Amino acid dipepetide frequency for Cohnella sp. CAU 1483

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.856AlaAla: 10.856 ± 0.14
0.763AlaCys: 0.763 ± 0.026
5.062AlaAsp: 5.062 ± 0.116
6.292AlaGlu: 6.292 ± 0.096
3.488AlaPhe: 3.488 ± 0.058
8.01AlaGly: 8.01 ± 0.1
1.552AlaHis: 1.552 ± 0.036
5.098AlaIle: 5.098 ± 0.073
4.426AlaLys: 4.426 ± 0.063
8.788AlaLeu: 8.788 ± 0.101
2.588AlaMet: 2.588 ± 0.049
2.566AlaAsn: 2.566 ± 0.049
3.016AlaPro: 3.016 ± 0.049
2.782AlaGln: 2.782 ± 0.05
4.292AlaArg: 4.292 ± 0.07
5.431AlaSer: 5.431 ± 0.077
3.418AlaThr: 3.418 ± 0.058
7.65AlaVal: 7.65 ± 0.092
1.043AlaTrp: 1.043 ± 0.035
2.565AlaTyr: 2.565 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.554CysAla: 0.554 ± 0.022
0.11CysCys: 0.11 ± 0.01
0.367CysAsp: 0.367 ± 0.017
0.41CysGlu: 0.41 ± 0.019
0.283CysPhe: 0.283 ± 0.015
0.813CysGly: 0.813 ± 0.027
0.172CysHis: 0.172 ± 0.013
0.434CysIle: 0.434 ± 0.019
0.272CysLys: 0.272 ± 0.017
0.726CysLeu: 0.726 ± 0.024
0.174CysMet: 0.174 ± 0.012
0.253CysAsn: 0.253 ± 0.017
0.357CysPro: 0.357 ± 0.018
0.178CysGln: 0.178 ± 0.012
0.534CysArg: 0.534 ± 0.023
0.555CysSer: 0.555 ± 0.02
0.391CysThr: 0.391 ± 0.017
0.507CysVal: 0.507 ± 0.021
0.089CysTrp: 0.089 ± 0.008
0.249CysTyr: 0.249 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.375AspAla: 4.375 ± 0.058
0.36AspCys: 0.36 ± 0.016
2.555AspAsp: 2.555 ± 0.051
3.7AspGlu: 3.7 ± 0.061
2.109AspPhe: 2.109 ± 0.038
4.275AspGly: 4.275 ± 0.096
1.162AspHis: 1.162 ± 0.031
3.3AspIle: 3.3 ± 0.05
2.704AspLys: 2.704 ± 0.053
5.021AspLeu: 5.021 ± 0.072
1.343AspMet: 1.343 ± 0.036
1.782AspAsn: 1.782 ± 0.037
2.715AspPro: 2.715 ± 0.051
1.745AspGln: 1.745 ± 0.034
3.369AspArg: 3.369 ± 0.064
2.621AspSer: 2.621 ± 0.056
2.589AspThr: 2.589 ± 0.047
3.804AspVal: 3.804 ± 0.055
0.866AspTrp: 0.866 ± 0.028
1.88AspTyr: 1.88 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.363GluAla: 6.363 ± 0.074
0.368GluCys: 0.368 ± 0.016
2.975GluAsp: 2.975 ± 0.05
5.151GluGlu: 5.151 ± 0.076
2.217GluPhe: 2.217 ± 0.048
4.319GluGly: 4.319 ± 0.052
1.467GluHis: 1.467 ± 0.041
4.145GluIle: 4.145 ± 0.076
3.7GluLys: 3.7 ± 0.067
6.809GluLeu: 6.809 ± 0.093
1.936GluMet: 1.936 ± 0.038
2.277GluAsn: 2.277 ± 0.041
2.513GluPro: 2.513 ± 0.046
3.191GluGln: 3.191 ± 0.055
4.505GluArg: 4.505 ± 0.068
3.551GluSer: 3.551 ± 0.06
3.473GluThr: 3.473 ± 0.053
4.233GluVal: 4.233 ± 0.064
1.005GluTrp: 1.005 ± 0.03
1.821GluTyr: 1.821 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.531PheAla: 3.531 ± 0.058
0.336PheCys: 0.336 ± 0.018
2.331PheAsp: 2.331 ± 0.045
2.427PheGlu: 2.427 ± 0.045
1.748PhePhe: 1.748 ± 0.047
3.581PheGly: 3.581 ± 0.055
0.946PheHis: 0.946 ± 0.03
2.473PheIle: 2.473 ± 0.053
1.609PheLys: 1.609 ± 0.035
3.932PheLeu: 3.932 ± 0.059
1.064PheMet: 1.064 ± 0.035
1.341PheAsn: 1.341 ± 0.034
1.764PhePro: 1.764 ± 0.041
1.405PheGln: 1.405 ± 0.033
2.498PheArg: 2.498 ± 0.05
2.563PheSer: 2.563 ± 0.045
2.349PheThr: 2.349 ± 0.052
3.087PheVal: 3.087 ± 0.046
0.529PheTrp: 0.529 ± 0.023
1.334PheTyr: 1.334 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
6.136GlyAla: 6.136 ± 0.082
0.729GlyCys: 0.729 ± 0.025
3.738GlyAsp: 3.738 ± 0.068
4.581GlyGlu: 4.581 ± 0.058
3.417GlyPhe: 3.417 ± 0.066
6.117GlyGly: 6.117 ± 0.106
1.646GlyHis: 1.646 ± 0.038
5.373GlyIle: 5.373 ± 0.064
4.695GlyLys: 4.695 ± 0.068
7.441GlyLeu: 7.441 ± 0.093
2.562GlyMet: 2.562 ± 0.049
2.694GlyAsn: 2.694 ± 0.072
2.215GlyPro: 2.215 ± 0.047
2.782GlyGln: 2.782 ± 0.055
4.26GlyArg: 4.26 ± 0.059
4.802GlySer: 4.802 ± 0.115
4.678GlyThr: 4.678 ± 0.072
5.892GlyVal: 5.892 ± 0.075
1.236GlyTrp: 1.236 ± 0.036
2.783GlyTyr: 2.783 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.679HisAla: 1.679 ± 0.038
0.185HisCys: 0.185 ± 0.013
1.087HisAsp: 1.087 ± 0.032
1.353HisGlu: 1.353 ± 0.033
0.966HisPhe: 0.966 ± 0.03
1.677HisGly: 1.677 ± 0.034
0.581HisHis: 0.581 ± 0.025
1.2HisIle: 1.2 ± 0.028
0.8HisLys: 0.8 ± 0.026
2.071HisLeu: 2.071 ± 0.077
0.543HisMet: 0.543 ± 0.02
0.598HisAsn: 0.598 ± 0.021
1.366HisPro: 1.366 ± 0.032
0.684HisGln: 0.684 ± 0.023
1.315HisArg: 1.315 ± 0.035
1.126HisSer: 1.126 ± 0.032
1.041HisThr: 1.041 ± 0.031
1.507HisVal: 1.507 ± 0.037
0.316HisTrp: 0.316 ± 0.015
0.766HisTyr: 0.766 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.841IleAla: 5.841 ± 0.083
0.537IleCys: 0.537 ± 0.02
3.456IleAsp: 3.456 ± 0.05
3.699IleGlu: 3.699 ± 0.059
2.194IlePhe: 2.194 ± 0.047
5.367IleGly: 5.367 ± 0.073
1.325IleHis: 1.325 ± 0.039
3.313IleIle: 3.313 ± 0.063
2.369IleLys: 2.369 ± 0.049
5.401IleLeu: 5.401 ± 0.074
1.427IleMet: 1.427 ± 0.033
1.878IleAsn: 1.878 ± 0.042
3.108IlePro: 3.108 ± 0.043
2.121IleGln: 2.121 ± 0.04
4.382IleArg: 4.382 ± 0.071
3.786IleSer: 3.786 ± 0.063
3.373IleThr: 3.373 ± 0.06
5.164IleVal: 5.164 ± 0.067
0.678IleTrp: 0.678 ± 0.022
1.696IleTyr: 1.696 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.393LysAla: 4.393 ± 0.074
0.226LysCys: 0.226 ± 0.015
2.662LysAsp: 2.662 ± 0.052
3.742LysGlu: 3.742 ± 0.058
1.604LysPhe: 1.604 ± 0.039
3.396LysGly: 3.396 ± 0.063
1.04LysHis: 1.04 ± 0.03
2.913LysIle: 2.913 ± 0.06
2.904LysLys: 2.904 ± 0.056
5.287LysLeu: 5.287 ± 0.114
1.505LysMet: 1.505 ± 0.039
1.821LysAsn: 1.821 ± 0.045
2.539LysPro: 2.539 ± 0.048
2.139LysGln: 2.139 ± 0.047
2.959LysArg: 2.959 ± 0.055
2.844LysSer: 2.844 ± 0.054
2.752LysThr: 2.752 ± 0.05
3.585LysVal: 3.585 ± 0.065
0.704LysTrp: 0.704 ± 0.023
1.581LysTyr: 1.581 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
9.219LeuAla: 9.219 ± 0.156
0.773LeuCys: 0.773 ± 0.027
5.13LeuAsp: 5.13 ± 0.064
6.094LeuGlu: 6.094 ± 0.083
4.419LeuPhe: 4.419 ± 0.074
7.053LeuGly: 7.053 ± 0.084
2.116LeuHis: 2.116 ± 0.043
5.994LeuIle: 5.994 ± 0.081
5.116LeuLys: 5.116 ± 0.074
11.033LeuLeu: 11.033 ± 0.134
2.585LeuMet: 2.585 ± 0.044
3.477LeuAsn: 3.477 ± 0.054
4.709LeuPro: 4.709 ± 0.063
3.824LeuGln: 3.824 ± 0.064
5.68LeuArg: 5.68 ± 0.075
6.814LeuSer: 6.814 ± 0.089
5.795LeuThr: 5.795 ± 0.065
6.438LeuVal: 6.438 ± 0.08
1.018LeuTrp: 1.018 ± 0.034
2.91LeuTyr: 2.91 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.483MetAla: 2.483 ± 0.045
0.158MetCys: 0.158 ± 0.011
1.459MetAsp: 1.459 ± 0.027
1.882MetGlu: 1.882 ± 0.041
1.011MetPhe: 1.011 ± 0.033
1.823MetGly: 1.823 ± 0.042
0.457MetHis: 0.457 ± 0.019
1.75MetIle: 1.75 ± 0.041
1.931MetLys: 1.931 ± 0.04
2.858MetLeu: 2.858 ± 0.05
0.87MetMet: 0.87 ± 0.029
1.368MetAsn: 1.368 ± 0.032
1.317MetPro: 1.317 ± 0.033
0.934MetGln: 0.934 ± 0.027
1.479MetArg: 1.479 ± 0.036
1.76MetSer: 1.76 ± 0.038
1.728MetThr: 1.728 ± 0.037
1.714MetVal: 1.714 ± 0.039
0.225MetTrp: 0.225 ± 0.014
0.704MetTyr: 0.704 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.89AsnAla: 2.89 ± 0.053
0.227AsnCys: 0.227 ± 0.013
1.69AsnAsp: 1.69 ± 0.039
2.126AsnGlu: 2.126 ± 0.046
1.233AsnPhe: 1.233 ± 0.031
3.2AsnGly: 3.2 ± 0.081
0.723AsnHis: 0.723 ± 0.025
2.102AsnIle: 2.102 ± 0.038
1.695AsnLys: 1.695 ± 0.04
3.16AsnLeu: 3.16 ± 0.05
0.919AsnMet: 0.919 ± 0.029
1.288AsnAsn: 1.288 ± 0.038
2.072AsnPro: 2.072 ± 0.043
1.139AsnGln: 1.139 ± 0.029
2.391AsnArg: 2.391 ± 0.045
1.734AsnSer: 1.734 ± 0.041
1.659AsnThr: 1.659 ± 0.04
2.687AsnVal: 2.687 ± 0.052
0.464AsnTrp: 0.464 ± 0.021
1.088AsnTyr: 1.088 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
4.061ProAla: 4.061 ± 0.07
0.263ProCys: 0.263 ± 0.015
3.043ProAsp: 3.043 ± 0.049
3.596ProGlu: 3.596 ± 0.053
1.987ProPhe: 1.987 ± 0.042
3.532ProGly: 3.532 ± 0.071
0.978ProHis: 0.978 ± 0.028
2.422ProIle: 2.422 ± 0.041
1.91ProLys: 1.91 ± 0.046
4.11ProLeu: 4.11 ± 0.061
1.048ProMet: 1.048 ± 0.03
1.578ProAsn: 1.578 ± 0.034
1.512ProPro: 1.512 ± 0.037
1.452ProGln: 1.452 ± 0.037
1.787ProArg: 1.787 ± 0.041
2.825ProSer: 2.825 ± 0.048
1.877ProThr: 1.877 ± 0.04
3.697ProVal: 3.697 ± 0.062
0.578ProTrp: 0.578 ± 0.021
1.535ProTyr: 1.535 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.433GlnAla: 3.433 ± 0.06
0.185GlnCys: 0.185 ± 0.012
1.632GlnAsp: 1.632 ± 0.039
2.38GlnGlu: 2.38 ± 0.048
1.41GlnPhe: 1.41 ± 0.034
2.509GlnGly: 2.509 ± 0.053
0.705GlnHis: 0.705 ± 0.022
2.243GlnIle: 2.243 ± 0.044
1.79GlnLys: 1.79 ± 0.037
3.846GlnLeu: 3.846 ± 0.06
1.086GlnMet: 1.086 ± 0.032
1.209GlnAsn: 1.209 ± 0.033
1.631GlnPro: 1.631 ± 0.041
1.626GlnGln: 1.626 ± 0.038
1.945GlnArg: 1.945 ± 0.048
2.093GlnSer: 2.093 ± 0.039
1.956GlnThr: 1.956 ± 0.044
2.498GlnVal: 2.498 ± 0.047
0.516GlnTrp: 0.516 ± 0.018
1.136GlnTyr: 1.136 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.993ArgAla: 3.993 ± 0.056
0.407ArgCys: 0.407 ± 0.018
2.856ArgAsp: 2.856 ± 0.043
4.44ArgGlu: 4.44 ± 0.078
2.603ArgPhe: 2.603 ± 0.05
3.511ArgGly: 3.511 ± 0.055
1.35ArgHis: 1.35 ± 0.033
3.952ArgIle: 3.952 ± 0.06
3.481ArgLys: 3.481 ± 0.061
6.276ArgLeu: 6.276 ± 0.09
1.952ArgMet: 1.952 ± 0.038
2.183ArgAsn: 2.183 ± 0.04
2.187ArgPro: 2.187 ± 0.047
2.403ArgGln: 2.403 ± 0.049
3.903ArgArg: 3.903 ± 0.075
3.434ArgSer: 3.434 ± 0.06
3.092ArgThr: 3.092 ± 0.05
3.717ArgVal: 3.717 ± 0.059
0.857ArgTrp: 0.857 ± 0.029
2.049ArgTyr: 2.049 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.424SerAla: 5.424 ± 0.079
0.433SerCys: 0.433 ± 0.02
3.054SerAsp: 3.054 ± 0.048
3.589SerGlu: 3.589 ± 0.058
2.75SerPhe: 2.75 ± 0.049
5.448SerGly: 5.448 ± 0.072
1.154SerHis: 1.154 ± 0.03
3.66SerIle: 3.66 ± 0.066
2.867SerLys: 2.867 ± 0.053
6.023SerLeu: 6.023 ± 0.076
1.685SerMet: 1.685 ± 0.036
1.89SerAsn: 1.89 ± 0.041
2.712SerPro: 2.712 ± 0.055
1.848SerGln: 1.848 ± 0.04
3.509SerArg: 3.509 ± 0.05
3.876SerSer: 3.876 ± 0.079
2.862SerThr: 2.862 ± 0.055
4.865SerVal: 4.865 ± 0.134
0.792SerTrp: 0.792 ± 0.025
1.897SerTyr: 1.897 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.134ThrAla: 5.134 ± 0.072
0.337ThrCys: 0.337 ± 0.016
2.979ThrAsp: 2.979 ± 0.058
3.254ThrGlu: 3.254 ± 0.059
2.234ThrPhe: 2.234 ± 0.043
4.732ThrGly: 4.732 ± 0.072
0.98ThrHis: 0.98 ± 0.027
3.306ThrIle: 3.306 ± 0.052
2.242ThrLys: 2.242 ± 0.046
5.269ThrLeu: 5.269 ± 0.068
1.359ThrMet: 1.359 ± 0.034
1.731ThrAsn: 1.731 ± 0.04
2.634ThrPro: 2.634 ± 0.045
1.486ThrGln: 1.486 ± 0.038
2.525ThrArg: 2.525 ± 0.044
2.985ThrSer: 2.985 ± 0.061
2.682ThrThr: 2.682 ± 0.062
4.772ThrVal: 4.772 ± 0.079
0.634ThrTrp: 0.634 ± 0.027
1.704ThrTyr: 1.704 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
5.821ValAla: 5.821 ± 0.078
0.66ValCys: 0.66 ± 0.022
3.756ValAsp: 3.756 ± 0.051
4.472ValGlu: 4.472 ± 0.07
3.087ValPhe: 3.087 ± 0.052
4.943ValGly: 4.943 ± 0.079
1.503ValHis: 1.503 ± 0.031
4.792ValIle: 4.792 ± 0.071
3.952ValLys: 3.952 ± 0.064
7.587ValLeu: 7.587 ± 0.085
2.051ValMet: 2.051 ± 0.042
2.806ValAsn: 2.806 ± 0.055
3.517ValPro: 3.517 ± 0.057
2.529ValGln: 2.529 ± 0.045
4.279ValArg: 4.279 ± 0.069
4.885ValSer: 4.885 ± 0.07
4.823ValThr: 4.823 ± 0.108
5.53ValVal: 5.53 ± 0.074
1.044ValTrp: 1.044 ± 0.032
2.351ValTyr: 2.351 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.929TrpAla: 0.929 ± 0.03
0.099TrpCys: 0.099 ± 0.01
0.645TrpAsp: 0.645 ± 0.025
0.743TrpGlu: 0.743 ± 0.026
0.588TrpPhe: 0.588 ± 0.021
0.875TrpGly: 0.875 ± 0.029
0.258TrpHis: 0.258 ± 0.012
0.919TrpIle: 0.919 ± 0.027
0.767TrpLys: 0.767 ± 0.027
1.551TrpLeu: 1.551 ± 0.04
0.475TrpMet: 0.475 ± 0.021
0.657TrpAsn: 0.657 ± 0.023
0.424TrpPro: 0.424 ± 0.018
0.487TrpGln: 0.487 ± 0.021
0.771TrpArg: 0.771 ± 0.025
0.839TrpSer: 0.839 ± 0.031
0.801TrpThr: 0.801 ± 0.032
0.85TrpVal: 0.85 ± 0.026
0.209TrpTrp: 0.209 ± 0.014
0.359TrpTyr: 0.359 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.571TyrAla: 2.571 ± 0.053
0.272TyrCys: 0.272 ± 0.015
1.798TyrAsp: 1.798 ± 0.044
2.089TyrGlu: 2.089 ± 0.041
1.498TyrPhe: 1.498 ± 0.038
2.596TyrGly: 2.596 ± 0.049
0.745TyrHis: 0.745 ± 0.023
1.725TyrIle: 1.725 ± 0.037
1.368TyrLys: 1.368 ± 0.035
3.008TyrLeu: 3.008 ± 0.054
0.738TyrMet: 0.738 ± 0.023
1.088TyrAsn: 1.088 ± 0.034
1.483TyrPro: 1.483 ± 0.032
1.07TyrGln: 1.07 ± 0.029
2.266TyrArg: 2.266 ± 0.047
1.816TyrSer: 1.816 ± 0.044
1.638TyrThr: 1.638 ± 0.044
2.194TyrVal: 2.194 ± 0.039
0.444TyrTrp: 0.444 ± 0.02
1.178TyrTyr: 1.178 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4000 proteins (1262812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski