Amino acid dipepetide frequency for Sphingomonas panacisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.715AlaAla: 19.715 ± 0.232
1.004AlaCys: 1.004 ± 0.034
8.095AlaAsp: 8.095 ± 0.097
6.876AlaGlu: 6.876 ± 0.1
4.485AlaPhe: 4.485 ± 0.067
11.303AlaGly: 11.303 ± 0.111
2.138AlaHis: 2.138 ± 0.053
7.374AlaIle: 7.374 ± 0.106
5.007AlaLys: 5.007 ± 0.091
13.374AlaLeu: 13.374 ± 0.161
4.098AlaMet: 4.098 ± 0.068
3.543AlaAsn: 3.543 ± 0.062
6.53AlaPro: 6.53 ± 0.104
4.07AlaGln: 4.07 ± 0.068
9.012AlaArg: 9.012 ± 0.122
6.658AlaSer: 6.658 ± 0.087
7.619AlaThr: 7.619 ± 0.081
8.925AlaVal: 8.925 ± 0.1
1.776AlaTrp: 1.776 ± 0.05
2.609AlaTyr: 2.609 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.894CysAla: 0.894 ± 0.035
0.078CysCys: 0.078 ± 0.008
0.486CysAsp: 0.486 ± 0.021
0.333CysGlu: 0.333 ± 0.019
0.272CysPhe: 0.272 ± 0.016
0.851CysGly: 0.851 ± 0.032
0.2CysHis: 0.2 ± 0.016
0.313CysIle: 0.313 ± 0.018
0.17CysLys: 0.17 ± 0.014
0.596CysLeu: 0.596 ± 0.022
0.142CysMet: 0.142 ± 0.013
0.201CysAsn: 0.201 ± 0.015
0.39CysPro: 0.39 ± 0.02
0.183CysGln: 0.183 ± 0.016
0.535CysArg: 0.535 ± 0.024
0.43CysSer: 0.43 ± 0.024
0.392CysThr: 0.392 ± 0.021
0.547CysVal: 0.547 ± 0.022
0.112CysTrp: 0.112 ± 0.011
0.163CysTyr: 0.163 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
8.33AspAla: 8.33 ± 0.11
0.481AspCys: 0.481 ± 0.025
3.896AspAsp: 3.896 ± 0.071
3.402AspGlu: 3.402 ± 0.077
2.231AspPhe: 2.231 ± 0.055
5.868AspGly: 5.868 ± 0.083
1.347AspHis: 1.347 ± 0.035
2.934AspIle: 2.934 ± 0.055
2.016AspLys: 2.016 ± 0.044
5.821AspLeu: 5.821 ± 0.077
1.378AspMet: 1.378 ± 0.042
1.454AspAsn: 1.454 ± 0.04
3.975AspPro: 3.975 ± 0.074
2.119AspGln: 2.119 ± 0.046
5.106AspArg: 5.106 ± 0.078
2.36AspSer: 2.36 ± 0.049
3.097AspThr: 3.097 ± 0.057
4.286AspVal: 4.286 ± 0.068
1.135AspTrp: 1.135 ± 0.039
1.711AspTyr: 1.711 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.855GluAla: 6.855 ± 0.118
0.267GluCys: 0.267 ± 0.017
2.478GluAsp: 2.478 ± 0.052
2.502GluGlu: 2.502 ± 0.063
1.433GluPhe: 1.433 ± 0.038
3.962GluGly: 3.962 ± 0.063
1.016GluHis: 1.016 ± 0.038
2.584GluIle: 2.584 ± 0.051
1.827GluLys: 1.827 ± 0.055
4.592GluLeu: 4.592 ± 0.071
1.328GluMet: 1.328 ± 0.038
1.221GluAsn: 1.221 ± 0.035
2.457GluPro: 2.457 ± 0.053
1.748GluGln: 1.748 ± 0.044
4.665GluArg: 4.665 ± 0.076
2.03GluSer: 2.03 ± 0.05
2.899GluThr: 2.899 ± 0.051
3.289GluVal: 3.289 ± 0.062
0.718GluTrp: 0.718 ± 0.029
0.885GluTyr: 0.885 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.969PheAla: 4.969 ± 0.072
0.298PheCys: 0.298 ± 0.018
2.876PheAsp: 2.876 ± 0.058
1.887PheGlu: 1.887 ± 0.05
1.253PhePhe: 1.253 ± 0.041
3.743PheGly: 3.743 ± 0.065
0.668PheHis: 0.668 ± 0.028
1.334PheIle: 1.334 ± 0.034
1.004PheLys: 1.004 ± 0.035
3.01PheLeu: 3.01 ± 0.057
0.708PheMet: 0.708 ± 0.028
1.031PheAsn: 1.031 ± 0.042
1.502PhePro: 1.502 ± 0.039
0.851PheGln: 0.851 ± 0.029
2.114PheArg: 2.114 ± 0.046
1.938PheSer: 1.938 ± 0.043
2.011PheThr: 2.011 ± 0.05
2.874PheVal: 2.874 ± 0.057
0.532PheTrp: 0.532 ± 0.026
0.895PheTyr: 0.895 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.007GlyAla: 10.007 ± 0.126
0.812GlyCys: 0.812 ± 0.029
5.383GlyAsp: 5.383 ± 0.077
4.451GlyGlu: 4.451 ± 0.081
3.671GlyPhe: 3.671 ± 0.062
8.478GlyGly: 8.478 ± 0.16
1.71GlyHis: 1.71 ± 0.039
4.442GlyIle: 4.442 ± 0.068
3.764GlyLys: 3.764 ± 0.077
8.364GlyLeu: 8.364 ± 0.099
2.316GlyMet: 2.316 ± 0.047
2.476GlyAsn: 2.476 ± 0.074
3.578GlyPro: 3.578 ± 0.065
2.97GlyGln: 2.97 ± 0.054
6.111GlyArg: 6.111 ± 0.1
4.86GlySer: 4.86 ± 0.079
5.15GlyThr: 5.15 ± 0.123
6.529GlyVal: 6.529 ± 0.086
1.776GlyTrp: 1.776 ± 0.05
2.469GlyTyr: 2.469 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
2.279HisAla: 2.279 ± 0.054
0.184HisCys: 0.184 ± 0.013
1.232HisAsp: 1.232 ± 0.034
0.886HisGlu: 0.886 ± 0.029
0.762HisPhe: 0.762 ± 0.027
1.818HisGly: 1.818 ± 0.042
0.511HisHis: 0.511 ± 0.024
0.86HisIle: 0.86 ± 0.031
0.407HisLys: 0.407 ± 0.017
1.75HisLeu: 1.75 ± 0.049
0.384HisMet: 0.384 ± 0.018
0.431HisAsn: 0.431 ± 0.021
1.208HisPro: 1.208 ± 0.033
0.528HisGln: 0.528 ± 0.027
1.387HisArg: 1.387 ± 0.038
0.767HisSer: 0.767 ± 0.028
0.728HisThr: 0.728 ± 0.028
1.395HisVal: 1.395 ± 0.036
0.355HisTrp: 0.355 ± 0.02
0.528HisTyr: 0.528 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
8.282IleAla: 8.282 ± 0.102
0.414IleCys: 0.414 ± 0.02
4.403IleAsp: 4.403 ± 0.071
3.371IleGlu: 3.371 ± 0.059
1.459IlePhe: 1.459 ± 0.039
5.411IleGly: 5.411 ± 0.081
0.807IleHis: 0.807 ± 0.028
1.882IleIle: 1.882 ± 0.048
1.433IleLys: 1.433 ± 0.039
3.9IleLeu: 3.9 ± 0.061
0.815IleMet: 0.815 ± 0.028
1.363IleAsn: 1.363 ± 0.043
2.247IlePro: 2.247 ± 0.053
1.121IleGln: 1.121 ± 0.032
2.971IleArg: 2.971 ± 0.052
2.38IleSer: 2.38 ± 0.06
2.674IleThr: 2.674 ± 0.051
4.453IleVal: 4.453 ± 0.063
0.62IleTrp: 0.62 ± 0.027
1.068IleTyr: 1.068 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.473LysAla: 4.473 ± 0.078
0.168LysCys: 0.168 ± 0.014
1.702LysAsp: 1.702 ± 0.047
1.208LysGlu: 1.208 ± 0.038
1.02LysPhe: 1.02 ± 0.037
2.745LysGly: 2.745 ± 0.067
0.557LysHis: 0.557 ± 0.027
1.58LysIle: 1.58 ± 0.039
1.302LysLys: 1.302 ± 0.049
3.566LysLeu: 3.566 ± 0.068
0.901LysMet: 0.901 ± 0.031
0.852LysAsn: 0.852 ± 0.031
2.403LysPro: 2.403 ± 0.074
0.943LysGln: 0.943 ± 0.036
2.508LysArg: 2.508 ± 0.052
1.787LysSer: 1.787 ± 0.045
1.944LysThr: 1.944 ± 0.052
2.393LysVal: 2.393 ± 0.048
0.474LysTrp: 0.474 ± 0.021
0.699LysTyr: 0.699 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
13.794LeuAla: 13.794 ± 0.166
0.667LeuCys: 0.667 ± 0.023
6.371LeuAsp: 6.371 ± 0.095
3.971LeuGlu: 3.971 ± 0.072
3.414LeuPhe: 3.414 ± 0.057
8.176LeuGly: 8.176 ± 0.104
1.661LeuHis: 1.661 ± 0.045
5.147LeuIle: 5.147 ± 0.076
3.265LeuLys: 3.265 ± 0.066
8.628LeuLeu: 8.628 ± 0.112
2.072LeuMet: 2.072 ± 0.051
2.436LeuAsn: 2.436 ± 0.056
5.328LeuPro: 5.328 ± 0.06
2.332LeuGln: 2.332 ± 0.046
6.236LeuArg: 6.236 ± 0.088
5.582LeuSer: 5.582 ± 0.079
5.836LeuThr: 5.836 ± 0.089
6.98LeuVal: 6.98 ± 0.094
1.196LeuTrp: 1.196 ± 0.04
2.017LeuTyr: 2.017 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.274MetAla: 3.274 ± 0.065
0.164MetCys: 0.164 ± 0.014
1.09MetAsp: 1.09 ± 0.033
0.899MetGlu: 0.899 ± 0.03
0.741MetPhe: 0.741 ± 0.025
1.807MetGly: 1.807 ± 0.051
0.422MetHis: 0.422 ± 0.02
1.458MetIle: 1.458 ± 0.035
1.002MetLys: 1.002 ± 0.032
2.666MetLeu: 2.666 ± 0.055
0.705MetMet: 0.705 ± 0.031
0.651MetAsn: 0.651 ± 0.023
1.511MetPro: 1.511 ± 0.039
0.642MetGln: 0.642 ± 0.026
1.802MetArg: 1.802 ± 0.042
1.374MetSer: 1.374 ± 0.039
1.933MetThr: 1.933 ± 0.048
1.683MetVal: 1.683 ± 0.049
0.249MetTrp: 0.249 ± 0.015
0.297MetTyr: 0.297 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.4AsnAla: 3.4 ± 0.062
0.251AsnCys: 0.251 ± 0.018
1.555AsnAsp: 1.555 ± 0.049
1.004AsnGlu: 1.004 ± 0.031
0.978AsnPhe: 0.978 ± 0.036
2.765AsnGly: 2.765 ± 0.079
0.464AsnHis: 0.464 ± 0.021
1.262AsnIle: 1.262 ± 0.044
0.736AsnLys: 0.736 ± 0.027
2.499AsnLeu: 2.499 ± 0.057
0.544AsnMet: 0.544 ± 0.022
0.837AsnAsn: 0.837 ± 0.039
1.789AsnPro: 1.789 ± 0.05
0.751AsnGln: 0.751 ± 0.029
1.833AsnArg: 1.833 ± 0.043
1.241AsnSer: 1.241 ± 0.041
1.34AsnThr: 1.34 ± 0.047
2.139AsnVal: 2.139 ± 0.051
0.449AsnTrp: 0.449 ± 0.024
0.8AsnTyr: 0.8 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
7.288ProAla: 7.288 ± 0.085
0.276ProCys: 0.276 ± 0.017
4.097ProAsp: 4.097 ± 0.08
3.047ProGlu: 3.047 ± 0.059
1.881ProPhe: 1.881 ± 0.044
4.913ProGly: 4.913 ± 0.072
0.991ProHis: 0.991 ± 0.032
2.788ProIle: 2.788 ± 0.051
1.778ProLys: 1.778 ± 0.056
4.723ProLeu: 4.723 ± 0.073
1.25ProMet: 1.25 ± 0.04
1.486ProAsn: 1.486 ± 0.041
2.961ProPro: 2.961 ± 0.076
1.686ProGln: 1.686 ± 0.044
3.013ProArg: 3.013 ± 0.059
2.711ProSer: 2.711 ± 0.053
3.046ProThr: 3.046 ± 0.068
4.288ProVal: 4.288 ± 0.075
0.69ProTrp: 0.69 ± 0.021
1.115ProTyr: 1.115 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.821GlnAla: 3.821 ± 0.073
0.21GlnCys: 0.21 ± 0.016
1.346GlnAsp: 1.346 ± 0.037
1.097GlnGlu: 1.097 ± 0.033
1.155GlnPhe: 1.155 ± 0.031
2.32GlnGly: 2.32 ± 0.047
0.591GlnHis: 0.591 ± 0.023
1.631GlnIle: 1.631 ± 0.038
0.888GlnLys: 0.888 ± 0.033
2.976GlnLeu: 2.976 ± 0.057
0.757GlnMet: 0.757 ± 0.029
0.739GlnAsn: 0.739 ± 0.029
1.928GlnPro: 1.928 ± 0.048
1.005GlnGln: 1.005 ± 0.037
2.388GlnArg: 2.388 ± 0.054
1.61GlnSer: 1.61 ± 0.042
1.612GlnThr: 1.612 ± 0.043
2.103GlnVal: 2.103 ± 0.042
0.422GlnTrp: 0.422 ± 0.02
0.662GlnTyr: 0.662 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.731ArgAla: 8.731 ± 0.11
0.451ArgCys: 0.451 ± 0.023
4.59ArgAsp: 4.59 ± 0.076
3.541ArgGlu: 3.541 ± 0.063
2.9ArgPhe: 2.9 ± 0.056
5.175ArgGly: 5.175 ± 0.08
1.528ArgHis: 1.528 ± 0.041
3.907ArgIle: 3.907 ± 0.063
2.04ArgLys: 2.04 ± 0.045
7.375ArgLeu: 7.375 ± 0.111
1.882ArgMet: 1.882 ± 0.038
1.75ArgAsn: 1.75 ± 0.046
3.557ArgPro: 3.557 ± 0.062
2.243ArgGln: 2.243 ± 0.053
5.791ArgArg: 5.791 ± 0.096
3.444ArgSer: 3.444 ± 0.061
3.617ArgThr: 3.617 ± 0.059
4.985ArgVal: 4.985 ± 0.087
1.236ArgTrp: 1.236 ± 0.034
1.865ArgTyr: 1.865 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
6.057SerAla: 6.057 ± 0.08
0.335SerCys: 0.335 ± 0.019
3.159SerAsp: 3.159 ± 0.057
2.13SerGlu: 2.13 ± 0.041
2.119SerPhe: 2.119 ± 0.046
5.341SerGly: 5.341 ± 0.089
0.88SerHis: 0.88 ± 0.03
2.736SerIle: 2.736 ± 0.057
1.505SerLys: 1.505 ± 0.041
4.867SerLeu: 4.867 ± 0.078
1.198SerMet: 1.198 ± 0.038
1.517SerAsn: 1.517 ± 0.04
2.908SerPro: 2.908 ± 0.05
1.383SerGln: 1.383 ± 0.036
3.23SerArg: 3.23 ± 0.061
2.874SerSer: 2.874 ± 0.071
2.865SerThr: 2.865 ± 0.058
3.815SerVal: 3.815 ± 0.061
0.791SerTrp: 0.791 ± 0.031
1.314SerTyr: 1.314 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
7.117ThrAla: 7.117 ± 0.103
0.387ThrCys: 0.387 ± 0.018
3.334ThrAsp: 3.334 ± 0.061
2.285ThrGlu: 2.285 ± 0.047
2.002ThrPhe: 2.002 ± 0.053
5.581ThrGly: 5.581 ± 0.108
0.9ThrHis: 0.9 ± 0.03
3.4ThrIle: 3.4 ± 0.061
1.716ThrLys: 1.716 ± 0.043
5.957ThrLeu: 5.957 ± 0.105
1.331ThrMet: 1.331 ± 0.034
1.531ThrAsn: 1.531 ± 0.045
3.903ThrPro: 3.903 ± 0.079
1.455ThrGln: 1.455 ± 0.043
3.403ThrArg: 3.403 ± 0.058
2.835ThrSer: 2.835 ± 0.06
3.298ThrThr: 3.298 ± 0.078
4.491ThrVal: 4.491 ± 0.07
0.696ThrTrp: 0.696 ± 0.028
1.303ThrTyr: 1.303 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
10.533ValAla: 10.533 ± 0.109
0.509ValCys: 0.509 ± 0.024
4.483ValAsp: 4.483 ± 0.066
4.239ValGlu: 4.239 ± 0.074
2.188ValPhe: 2.188 ± 0.044
5.945ValGly: 5.945 ± 0.091
1.236ValHis: 1.236 ± 0.036
3.881ValIle: 3.881 ± 0.071
2.256ValLys: 2.256 ± 0.056
6.602ValLeu: 6.602 ± 0.082
1.788ValMet: 1.788 ± 0.05
1.947ValAsn: 1.947 ± 0.051
3.989ValPro: 3.989 ± 0.067
1.896ValGln: 1.896 ± 0.04
5.105ValArg: 5.105 ± 0.075
3.99ValSer: 3.99 ± 0.072
4.864ValThr: 4.864 ± 0.073
5.839ValVal: 5.839 ± 0.092
0.943ValTrp: 0.943 ± 0.031
1.433ValTyr: 1.433 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.526TrpAla: 1.526 ± 0.046
0.124TrpCys: 0.124 ± 0.011
0.753TrpAsp: 0.753 ± 0.028
0.544TrpGlu: 0.544 ± 0.022
0.628TrpPhe: 0.628 ± 0.031
0.993TrpGly: 0.993 ± 0.032
0.31TrpHis: 0.31 ± 0.018
0.669TrpIle: 0.669 ± 0.026
0.497TrpLys: 0.497 ± 0.024
1.771TrpLeu: 1.771 ± 0.042
0.366TrpMet: 0.366 ± 0.02
0.458TrpAsn: 0.458 ± 0.023
0.78TrpPro: 0.78 ± 0.028
0.594TrpGln: 0.594 ± 0.023
1.467TrpArg: 1.467 ± 0.037
0.928TrpSer: 0.928 ± 0.035
0.888TrpThr: 0.888 ± 0.034
0.965TrpVal: 0.965 ± 0.03
0.304TrpTrp: 0.304 ± 0.017
0.307TrpTyr: 0.307 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.869TyrAla: 2.869 ± 0.05
0.207TyrCys: 0.207 ± 0.014
1.62TyrAsp: 1.62 ± 0.046
1.084TyrGlu: 1.084 ± 0.033
0.906TyrPhe: 0.906 ± 0.035
2.123TyrGly: 2.123 ± 0.05
0.463TyrHis: 0.463 ± 0.017
0.891TyrIle: 0.891 ± 0.036
0.613TyrLys: 0.613 ± 0.028
2.072TyrLeu: 2.072 ± 0.049
0.405TyrMet: 0.405 ± 0.024
0.713TyrAsn: 0.713 ± 0.026
1.083TyrPro: 1.083 ± 0.036
0.743TyrGln: 0.743 ± 0.03
1.925TyrArg: 1.925 ± 0.045
1.226TyrSer: 1.226 ± 0.038
1.111TyrThr: 1.111 ± 0.039
1.688TyrVal: 1.688 ± 0.042
0.397TyrTrp: 0.397 ± 0.022
0.652TyrTyr: 0.652 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3225 proteins (991115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski