Amino acid dipepetide frequency for Sinirhodobacter hankyongi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.687AlaAla: 21.687 ± 0.214	1.213AlaCys: 1.213 ± 0.033	6.696AlaAsp: 6.696 ± 0.082	9.875AlaGlu: 9.875 ± 0.114	4.54AlaPhe: 4.54 ± 0.077	12.776AlaGly: 12.776 ± 0.124	2.479AlaHis: 2.479 ± 0.054	5.792AlaIle: 5.792 ± 0.064	3.737AlaLys: 3.737 ± 0.076	16.603AlaLeu: 16.603 ± 0.174	3.926AlaMet: 3.926 ± 0.061	2.454AlaAsn: 2.454 ± 0.052	7.685AlaPro: 7.685 ± 0.119	4.745AlaGln: 4.745 ± 0.079	11.098AlaArg: 11.098 ± 0.125	5.249AlaSer: 5.249 ± 0.076	6.61AlaThr: 6.61 ± 0.072	9.179AlaVal: 9.179 ± 0.1	1.522AlaTrp: 1.522 ± 0.034	2.427AlaTyr: 2.427 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.203CysAla: 1.203 ± 0.033	0.104CysCys: 0.104 ± 0.009	0.589CysAsp: 0.589 ± 0.024	0.431CysGlu: 0.431 ± 0.022	0.312CysPhe: 0.312 ± 0.016	0.953CysGly: 0.953 ± 0.033	0.25CysHis: 0.25 ± 0.017	0.352CysIle: 0.352 ± 0.017	0.187CysLys: 0.187 ± 0.014	0.887CysLeu: 0.887 ± 0.03	0.156CysMet: 0.156 ± 0.012	0.17CysAsn: 0.17 ± 0.012	0.571CysPro: 0.571 ± 0.024	0.169CysGln: 0.169 ± 0.012	0.59CysArg: 0.59 ± 0.022	0.42CysSer: 0.42 ± 0.02	0.498CysThr: 0.498 ± 0.022	0.576CysVal: 0.576 ± 0.024	0.12CysTrp: 0.12 ± 0.011	0.187CysTyr: 0.187 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.894AspAla: 6.894 ± 0.084	0.504AspCys: 0.504 ± 0.021	2.598AspAsp: 2.598 ± 0.05	3.177AspGlu: 3.177 ± 0.06	2.205AspPhe: 2.205 ± 0.042	4.8AspGly: 4.8 ± 0.074	1.185AspHis: 1.185 ± 0.031	2.412AspIle: 2.412 ± 0.049	1.356AspLys: 1.356 ± 0.043	6.29AspLeu: 6.29 ± 0.08	1.373AspMet: 1.373 ± 0.04	0.923AspAsn: 0.923 ± 0.029	3.765AspPro: 3.765 ± 0.062	1.349AspGln: 1.349 ± 0.036	4.078AspArg: 4.078 ± 0.054	1.986AspSer: 1.986 ± 0.046	2.623AspThr: 2.623 ± 0.06	3.439AspVal: 3.439 ± 0.054	1.233AspTrp: 1.233 ± 0.035	1.468AspTyr: 1.468 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	9.295GluAla: 9.295 ± 0.113	0.34GluCys: 0.34 ± 0.017	3.013GluAsp: 3.013 ± 0.053	3.493GluGlu: 3.493 ± 0.07	1.726GluPhe: 1.726 ± 0.042	5.441GluGly: 5.441 ± 0.08	1.085GluHis: 1.085 ± 0.032	3.73GluIle: 3.73 ± 0.062	2.057GluLys: 2.057 ± 0.054	5.237GluLeu: 5.237 ± 0.068	1.742GluMet: 1.742 ± 0.044	1.463GluAsn: 1.463 ± 0.039	2.743GluPro: 2.743 ± 0.049	1.678GluGln: 1.678 ± 0.04	4.523GluArg: 4.523 ± 0.065	1.985GluSer: 1.985 ± 0.044	3.83GluThr: 3.83 ± 0.064	4.573GluVal: 4.573 ± 0.073	0.646GluTrp: 0.646 ± 0.026	0.934GluTyr: 0.934 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.754PheAla: 4.754 ± 0.067	0.39PheCys: 0.39 ± 0.02	2.584PheAsp: 2.584 ± 0.05	2.167PheGlu: 2.167 ± 0.052	1.332PhePhe: 1.332 ± 0.041	3.764PheGly: 3.764 ± 0.06	0.739PheHis: 0.739 ± 0.023	1.472PheIle: 1.472 ± 0.036	0.731PheLys: 0.731 ± 0.029	3.52PheLeu: 3.52 ± 0.073	0.73PheMet: 0.73 ± 0.025	0.879PheAsn: 0.879 ± 0.03	1.583PhePro: 1.583 ± 0.04	0.86PheGln: 0.86 ± 0.028	2.285PheArg: 2.285 ± 0.051	2.036PheSer: 2.036 ± 0.05	2.115PheThr: 2.115 ± 0.042	2.648PheVal: 2.648 ± 0.052	0.59PheTrp: 0.59 ± 0.023	0.836PheTyr: 0.836 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.996GlyAla: 11.996 ± 0.133	0.933GlyCys: 0.933 ± 0.035	4.242GlyAsp: 4.242 ± 0.074	4.941GlyGlu: 4.941 ± 0.065	3.774GlyPhe: 3.774 ± 0.056	7.673GlyGly: 7.673 ± 0.109	1.97GlyHis: 1.97 ± 0.048	4.383GlyIle: 4.383 ± 0.067	3.024GlyLys: 3.024 ± 0.06	9.911GlyLeu: 9.911 ± 0.109	2.602GlyMet: 2.602 ± 0.049	1.86GlyAsn: 1.86 ± 0.061	4.168GlyPro: 4.168 ± 0.067	2.841GlyGln: 2.841 ± 0.054	6.78GlyArg: 6.78 ± 0.079	3.98GlySer: 3.98 ± 0.07	5.046GlyThr: 5.046 ± 0.066	6.527GlyVal: 6.527 ± 0.081	1.592GlyTrp: 1.592 ± 0.041	2.181GlyTyr: 2.181 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.437HisAla: 2.437 ± 0.055	0.22HisCys: 0.22 ± 0.013	1.249HisAsp: 1.249 ± 0.036	1.039HisGlu: 1.039 ± 0.029	0.826HisPhe: 0.826 ± 0.028	1.878HisGly: 1.878 ± 0.042	0.494HisHis: 0.494 ± 0.02	0.795HisIle: 0.795 ± 0.028	0.429HisLys: 0.429 ± 0.018	2.205HisLeu: 2.205 ± 0.044	0.489HisMet: 0.489 ± 0.023	0.405HisAsn: 0.405 ± 0.018	1.465HisPro: 1.465 ± 0.048	0.456HisGln: 0.456 ± 0.02	1.402HisArg: 1.402 ± 0.035	0.805HisSer: 0.805 ± 0.023	0.722HisThr: 0.722 ± 0.024	1.473HisVal: 1.473 ± 0.037	0.364HisTrp: 0.364 ± 0.017	0.574HisTyr: 0.574 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.392IleAla: 7.392 ± 0.084	0.582IleCys: 0.582 ± 0.024	3.148IleAsp: 3.148 ± 0.051	3.512IleGlu: 3.512 ± 0.054	1.694IlePhe: 1.694 ± 0.041	4.847IleGly: 4.847 ± 0.068	0.832IleHis: 0.832 ± 0.032	1.652IleIle: 1.652 ± 0.041	0.984IleLys: 0.984 ± 0.038	4.277IleLeu: 4.277 ± 0.068	0.825IleMet: 0.825 ± 0.028	1.023IleAsn: 1.023 ± 0.03	2.207IlePro: 2.207 ± 0.036	0.861IleGln: 0.861 ± 0.031	3.308IleArg: 3.308 ± 0.054	2.614IleSer: 2.614 ± 0.053	2.603IleThr: 2.603 ± 0.043	3.603IleVal: 3.603 ± 0.065	0.695IleTrp: 0.695 ± 0.026	1.013IleTyr: 1.013 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.812LysAla: 3.812 ± 0.073	0.17LysCys: 0.17 ± 0.013	1.422LysAsp: 1.422 ± 0.039	1.354LysGlu: 1.354 ± 0.039	0.821LysPhe: 0.821 ± 0.027	2.624LysGly: 2.624 ± 0.053	0.491LysHis: 0.491 ± 0.025	1.614LysIle: 1.614 ± 0.039	1.076LysLys: 1.076 ± 0.04	2.685LysLeu: 2.685 ± 0.051	0.869LysMet: 0.869 ± 0.029	0.627LysAsn: 0.627 ± 0.025	1.683LysPro: 1.683 ± 0.048	0.717LysGln: 0.717 ± 0.027	1.925LysArg: 1.925 ± 0.048	1.366LysSer: 1.366 ± 0.033	1.784LysThr: 1.784 ± 0.042	2.32LysVal: 2.32 ± 0.053	0.338LysTrp: 0.338 ± 0.018	0.581LysTyr: 0.581 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.025LeuAla: 16.025 ± 0.171	0.937LeuCys: 0.937 ± 0.031	5.855LeuAsp: 5.855 ± 0.081	5.344LeuGlu: 5.344 ± 0.074	3.587LeuPhe: 3.587 ± 0.066	9.283LeuGly: 9.283 ± 0.097	2.007LeuHis: 2.007 ± 0.043	5.068LeuIle: 5.068 ± 0.073	3.032LeuLys: 3.032 ± 0.057	9.248LeuLeu: 9.248 ± 0.125	2.597LeuMet: 2.597 ± 0.049	2.292LeuAsn: 2.292 ± 0.045	6.375LeuPro: 6.375 ± 0.078	2.369LeuGln: 2.369 ± 0.044	8.082LeuArg: 8.082 ± 0.101	6.193LeuSer: 6.193 ± 0.083	6.017LeuThr: 6.017 ± 0.077	7.332LeuVal: 7.332 ± 0.105	1.416LeuTrp: 1.416 ± 0.036	1.976LeuTyr: 1.976 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.501MetAla: 3.501 ± 0.057	0.175MetCys: 0.175 ± 0.01	1.137MetAsp: 1.137 ± 0.033	1.272MetGlu: 1.272 ± 0.036	0.709MetPhe: 0.709 ± 0.026	2.173MetGly: 2.173 ± 0.044	0.415MetHis: 0.415 ± 0.021	1.425MetIle: 1.425 ± 0.04	1.001MetLys: 1.001 ± 0.031	2.62MetLeu: 2.62 ± 0.052	0.768MetMet: 0.768 ± 0.029	0.732MetAsn: 0.732 ± 0.025	1.515MetPro: 1.515 ± 0.039	0.861MetGln: 0.861 ± 0.027	1.911MetArg: 1.911 ± 0.043	1.562MetSer: 1.562 ± 0.038	2.076MetThr: 2.076 ± 0.042	1.838MetVal: 1.838 ± 0.039	0.207MetTrp: 0.207 ± 0.016	0.282MetTyr: 0.282 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.733AsnAla: 2.733 ± 0.054	0.219AsnCys: 0.219 ± 0.015	1.243AsnAsp: 1.243 ± 0.049	0.966AsnGlu: 0.966 ± 0.028	0.806AsnPhe: 0.806 ± 0.029	2.056AsnGly: 2.056 ± 0.053	0.384AsnHis: 0.384 ± 0.018	1.051AsnIle: 1.051 ± 0.031	0.518AsnLys: 0.518 ± 0.021	2.233AsnLeu: 2.233 ± 0.046	0.553AsnMet: 0.553 ± 0.027	0.436AsnAsn: 0.436 ± 0.021	1.733AsnPro: 1.733 ± 0.044	0.532AsnGln: 0.532 ± 0.023	1.582AsnArg: 1.582 ± 0.04	0.882AsnSer: 0.882 ± 0.026	1.098AsnThr: 1.098 ± 0.029	1.484AsnVal: 1.484 ± 0.043	0.342AsnTrp: 0.342 ± 0.02	0.573AsnTyr: 0.573 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.92ProAla: 7.92 ± 0.098	0.404ProCys: 0.404 ± 0.017	3.584ProAsp: 3.584 ± 0.062	4.732ProGlu: 4.732 ± 0.072	2.039ProPhe: 2.039 ± 0.04	5.53ProGly: 5.53 ± 0.074	1.042ProHis: 1.042 ± 0.031	1.982ProIle: 1.982 ± 0.042	1.648ProLys: 1.648 ± 0.043	5.172ProLeu: 5.172 ± 0.071	1.368ProMet: 1.368 ± 0.036	1.102ProAsn: 1.102 ± 0.033	2.662ProPro: 2.662 ± 0.078	1.575ProGln: 1.575 ± 0.036	3.452ProArg: 3.452 ± 0.06	2.312ProSer: 2.312 ± 0.049	2.352ProThr: 2.352 ± 0.045	4.771ProVal: 4.771 ± 0.063	0.766ProTrp: 0.766 ± 0.032	1.034ProTyr: 1.034 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.935GlnAla: 3.935 ± 0.063	0.177GlnCys: 0.177 ± 0.014	1.264GlnAsp: 1.264 ± 0.037	1.286GlnGlu: 1.286 ± 0.037	0.882GlnPhe: 0.882 ± 0.029	2.58GlnGly: 2.58 ± 0.054	0.474GlnHis: 0.474 ± 0.022	1.838GlnIle: 1.838 ± 0.037	0.892GlnLys: 0.892 ± 0.028	2.579GlnLeu: 2.579 ± 0.053	0.912GlnMet: 0.912 ± 0.029	0.717GlnAsn: 0.717 ± 0.022	1.394GlnPro: 1.394 ± 0.033	0.842GlnGln: 0.842 ± 0.032	1.999GlnArg: 1.999 ± 0.053	1.416GlnSer: 1.416 ± 0.036	1.445GlnThr: 1.445 ± 0.037	2.287GlnVal: 2.287 ± 0.046	0.347GlnTrp: 0.347 ± 0.017	0.495GlnTyr: 0.495 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.332ArgAla: 10.332 ± 0.124	0.517ArgCys: 0.517 ± 0.024	4.032ArgAsp: 4.032 ± 0.061	4.144ArgGlu: 4.144 ± 0.067	2.916ArgPhe: 2.916 ± 0.05	5.303ArgGly: 5.303 ± 0.075	1.697ArgHis: 1.697 ± 0.042	3.986ArgIle: 3.986 ± 0.066	2.037ArgLys: 2.037 ± 0.049	8.583ArgLeu: 8.583 ± 0.105	2.046ArgMet: 2.046 ± 0.045	1.544ArgAsn: 1.544 ± 0.045	4.027ArgPro: 4.027 ± 0.061	2.097ArgGln: 2.097 ± 0.046	5.826ArgArg: 5.826 ± 0.091	3.052ArgSer: 3.052 ± 0.05	3.108ArgThr: 3.108 ± 0.057	4.982ArgVal: 4.982 ± 0.062	1.038ArgTrp: 1.038 ± 0.029	1.446ArgTyr: 1.446 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.812SerAla: 5.812 ± 0.074	0.382SerCys: 0.382 ± 0.02	2.56SerAsp: 2.56 ± 0.047	2.459SerGlu: 2.459 ± 0.048	2.024SerPhe: 2.024 ± 0.04	5.044SerGly: 5.044 ± 0.076	0.951SerHis: 0.951 ± 0.031	1.932SerIle: 1.932 ± 0.042	1.191SerLys: 1.191 ± 0.036	4.729SerLeu: 4.729 ± 0.07	1.11SerMet: 1.11 ± 0.032	1.019SerAsn: 1.019 ± 0.034	2.465SerPro: 2.465 ± 0.043	1.227SerGln: 1.227 ± 0.032	3.087SerArg: 3.087 ± 0.057	2.231SerSer: 2.231 ± 0.051	2.327SerThr: 2.327 ± 0.044	3.461SerVal: 3.461 ± 0.057	0.763SerTrp: 0.763 ± 0.029	1.173SerTyr: 1.173 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.697ThrAla: 6.697 ± 0.091	0.481ThrCys: 0.481 ± 0.022	2.834ThrAsp: 2.834 ± 0.053	3.089ThrGlu: 3.089 ± 0.049	1.859ThrPhe: 1.859 ± 0.043	5.554ThrGly: 5.554 ± 0.077	1.022ThrHis: 1.022 ± 0.033	2.554ThrIle: 2.554 ± 0.053	1.284ThrLys: 1.284 ± 0.041	6.289ThrLeu: 6.289 ± 0.079	1.175ThrMet: 1.175 ± 0.031	1.101ThrAsn: 1.101 ± 0.034	3.629ThrPro: 3.629 ± 0.059	1.393ThrGln: 1.393 ± 0.037	3.783ThrArg: 3.783 ± 0.05	2.271ThrSer: 2.271 ± 0.045	2.779ThrThr: 2.779 ± 0.058	4.34ThrVal: 4.34 ± 0.059	0.648ThrTrp: 0.648 ± 0.023	1.059ThrTyr: 1.059 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.852ValAla: 9.852 ± 0.108	0.627ValCys: 0.627 ± 0.024	3.466ValAsp: 3.466 ± 0.055	4.456ValGlu: 4.456 ± 0.062	2.674ValPhe: 2.674 ± 0.053	5.079ValGly: 5.079 ± 0.073	1.372ValHis: 1.372 ± 0.033	4.099ValIle: 4.099 ± 0.07	2.136ValLys: 2.136 ± 0.05	8.101ValLeu: 8.101 ± 0.096	2.097ValMet: 2.097 ± 0.047	1.773ValAsn: 1.773 ± 0.035	4.004ValPro: 4.004 ± 0.068	2.026ValGln: 2.026 ± 0.047	4.314ValArg: 4.314 ± 0.064	3.795ValSer: 3.795 ± 0.056	4.974ValThr: 4.974 ± 0.071	5.655ValVal: 5.655 ± 0.081	0.97ValTrp: 0.97 ± 0.03	1.322ValTyr: 1.322 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.5TrpAla: 1.5 ± 0.041	0.138TrpCys: 0.138 ± 0.011	0.709TrpAsp: 0.709 ± 0.025	0.635TrpGlu: 0.635 ± 0.022	0.535TrpPhe: 0.535 ± 0.023	1.082TrpGly: 1.082 ± 0.034	0.364TrpHis: 0.364 ± 0.017	0.695TrpIle: 0.695 ± 0.025	0.457TrpLys: 0.457 ± 0.019	1.736TrpLeu: 1.736 ± 0.043	0.376TrpMet: 0.376 ± 0.019	0.387TrpAsn: 0.387 ± 0.019	0.766TrpPro: 0.766 ± 0.025	0.584TrpGln: 0.584 ± 0.022	1.178TrpArg: 1.178 ± 0.035	0.782TrpSer: 0.782 ± 0.028	0.767TrpThr: 0.767 ± 0.025	0.945TrpVal: 0.945 ± 0.032	0.23TrpTrp: 0.23 ± 0.015	0.292TrpTyr: 0.292 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.518TyrAla: 2.518 ± 0.049	0.213TyrCys: 0.213 ± 0.013	1.435TyrAsp: 1.435 ± 0.035	1.164TyrGlu: 1.164 ± 0.037	0.752TyrPhe: 0.752 ± 0.027	1.986TyrGly: 1.986 ± 0.045	0.476TyrHis: 0.476 ± 0.025	0.839TyrIle: 0.839 ± 0.027	0.501TyrLys: 0.501 ± 0.021	2.13TyrLeu: 2.13 ± 0.045	0.465TyrMet: 0.465 ± 0.019	0.516TyrAsn: 0.516 ± 0.022	1.009TyrPro: 1.009 ± 0.03	0.579TyrGln: 0.579 ± 0.023	1.51TyrArg: 1.51 ± 0.043	1.009TyrSer: 1.009 ± 0.03	1.068TyrThr: 1.068 ± 0.032	1.361TyrVal: 1.361 ± 0.035	0.328TyrTrp: 0.328 ± 0.019	0.513TyrTyr: 0.513 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3573 proteins (1138740 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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