Amino acid dipepetide frequency for Streptococcus satellite phage Javan297

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.335AlaAla: 0.335 ± 0.288
0.0AlaCys: 0.0 ± 0.0
2.344AlaAsp: 2.344 ± 0.597
5.693AlaGlu: 5.693 ± 1.709
2.679AlaPhe: 2.679 ± 1.042
2.344AlaGly: 2.344 ± 0.943
0.335AlaHis: 0.335 ± 0.288
4.019AlaIle: 4.019 ± 0.963
5.693AlaLys: 5.693 ± 1.378
5.693AlaLeu: 5.693 ± 1.536
2.344AlaMet: 2.344 ± 1.104
1.34AlaAsn: 1.34 ± 0.546
0.67AlaPro: 0.67 ± 0.452
2.009AlaGln: 2.009 ± 0.978
3.014AlaArg: 3.014 ± 1.009
3.014AlaSer: 3.014 ± 1.182
3.349AlaThr: 3.349 ± 1.109
2.344AlaVal: 2.344 ± 0.856
1.005AlaTrp: 1.005 ± 0.553
2.009AlaTyr: 2.009 ± 0.913
0.0AlaXaa: 0.0 ± 0.0
Cys
0.335CysAla: 0.335 ± 0.342
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.67CysGlu: 0.67 ± 0.411
0.0CysPhe: 0.0 ± 0.0
0.335CysGly: 0.335 ± 0.325
1.005CysHis: 1.005 ± 0.536
0.0CysIle: 0.0 ± 0.0
0.67CysLys: 0.67 ± 0.427
0.67CysLeu: 0.67 ± 0.47
0.67CysMet: 0.67 ± 0.481
0.335CysAsn: 0.335 ± 0.359
0.335CysPro: 0.335 ± 0.32
0.0CysGln: 0.0 ± 0.0
0.335CysArg: 0.335 ± 0.33
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.335CysVal: 0.335 ± 0.305
0.0CysTrp: 0.0 ± 0.0
0.67CysTyr: 0.67 ± 0.379
0.0CysXaa: 0.0 ± 0.0
Asp
2.344AspAla: 2.344 ± 1.055
0.0AspCys: 0.0 ± 0.0
3.684AspAsp: 3.684 ± 1.156
5.023AspGlu: 5.023 ± 1.158
5.023AspPhe: 5.023 ± 1.137
2.344AspGly: 2.344 ± 0.953
0.67AspHis: 0.67 ± 0.387
5.023AspIle: 5.023 ± 1.106
4.689AspLys: 4.689 ± 1.434
8.038AspLeu: 8.038 ± 2.283
1.005AspMet: 1.005 ± 0.562
4.019AspAsn: 4.019 ± 1.225
1.34AspPro: 1.34 ± 0.689
1.674AspGln: 1.674 ± 0.748
4.689AspArg: 4.689 ± 1.615
2.679AspSer: 2.679 ± 0.993
4.354AspThr: 4.354 ± 1.232
2.679AspVal: 2.679 ± 1.23
0.0AspTrp: 0.0 ± 0.0
3.014AspTyr: 3.014 ± 0.982
0.0AspXaa: 0.0 ± 0.0
Glu
2.679GluAla: 2.679 ± 0.806
1.005GluCys: 1.005 ± 0.562
5.023GluAsp: 5.023 ± 1.326
5.693GluGlu: 5.693 ± 1.76
2.679GluPhe: 2.679 ± 1.017
2.344GluGly: 2.344 ± 0.91
1.674GluHis: 1.674 ± 0.574
8.372GluIle: 8.372 ± 1.472
9.377GluLys: 9.377 ± 1.919
12.391GluLeu: 12.391 ± 2.278
3.684GluMet: 3.684 ± 0.782
5.358GluAsn: 5.358 ± 1.163
2.009GluPro: 2.009 ± 0.811
4.019GluGln: 4.019 ± 1.139
5.358GluArg: 5.358 ± 1.243
2.344GluSer: 2.344 ± 0.719
6.028GluThr: 6.028 ± 1.56
6.028GluVal: 6.028 ± 1.618
0.335GluTrp: 0.335 ± 0.317
3.014GluTyr: 3.014 ± 0.809
0.0GluXaa: 0.0 ± 0.0
Phe
1.005PheAla: 1.005 ± 0.558
0.335PheCys: 0.335 ± 0.317
5.358PheAsp: 5.358 ± 0.987
5.023PheGlu: 5.023 ± 1.152
3.349PhePhe: 3.349 ± 1.318
3.014PheGly: 3.014 ± 0.867
1.674PheHis: 1.674 ± 0.745
2.344PheIle: 2.344 ± 0.925
4.019PheLys: 4.019 ± 1.314
4.689PheLeu: 4.689 ± 1.556
1.005PheMet: 1.005 ± 0.632
1.674PheAsn: 1.674 ± 0.73
1.34PhePro: 1.34 ± 0.694
1.34PheGln: 1.34 ± 0.816
2.344PheArg: 2.344 ± 0.938
2.344PheSer: 2.344 ± 0.769
2.344PheThr: 2.344 ± 1.001
1.34PheVal: 1.34 ± 0.877
0.335PheTrp: 0.335 ± 0.305
0.67PheTyr: 0.67 ± 0.471
0.0PheXaa: 0.0 ± 0.0
Gly
3.014GlyAla: 3.014 ± 0.621
0.335GlyCys: 0.335 ± 0.32
3.014GlyAsp: 3.014 ± 0.856
4.019GlyGlu: 4.019 ± 1.473
1.674GlyPhe: 1.674 ± 0.667
1.674GlyGly: 1.674 ± 1.106
1.005GlyHis: 1.005 ± 0.511
4.019GlyIle: 4.019 ± 1.254
4.354GlyLys: 4.354 ± 1.261
4.354GlyLeu: 4.354 ± 1.116
1.674GlyMet: 1.674 ± 0.711
2.009GlyAsn: 2.009 ± 0.67
0.335GlyPro: 0.335 ± 0.288
1.34GlyGln: 1.34 ± 0.606
3.014GlyArg: 3.014 ± 0.889
2.009GlySer: 2.009 ± 1.05
2.679GlyThr: 2.679 ± 0.883
4.019GlyVal: 4.019 ± 1.05
1.34GlyTrp: 1.34 ± 0.793
4.019GlyTyr: 4.019 ± 1.041
0.0GlyXaa: 0.0 ± 0.0
His
1.34HisAla: 1.34 ± 0.711
0.335HisCys: 0.335 ± 0.288
0.67HisAsp: 0.67 ± 0.443
0.67HisGlu: 0.67 ± 0.404
1.34HisPhe: 1.34 ± 0.605
1.005HisGly: 1.005 ± 0.557
1.005HisHis: 1.005 ± 0.467
0.67HisIle: 0.67 ± 0.408
1.005HisLys: 1.005 ± 0.681
2.009HisLeu: 2.009 ± 0.938
0.0HisMet: 0.0 ± 0.0
0.67HisAsn: 0.67 ± 0.451
0.0HisPro: 0.0 ± 0.0
1.005HisGln: 1.005 ± 0.701
0.67HisArg: 0.67 ± 0.392
2.679HisSer: 2.679 ± 0.915
1.34HisThr: 1.34 ± 0.64
0.335HisVal: 0.335 ± 0.32
0.0HisTrp: 0.0 ± 0.0
2.009HisTyr: 2.009 ± 0.533
0.0HisXaa: 0.0 ± 0.0
Ile
4.689IleAla: 4.689 ± 1.479
1.34IleCys: 1.34 ± 0.652
2.679IleAsp: 2.679 ± 0.711
7.703IleGlu: 7.703 ± 2.274
2.344IlePhe: 2.344 ± 0.678
3.349IleGly: 3.349 ± 1.09
0.335IleHis: 0.335 ± 0.38
4.689IleIle: 4.689 ± 1.067
6.698IleLys: 6.698 ± 1.383
6.363IleLeu: 6.363 ± 1.396
1.005IleMet: 1.005 ± 0.444
3.349IleAsn: 3.349 ± 0.738
2.009IlePro: 2.009 ± 0.71
3.014IleGln: 3.014 ± 0.954
4.689IleArg: 4.689 ± 1.149
4.019IleSer: 4.019 ± 1.222
3.684IleThr: 3.684 ± 0.804
2.009IleVal: 2.009 ± 0.933
0.335IleTrp: 0.335 ± 0.288
3.014IleTyr: 3.014 ± 0.729
0.0IleXaa: 0.0 ± 0.0
Lys
8.038LysAla: 8.038 ± 2.171
0.335LysCys: 0.335 ± 0.325
6.698LysAsp: 6.698 ± 1.534
9.377LysGlu: 9.377 ± 1.41
3.349LysPhe: 3.349 ± 1.038
5.693LysGly: 5.693 ± 1.003
2.344LysHis: 2.344 ± 0.681
7.368LysIle: 7.368 ± 1.783
10.717LysLys: 10.717 ± 2.032
7.033LysLeu: 7.033 ± 1.711
3.349LysMet: 3.349 ± 1.059
7.033LysAsn: 7.033 ± 1.778
2.679LysPro: 2.679 ± 0.857
2.344LysGln: 2.344 ± 0.888
4.689LysArg: 4.689 ± 1.074
6.698LysSer: 6.698 ± 0.952
4.354LysThr: 4.354 ± 1.001
5.023LysVal: 5.023 ± 1.226
1.34LysTrp: 1.34 ± 0.549
3.684LysTyr: 3.684 ± 0.91
0.0LysXaa: 0.0 ± 0.0
Leu
5.023LeuAla: 5.023 ± 1.491
0.335LeuCys: 0.335 ± 0.313
7.703LeuAsp: 7.703 ± 1.692
9.712LeuGlu: 9.712 ± 1.542
5.358LeuPhe: 5.358 ± 1.817
6.363LeuGly: 6.363 ± 1.146
1.34LeuHis: 1.34 ± 0.822
5.023LeuIle: 5.023 ± 1.782
11.386LeuLys: 11.386 ± 1.709
7.368LeuLeu: 7.368 ± 1.94
2.009LeuMet: 2.009 ± 0.6
5.358LeuAsn: 5.358 ± 1.0
2.009LeuPro: 2.009 ± 0.738
2.679LeuGln: 2.679 ± 1.087
4.689LeuArg: 4.689 ± 1.176
5.023LeuSer: 5.023 ± 1.248
7.368LeuThr: 7.368 ± 1.819
5.023LeuVal: 5.023 ± 1.194
0.67LeuTrp: 0.67 ± 0.475
5.023LeuTyr: 5.023 ± 1.334
0.0LeuXaa: 0.0 ± 0.0
Met
1.674MetAla: 1.674 ± 0.574
0.0MetCys: 0.0 ± 0.0
2.009MetAsp: 2.009 ± 0.678
3.349MetGlu: 3.349 ± 1.335
0.67MetPhe: 0.67 ± 0.446
1.34MetGly: 1.34 ± 0.823
0.0MetHis: 0.0 ± 0.0
1.674MetIle: 1.674 ± 0.748
1.674MetLys: 1.674 ± 0.551
1.005MetLeu: 1.005 ± 0.551
1.005MetMet: 1.005 ± 0.685
2.679MetAsn: 2.679 ± 0.806
0.67MetPro: 0.67 ± 0.47
0.67MetGln: 0.67 ± 0.444
1.674MetArg: 1.674 ± 1.101
0.67MetSer: 0.67 ± 0.392
2.679MetThr: 2.679 ± 0.857
1.34MetVal: 1.34 ± 0.985
0.0MetTrp: 0.0 ± 0.0
0.67MetTyr: 0.67 ± 0.442
0.0MetXaa: 0.0 ± 0.0
Asn
2.344AsnAla: 2.344 ± 0.885
0.335AsnCys: 0.335 ± 0.35
2.679AsnAsp: 2.679 ± 0.858
4.019AsnGlu: 4.019 ± 0.809
2.009AsnPhe: 2.009 ± 0.755
5.693AsnGly: 5.693 ± 1.513
1.34AsnHis: 1.34 ± 0.711
2.679AsnIle: 2.679 ± 0.888
6.698AsnLys: 6.698 ± 1.778
6.363AsnLeu: 6.363 ± 1.724
1.005AsnMet: 1.005 ± 0.652
2.009AsnAsn: 2.009 ± 0.668
1.674AsnPro: 1.674 ± 0.542
2.009AsnGln: 2.009 ± 0.756
2.009AsnArg: 2.009 ± 0.968
2.679AsnSer: 2.679 ± 0.86
2.344AsnThr: 2.344 ± 0.82
0.67AsnVal: 0.67 ± 0.487
0.335AsnTrp: 0.335 ± 0.305
3.014AsnTyr: 3.014 ± 1.014
0.0AsnXaa: 0.0 ± 0.0
Pro
1.34ProAla: 1.34 ± 0.523
0.335ProCys: 0.335 ± 0.32
1.674ProAsp: 1.674 ± 0.728
1.005ProGlu: 1.005 ± 0.532
1.674ProPhe: 1.674 ± 0.582
0.67ProGly: 0.67 ± 0.446
0.0ProHis: 0.0 ± 0.0
1.674ProIle: 1.674 ± 1.109
3.014ProLys: 3.014 ± 1.107
1.674ProLeu: 1.674 ± 0.66
0.335ProMet: 0.335 ± 0.342
1.34ProAsn: 1.34 ± 0.772
2.009ProPro: 2.009 ± 0.889
1.005ProGln: 1.005 ± 0.494
1.34ProArg: 1.34 ± 0.585
0.67ProSer: 0.67 ± 0.464
1.674ProThr: 1.674 ± 0.636
0.335ProVal: 0.335 ± 0.342
0.335ProTrp: 0.335 ± 0.288
1.34ProTyr: 1.34 ± 0.68
0.0ProXaa: 0.0 ± 0.0
Gln
4.689GlnAla: 4.689 ± 1.414
0.0GlnCys: 0.0 ± 0.0
1.34GlnAsp: 1.34 ± 0.631
4.019GlnGlu: 4.019 ± 1.056
1.34GlnPhe: 1.34 ± 0.737
1.674GlnGly: 1.674 ± 0.543
0.67GlnHis: 0.67 ± 0.492
2.679GlnIle: 2.679 ± 0.861
3.014GlnLys: 3.014 ± 0.946
4.019GlnLeu: 4.019 ± 1.415
0.335GlnMet: 0.335 ± 0.35
1.34GlnAsn: 1.34 ± 0.525
1.005GlnPro: 1.005 ± 0.528
1.674GlnGln: 1.674 ± 0.689
3.014GlnArg: 3.014 ± 0.741
2.679GlnSer: 2.679 ± 0.88
1.34GlnThr: 1.34 ± 0.606
1.674GlnVal: 1.674 ± 0.816
0.0GlnTrp: 0.0 ± 0.0
2.009GlnTyr: 2.009 ± 0.939
0.0GlnXaa: 0.0 ± 0.0
Arg
2.679ArgAla: 2.679 ± 1.003
0.335ArgCys: 0.335 ± 0.305
3.684ArgAsp: 3.684 ± 1.088
5.023ArgGlu: 5.023 ± 1.331
2.009ArgPhe: 2.009 ± 0.768
2.009ArgGly: 2.009 ± 1.109
1.34ArgHis: 1.34 ± 0.663
4.354ArgIle: 4.354 ± 1.035
5.023ArgLys: 5.023 ± 1.553
7.703ArgLeu: 7.703 ± 1.741
1.674ArgMet: 1.674 ± 0.735
3.349ArgAsn: 3.349 ± 1.129
0.67ArgPro: 0.67 ± 0.444
4.689ArgGln: 4.689 ± 0.903
2.679ArgArg: 2.679 ± 1.304
1.674ArgSer: 1.674 ± 0.658
2.344ArgThr: 2.344 ± 0.669
1.674ArgVal: 1.674 ± 0.592
0.0ArgTrp: 0.0 ± 0.0
3.684ArgTyr: 3.684 ± 1.179
0.0ArgXaa: 0.0 ± 0.0
Ser
1.005SerAla: 1.005 ± 0.621
0.67SerCys: 0.67 ± 0.443
5.023SerAsp: 5.023 ± 1.089
4.019SerGlu: 4.019 ± 1.244
2.344SerPhe: 2.344 ± 1.046
2.679SerGly: 2.679 ± 0.77
1.34SerHis: 1.34 ± 0.643
3.014SerIle: 3.014 ± 0.977
5.358SerLys: 5.358 ± 1.021
3.684SerLeu: 3.684 ± 0.99
2.009SerMet: 2.009 ± 0.977
1.005SerAsn: 1.005 ± 0.51
0.67SerPro: 0.67 ± 0.471
2.009SerGln: 2.009 ± 0.763
2.009SerArg: 2.009 ± 0.823
2.344SerSer: 2.344 ± 1.286
4.019SerThr: 4.019 ± 0.926
2.679SerVal: 2.679 ± 1.134
0.67SerTrp: 0.67 ± 0.458
2.344SerTyr: 2.344 ± 0.719
0.0SerXaa: 0.0 ± 0.0
Thr
3.349ThrAla: 3.349 ± 1.063
0.0ThrCys: 0.0 ± 0.0
3.684ThrAsp: 3.684 ± 1.48
4.019ThrGlu: 4.019 ± 1.126
3.349ThrPhe: 3.349 ± 1.087
3.014ThrGly: 3.014 ± 0.881
1.674ThrHis: 1.674 ± 0.592
4.019ThrIle: 4.019 ± 0.973
4.689ThrLys: 4.689 ± 1.013
6.028ThrLeu: 6.028 ± 1.097
0.67ThrMet: 0.67 ± 0.445
3.349ThrAsn: 3.349 ± 0.993
3.014ThrPro: 3.014 ± 0.851
3.014ThrGln: 3.014 ± 0.894
3.349ThrArg: 3.349 ± 0.608
2.679ThrSer: 2.679 ± 1.037
3.684ThrThr: 3.684 ± 1.397
5.023ThrVal: 5.023 ± 1.577
0.0ThrTrp: 0.0 ± 0.0
2.344ThrTyr: 2.344 ± 0.611
0.0ThrXaa: 0.0 ± 0.0
Val
4.019ValAla: 4.019 ± 1.466
0.0ValCys: 0.0 ± 0.0
3.684ValAsp: 3.684 ± 0.953
6.028ValGlu: 6.028 ± 1.634
2.344ValPhe: 2.344 ± 0.822
1.005ValGly: 1.005 ± 0.501
0.335ValHis: 0.335 ± 0.305
2.009ValIle: 2.009 ± 0.713
4.689ValLys: 4.689 ± 1.438
4.019ValLeu: 4.019 ± 0.783
0.335ValMet: 0.335 ± 0.305
4.019ValAsn: 4.019 ± 0.97
0.335ValPro: 0.335 ± 0.305
1.34ValGln: 1.34 ± 0.672
2.344ValArg: 2.344 ± 1.055
1.674ValSer: 1.674 ± 0.871
3.684ValThr: 3.684 ± 1.117
3.014ValVal: 3.014 ± 0.832
0.0ValTrp: 0.0 ± 0.0
3.349ValTyr: 3.349 ± 0.926
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.335TrpCys: 0.335 ± 0.305
0.0TrpAsp: 0.0 ± 0.0
1.34TrpGlu: 1.34 ± 0.577
0.0TrpPhe: 0.0 ± 0.0
0.67TrpGly: 0.67 ± 0.427
0.0TrpHis: 0.0 ± 0.0
1.005TrpIle: 1.005 ± 0.519
0.67TrpLys: 0.67 ± 0.495
0.335TrpLeu: 0.335 ± 0.355
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.335TrpGln: 0.335 ± 0.315
0.67TrpArg: 0.67 ± 0.438
0.67TrpSer: 0.67 ± 0.427
0.67TrpThr: 0.67 ± 0.442
0.335TrpVal: 0.335 ± 0.359
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.67TyrAla: 0.67 ± 0.443
0.335TyrCys: 0.335 ± 0.355
1.34TyrAsp: 1.34 ± 0.521
3.014TyrGlu: 3.014 ± 1.031
2.009TyrPhe: 2.009 ± 0.719
2.679TyrGly: 2.679 ± 0.805
0.67TyrHis: 0.67 ± 0.433
2.679TyrIle: 2.679 ± 0.841
8.707TyrLys: 8.707 ± 1.287
6.028TyrLeu: 6.028 ± 1.296
1.005TyrMet: 1.005 ± 0.454
1.674TyrAsn: 1.674 ± 0.658
0.67TyrPro: 0.67 ± 0.379
2.344TyrGln: 2.344 ± 0.908
4.019TyrArg: 4.019 ± 0.723
2.344TyrSer: 2.344 ± 0.703
3.014TyrThr: 3.014 ± 0.902
2.344TyrVal: 2.344 ± 0.75
0.335TyrTrp: 0.335 ± 0.304
1.674TyrTyr: 1.674 ± 0.783
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (2987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski