Amino acid dipepetide frequency for Pigeon adenovirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.85AlaAla: 5.85 ± 0.881
1.539AlaCys: 1.539 ± 0.351
3.002AlaAsp: 3.002 ± 0.475
3.695AlaGlu: 3.695 ± 0.478
2.694AlaPhe: 2.694 ± 0.36
3.31AlaGly: 3.31 ± 0.628
2.001AlaHis: 2.001 ± 0.464
4.31AlaIle: 4.31 ± 0.602
2.386AlaLys: 2.386 ± 0.45
6.927AlaLeu: 6.927 ± 1.099
1.924AlaMet: 1.924 ± 0.583
2.694AlaAsn: 2.694 ± 0.493
3.387AlaPro: 3.387 ± 0.654
2.925AlaGln: 2.925 ± 0.606
3.618AlaArg: 3.618 ± 0.424
4.618AlaSer: 4.618 ± 0.633
5.619AlaThr: 5.619 ± 0.859
4.233AlaVal: 4.233 ± 0.494
0.539AlaTrp: 0.539 ± 0.163
2.309AlaTyr: 2.309 ± 0.321
0.0AlaXaa: 0.0 ± 0.0
Cys
1.155CysAla: 1.155 ± 0.319
0.308CysCys: 0.308 ± 0.153
0.77CysAsp: 0.77 ± 0.224
0.77CysGlu: 0.77 ± 0.321
1.462CysPhe: 1.462 ± 0.318
1.308CysGly: 1.308 ± 0.339
0.77CysHis: 0.77 ± 0.185
0.616CysIle: 0.616 ± 0.294
0.924CysLys: 0.924 ± 0.297
1.232CysLeu: 1.232 ± 0.379
0.385CysMet: 0.385 ± 0.151
1.001CysAsn: 1.001 ± 0.27
1.001CysPro: 1.001 ± 0.264
0.539CysGln: 0.539 ± 0.132
1.232CysArg: 1.232 ± 0.281
2.001CysSer: 2.001 ± 0.448
0.616CysThr: 0.616 ± 0.27
0.924CysVal: 0.924 ± 0.316
0.231CysTrp: 0.231 ± 0.121
0.693CysTyr: 0.693 ± 0.191
0.0CysXaa: 0.0 ± 0.0
Asp
3.695AspAla: 3.695 ± 0.666
0.308AspCys: 0.308 ± 0.151
2.694AspAsp: 2.694 ± 0.48
3.387AspGlu: 3.387 ± 0.506
2.001AspPhe: 2.001 ± 0.343
3.464AspGly: 3.464 ± 0.581
0.77AspHis: 0.77 ± 0.234
3.695AspIle: 3.695 ± 0.6
1.77AspLys: 1.77 ± 0.341
5.619AspLeu: 5.619 ± 0.65
1.308AspMet: 1.308 ± 0.362
2.694AspAsn: 2.694 ± 0.543
3.772AspPro: 3.772 ± 0.52
1.693AspGln: 1.693 ± 0.314
2.463AspArg: 2.463 ± 0.409
4.002AspSer: 4.002 ± 0.589
2.925AspThr: 2.925 ± 0.417
3.695AspVal: 3.695 ± 0.577
0.539AspTrp: 0.539 ± 0.243
2.078AspTyr: 2.078 ± 0.441
0.0AspXaa: 0.0 ± 0.0
Glu
3.156GluAla: 3.156 ± 0.341
1.001GluCys: 1.001 ± 0.284
3.541GluAsp: 3.541 ± 0.518
5.465GluGlu: 5.465 ± 1.323
1.693GluPhe: 1.693 ± 0.381
3.618GluGly: 3.618 ± 0.753
1.924GluHis: 1.924 ± 0.337
2.386GluIle: 2.386 ± 0.429
3.156GluLys: 3.156 ± 0.625
5.542GluLeu: 5.542 ± 0.658
1.308GluMet: 1.308 ± 0.407
2.463GluAsn: 2.463 ± 0.516
2.001GluPro: 2.001 ± 0.428
2.232GluGln: 2.232 ± 0.642
3.772GluArg: 3.772 ± 0.572
3.464GluSer: 3.464 ± 0.632
4.772GluThr: 4.772 ± 0.617
2.925GluVal: 2.925 ± 0.548
0.847GluTrp: 0.847 ± 0.231
2.232GluTyr: 2.232 ± 0.378
0.0GluXaa: 0.0 ± 0.0
Phe
3.156PheAla: 3.156 ± 0.689
0.77PheCys: 0.77 ± 0.211
2.848PheAsp: 2.848 ± 0.473
2.232PheGlu: 2.232 ± 0.41
2.155PhePhe: 2.155 ± 0.45
1.078PheGly: 1.078 ± 0.329
1.616PheHis: 1.616 ± 0.347
1.77PheIle: 1.77 ± 0.425
1.616PheLys: 1.616 ± 0.34
4.695PheLeu: 4.695 ± 0.795
1.385PheMet: 1.385 ± 0.43
2.155PheAsn: 2.155 ± 0.365
2.54PhePro: 2.54 ± 0.453
1.308PheGln: 1.308 ± 0.325
3.849PheArg: 3.849 ± 0.526
3.925PheSer: 3.925 ± 0.548
2.155PheThr: 2.155 ± 0.351
2.771PheVal: 2.771 ± 0.369
0.616PheTrp: 0.616 ± 0.282
2.617PheTyr: 2.617 ± 0.403
0.0PheXaa: 0.0 ± 0.0
Gly
4.772GlyAla: 4.772 ± 0.592
0.847GlyCys: 0.847 ± 0.278
2.309GlyAsp: 2.309 ± 0.397
3.156GlyGlu: 3.156 ± 0.607
2.386GlyPhe: 2.386 ± 0.498
4.541GlyGly: 4.541 ± 0.699
0.77GlyHis: 0.77 ± 0.358
2.309GlyIle: 2.309 ± 0.567
2.617GlyLys: 2.617 ± 0.479
5.465GlyLeu: 5.465 ± 0.649
1.385GlyMet: 1.385 ± 0.298
2.771GlyAsn: 2.771 ± 0.553
2.848GlyPro: 2.848 ± 0.485
2.309GlyGln: 2.309 ± 0.328
4.233GlyArg: 4.233 ± 0.731
2.848GlySer: 2.848 ± 0.466
3.772GlyThr: 3.772 ± 0.608
4.387GlyVal: 4.387 ± 0.721
1.078GlyTrp: 1.078 ± 0.328
2.309GlyTyr: 2.309 ± 0.292
0.0GlyXaa: 0.0 ± 0.0
His
1.616HisAla: 1.616 ± 0.319
1.001HisCys: 1.001 ± 0.319
0.77HisAsp: 0.77 ± 0.243
1.155HisGlu: 1.155 ± 0.348
0.77HisPhe: 0.77 ± 0.298
1.308HisGly: 1.308 ± 0.344
0.924HisHis: 0.924 ± 0.249
1.155HisIle: 1.155 ± 0.256
0.77HisLys: 0.77 ± 0.226
2.155HisLeu: 2.155 ± 0.433
0.308HisMet: 0.308 ± 0.147
1.308HisAsn: 1.308 ± 0.291
2.771HisPro: 2.771 ± 0.596
0.77HisGln: 0.77 ± 0.29
2.309HisArg: 2.309 ± 0.399
1.693HisSer: 1.693 ± 0.282
0.924HisThr: 0.924 ± 0.201
2.771HisVal: 2.771 ± 0.595
0.308HisTrp: 0.308 ± 0.151
1.232HisTyr: 1.232 ± 0.286
0.0HisXaa: 0.0 ± 0.0
Ile
3.925IleAla: 3.925 ± 0.461
1.078IleCys: 1.078 ± 0.225
2.694IleAsp: 2.694 ± 0.557
1.77IleGlu: 1.77 ± 0.38
1.616IlePhe: 1.616 ± 0.444
2.617IleGly: 2.617 ± 0.394
1.078IleHis: 1.078 ± 0.255
1.616IleIle: 1.616 ± 0.426
2.309IleLys: 2.309 ± 0.377
3.387IleLeu: 3.387 ± 0.441
1.001IleMet: 1.001 ± 0.194
2.078IleAsn: 2.078 ± 0.452
3.618IlePro: 3.618 ± 0.532
1.77IleGln: 1.77 ± 0.398
3.002IleArg: 3.002 ± 0.514
2.386IleSer: 2.386 ± 0.475
2.54IleThr: 2.54 ± 0.382
2.771IleVal: 2.771 ± 0.498
0.77IleTrp: 0.77 ± 0.208
2.155IleTyr: 2.155 ± 0.374
0.0IleXaa: 0.0 ± 0.0
Lys
2.617LysAla: 2.617 ± 0.56
0.847LysCys: 0.847 ± 0.258
2.386LysAsp: 2.386 ± 0.579
2.078LysGlu: 2.078 ± 0.482
1.693LysPhe: 1.693 ± 0.315
2.386LysGly: 2.386 ± 0.405
1.078LysHis: 1.078 ± 0.227
1.693LysIle: 1.693 ± 0.464
1.616LysLys: 1.616 ± 0.428
3.464LysLeu: 3.464 ± 0.571
0.847LysMet: 0.847 ± 0.261
1.693LysAsn: 1.693 ± 0.362
1.77LysPro: 1.77 ± 0.278
1.308LysGln: 1.308 ± 0.27
4.002LysArg: 4.002 ± 0.601
2.386LysSer: 2.386 ± 0.46
3.156LysThr: 3.156 ± 0.435
1.77LysVal: 1.77 ± 0.297
0.847LysTrp: 0.847 ± 0.258
1.462LysTyr: 1.462 ± 0.386
0.0LysXaa: 0.0 ± 0.0
Leu
4.849LeuAla: 4.849 ± 0.48
1.847LeuCys: 1.847 ± 0.358
4.541LeuAsp: 4.541 ± 0.415
4.387LeuGlu: 4.387 ± 0.698
4.233LeuPhe: 4.233 ± 0.726
4.618LeuGly: 4.618 ± 0.658
3.233LeuHis: 3.233 ± 0.576
4.002LeuIle: 4.002 ± 0.556
3.541LeuLys: 3.541 ± 0.499
8.929LeuLeu: 8.929 ± 0.825
2.463LeuMet: 2.463 ± 0.366
4.926LeuAsn: 4.926 ± 0.714
4.772LeuPro: 4.772 ± 0.612
5.234LeuGln: 5.234 ± 0.786
8.236LeuArg: 8.236 ± 0.949
7.389LeuSer: 7.389 ± 0.836
6.235LeuThr: 6.235 ± 0.798
4.387LeuVal: 4.387 ± 0.593
1.462LeuTrp: 1.462 ± 0.276
4.772LeuTyr: 4.772 ± 0.663
0.0LeuXaa: 0.0 ± 0.0
Met
2.309MetAla: 2.309 ± 0.389
0.539MetCys: 0.539 ± 0.193
1.385MetAsp: 1.385 ± 0.227
1.539MetGlu: 1.539 ± 0.379
1.308MetPhe: 1.308 ± 0.376
1.155MetGly: 1.155 ± 0.273
0.77MetHis: 0.77 ± 0.269
0.77MetIle: 0.77 ± 0.241
0.693MetLys: 0.693 ± 0.295
2.232MetLeu: 2.232 ± 0.312
0.924MetMet: 0.924 ± 0.283
0.847MetAsn: 0.847 ± 0.254
1.308MetPro: 1.308 ± 0.36
0.77MetGln: 0.77 ± 0.224
1.77MetArg: 1.77 ± 0.48
2.771MetSer: 2.771 ± 0.569
1.078MetThr: 1.078 ± 0.276
1.232MetVal: 1.232 ± 0.265
0.385MetTrp: 0.385 ± 0.223
1.385MetTyr: 1.385 ± 0.373
0.0MetXaa: 0.0 ± 0.0
Asn
3.618AsnAla: 3.618 ± 0.619
0.616AsnCys: 0.616 ± 0.25
1.924AsnAsp: 1.924 ± 0.417
3.079AsnGlu: 3.079 ± 0.608
1.924AsnPhe: 1.924 ± 0.517
3.233AsnGly: 3.233 ± 0.67
1.078AsnHis: 1.078 ± 0.179
2.001AsnIle: 2.001 ± 0.547
1.693AsnLys: 1.693 ± 0.319
3.31AsnLeu: 3.31 ± 0.584
1.078AsnMet: 1.078 ± 0.302
2.54AsnAsn: 2.54 ± 0.704
4.233AsnPro: 4.233 ± 0.41
1.616AsnGln: 1.616 ± 0.362
3.079AsnArg: 3.079 ± 0.461
3.002AsnSer: 3.002 ± 0.556
2.617AsnThr: 2.617 ± 0.461
3.618AsnVal: 3.618 ± 0.814
0.924AsnTrp: 0.924 ± 0.394
2.078AsnTyr: 2.078 ± 0.427
0.0AsnXaa: 0.0 ± 0.0
Pro
3.695ProAla: 3.695 ± 0.674
0.77ProCys: 0.77 ± 0.264
3.695ProAsp: 3.695 ± 0.568
3.464ProGlu: 3.464 ± 0.45
3.233ProPhe: 3.233 ± 0.602
2.617ProGly: 2.617 ± 0.54
2.001ProHis: 2.001 ± 0.32
2.463ProIle: 2.463 ± 0.483
2.155ProLys: 2.155 ± 0.407
6.004ProLeu: 6.004 ± 0.805
1.616ProMet: 1.616 ± 0.364
2.155ProAsn: 2.155 ± 0.516
4.541ProPro: 4.541 ± 0.824
1.77ProGln: 1.77 ± 0.352
3.002ProArg: 3.002 ± 0.446
6.235ProSer: 6.235 ± 0.747
3.541ProThr: 3.541 ± 0.521
4.233ProVal: 4.233 ± 0.617
0.462ProTrp: 0.462 ± 0.185
2.617ProTyr: 2.617 ± 0.442
0.0ProXaa: 0.0 ± 0.0
Gln
3.079GlnAla: 3.079 ± 0.541
0.308GlnCys: 0.308 ± 0.173
1.77GlnAsp: 1.77 ± 0.364
2.078GlnGlu: 2.078 ± 0.445
2.155GlnPhe: 2.155 ± 0.369
1.616GlnGly: 1.616 ± 0.403
0.616GlnHis: 0.616 ± 0.21
1.078GlnIle: 1.078 ± 0.312
1.308GlnLys: 1.308 ± 0.268
4.464GlnLeu: 4.464 ± 0.512
1.385GlnMet: 1.385 ± 0.39
2.001GlnAsn: 2.001 ± 0.42
2.771GlnPro: 2.771 ± 0.49
1.77GlnGln: 1.77 ± 0.461
2.386GlnArg: 2.386 ± 0.497
2.463GlnSer: 2.463 ± 0.415
2.001GlnThr: 2.001 ± 0.377
1.616GlnVal: 1.616 ± 0.235
0.385GlnTrp: 0.385 ± 0.192
1.77GlnTyr: 1.77 ± 0.371
0.0GlnXaa: 0.0 ± 0.0
Arg
3.695ArgAla: 3.695 ± 0.545
1.078ArgCys: 1.078 ± 0.421
3.156ArgAsp: 3.156 ± 0.543
4.31ArgGlu: 4.31 ± 0.819
4.002ArgPhe: 4.002 ± 0.488
4.772ArgGly: 4.772 ± 0.699
1.693ArgHis: 1.693 ± 0.316
2.925ArgIle: 2.925 ± 0.601
3.695ArgLys: 3.695 ± 0.501
6.927ArgLeu: 6.927 ± 0.798
1.77ArgMet: 1.77 ± 0.363
3.31ArgAsn: 3.31 ± 0.66
3.31ArgPro: 3.31 ± 0.463
3.002ArgGln: 3.002 ± 0.417
7.004ArgArg: 7.004 ± 1.592
5.003ArgSer: 5.003 ± 0.727
4.233ArgThr: 4.233 ± 0.44
4.695ArgVal: 4.695 ± 0.903
1.155ArgTrp: 1.155 ± 0.248
2.771ArgTyr: 2.771 ± 0.347
0.0ArgXaa: 0.0 ± 0.0
Ser
4.541SerAla: 4.541 ± 0.514
1.77SerCys: 1.77 ± 0.455
3.772SerAsp: 3.772 ± 0.617
4.618SerGlu: 4.618 ± 0.601
3.079SerPhe: 3.079 ± 0.455
5.465SerGly: 5.465 ± 0.927
1.693SerHis: 1.693 ± 0.322
3.772SerIle: 3.772 ± 0.46
2.617SerLys: 2.617 ± 0.432
7.004SerLeu: 7.004 ± 0.668
1.693SerMet: 1.693 ± 0.352
3.31SerAsn: 3.31 ± 0.378
4.387SerPro: 4.387 ± 0.651
2.309SerGln: 2.309 ± 0.462
5.696SerArg: 5.696 ± 0.741
7.389SerSer: 7.389 ± 0.939
4.002SerThr: 4.002 ± 0.496
4.387SerVal: 4.387 ± 0.549
1.462SerTrp: 1.462 ± 0.384
2.463SerTyr: 2.463 ± 0.514
0.0SerXaa: 0.0 ± 0.0
Thr
4.31ThrAla: 4.31 ± 0.578
0.462ThrCys: 0.462 ± 0.163
4.233ThrAsp: 4.233 ± 0.591
4.156ThrGlu: 4.156 ± 0.641
3.156ThrPhe: 3.156 ± 0.443
3.156ThrGly: 3.156 ± 0.514
1.385ThrHis: 1.385 ± 0.308
2.309ThrIle: 2.309 ± 0.37
1.693ThrLys: 1.693 ± 0.329
5.234ThrLeu: 5.234 ± 0.735
1.232ThrMet: 1.232 ± 0.291
2.694ThrAsn: 2.694 ± 0.541
4.31ThrPro: 4.31 ± 0.688
1.462ThrGln: 1.462 ± 0.298
4.926ThrArg: 4.926 ± 0.647
4.31ThrSer: 4.31 ± 0.666
3.079ThrThr: 3.079 ± 0.541
4.618ThrVal: 4.618 ± 0.623
0.462ThrTrp: 0.462 ± 0.175
2.848ThrTyr: 2.848 ± 0.464
0.0ThrXaa: 0.0 ± 0.0
Val
3.849ValAla: 3.849 ± 0.536
1.693ValCys: 1.693 ± 0.294
3.464ValAsp: 3.464 ± 0.383
2.848ValGlu: 2.848 ± 0.435
3.002ValPhe: 3.002 ± 0.574
3.156ValGly: 3.156 ± 0.52
1.539ValHis: 1.539 ± 0.368
3.079ValIle: 3.079 ± 0.516
2.078ValLys: 2.078 ± 0.394
6.389ValLeu: 6.389 ± 0.573
1.232ValMet: 1.232 ± 0.229
3.618ValAsn: 3.618 ± 0.528
3.849ValPro: 3.849 ± 0.528
2.54ValGln: 2.54 ± 0.483
4.926ValArg: 4.926 ± 0.591
5.157ValSer: 5.157 ± 0.716
3.925ValThr: 3.925 ± 0.664
4.926ValVal: 4.926 ± 0.574
0.385ValTrp: 0.385 ± 0.183
2.694ValTyr: 2.694 ± 0.558
0.0ValXaa: 0.0 ± 0.0
Trp
1.001TrpAla: 1.001 ± 0.208
0.308TrpCys: 0.308 ± 0.154
0.924TrpAsp: 0.924 ± 0.29
0.924TrpGlu: 0.924 ± 0.193
0.539TrpPhe: 0.539 ± 0.21
0.847TrpGly: 0.847 ± 0.297
0.154TrpHis: 0.154 ± 0.093
0.616TrpIle: 0.616 ± 0.229
0.693TrpLys: 0.693 ± 0.25
0.847TrpLeu: 0.847 ± 0.27
0.539TrpMet: 0.539 ± 0.22
1.078TrpAsn: 1.078 ± 0.29
0.539TrpPro: 0.539 ± 0.316
0.693TrpGln: 0.693 ± 0.195
0.231TrpArg: 0.231 ± 0.147
1.155TrpSer: 1.155 ± 0.375
0.847TrpThr: 0.847 ± 0.203
0.924TrpVal: 0.924 ± 0.26
0.539TrpTrp: 0.539 ± 0.268
0.693TrpTyr: 0.693 ± 0.202
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.694TyrAla: 2.694 ± 0.502
0.847TyrCys: 0.847 ± 0.221
2.694TyrAsp: 2.694 ± 0.569
2.386TyrGlu: 2.386 ± 0.432
2.155TyrPhe: 2.155 ± 0.48
2.848TyrGly: 2.848 ± 0.519
0.924TyrHis: 0.924 ± 0.248
1.616TyrIle: 1.616 ± 0.366
1.77TyrLys: 1.77 ± 0.412
4.233TyrLeu: 4.233 ± 0.399
1.308TyrMet: 1.308 ± 0.391
1.924TyrAsn: 1.924 ± 0.3
2.54TyrPro: 2.54 ± 0.459
1.001TyrGln: 1.001 ± 0.308
2.771TyrArg: 2.771 ± 0.446
3.233TyrSer: 3.233 ± 0.505
2.078TyrThr: 2.078 ± 0.381
3.464TyrVal: 3.464 ± 0.589
0.693TyrTrp: 0.693 ± 0.248
1.385TyrTyr: 1.385 ± 0.347
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 35 proteins (12993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski