Amino acid dipepetide frequency for Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.381AlaAla: 5.381 ± 0.07
0.824AlaCys: 0.824 ± 0.018
3.408AlaAsp: 3.408 ± 0.037
4.193AlaGlu: 4.193 ± 0.054
2.534AlaPhe: 2.534 ± 0.034
3.766AlaGly: 3.766 ± 0.049
1.277AlaHis: 1.277 ± 0.022
3.812AlaIle: 3.812 ± 0.044
4.487AlaLys: 4.487 ± 0.052
6.294AlaLeu: 6.294 ± 0.067
1.353AlaMet: 1.353 ± 0.023
2.932AlaAsn: 2.932 ± 0.039
2.855AlaPro: 2.855 ± 0.045
2.732AlaGln: 2.732 ± 0.035
3.286AlaArg: 3.286 ± 0.04
5.497AlaSer: 5.497 ± 0.095
3.901AlaThr: 3.901 ± 0.047
4.238AlaVal: 4.238 ± 0.048
0.584AlaTrp: 0.584 ± 0.015
1.973AlaTyr: 1.973 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
0.809CysAla: 0.809 ± 0.02
0.279CysCys: 0.279 ± 0.012
0.694CysAsp: 0.694 ± 0.018
0.664CysGlu: 0.664 ± 0.019
0.692CysPhe: 0.692 ± 0.019
0.881CysGly: 0.881 ± 0.021
0.313CysHis: 0.313 ± 0.012
0.807CysIle: 0.807 ± 0.018
0.668CysLys: 0.668 ± 0.016
1.368CysLeu: 1.368 ± 0.027
0.262CysMet: 0.262 ± 0.011
0.504CysAsn: 0.504 ± 0.013
0.518CysPro: 0.518 ± 0.015
0.423CysGln: 0.423 ± 0.013
0.552CysArg: 0.552 ± 0.015
1.012CysSer: 1.012 ± 0.022
0.601CysThr: 0.601 ± 0.018
0.853CysVal: 0.853 ± 0.02
0.168CysTrp: 0.168 ± 0.008
0.506CysTyr: 0.506 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.496AspAla: 3.496 ± 0.046
0.651AspCys: 0.651 ± 0.016
4.249AspAsp: 4.249 ± 0.061
5.117AspGlu: 5.117 ± 0.063
2.674AspPhe: 2.674 ± 0.03
2.995AspGly: 2.995 ± 0.039
1.183AspHis: 1.183 ± 0.022
3.455AspIle: 3.455 ± 0.034
3.409AspLys: 3.409 ± 0.044
6.013AspLeu: 6.013 ± 0.054
1.149AspMet: 1.149 ± 0.022
2.339AspAsn: 2.339 ± 0.028
2.836AspPro: 2.836 ± 0.034
2.109AspGln: 2.109 ± 0.028
2.495AspArg: 2.495 ± 0.032
4.622AspSer: 4.622 ± 0.053
2.923AspThr: 2.923 ± 0.035
3.626AspVal: 3.626 ± 0.044
0.685AspTrp: 0.685 ± 0.016
2.271AspTyr: 2.271 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
4.123GluAla: 4.123 ± 0.053
0.695GluCys: 0.695 ± 0.017
4.204GluAsp: 4.204 ± 0.054
6.015GluGlu: 6.015 ± 0.096
2.884GluPhe: 2.884 ± 0.037
2.675GluGly: 2.675 ± 0.038
1.424GluHis: 1.424 ± 0.023
4.139GluIle: 4.139 ± 0.042
5.278GluLys: 5.278 ± 0.063
7.393GluLeu: 7.393 ± 0.072
1.551GluMet: 1.551 ± 0.026
3.541GluAsn: 3.541 ± 0.036
2.649GluPro: 2.649 ± 0.039
3.053GluGln: 3.053 ± 0.042
3.341GluArg: 3.341 ± 0.046
5.027GluSer: 5.027 ± 0.047
3.907GluThr: 3.907 ± 0.039
3.762GluVal: 3.762 ± 0.04
0.656GluTrp: 0.656 ± 0.015
2.405GluTyr: 2.405 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
2.808PheAla: 2.808 ± 0.034
0.597PheCys: 0.597 ± 0.016
2.909PheAsp: 2.909 ± 0.035
3.044PheGlu: 3.044 ± 0.034
1.975PhePhe: 1.975 ± 0.031
2.962PheGly: 2.962 ± 0.048
0.922PheHis: 0.922 ± 0.019
2.334PheIle: 2.334 ± 0.033
2.768PheLys: 2.768 ± 0.033
4.105PheLeu: 4.105 ± 0.051
0.863PheMet: 0.863 ± 0.018
2.119PheAsn: 2.119 ± 0.028
1.698PhePro: 1.698 ± 0.031
1.722PheGln: 1.722 ± 0.026
1.963PheArg: 1.963 ± 0.028
3.424PheSer: 3.424 ± 0.038
2.201PheThr: 2.201 ± 0.028
3.093PheVal: 3.093 ± 0.037
0.574PheTrp: 0.574 ± 0.017
1.598PheTyr: 1.598 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
3.489GlyAla: 3.489 ± 0.047
0.814GlyCys: 0.814 ± 0.018
2.89GlyAsp: 2.89 ± 0.04
3.147GlyGlu: 3.147 ± 0.041
2.629GlyPhe: 2.629 ± 0.036
3.41GlyGly: 3.41 ± 0.061
1.178GlyHis: 1.178 ± 0.025
3.212GlyIle: 3.212 ± 0.037
3.359GlyLys: 3.359 ± 0.044
5.429GlyLeu: 5.429 ± 0.053
1.097GlyMet: 1.097 ± 0.023
2.183GlyAsn: 2.183 ± 0.03
2.002GlyPro: 2.002 ± 0.027
1.832GlyGln: 1.832 ± 0.029
2.555GlyArg: 2.555 ± 0.039
4.859GlySer: 4.859 ± 0.086
2.983GlyThr: 2.983 ± 0.041
3.599GlyVal: 3.599 ± 0.045
0.692GlyTrp: 0.692 ± 0.02
2.113GlyTyr: 2.113 ± 0.031
0.0GlyXaa: 0.0 ± 0.0
His
1.211HisAla: 1.211 ± 0.023
0.316HisCys: 0.316 ± 0.012
1.12HisAsp: 1.12 ± 0.02
1.385HisGlu: 1.385 ± 0.025
0.961HisPhe: 0.961 ± 0.021
1.222HisGly: 1.222 ± 0.024
0.621HisHis: 0.621 ± 0.019
1.235HisIle: 1.235 ± 0.023
1.309HisLys: 1.309 ± 0.021
2.136HisLeu: 2.136 ± 0.033
0.44HisMet: 0.44 ± 0.014
0.93HisAsn: 0.93 ± 0.023
1.152HisPro: 1.152 ± 0.023
0.898HisGln: 0.898 ± 0.021
1.136HisArg: 1.136 ± 0.021
1.703HisSer: 1.703 ± 0.027
1.069HisThr: 1.069 ± 0.021
1.308HisVal: 1.308 ± 0.022
0.241HisTrp: 0.241 ± 0.011
0.829HisTyr: 0.829 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
3.747IleAla: 3.747 ± 0.042
0.816IleCys: 0.816 ± 0.02
3.784IleAsp: 3.784 ± 0.045
3.821IleGlu: 3.821 ± 0.046
2.452IlePhe: 2.452 ± 0.034
3.227IleGly: 3.227 ± 0.046
1.198IleHis: 1.198 ± 0.019
3.085IleIle: 3.085 ± 0.039
3.716IleLys: 3.716 ± 0.042
5.543IleLeu: 5.543 ± 0.058
1.221IleMet: 1.221 ± 0.025
2.823IleAsn: 2.823 ± 0.037
2.863IlePro: 2.863 ± 0.036
2.187IleGln: 2.187 ± 0.036
2.734IleArg: 2.734 ± 0.036
4.672IleSer: 4.672 ± 0.051
2.973IleThr: 2.973 ± 0.037
3.757IleVal: 3.757 ± 0.043
0.663IleTrp: 0.663 ± 0.016
1.982IleTyr: 1.982 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.806LysAla: 3.806 ± 0.043
0.723LysCys: 0.723 ± 0.018
3.663LysAsp: 3.663 ± 0.041
4.801LysGlu: 4.801 ± 0.058
2.729LysPhe: 2.729 ± 0.03
2.791LysGly: 2.791 ± 0.037
1.474LysHis: 1.474 ± 0.024
4.051LysIle: 4.051 ± 0.044
5.245LysLys: 5.245 ± 0.065
7.37LysLeu: 7.37 ± 0.058
1.541LysMet: 1.541 ± 0.026
3.256LysAsn: 3.256 ± 0.038
3.015LysPro: 3.015 ± 0.042
2.873LysGln: 2.873 ± 0.034
3.685LysArg: 3.685 ± 0.042
4.9LysSer: 4.9 ± 0.057
3.76LysThr: 3.76 ± 0.048
4.032LysVal: 4.032 ± 0.042
0.708LysTrp: 0.708 ± 0.017
2.521LysTyr: 2.521 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
7.186LeuAla: 7.186 ± 0.063
1.357LeuCys: 1.357 ± 0.026
6.055LeuAsp: 6.055 ± 0.054
6.997LeuGlu: 6.997 ± 0.064
4.204LeuPhe: 4.204 ± 0.049
5.258LeuGly: 5.258 ± 0.056
2.079LeuHis: 2.079 ± 0.034
5.495LeuIle: 5.495 ± 0.059
6.97LeuLys: 6.97 ± 0.054
10.068LeuLeu: 10.068 ± 0.087
2.126LeuMet: 2.126 ± 0.032
4.992LeuAsn: 4.992 ± 0.049
4.676LeuPro: 4.676 ± 0.053
4.36LeuGln: 4.36 ± 0.042
5.35LeuArg: 5.35 ± 0.056
8.213LeuSer: 8.213 ± 0.061
5.285LeuThr: 5.285 ± 0.051
6.728LeuVal: 6.728 ± 0.06
0.976LeuTrp: 0.976 ± 0.024
3.203LeuTyr: 3.203 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
1.547MetAla: 1.547 ± 0.027
0.257MetCys: 0.257 ± 0.011
1.283MetAsp: 1.283 ± 0.024
1.354MetGlu: 1.354 ± 0.024
0.938MetPhe: 0.938 ± 0.021
1.124MetGly: 1.124 ± 0.024
0.37MetHis: 0.37 ± 0.013
1.179MetIle: 1.179 ± 0.021
1.329MetLys: 1.329 ± 0.024
2.04MetLeu: 2.04 ± 0.033
0.528MetMet: 0.528 ± 0.018
1.044MetAsn: 1.044 ± 0.024
0.874MetPro: 0.874 ± 0.019
0.668MetGln: 0.668 ± 0.02
0.973MetArg: 0.973 ± 0.021
2.075MetSer: 2.075 ± 0.029
1.145MetThr: 1.145 ± 0.023
1.422MetVal: 1.422 ± 0.025
0.182MetTrp: 0.182 ± 0.009
0.65MetTyr: 0.65 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.788AsnAla: 2.788 ± 0.039
0.599AsnCys: 0.599 ± 0.017
2.677AsnAsp: 2.677 ± 0.041
3.135AsnGlu: 3.135 ± 0.039
2.127AsnPhe: 2.127 ± 0.031
2.76AsnGly: 2.76 ± 0.035
0.947AsnHis: 0.947 ± 0.023
2.779AsnIle: 2.779 ± 0.038
2.974AsnLys: 2.974 ± 0.037
4.617AsnLeu: 4.617 ± 0.045
1.041AsnMet: 1.041 ± 0.022
2.218AsnAsn: 2.218 ± 0.042
2.237AsnPro: 2.237 ± 0.035
1.739AsnGln: 1.739 ± 0.032
2.018AsnArg: 2.018 ± 0.032
3.93AsnSer: 3.93 ± 0.057
2.445AsnThr: 2.445 ± 0.035
2.933AsnVal: 2.933 ± 0.032
0.598AsnTrp: 0.598 ± 0.018
1.879AsnTyr: 1.879 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
3.236ProAla: 3.236 ± 0.048
0.374ProCys: 0.374 ± 0.012
2.612ProAsp: 2.612 ± 0.033
3.713ProGlu: 3.713 ± 0.038
1.923ProPhe: 1.923 ± 0.028
2.338ProGly: 2.338 ± 0.034
0.956ProHis: 0.956 ± 0.019
2.462ProIle: 2.462 ± 0.034
2.902ProLys: 2.902 ± 0.039
4.28ProLeu: 4.28 ± 0.047
0.783ProMet: 0.783 ± 0.017
2.072ProAsn: 2.072 ± 0.031
2.655ProPro: 2.655 ± 0.061
2.118ProGln: 2.118 ± 0.037
2.041ProArg: 2.041 ± 0.033
3.965ProSer: 3.965 ± 0.052
2.609ProThr: 2.609 ± 0.037
3.253ProVal: 3.253 ± 0.043
0.425ProTrp: 0.425 ± 0.012
1.446ProTyr: 1.446 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
2.417GlnAla: 2.417 ± 0.033
0.416GlnCys: 0.416 ± 0.012
2.08GlnAsp: 2.08 ± 0.031
2.763GlnGlu: 2.763 ± 0.036
1.818GlnPhe: 1.818 ± 0.025
1.695GlnGly: 1.695 ± 0.029
0.946GlnHis: 0.946 ± 0.02
2.454GlnIle: 2.454 ± 0.032
2.798GlnLys: 2.798 ± 0.037
4.76GlnLeu: 4.76 ± 0.052
0.964GlnMet: 0.964 ± 0.021
1.897GlnAsn: 1.897 ± 0.027
1.899GlnPro: 1.899 ± 0.04
2.545GlnGln: 2.545 ± 0.063
2.081GlnArg: 2.081 ± 0.031
2.968GlnSer: 2.968 ± 0.037
2.317GlnThr: 2.317 ± 0.033
2.274GlnVal: 2.274 ± 0.032
0.385GlnTrp: 0.385 ± 0.011
1.44GlnTyr: 1.44 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
3.12ArgAla: 3.12 ± 0.04
0.605ArgCys: 0.605 ± 0.016
2.533ArgAsp: 2.533 ± 0.036
3.211ArgGlu: 3.211 ± 0.043
2.215ArgPhe: 2.215 ± 0.032
2.34ArgGly: 2.34 ± 0.042
1.133ArgHis: 1.133 ± 0.02
2.758ArgIle: 2.758 ± 0.034
3.84ArgLys: 3.84 ± 0.044
5.277ArgLeu: 5.277 ± 0.05
1.025ArgMet: 1.025 ± 0.022
2.305ArgAsn: 2.305 ± 0.03
2.137ArgPro: 2.137 ± 0.032
2.147ArgGln: 2.147 ± 0.032
3.225ArgArg: 3.225 ± 0.042
3.758ArgSer: 3.758 ± 0.042
2.6ArgThr: 2.6 ± 0.03
2.844ArgVal: 2.844 ± 0.037
0.545ArgTrp: 0.545 ± 0.015
1.702ArgTyr: 1.702 ± 0.029
0.0ArgXaa: 0.0 ± 0.0
Ser
5.16SerAla: 5.16 ± 0.075
0.905SerCys: 0.905 ± 0.02
4.419SerAsp: 4.419 ± 0.059
4.958SerGlu: 4.958 ± 0.049
3.597SerPhe: 3.597 ± 0.046
4.58SerGly: 4.58 ± 0.093
1.735SerHis: 1.735 ± 0.027
4.685SerIle: 4.685 ± 0.043
5.48SerLys: 5.48 ± 0.049
8.419SerLeu: 8.419 ± 0.064
1.708SerMet: 1.708 ± 0.028
3.757SerAsn: 3.757 ± 0.054
3.993SerPro: 3.993 ± 0.056
3.36SerGln: 3.36 ± 0.039
4.005SerArg: 4.005 ± 0.048
8.982SerSer: 8.982 ± 0.225
5.012SerThr: 5.012 ± 0.073
5.089SerVal: 5.089 ± 0.044
0.84SerTrp: 0.84 ± 0.019
2.595SerTyr: 2.595 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
3.783ThrAla: 3.783 ± 0.045
0.672ThrCys: 0.672 ± 0.018
2.913ThrAsp: 2.913 ± 0.032
3.342ThrGlu: 3.342 ± 0.039
2.312ThrPhe: 2.312 ± 0.028
3.349ThrGly: 3.349 ± 0.048
1.036ThrHis: 1.036 ± 0.019
3.254ThrIle: 3.254 ± 0.037
3.584ThrLys: 3.584 ± 0.034
5.336ThrLeu: 5.336 ± 0.049
1.089ThrMet: 1.089 ± 0.021
2.483ThrAsn: 2.483 ± 0.029
3.055ThrPro: 3.055 ± 0.041
2.028ThrGln: 2.028 ± 0.026
2.484ThrArg: 2.484 ± 0.033
4.705ThrSer: 4.705 ± 0.075
3.284ThrThr: 3.284 ± 0.05
3.648ThrVal: 3.648 ± 0.039
0.537ThrTrp: 0.537 ± 0.016
1.723ThrTyr: 1.723 ± 0.026
0.0ThrXaa: 0.0 ± 0.0
Val
4.536ValAla: 4.536 ± 0.042
0.925ValCys: 0.925 ± 0.02
4.026ValAsp: 4.026 ± 0.041
4.18ValGlu: 4.18 ± 0.043
2.864ValPhe: 2.864 ± 0.034
3.428ValGly: 3.428 ± 0.044
1.347ValHis: 1.347 ± 0.025
3.483ValIle: 3.483 ± 0.038
3.845ValLys: 3.845 ± 0.044
6.428ValLeu: 6.428 ± 0.058
1.272ValMet: 1.272 ± 0.025
2.72ValAsn: 2.72 ± 0.031
3.25ValPro: 3.25 ± 0.041
2.355ValGln: 2.355 ± 0.028
3.094ValArg: 3.094 ± 0.043
5.425ValSer: 5.425 ± 0.047
3.173ValThr: 3.173 ± 0.042
4.469ValVal: 4.469 ± 0.052
0.682ValTrp: 0.682 ± 0.016
2.157ValTyr: 2.157 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
0.604TrpAla: 0.604 ± 0.015
0.223TrpCys: 0.223 ± 0.009
0.653TrpAsp: 0.653 ± 0.019
0.596TrpGlu: 0.596 ± 0.017
0.518TrpPhe: 0.518 ± 0.015
0.582TrpGly: 0.582 ± 0.017
0.232TrpHis: 0.232 ± 0.009
0.659TrpIle: 0.659 ± 0.018
0.839TrpLys: 0.839 ± 0.02
1.085TrpLeu: 1.085 ± 0.025
0.24TrpMet: 0.24 ± 0.009
0.57TrpAsn: 0.57 ± 0.016
0.349TrpPro: 0.349 ± 0.011
0.387TrpGln: 0.387 ± 0.013
0.592TrpArg: 0.592 ± 0.017
0.838TrpSer: 0.838 ± 0.018
0.633TrpThr: 0.633 ± 0.016
0.572TrpVal: 0.572 ± 0.013
0.177TrpTrp: 0.177 ± 0.008
0.378TrpTyr: 0.378 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.075TyrAla: 2.075 ± 0.03
0.528TyrCys: 0.528 ± 0.015
2.123TyrAsp: 2.123 ± 0.03
2.288TyrGlu: 2.288 ± 0.029
1.635TyrPhe: 1.635 ± 0.027
2.087TyrGly: 2.087 ± 0.032
0.854TyrHis: 0.854 ± 0.021
1.927TyrIle: 1.927 ± 0.028
2.145TyrLys: 2.145 ± 0.029
3.62TyrLeu: 3.62 ± 0.05
0.729TyrMet: 0.729 ± 0.018
1.755TyrAsn: 1.755 ± 0.031
1.451TyrPro: 1.451 ± 0.026
1.381TyrGln: 1.381 ± 0.024
1.713TyrArg: 1.713 ± 0.026
2.7TyrSer: 2.7 ± 0.03
1.796TyrThr: 1.796 ± 0.03
2.157TyrVal: 2.157 ± 0.033
0.408TyrTrp: 0.408 ± 0.014
1.453TyrTyr: 1.453 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5338 proteins (2502102 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski