Amino acid dipepetide frequency for Trichinella sp. T6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.523AlaAla: 5.523 ± 0.044
1.5AlaCys: 1.5 ± 0.015
3.55AlaAsp: 3.55 ± 0.022
4.479AlaGlu: 4.479 ± 0.027
2.77AlaPhe: 2.77 ± 0.018
3.297AlaGly: 3.297 ± 0.022
1.303AlaHis: 1.303 ± 0.012
3.441AlaIle: 3.441 ± 0.023
3.623AlaLys: 3.623 ± 0.022
6.114AlaLeu: 6.114 ± 0.035
1.594AlaMet: 1.594 ± 0.015
2.94AlaAsn: 2.94 ± 0.02
2.326AlaPro: 2.326 ± 0.023
2.279AlaGln: 2.279 ± 0.018
2.926AlaArg: 2.926 ± 0.02
5.231AlaSer: 5.231 ± 0.026
3.557AlaThr: 3.557 ± 0.019
5.091AlaVal: 5.091 ± 0.027
0.678AlaTrp: 0.678 ± 0.011
1.855AlaTyr: 1.855 ± 0.016
0.001AlaXaa: 0.001 ± 0.0
Cys
1.445CysAla: 1.445 ± 0.015
0.904CysCys: 0.904 ± 0.015
1.355CysAsp: 1.355 ± 0.02
1.463CysGlu: 1.463 ± 0.019
1.32CysPhe: 1.32 ± 0.014
1.419CysGly: 1.419 ± 0.016
0.686CysHis: 0.686 ± 0.011
1.555CysIle: 1.555 ± 0.018
1.471CysLys: 1.471 ± 0.015
2.596CysLeu: 2.596 ± 0.019
0.558CysMet: 0.558 ± 0.008
1.221CysAsn: 1.221 ± 0.016
1.246CysPro: 1.246 ± 0.023
1.119CysGln: 1.119 ± 0.014
1.618CysArg: 1.618 ± 0.018
2.449CysSer: 2.449 ± 0.023
1.384CysThr: 1.384 ± 0.014
1.525CysVal: 1.525 ± 0.016
0.35CysTrp: 0.35 ± 0.007
0.799CysTyr: 0.799 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.268AspAla: 3.268 ± 0.022
1.367AspCys: 1.367 ± 0.02
3.927AspAsp: 3.927 ± 0.032
4.24AspGlu: 4.24 ± 0.027
2.369AspPhe: 2.369 ± 0.018
3.142AspGly: 3.142 ± 0.03
1.212AspHis: 1.212 ± 0.013
2.816AspIle: 2.816 ± 0.019
2.573AspLys: 2.573 ± 0.018
4.628AspLeu: 4.628 ± 0.026
1.141AspMet: 1.141 ± 0.013
2.36AspAsn: 2.36 ± 0.017
2.062AspPro: 2.062 ± 0.016
2.028AspGln: 2.028 ± 0.018
2.762AspArg: 2.762 ± 0.021
4.147AspSer: 4.147 ± 0.027
2.211AspThr: 2.211 ± 0.017
3.666AspVal: 3.666 ± 0.027
0.683AspTrp: 0.683 ± 0.011
1.633AspTyr: 1.633 ± 0.017
0.001AspXaa: 0.001 ± 0.0
Glu
3.863GluAla: 3.863 ± 0.032
1.34GluCys: 1.34 ± 0.018
3.158GluAsp: 3.158 ± 0.024
5.438GluGlu: 5.438 ± 0.047
2.445GluPhe: 2.445 ± 0.02
2.257GluGly: 2.257 ± 0.018
1.4GluHis: 1.4 ± 0.014
3.996GluIle: 3.996 ± 0.029
5.006GluLys: 5.006 ± 0.038
5.701GluLeu: 5.701 ± 0.031
1.939GluMet: 1.939 ± 0.017
4.041GluAsn: 4.041 ± 0.028
2.147GluPro: 2.147 ± 0.019
3.035GluGln: 3.035 ± 0.023
3.524GluArg: 3.524 ± 0.029
4.473GluSer: 4.473 ± 0.026
3.282GluThr: 3.282 ± 0.022
3.458GluVal: 3.458 ± 0.022
0.702GluTrp: 0.702 ± 0.01
1.734GluTyr: 1.734 ± 0.016
0.0GluXaa: 0.0 ± 0.0
Phe
2.829PheAla: 2.829 ± 0.019
1.443PheCys: 1.443 ± 0.015
2.632PheAsp: 2.632 ± 0.023
2.622PheGlu: 2.622 ± 0.018
2.231PhePhe: 2.231 ± 0.022
2.603PheGly: 2.603 ± 0.02
1.304PheHis: 1.304 ± 0.012
2.616PheIle: 2.616 ± 0.021
2.241PheLys: 2.241 ± 0.019
4.341PheLeu: 4.341 ± 0.029
0.901PheMet: 0.901 ± 0.012
2.109PheAsn: 2.109 ± 0.017
1.988PhePro: 1.988 ± 0.018
1.916PheGln: 1.916 ± 0.015
2.347PheArg: 2.347 ± 0.019
3.919PheSer: 3.919 ± 0.024
2.413PheThr: 2.413 ± 0.018
3.114PheVal: 3.114 ± 0.023
0.6PheTrp: 0.6 ± 0.009
1.712PheTyr: 1.712 ± 0.015
0.001PheXaa: 0.001 ± 0.0
Gly
2.753GlyAla: 2.753 ± 0.022
1.277GlyCys: 1.277 ± 0.015
2.574GlyAsp: 2.574 ± 0.021
2.864GlyGlu: 2.864 ± 0.022
2.235GlyPhe: 2.235 ± 0.019
3.299GlyGly: 3.299 ± 0.035
1.289GlyHis: 1.289 ± 0.013
2.95GlyIle: 2.95 ± 0.022
3.369GlyLys: 3.369 ± 0.024
4.037GlyLeu: 4.037 ± 0.027
1.237GlyMet: 1.237 ± 0.013
2.516GlyAsn: 2.516 ± 0.021
1.797GlyPro: 1.797 ± 0.024
2.035GlyGln: 2.035 ± 0.018
3.244GlyArg: 3.244 ± 0.028
4.229GlySer: 4.229 ± 0.031
2.609GlyThr: 2.609 ± 0.021
3.067GlyVal: 3.067 ± 0.024
0.65GlyTrp: 0.65 ± 0.009
1.715GlyTyr: 1.715 ± 0.018
0.001GlyXaa: 0.001 ± 0.0
His
1.415HisAla: 1.415 ± 0.014
0.891HisCys: 0.891 ± 0.012
1.021HisAsp: 1.021 ± 0.011
1.226HisGlu: 1.226 ± 0.015
1.413HisPhe: 1.413 ± 0.014
1.323HisGly: 1.323 ± 0.013
0.95HisHis: 0.95 ± 0.016
1.304HisIle: 1.304 ± 0.015
1.007HisLys: 1.007 ± 0.012
2.716HisLeu: 2.716 ± 0.019
0.551HisMet: 0.551 ± 0.009
0.985HisAsn: 0.985 ± 0.011
1.235HisPro: 1.235 ± 0.011
1.101HisGln: 1.101 ± 0.012
1.54HisArg: 1.54 ± 0.017
2.071HisSer: 2.071 ± 0.015
1.09HisThr: 1.09 ± 0.013
1.574HisVal: 1.574 ± 0.015
0.362HisTrp: 0.362 ± 0.007
0.851HisTyr: 0.851 ± 0.011
0.0HisXaa: 0.0 ± 0.0
Ile
3.74IleAla: 3.74 ± 0.02
1.724IleCys: 1.724 ± 0.019
2.999IleAsp: 2.999 ± 0.021
3.306IleGlu: 3.306 ± 0.021
2.886IlePhe: 2.886 ± 0.023
2.911IleGly: 2.911 ± 0.022
1.345IleHis: 1.345 ± 0.013
3.208IleIle: 3.208 ± 0.021
2.927IleLys: 2.927 ± 0.023
5.349IleLeu: 5.349 ± 0.029
1.186IleMet: 1.186 ± 0.012
2.501IleAsn: 2.501 ± 0.017
2.644IlePro: 2.644 ± 0.019
2.192IleGln: 2.192 ± 0.014
3.186IleArg: 3.186 ± 0.021
4.809IleSer: 4.809 ± 0.025
2.883IleThr: 2.883 ± 0.022
3.697IleVal: 3.697 ± 0.022
0.688IleTrp: 0.688 ± 0.011
1.936IleTyr: 1.936 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
3.561LysAla: 3.561 ± 0.025
1.5LysCys: 1.5 ± 0.017
2.699LysAsp: 2.699 ± 0.019
3.971LysGlu: 3.971 ± 0.03
2.551LysPhe: 2.551 ± 0.019
2.279LysGly: 2.279 ± 0.022
1.499LysHis: 1.499 ± 0.013
3.684LysIle: 3.684 ± 0.027
4.814LysLys: 4.814 ± 0.048
6.155LysLeu: 6.155 ± 0.029
1.772LysMet: 1.772 ± 0.013
3.235LysAsn: 3.235 ± 0.023
2.484LysPro: 2.484 ± 0.022
2.851LysGln: 2.851 ± 0.022
3.914LysArg: 3.914 ± 0.027
4.775LysSer: 4.775 ± 0.034
3.06LysThr: 3.06 ± 0.022
3.356LysVal: 3.356 ± 0.022
0.752LysTrp: 0.752 ± 0.011
1.895LysTyr: 1.895 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
5.994LeuAla: 5.994 ± 0.03
2.463LeuCys: 2.463 ± 0.019
4.538LeuAsp: 4.538 ± 0.024
5.671LeuGlu: 5.671 ± 0.035
4.608LeuPhe: 4.608 ± 0.029
3.824LeuGly: 3.824 ± 0.027
2.688LeuHis: 2.688 ± 0.02
5.448LeuIle: 5.448 ± 0.029
6.577LeuLys: 6.577 ± 0.035
10.588LeuLeu: 10.588 ± 0.053
2.252LeuMet: 2.252 ± 0.017
4.984LeuAsn: 4.984 ± 0.025
4.75LeuPro: 4.75 ± 0.033
4.425LeuGln: 4.425 ± 0.025
5.424LeuArg: 5.424 ± 0.033
7.609LeuSer: 7.609 ± 0.035
5.007LeuThr: 5.007 ± 0.025
5.457LeuVal: 5.457 ± 0.031
1.094LeuTrp: 1.094 ± 0.013
2.936LeuTyr: 2.936 ± 0.019
0.001LeuXaa: 0.001 ± 0.0
Met
1.61MetAla: 1.61 ± 0.013
0.494MetCys: 0.494 ± 0.007
1.28MetAsp: 1.28 ± 0.011
1.662MetGlu: 1.662 ± 0.014
1.026MetPhe: 1.026 ± 0.013
0.91MetGly: 0.91 ± 0.011
0.649MetHis: 0.649 ± 0.009
1.304MetIle: 1.304 ± 0.015
1.795MetLys: 1.795 ± 0.017
2.471MetLeu: 2.471 ± 0.018
0.687MetMet: 0.687 ± 0.01
1.354MetAsn: 1.354 ± 0.013
1.17MetPro: 1.17 ± 0.015
1.164MetGln: 1.164 ± 0.012
1.259MetArg: 1.259 ± 0.013
1.71MetSer: 1.71 ± 0.015
1.269MetThr: 1.269 ± 0.01
1.377MetVal: 1.377 ± 0.012
0.229MetTrp: 0.229 ± 0.005
0.689MetTyr: 0.689 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.236AsnAla: 3.236 ± 0.021
1.445AsnCys: 1.445 ± 0.016
2.789AsnAsp: 2.789 ± 0.021
3.27AsnGlu: 3.27 ± 0.023
2.518AsnPhe: 2.518 ± 0.018
3.066AsnGly: 3.066 ± 0.026
1.06AsnHis: 1.06 ± 0.011
2.788AsnIle: 2.788 ± 0.021
2.555AsnLys: 2.555 ± 0.019
4.517AsnLeu: 4.517 ± 0.025
1.172AsnMet: 1.172 ± 0.011
2.949AsnAsn: 2.949 ± 0.029
1.929AsnPro: 1.929 ± 0.019
1.835AsnGln: 1.835 ± 0.017
2.66AsnArg: 2.66 ± 0.02
4.324AsnSer: 4.324 ± 0.026
2.273AsnThr: 2.273 ± 0.018
3.489AsnVal: 3.489 ± 0.022
0.598AsnTrp: 0.598 ± 0.008
1.699AsnTyr: 1.699 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
2.842ProAla: 2.842 ± 0.021
0.963ProCys: 0.963 ± 0.015
2.242ProAsp: 2.242 ± 0.019
2.602ProGlu: 2.602 ± 0.02
1.968ProPhe: 1.968 ± 0.015
2.331ProGly: 2.331 ± 0.05
0.919ProHis: 0.919 ± 0.011
2.213ProIle: 2.213 ± 0.017
2.454ProLys: 2.454 ± 0.02
4.079ProLeu: 4.079 ± 0.024
0.961ProMet: 0.961 ± 0.011
2.124ProAsn: 2.124 ± 0.017
2.994ProPro: 2.994 ± 0.042
1.54ProGln: 1.54 ± 0.018
1.973ProArg: 1.973 ± 0.018
3.804ProSer: 3.804 ± 0.028
2.656ProThr: 2.656 ± 0.021
3.139ProVal: 3.139 ± 0.023
0.483ProTrp: 0.483 ± 0.009
1.383ProTyr: 1.383 ± 0.015
0.0ProXaa: 0.0 ± 0.0
Gln
2.576GlnAla: 2.576 ± 0.018
1.152GlnCys: 1.152 ± 0.015
1.457GlnAsp: 1.457 ± 0.014
2.174GlnGlu: 2.174 ± 0.018
1.957GlnPhe: 1.957 ± 0.015
1.47GlnGly: 1.47 ± 0.015
1.217GlnHis: 1.217 ± 0.014
2.442GlnIle: 2.442 ± 0.019
2.538GlnLys: 2.538 ± 0.018
4.794GlnLeu: 4.794 ± 0.029
1.195GlnMet: 1.195 ± 0.013
2.111GlnAsn: 2.111 ± 0.017
1.912GlnPro: 1.912 ± 0.021
3.641GlnGln: 3.641 ± 0.067
2.639GlnArg: 2.639 ± 0.021
3.289GlnSer: 3.289 ± 0.02
2.109GlnThr: 2.109 ± 0.018
2.079GlnVal: 2.079 ± 0.018
0.604GlnTrp: 0.604 ± 0.009
1.28GlnTyr: 1.28 ± 0.014
0.001GlnXaa: 0.001 ± 0.0
Arg
2.988ArgAla: 2.988 ± 0.022
1.635ArgCys: 1.635 ± 0.022
2.437ArgAsp: 2.437 ± 0.019
2.996ArgGlu: 2.996 ± 0.023
2.61ArgPhe: 2.61 ± 0.019
2.497ArgGly: 2.497 ± 0.023
1.566ArgHis: 1.566 ± 0.015
3.248ArgIle: 3.248 ± 0.019
3.767ArgLys: 3.767 ± 0.025
5.81ArgLeu: 5.81 ± 0.032
1.454ArgMet: 1.454 ± 0.012
2.736ArgAsn: 2.736 ± 0.021
2.365ArgPro: 2.365 ± 0.023
2.609ArgGln: 2.609 ± 0.019
4.76ArgArg: 4.76 ± 0.036
4.482ArgSer: 4.482 ± 0.032
2.787ArgThr: 2.787 ± 0.02
2.997ArgVal: 2.997 ± 0.02
0.803ArgTrp: 0.803 ± 0.011
1.714ArgTyr: 1.714 ± 0.015
0.001ArgXaa: 0.001 ± 0.0
Ser
5.508SerAla: 5.508 ± 0.03
2.111SerCys: 2.111 ± 0.021
4.481SerAsp: 4.481 ± 0.028
4.869SerGlu: 4.869 ± 0.029
3.596SerPhe: 3.596 ± 0.023
4.598SerGly: 4.598 ± 0.022
1.647SerHis: 1.647 ± 0.014
4.208SerIle: 4.208 ± 0.021
4.895SerLys: 4.895 ± 0.035
7.429SerLeu: 7.429 ± 0.035
1.805SerMet: 1.805 ± 0.014
4.192SerAsn: 4.192 ± 0.028
3.584SerPro: 3.584 ± 0.031
2.87SerGln: 2.87 ± 0.02
4.336SerArg: 4.336 ± 0.03
9.471SerSer: 9.471 ± 0.067
5.169SerThr: 5.169 ± 0.031
5.654SerVal: 5.654 ± 0.031
0.917SerTrp: 0.917 ± 0.012
2.225SerTyr: 2.225 ± 0.016
0.001SerXaa: 0.001 ± 0.0
Thr
4.172ThrAla: 4.172 ± 0.028
1.319ThrCys: 1.319 ± 0.018
2.825ThrAsp: 2.825 ± 0.021
3.11ThrGlu: 3.11 ± 0.022
2.393ThrPhe: 2.393 ± 0.019
2.952ThrGly: 2.952 ± 0.023
0.959ThrHis: 0.959 ± 0.013
2.914ThrIle: 2.914 ± 0.021
2.775ThrLys: 2.775 ± 0.023
4.992ThrLeu: 4.992 ± 0.032
1.259ThrMet: 1.259 ± 0.011
2.472ThrAsn: 2.472 ± 0.018
2.424ThrPro: 2.424 ± 0.021
1.496ThrGln: 1.496 ± 0.013
2.272ThrArg: 2.272 ± 0.019
4.477ThrSer: 4.477 ± 0.029
3.819ThrThr: 3.819 ± 0.038
4.48ThrVal: 4.48 ± 0.029
0.545ThrTrp: 0.545 ± 0.008
1.398ThrTyr: 1.398 ± 0.014
0.0ThrXaa: 0.0 ± 0.0
Val
4.271ValAla: 4.271 ± 0.024
1.67ValCys: 1.67 ± 0.016
4.107ValAsp: 4.107 ± 0.027
4.646ValGlu: 4.646 ± 0.03
2.626ValPhe: 2.626 ± 0.018
3.378ValGly: 3.378 ± 0.022
1.789ValHis: 1.789 ± 0.014
3.552ValIle: 3.552 ± 0.026
3.823ValLys: 3.823 ± 0.026
5.742ValLeu: 5.742 ± 0.031
1.397ValMet: 1.397 ± 0.014
3.077ValAsn: 3.077 ± 0.02
2.772ValPro: 2.772 ± 0.019
2.767ValGln: 2.767 ± 0.019
3.338ValArg: 3.338 ± 0.022
4.771ValSer: 4.771 ± 0.028
3.305ValThr: 3.305 ± 0.024
4.562ValVal: 4.562 ± 0.029
0.742ValTrp: 0.742 ± 0.011
1.859ValTyr: 1.859 ± 0.016
0.001ValXaa: 0.001 ± 0.0
Trp
0.609TrpAla: 0.609 ± 0.01
0.283TrpCys: 0.283 ± 0.006
0.548TrpAsp: 0.548 ± 0.01
0.562TrpGlu: 0.562 ± 0.009
0.555TrpPhe: 0.555 ± 0.01
0.404TrpGly: 0.404 ± 0.008
0.319TrpHis: 0.319 ± 0.007
0.826TrpIle: 0.826 ± 0.01
0.967TrpLys: 0.967 ± 0.012
1.285TrpLeu: 1.285 ± 0.015
0.343TrpMet: 0.343 ± 0.006
0.769TrpAsn: 0.769 ± 0.011
0.527TrpPro: 0.527 ± 0.01
0.553TrpGln: 0.553 ± 0.007
0.749TrpArg: 0.749 ± 0.008
1.015TrpSer: 1.015 ± 0.013
0.702TrpThr: 0.702 ± 0.009
0.508TrpVal: 0.508 ± 0.008
0.192TrpTrp: 0.192 ± 0.005
0.401TrpTyr: 0.401 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.873TyrAla: 1.873 ± 0.016
1.0TyrCys: 1.0 ± 0.012
1.616TyrAsp: 1.616 ± 0.016
1.765TyrGlu: 1.765 ± 0.016
1.806TyrPhe: 1.806 ± 0.016
1.788TyrGly: 1.788 ± 0.015
0.826TyrHis: 0.826 ± 0.011
1.606TyrIle: 1.606 ± 0.015
1.63TyrLys: 1.63 ± 0.014
2.994TyrLeu: 2.994 ± 0.019
0.705TyrMet: 0.705 ± 0.01
1.497TyrAsn: 1.497 ± 0.014
1.314TyrPro: 1.314 ± 0.014
1.182TyrGln: 1.182 ± 0.012
1.789TyrArg: 1.789 ± 0.018
2.509TyrSer: 2.509 ± 0.019
1.465TyrThr: 1.465 ± 0.014
1.905TyrVal: 1.905 ± 0.016
0.444TyrTrp: 0.444 ± 0.009
1.235TyrTyr: 1.235 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.001XaaLys: 0.001 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.001XaaMet: 0.001 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.0
0.001XaaArg: 0.001 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.001XaaThr: 0.001 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.002
Statistics based on 18636 proteins (8581469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski