Amino acid dipepetide frequency for Vibrio galatheae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.747AlaAla: 7.747 ± 0.113	0.907AlaCys: 0.907 ± 0.032	4.462AlaAsp: 4.462 ± 0.063	5.707AlaGlu: 5.707 ± 0.086	3.362AlaPhe: 3.362 ± 0.064	5.875AlaGly: 5.875 ± 0.084	1.721AlaHis: 1.721 ± 0.04	6.111AlaIle: 6.111 ± 0.073	5.18AlaLys: 5.18 ± 0.08	10.01AlaLeu: 10.01 ± 0.115	2.832AlaMet: 2.832 ± 0.057	3.597AlaAsn: 3.597 ± 0.055	2.819AlaPro: 2.819 ± 0.058	4.226AlaGln: 4.226 ± 0.071	3.717AlaArg: 3.717 ± 0.063	5.479AlaSer: 5.479 ± 0.079	4.501AlaThr: 4.501 ± 0.063	5.861AlaVal: 5.861 ± 0.082	0.95AlaTrp: 0.95 ± 0.03	2.261AlaTyr: 2.261 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.805CysAla: 0.805 ± 0.029	0.143CysCys: 0.143 ± 0.01	0.638CysAsp: 0.638 ± 0.027	0.595CysGlu: 0.595 ± 0.026	0.464CysPhe: 0.464 ± 0.021	0.919CysGly: 0.919 ± 0.032	0.338CysHis: 0.338 ± 0.019	0.582CysIle: 0.582 ± 0.024	0.419CysLys: 0.419 ± 0.021	0.955CysLeu: 0.955 ± 0.026	0.215CysMet: 0.215 ± 0.015	0.356CysAsn: 0.356 ± 0.018	0.447CysPro: 0.447 ± 0.02	0.502CysGln: 0.502 ± 0.024	0.484CysArg: 0.484 ± 0.021	0.673CysSer: 0.673 ± 0.024	0.491CysThr: 0.491 ± 0.02	0.671CysVal: 0.671 ± 0.024	0.13CysTrp: 0.13 ± 0.01	0.34CysTyr: 0.34 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.461AspAla: 4.461 ± 0.066	0.531AspCys: 0.531 ± 0.024	2.948AspAsp: 2.948 ± 0.06	3.898AspGlu: 3.898 ± 0.06	2.39AspPhe: 2.39 ± 0.041	3.568AspGly: 3.568 ± 0.073	1.122AspHis: 1.122 ± 0.033	3.98AspIle: 3.98 ± 0.059	3.329AspLys: 3.329 ± 0.057	5.336AspLeu: 5.336 ± 0.081	1.423AspMet: 1.423 ± 0.04	2.407AspAsn: 2.407 ± 0.048	2.0AspPro: 2.0 ± 0.045	2.147AspGln: 2.147 ± 0.043	2.31AspArg: 2.31 ± 0.048	3.487AspSer: 3.487 ± 0.067	2.592AspThr: 2.592 ± 0.053	4.113AspVal: 4.113 ± 0.069	0.874AspTrp: 0.874 ± 0.029	2.037AspTyr: 2.037 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.347GluAla: 5.347 ± 0.081	0.563GluCys: 0.563 ± 0.024	2.789GluAsp: 2.789 ± 0.056	4.001GluGlu: 4.001 ± 0.076	2.609GluPhe: 2.609 ± 0.047	3.605GluGly: 3.605 ± 0.062	1.654GluHis: 1.654 ± 0.048	3.932GluIle: 3.932 ± 0.068	3.771GluLys: 3.771 ± 0.061	7.434GluLeu: 7.434 ± 0.099	1.861GluMet: 1.861 ± 0.041	2.533GluAsn: 2.533 ± 0.044	2.116GluPro: 2.116 ± 0.046	4.494GluGln: 4.494 ± 0.08	3.578GluArg: 3.578 ± 0.061	3.955GluSer: 3.955 ± 0.064	3.124GluThr: 3.124 ± 0.053	4.652GluVal: 4.652 ± 0.07	0.811GluTrp: 0.811 ± 0.025	1.801GluTyr: 1.801 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.708PheAla: 3.708 ± 0.066	0.511PheCys: 0.511 ± 0.021	2.752PheAsp: 2.752 ± 0.054	2.626PheGlu: 2.626 ± 0.052	1.567PhePhe: 1.567 ± 0.045	3.21PheGly: 3.21 ± 0.055	0.85PheHis: 0.85 ± 0.029	2.664PheIle: 2.664 ± 0.049	1.912PheLys: 1.912 ± 0.044	3.292PheLeu: 3.292 ± 0.071	0.983PheMet: 0.983 ± 0.029	1.994PheAsn: 1.994 ± 0.046	1.459PhePro: 1.459 ± 0.037	1.252PheGln: 1.252 ± 0.033	1.495PheArg: 1.495 ± 0.034	3.253PheSer: 3.253 ± 0.053	2.278PheThr: 2.278 ± 0.045	2.936PheVal: 2.936 ± 0.054	0.521PheTrp: 0.521 ± 0.023	1.344PheTyr: 1.344 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.298GlyAla: 5.298 ± 0.076	0.881GlyCys: 0.881 ± 0.027	3.617GlyAsp: 3.617 ± 0.062	4.608GlyGlu: 4.608 ± 0.07	3.251GlyPhe: 3.251 ± 0.054	4.703GlyGly: 4.703 ± 0.077	1.549GlyHis: 1.549 ± 0.044	4.663GlyIle: 4.663 ± 0.065	3.924GlyLys: 3.924 ± 0.06	6.95GlyLeu: 6.95 ± 0.093	2.019GlyMet: 2.019 ± 0.044	2.502GlyAsn: 2.502 ± 0.048	1.563GlyPro: 1.563 ± 0.035	2.94GlyGln: 2.94 ± 0.047	3.117GlyArg: 3.117 ± 0.059	4.032GlySer: 4.032 ± 0.077	3.297GlyThr: 3.297 ± 0.064	5.314GlyVal: 5.314 ± 0.073	0.935GlyTrp: 0.935 ± 0.033	2.562GlyTyr: 2.562 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.653HisAla: 1.653 ± 0.037	0.324HisCys: 0.324 ± 0.017	1.138HisAsp: 1.138 ± 0.034	1.154HisGlu: 1.154 ± 0.033	1.076HisPhe: 1.076 ± 0.033	1.508HisGly: 1.508 ± 0.037	0.722HisHis: 0.722 ± 0.027	1.438HisIle: 1.438 ± 0.041	1.077HisLys: 1.077 ± 0.032	2.328HisLeu: 2.328 ± 0.047	0.521HisMet: 0.521 ± 0.022	0.959HisAsn: 0.959 ± 0.029	1.137HisPro: 1.137 ± 0.032	1.321HisGln: 1.321 ± 0.034	1.037HisArg: 1.037 ± 0.033	1.438HisSer: 1.438 ± 0.037	1.129HisThr: 1.129 ± 0.034	1.29HisVal: 1.29 ± 0.032	0.338HisTrp: 0.338 ± 0.018	0.836HisTyr: 0.836 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.597IleAla: 6.597 ± 0.083	0.7IleCys: 0.7 ± 0.026	4.245IleAsp: 4.245 ± 0.07	5.13IleGlu: 5.13 ± 0.063	2.141IlePhe: 2.141 ± 0.049	4.75IleGly: 4.75 ± 0.072	1.26IleHis: 1.26 ± 0.036	3.457IleIle: 3.457 ± 0.068	3.233IleLys: 3.233 ± 0.054	5.169IleLeu: 5.169 ± 0.082	1.306IleMet: 1.306 ± 0.035	2.853IleAsn: 2.853 ± 0.054	2.594IlePro: 2.594 ± 0.041	2.323IleGln: 2.323 ± 0.049	2.806IleArg: 2.806 ± 0.046	4.466IleSer: 4.466 ± 0.055	3.559IleThr: 3.559 ± 0.062	4.33IleVal: 4.33 ± 0.058	0.623IleTrp: 0.623 ± 0.027	1.675IleTyr: 1.675 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.787LysAla: 4.787 ± 0.069	0.324LysCys: 0.324 ± 0.02	2.586LysAsp: 2.586 ± 0.055	3.373LysGlu: 3.373 ± 0.058	1.61LysPhe: 1.61 ± 0.035	3.389LysGly: 3.389 ± 0.053	1.306LysHis: 1.306 ± 0.038	2.828LysIle: 2.828 ± 0.053	2.718LysLys: 2.718 ± 0.062	5.562LysLeu: 5.562 ± 0.079	1.435LysMet: 1.435 ± 0.037	1.889LysAsn: 1.889 ± 0.042	2.44LysPro: 2.44 ± 0.045	3.341LysGln: 3.341 ± 0.06	2.771LysArg: 2.771 ± 0.052	3.094LysSer: 3.094 ± 0.05	2.635LysThr: 2.635 ± 0.053	4.001LysVal: 4.001 ± 0.058	0.58LysTrp: 0.58 ± 0.022	1.354LysTyr: 1.354 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	10.095LeuAla: 10.095 ± 0.108	1.061LeuCys: 1.061 ± 0.032	6.159LeuAsp: 6.159 ± 0.086	6.661LeuGlu: 6.661 ± 0.096	4.264LeuPhe: 4.264 ± 0.083	7.043LeuGly: 7.043 ± 0.087	2.032LeuHis: 2.032 ± 0.053	6.177LeuIle: 6.177 ± 0.087	5.317LeuLys: 5.317 ± 0.071	10.405LeuLeu: 10.405 ± 0.141	2.769LeuMet: 2.769 ± 0.054	4.61LeuAsn: 4.61 ± 0.062	4.628LeuPro: 4.628 ± 0.073	3.66LeuGln: 3.66 ± 0.059	4.311LeuArg: 4.311 ± 0.063	7.943LeuSer: 7.943 ± 0.098	6.125LeuThr: 6.125 ± 0.067	7.414LeuVal: 7.414 ± 0.086	1.037LeuTrp: 1.037 ± 0.033	2.646LeuTyr: 2.646 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.546MetAla: 2.546 ± 0.049	0.225MetCys: 0.225 ± 0.012	1.291MetAsp: 1.291 ± 0.033	1.424MetGlu: 1.424 ± 0.035	0.966MetPhe: 0.966 ± 0.032	1.785MetGly: 1.785 ± 0.04	0.492MetHis: 0.492 ± 0.02	1.617MetIle: 1.617 ± 0.038	1.525MetLys: 1.525 ± 0.035	2.903MetLeu: 2.903 ± 0.05	0.813MetMet: 0.813 ± 0.028	1.112MetAsn: 1.112 ± 0.033	1.247MetPro: 1.247 ± 0.037	1.107MetGln: 1.107 ± 0.031	1.222MetArg: 1.222 ± 0.032	2.07MetSer: 2.07 ± 0.04	1.633MetThr: 1.633 ± 0.04	1.979MetVal: 1.979 ± 0.041	0.25MetTrp: 0.25 ± 0.018	0.542MetTyr: 0.542 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.372AsnAla: 3.372 ± 0.058	0.381AsnCys: 0.381 ± 0.017	2.275AsnAsp: 2.275 ± 0.047	2.358AsnGlu: 2.358 ± 0.05	1.489AsnPhe: 1.489 ± 0.037	2.871AsnGly: 2.871 ± 0.055	1.008AsnHis: 1.008 ± 0.029	2.609AsnIle: 2.609 ± 0.048	2.235AsnLys: 2.235 ± 0.042	4.067AsnLeu: 4.067 ± 0.06	1.041AsnMet: 1.041 ± 0.027	1.746AsnAsn: 1.746 ± 0.051	2.098AsnPro: 2.098 ± 0.045	2.347AsnGln: 2.347 ± 0.043	1.971AsnArg: 1.971 ± 0.045	2.462AsnSer: 2.462 ± 0.046	2.047AsnThr: 2.047 ± 0.043	2.702AsnVal: 2.702 ± 0.056	0.569AsnTrp: 0.569 ± 0.025	1.368AsnTyr: 1.368 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.968ProAla: 2.968 ± 0.059	0.319ProCys: 0.319 ± 0.015	2.236ProAsp: 2.236 ± 0.048	3.072ProGlu: 3.072 ± 0.051	1.677ProPhe: 1.677 ± 0.038	2.145ProGly: 2.145 ± 0.05	0.858ProHis: 0.858 ± 0.028	2.529ProIle: 2.529 ± 0.044	1.954ProLys: 1.954 ± 0.039	4.085ProLeu: 4.085 ± 0.055	1.04ProMet: 1.04 ± 0.037	1.703ProAsn: 1.703 ± 0.043	1.1ProPro: 1.1 ± 0.03	1.866ProGln: 1.866 ± 0.043	1.35ProArg: 1.35 ± 0.034	2.568ProSer: 2.568 ± 0.054	2.176ProThr: 2.176 ± 0.048	3.008ProVal: 3.008 ± 0.054	0.493ProTrp: 0.493 ± 0.025	1.273ProTyr: 1.273 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.669GlnAla: 4.669 ± 0.073	0.416GlnCys: 0.416 ± 0.019	2.346GlnAsp: 2.346 ± 0.046	2.644GlnGlu: 2.644 ± 0.056	1.881GlnPhe: 1.881 ± 0.043	3.329GlnGly: 3.329 ± 0.056	1.218GlnHis: 1.218 ± 0.035	2.788GlnIle: 2.788 ± 0.05	2.104GlnLys: 2.104 ± 0.045	5.493GlnLeu: 5.493 ± 0.077	1.258GlnMet: 1.258 ± 0.031	1.586GlnAsn: 1.586 ± 0.044	1.829GlnPro: 1.829 ± 0.042	3.215GlnGln: 3.215 ± 0.069	2.481GlnArg: 2.481 ± 0.053	2.996GlnSer: 2.996 ± 0.057	2.39GlnThr: 2.39 ± 0.046	3.482GlnVal: 3.482 ± 0.061	0.687GlnTrp: 0.687 ± 0.026	1.435GlnTyr: 1.435 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.537ArgAla: 3.537 ± 0.058	0.466ArgCys: 0.466 ± 0.021	2.578ArgAsp: 2.578 ± 0.055	3.059ArgGlu: 3.059 ± 0.062	2.197ArgPhe: 2.197 ± 0.047	2.597ArgGly: 2.597 ± 0.05	1.061ArgHis: 1.061 ± 0.031	2.937ArgIle: 2.937 ± 0.051	2.36ArgLys: 2.36 ± 0.045	4.923ArgLeu: 4.923 ± 0.075	1.214ArgMet: 1.214 ± 0.029	1.947ArgAsn: 1.947 ± 0.04	1.532ArgPro: 1.532 ± 0.042	2.197ArgGln: 2.197 ± 0.043	2.343ArgArg: 2.343 ± 0.052	2.727ArgSer: 2.727 ± 0.05	2.19ArgThr: 2.19 ± 0.046	3.244ArgVal: 3.244 ± 0.051	0.613ArgTrp: 0.613 ± 0.02	1.735ArgTyr: 1.735 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.538SerAla: 5.538 ± 0.069	0.582SerCys: 0.582 ± 0.024	3.706SerAsp: 3.706 ± 0.068	4.177SerGlu: 4.177 ± 0.073	2.806SerPhe: 2.806 ± 0.05	4.945SerGly: 4.945 ± 0.076	1.571SerHis: 1.571 ± 0.04	4.308SerIle: 4.308 ± 0.076	3.275SerLys: 3.275 ± 0.061	7.046SerLeu: 7.046 ± 0.08	1.772SerMet: 1.772 ± 0.04	2.739SerAsn: 2.739 ± 0.052	2.453SerPro: 2.453 ± 0.044	3.314SerGln: 3.314 ± 0.066	2.842SerArg: 2.842 ± 0.049	4.475SerSer: 4.475 ± 0.07	3.241SerThr: 3.241 ± 0.055	4.634SerVal: 4.634 ± 0.072	0.783SerTrp: 0.783 ± 0.027	2.007SerTyr: 2.007 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.298ThrAla: 4.298 ± 0.071	0.477ThrCys: 0.477 ± 0.021	2.715ThrAsp: 2.715 ± 0.051	3.107ThrGlu: 3.107 ± 0.05	2.083ThrPhe: 2.083 ± 0.046	3.921ThrGly: 3.921 ± 0.065	1.261ThrHis: 1.261 ± 0.032	3.48ThrIle: 3.48 ± 0.051	2.287ThrLys: 2.287 ± 0.047	6.385ThrLeu: 6.385 ± 0.077	1.215ThrMet: 1.215 ± 0.034	2.003ThrAsn: 2.003 ± 0.034	2.553ThrPro: 2.553 ± 0.044	2.61ThrGln: 2.61 ± 0.05	2.184ThrArg: 2.184 ± 0.047	3.378ThrSer: 3.378 ± 0.055	2.897ThrThr: 2.897 ± 0.049	3.668ThrVal: 3.668 ± 0.055	0.605ThrTrp: 0.605 ± 0.023	1.374ThrTyr: 1.374 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.782ValAla: 6.782 ± 0.073	0.853ValCys: 0.853 ± 0.026	4.287ValAsp: 4.287 ± 0.063	5.109ValGlu: 5.109 ± 0.078	2.813ValPhe: 2.813 ± 0.052	4.768ValGly: 4.768 ± 0.06	1.249ValHis: 1.249 ± 0.034	4.788ValIle: 4.788 ± 0.074	3.652ValLys: 3.652 ± 0.06	6.911ValLeu: 6.911 ± 0.091	2.052ValMet: 2.052 ± 0.049	2.924ValAsn: 2.924 ± 0.057	2.624ValPro: 2.624 ± 0.045	2.331ValGln: 2.331 ± 0.049	3.095ValArg: 3.095 ± 0.05	5.003ValSer: 5.003 ± 0.071	4.207ValThr: 4.207 ± 0.062	5.893ValVal: 5.893 ± 0.08	0.786ValTrp: 0.786 ± 0.03	1.828ValTyr: 1.828 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.83TrpAla: 0.83 ± 0.031	0.143TrpCys: 0.143 ± 0.011	0.575TrpAsp: 0.575 ± 0.02	0.522TrpGlu: 0.522 ± 0.021	0.596TrpPhe: 0.596 ± 0.026	0.74TrpGly: 0.74 ± 0.031	0.348TrpHis: 0.348 ± 0.017	0.705TrpIle: 0.705 ± 0.024	0.491TrpLys: 0.491 ± 0.02	1.768TrpLeu: 1.768 ± 0.045	0.349TrpMet: 0.349 ± 0.017	0.499TrpAsn: 0.499 ± 0.021	0.426TrpPro: 0.426 ± 0.02	0.973TrpGln: 0.973 ± 0.032	0.653TrpArg: 0.653 ± 0.023	0.725TrpSer: 0.725 ± 0.029	0.515TrpThr: 0.515 ± 0.019	0.826TrpVal: 0.826 ± 0.027	0.203TrpTrp: 0.203 ± 0.014	0.374TrpTyr: 0.374 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.288TyrAla: 2.288 ± 0.042	0.36TyrCys: 0.36 ± 0.019	1.607TyrAsp: 1.607 ± 0.037	1.404TyrGlu: 1.404 ± 0.033	1.367TyrPhe: 1.367 ± 0.037	2.055TyrGly: 2.055 ± 0.041	0.801TyrHis: 0.801 ± 0.029	1.624TyrIle: 1.624 ± 0.041	1.258TyrLys: 1.258 ± 0.032	3.336TyrLeu: 3.336 ± 0.056	0.635TyrMet: 0.635 ± 0.024	1.057TyrAsn: 1.057 ± 0.031	1.355TyrPro: 1.355 ± 0.035	2.082TyrGln: 2.082 ± 0.049	1.687TyrArg: 1.687 ± 0.041	1.989TyrSer: 1.989 ± 0.04	1.474TyrThr: 1.474 ± 0.038	1.935TyrVal: 1.935 ± 0.042	0.475TyrTrp: 0.475 ± 0.02	0.967TyrTyr: 0.967 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3604 proteins (1164118 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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