysIle: 2.611 ± 0.024	3.717LysLys: 3.717 ± 0.049	5.002LysLeu: 5.002 ± 0.036	1.302LysMet: 1.302 ± 0.017	2.093LysAsn: 2.093 ± 0.022	2.809LysPro: 2.809 ± 0.034	2.64LysGln: 2.64 ± 0.027	3.509LysArg: 3.509 ± 0.03	3.625LysSer: 3.625 ± 0.032	2.815LysThr: 2.815 ± 0.023	3.041LysVal: 3.041 ± 0.028	0.489LysTrp: 0.489 ± 0.01	1.603LysTyr: 1.603 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	6.714LeuAla: 6.714 ± 0.043	1.645LeuCys: 1.645 ± 0.022	4.68LeuAsp: 4.68 ± 0.031	5.795LeuGlu: 5.795 ± 0.046	3.126LeuPhe: 3.126 ± 0.031	4.78LeuGly: 4.78 ± 0.034	2.439LeuHis: 2.439 ± 0.024	4.108LeuIle: 4.108 ± 0.034	4.969LeuLys: 4.969 ± 0.037	9.314LeuLeu: 9.314 ± 0.071	2.018LeuMet: 2.018 ± 0.021	3.84LeuAsn: 3.84 ± 0.028	4.864LeuPro: 4.864 ± 0.032	4.639LeuGln: 4.639 ± 0.034	5.393LeuArg: 5.393 ± 0.04	6.57LeuSer: 6.57 ± 0.037	4.95LeuThr: 4.95 ± 0.031	5.49LeuVal: 5.49 ± 0.034	0.883LeuTrp: 0.883 ± 0.013	2.594LeuTyr: 2.594 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.981MetAla: 1.981 ± 0.017	0.372MetCys: 0.372 ± 0.008	1.249MetAsp: 1.249 ± 0.014	1.483MetGlu: 1.483 ± 0.017	0.83MetPhe: 0.83 ± 0.013	1.24MetGly: 1.24 ± 0.02	0.56MetHis: 0.56 ± 0.01	1.112MetIle: 1.112 ± 0.013	1.312MetLys: 1.312 ± 0.015	2.186MetLeu: 2.186 ± 0.021	0.766MetMet: 0.766 ± 0.012	0.986MetAsn: 0.986 ± 0.013	1.084MetPro: 1.084 ± 0.016	1.05MetGln: 1.05 ± 0.016	1.263MetArg: 1.263 ± 0.016	1.62MetSer: 1.62 ± 0.02	1.187MetThr: 1.187 ± 0.012	1.475MetVal: 1.475 ± 0.018	0.21MetTrp: 0.21 ± 0.006	0.632MetTyr: 0.632 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.1AsnAla: 3.1 ± 0.027	0.792AsnCys: 0.792 ± 0.013	2.371AsnAsp: 2.371 ± 0.022	2.707AsnGlu: 2.707 ± 0.023	1.479AsnPhe: 1.479 ± 0.018	3.784AsnGly: 3.784 ± 0.039	1.175AsnHis: 1.175 ± 0.017	2.253AsnIle: 2.253 ± 0.024	1.861AsnLys: 1.861 ± 0.02	3.722AsnLeu: 3.722 ± 0.033	0.965AsnMet: 0.965 ± 0.015	2.727AsnAsn: 2.727 ± 0.045	2.194AsnPro: 2.194 ± 0.023	1.8AsnGln: 1.8 ± 0.022	2.655AsnArg: 2.655 ± 0.025	3.546AsnSer: 3.546 ± 0.037	2.34AsnThr: 2.34 ± 0.02	2.951AsnVal: 2.951 ± 0.025	0.43AsnTrp: 0.43 ± 0.008	1.35AsnTyr: 1.35 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	4.316ProAla: 4.316 ± 0.038	0.712ProCys: 0.712 ± 0.024	2.585ProAsp: 2.585 ± 0.025	3.258ProGlu: 3.258 ± 0.032	1.686ProPhe: 1.686 ± 0.019	3.334ProGly: 3.334 ± 0.051	1.285ProHis: 1.285 ± 0.02	2.562ProIle: 2.562 ± 0.019	2.651ProLys: 2.651 ± 0.028	4.273ProLeu: 4.273 ± 0.032	1.118ProMet: 1.118 ± 0.017	2.229ProAsn: 2.229 ± 0.021	4.716ProPro: 4.716 ± 0.07	2.327ProGln: 2.327 ± 0.033	2.446ProArg: 2.446 ± 0.021	4.84ProSer: 4.84 ± 0.046	3.616ProThr: 3.616 ± 0.033	3.657ProVal: 3.657 ± 0.034	0.459ProTrp: 0.459 ± 0.01	1.494ProTyr: 1.494 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.78GlnAla: 2.78 ± 0.027	0.825GlnCys: 0.825 ± 0.019	1.787GlnAsp: 1.787 ± 0.017	2.757GlnGlu: 2.757 ± 0.024	1.446GlnPhe: 1.446 ± 0.016	1.93GlnGly: 1.93 ± 0.024	2.035GlnHis: 2.035 ± 0.033	2.093GlnIle: 2.093 ± 0.022	2.266GlnLys: 2.266 ± 0.021	4.657GlnLeu: 4.657 ± 0.036	1.096GlnMet: 1.096 ± 0.016	1.822GlnAsn: 1.822 ± 0.019	2.75GlnPro: 2.75 ± 0.036	7.917GlnGln: 7.917 ± 0.201	2.917GlnArg: 2.917 ± 0.029	3.26GlnSer: 3.26 ± 0.027	2.445GlnThr: 2.445 ± 0.026	2.102GlnVal: 2.102 ± 0.023	0.444GlnTrp: 0.444 ± 0.009	1.401GlnTyr: 1.401 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	3.531ArgAla: 3.531 ± 0.03	1.175ArgCys: 1.175 ± 0.023	2.931ArgAsp: 2.931 ± 0.029	3.683ArgGlu: 3.683 ± 0.037	2.193ArgPhe: 2.193 ± 0.023	3.006ArgGly: 3.006 ± 0.034	1.602ArgHis: 1.602 ± 0.02	2.895ArgIle: 2.895 ± 0.023	3.734ArgLys: 3.734 ± 0.039	5.187ArgLeu: 5.187 ± 0.04	1.368ArgMet: 1.368 ± 0.016	2.764ArgAsn: 2.764 ± 0.026	2.737ArgPro: 2.737 ± 0.027	2.664ArgGln: 2.664 ± 0.023	4.295ArgArg: 4.295 ± 0.043	4.717ArgSer: 4.717 ± 0.049	3.346ArgThr: 3.346 ± 0.027	3.008ArgVal: 3.008 ± 0.025	0.689ArgTrp: 0.689 ± 0.011	1.956ArgTyr: 1.956 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.091SerAla: 6.091 ± 0.052	1.373SerCys: 1.373 ± 0.022	4.08SerAsp: 4.08 ± 0.032	4.304SerGlu: 4.304 ± 0.028	2.769SerPhe: 2.769 ± 0.022	6.325SerGly: 6.325 ± 0.061	1.773SerHis: 1.773 ± 0.021	3.955SerIle: 3.955 ± 0.03	3.825SerLys: 3.825 ± 0.029	6.56SerLeu: 6.56 ± 0.04	1.695SerMet: 1.695 ± 0.019	4.043SerAsn: 4.043 ± 0.04	4.428SerPro: 4.428 ± 0.055	2.942SerGln: 2.942 ± 0.028	4.025SerArg: 4.025 ± 0.04	11.226SerSer: 11.226 ± 0.155	5.638SerThr: 5.638 ± 0.052	5.03SerVal: 5.03 ± 0.031	0.73SerTrp: 0.73 ± 0.011	2.179SerTyr: 2.179 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.186ThrAla: 5.186 ± 0.043	0.943ThrCys: 0.943 ± 0.019	3.02ThrAsp: 3.02 ± 0.025	3.455ThrGlu: 3.455 ± 0.03	1.957ThrPhe: 1.957 ± 0.019	4.445ThrGly: 4.445 ± 0.032	1.257ThrHis: 1.257 ± 0.017	3.524ThrIle: 3.524 ± 0.024	2.845ThrLys: 2.845 ± 0.027	5.171ThrLeu: 5.171 ± 0.035	1.388ThrMet: 1.388 ± 0.015	2.713ThrAsn: 2.713 ± 0.022	3.578ThrPro: 3.578 ± 0.034	2.003ThrGln: 2.003 ± 0.018	2.571ThrArg: 2.571 ± 0.028	5.146ThrSer: 5.146 ± 0.042	5.571ThrThr: 5.571 ± 0.092	4.647ThrVal: 4.647 ± 0.037	0.471ThrTrp: 0.471 ± 0.011	1.45ThrTyr: 1.45 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.194ValAla: 5.194 ± 0.034	1.32ValCys: 1.32 ± 0.023	3.244ValAsp: 3.244 ± 0.03	3.791ValGlu: 3.791 ± 0.037	2.204ValPhe: 2.204 ± 0.023	3.836ValGly: 3.836 ± 0.029	1.533ValHis: 1.533 ± 0.018	3.002ValIle: 3.002 ± 0.025	3.136ValLys: 3.136 ± 0.026	5.827ValLeu: 5.827 ± 0.04	1.346ValMet: 1.346 ± 0.015	2.537ValAsn: 2.537 ± 0.023	3.626ValPro: 3.626 ± 0.032	2.672ValGln: 2.672 ± 0.027	3.526ValArg: 3.526 ± 0.03	4.628ValSer: 4.628 ± 0.032	3.95ValThr: 3.95 ± 0.031	4.373ValVal: 4.373 ± 0.035	0.63ValTrp: 0.63 ± 0.011	1.808ValTyr: 1.808 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.528TrpAla: 0.528 ± 0.01	0.21TrpCys: 0.21 ± 0.006	0.53TrpAsp: 0.53 ± 0.011	0.538TrpGlu: 0.538 ± 0.011	0.412TrpPhe: 0.412 ± 0.01	0.518TrpGly: 0.518 ± 0.011	0.253TrpHis: 0.253 ± 0.007	0.604TrpIle: 0.604 ± 0.012	0.577TrpLys: 0.577 ± 0.011	0.999TrpLeu: 0.999 ± 0.015	0.283TrpMet: 0.283 ± 0.008	0.555TrpAsn: 0.555 ± 0.009	0.405TrpPro: 0.405 ± 0.01	0.421TrpGln: 0.421 ± 0.009	0.633TrpArg: 0.633 ± 0.011	0.742TrpSer: 0.742 ± 0.013	0.57TrpThr: 0.57 ± 0.011	0.525TrpVal: 0.525 ± 0.01	0.163TrpTrp: 0.163 ± 0.006	0.339TrpTyr: 0.339 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.887TyrAla: 1.887 ± 0.02	0.668TyrCys: 0.668 ± 0.013	1.82TyrAsp: 1.82 ± 0.02	1.875TyrGlu: 1.875 ± 0.02	1.184TyrPhe: 1.184 ± 0.016	2.1TyrGly: 2.1 ± 0.021	0.901TyrHis: 0.901 ± 0.013	1.417TyrIle: 1.417 ± 0.017	1.33TyrLys: 1.33 ± 0.017	2.651TyrLeu: 2.651 ± 0.026	0.63TyrMet: 0.63 ± 0.01	1.366TyrAsn: 1.366 ± 0.018	1.346TyrPro: 1.346 ± 0.021	1.3TyrGln: 1.3 ± 0.016	2.02TyrArg: 2.02 ± 0.024	2.075TyrSer: 2.075 ± 0.021	1.588TyrThr: 1.588 ± 0.018	1.787TyrVal: 1.787 ± 0.019	0.345TyrTrp: 0.345 ± 0.01	1.17TyrTyr: 1.17 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.001

Statistics based on 10447 proteins (6035843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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