Amino acid dipepetide frequency for Burkholderiales bacterium JOSHI_001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.629AlaAla: 21.629 ± 0.237	1.377AlaCys: 1.377 ± 0.034	7.275AlaAsp: 7.275 ± 0.081	6.63AlaGlu: 6.63 ± 0.098	3.995AlaPhe: 3.995 ± 0.053	11.988AlaGly: 11.988 ± 0.123	2.755AlaHis: 2.755 ± 0.049	4.338AlaIle: 4.338 ± 0.062	3.795AlaLys: 3.795 ± 0.065	18.056AlaLeu: 18.056 ± 0.21	3.561AlaMet: 3.561 ± 0.057	3.024AlaAsn: 3.024 ± 0.072	7.784AlaPro: 7.784 ± 0.126	6.946AlaGln: 6.946 ± 0.114	9.715AlaArg: 9.715 ± 0.114	7.145AlaSer: 7.145 ± 0.088	6.965AlaThr: 6.965 ± 0.094	9.761AlaVal: 9.761 ± 0.089	2.382AlaTrp: 2.382 ± 0.052	2.269AlaTyr: 2.269 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.195CysAla: 1.195 ± 0.031	0.105CysCys: 0.105 ± 0.008	0.541CysAsp: 0.541 ± 0.019	0.451CysGlu: 0.451 ± 0.014	0.297CysPhe: 0.297 ± 0.013	0.947CysGly: 0.947 ± 0.026	0.337CysHis: 0.337 ± 0.019	0.366CysIle: 0.366 ± 0.016	0.2CysLys: 0.2 ± 0.012	0.856CysLeu: 0.856 ± 0.023	0.19CysMet: 0.19 ± 0.011	0.231CysAsn: 0.231 ± 0.012	0.53CysPro: 0.53 ± 0.02	0.289CysGln: 0.289 ± 0.012	0.612CysArg: 0.612 ± 0.02	0.478CysSer: 0.478 ± 0.016	0.49CysThr: 0.49 ± 0.016	0.643CysVal: 0.643 ± 0.022	0.107CysTrp: 0.107 ± 0.009	0.172CysTyr: 0.172 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.026AspAla: 8.026 ± 0.086	0.449AspCys: 0.449 ± 0.018	2.874AspAsp: 2.874 ± 0.047	3.155AspGlu: 3.155 ± 0.05	1.99AspPhe: 1.99 ± 0.036	4.922AspGly: 4.922 ± 0.081	1.136AspHis: 1.136 ± 0.025	2.131AspIle: 2.131 ± 0.041	1.648AspLys: 1.648 ± 0.039	5.726AspLeu: 5.726 ± 0.072	1.098AspMet: 1.098 ± 0.027	1.279AspAsn: 1.279 ± 0.034	3.251AspPro: 3.251 ± 0.062	1.686AspGln: 1.686 ± 0.044	3.349AspArg: 3.349 ± 0.052	2.385AspSer: 2.385 ± 0.048	2.67AspThr: 2.67 ± 0.066	3.67AspVal: 3.67 ± 0.056	0.967AspTrp: 0.967 ± 0.022	1.119AspTyr: 1.119 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.479GluAla: 6.479 ± 0.082	0.396GluCys: 0.396 ± 0.016	2.008GluAsp: 2.008 ± 0.046	1.945GluGlu: 1.945 ± 0.035	1.592GluPhe: 1.592 ± 0.035	3.569GluGly: 3.569 ± 0.046	1.254GluHis: 1.254 ± 0.031	1.897GluIle: 1.897 ± 0.044	1.415GluLys: 1.415 ± 0.04	5.668GluLeu: 5.668 ± 0.08	1.096GluMet: 1.096 ± 0.025	1.024GluAsn: 1.024 ± 0.028	2.54GluPro: 2.54 ± 0.047	2.34GluGln: 2.34 ± 0.042	4.502GluArg: 4.502 ± 0.068	2.11GluSer: 2.11 ± 0.034	2.109GluThr: 2.109 ± 0.041	3.837GluVal: 3.837 ± 0.059	0.65GluTrp: 0.65 ± 0.021	0.799GluTyr: 0.799 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.036PheAla: 4.036 ± 0.05	0.331PheCys: 0.331 ± 0.015	2.482PheAsp: 2.482 ± 0.044	1.885PheGlu: 1.885 ± 0.036	1.14PhePhe: 1.14 ± 0.034	3.199PheGly: 3.199 ± 0.052	0.706PheHis: 0.706 ± 0.023	1.338PheIle: 1.338 ± 0.028	1.117PheLys: 1.117 ± 0.031	2.55PheLeu: 2.55 ± 0.04	0.721PheMet: 0.721 ± 0.023	1.126PheAsn: 1.126 ± 0.033	1.326PhePro: 1.326 ± 0.028	1.073PheGln: 1.073 ± 0.026	1.754PheArg: 1.754 ± 0.037	1.965PheSer: 1.965 ± 0.039	1.871PheThr: 1.871 ± 0.046	2.58PheVal: 2.58 ± 0.051	0.462PheTrp: 0.462 ± 0.017	0.732PheTyr: 0.732 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.615GlyAla: 10.615 ± 0.148	0.915GlyCys: 0.915 ± 0.026	4.277GlyAsp: 4.277 ± 0.058	4.011GlyGlu: 4.011 ± 0.06	3.148GlyPhe: 3.148 ± 0.044	7.46GlyGly: 7.46 ± 0.123	2.14GlyHis: 2.14 ± 0.041	3.097GlyIle: 3.097 ± 0.05	2.824GlyLys: 2.824 ± 0.058	9.892GlyLeu: 9.892 ± 0.08	2.058GlyMet: 2.058 ± 0.038	2.174GlyAsn: 2.174 ± 0.081	3.783GlyPro: 3.783 ± 0.053	3.883GlyGln: 3.883 ± 0.047	5.868GlyArg: 5.868 ± 0.068	4.883GlySer: 4.883 ± 0.082	4.759GlyThr: 4.759 ± 0.123	6.548GlyVal: 6.548 ± 0.069	1.55GlyTrp: 1.55 ± 0.039	1.853GlyTyr: 1.853 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	3.009HisAla: 3.009 ± 0.048	0.297HisCys: 0.297 ± 0.015	1.167HisAsp: 1.167 ± 0.033	1.136HisGlu: 1.136 ± 0.028	0.888HisPhe: 0.888 ± 0.024	2.222HisGly: 2.222 ± 0.032	0.661HisHis: 0.661 ± 0.021	0.807HisIle: 0.807 ± 0.022	0.498HisLys: 0.498 ± 0.017	2.466HisLeu: 2.466 ± 0.042	0.447HisMet: 0.447 ± 0.017	0.487HisAsn: 0.487 ± 0.019	1.524HisPro: 1.524 ± 0.034	0.824HisGln: 0.824 ± 0.023	1.662HisArg: 1.662 ± 0.037	1.024HisSer: 1.024 ± 0.025	1.099HisThr: 1.099 ± 0.024	1.527HisVal: 1.527 ± 0.034	0.46HisTrp: 0.46 ± 0.016	0.529HisTyr: 0.529 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.822IleAla: 4.822 ± 0.065	0.275IleCys: 0.275 ± 0.013	2.637IleAsp: 2.637 ± 0.042	2.291IleGlu: 2.291 ± 0.045	0.929IlePhe: 0.929 ± 0.025	3.413IleGly: 3.413 ± 0.054	0.702IleHis: 0.702 ± 0.022	1.048IleIle: 1.048 ± 0.03	1.151IleLys: 1.151 ± 0.031	2.436IleLeu: 2.436 ± 0.041	0.532IleMet: 0.532 ± 0.018	1.167IleAsn: 1.167 ± 0.039	1.619IlePro: 1.619 ± 0.04	1.128IleGln: 1.128 ± 0.029	2.088IleArg: 2.088 ± 0.036	1.882IleSer: 1.882 ± 0.039	2.252IleThr: 2.252 ± 0.055	2.837IleVal: 2.837 ± 0.046	0.337IleTrp: 0.337 ± 0.014	0.698IleTyr: 0.698 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.009LysAla: 4.009 ± 0.073	0.166LysCys: 0.166 ± 0.01	1.542LysAsp: 1.542 ± 0.034	1.195LysGlu: 1.195 ± 0.039	0.827LysPhe: 0.827 ± 0.027	2.308LysGly: 2.308 ± 0.048	0.609LysHis: 0.609 ± 0.021	1.048LysIle: 1.048 ± 0.032	1.235LysLys: 1.235 ± 0.037	3.313LysLeu: 3.313 ± 0.054	0.678LysMet: 0.678 ± 0.023	0.787LysAsn: 0.787 ± 0.024	2.008LysPro: 2.008 ± 0.044	1.054LysGln: 1.054 ± 0.029	2.104LysArg: 2.104 ± 0.043	1.448LysSer: 1.448 ± 0.028	1.601LysThr: 1.601 ± 0.036	2.373LysVal: 2.373 ± 0.05	0.307LysTrp: 0.307 ± 0.013	0.549LysTyr: 0.549 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	18.04LeuAla: 18.04 ± 0.157	0.989LeuCys: 0.989 ± 0.026	6.266LeuAsp: 6.266 ± 0.068	4.686LeuGlu: 4.686 ± 0.071	3.162LeuPhe: 3.162 ± 0.05	9.281LeuGly: 9.281 ± 0.082	2.528LeuHis: 2.528 ± 0.043	3.254LeuIle: 3.254 ± 0.058	3.652LeuLys: 3.652 ± 0.055	12.299LeuLeu: 12.299 ± 0.141	2.486LeuMet: 2.486 ± 0.039	2.879LeuAsn: 2.879 ± 0.049	6.963LeuPro: 6.963 ± 0.074	4.814LeuGln: 4.814 ± 0.064	8.544LeuArg: 8.544 ± 0.099	6.037LeuSer: 6.037 ± 0.084	5.152LeuThr: 5.152 ± 0.09	8.43LeuVal: 8.43 ± 0.089	1.519LeuTrp: 1.519 ± 0.037	1.843LeuTyr: 1.843 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.173MetAla: 3.173 ± 0.043	0.158MetCys: 0.158 ± 0.011	1.122MetAsp: 1.122 ± 0.027	0.856MetGlu: 0.856 ± 0.022	0.631MetPhe: 0.631 ± 0.021	1.748MetGly: 1.748 ± 0.034	0.488MetHis: 0.488 ± 0.02	0.667MetIle: 0.667 ± 0.021	0.98MetLys: 0.98 ± 0.025	2.477MetLeu: 2.477 ± 0.045	0.478MetMet: 0.478 ± 0.02	0.83MetAsn: 0.83 ± 0.023	1.422MetPro: 1.422 ± 0.031	0.957MetGln: 0.957 ± 0.024	1.622MetArg: 1.622 ± 0.032	1.463MetSer: 1.463 ± 0.035	1.28MetThr: 1.28 ± 0.03	1.686MetVal: 1.686 ± 0.035	0.2MetTrp: 0.2 ± 0.01	0.321MetTyr: 0.321 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.429AsnAla: 3.429 ± 0.069	0.282AsnCys: 0.282 ± 0.013	1.352AsnAsp: 1.352 ± 0.056	1.109AsnGlu: 1.109 ± 0.026	0.918AsnPhe: 0.918 ± 0.026	2.281AsnGly: 2.281 ± 0.073	0.513AsnHis: 0.513 ± 0.018	0.971AsnIle: 0.971 ± 0.03	0.741AsnLys: 0.741 ± 0.021	2.646AsnLeu: 2.646 ± 0.052	0.503AsnMet: 0.503 ± 0.017	0.768AsnAsn: 0.768 ± 0.033	1.922AsnPro: 1.922 ± 0.045	0.897AsnGln: 0.897 ± 0.03	1.578AsnArg: 1.578 ± 0.031	1.116AsnSer: 1.116 ± 0.034	1.471AsnThr: 1.471 ± 0.044	1.781AsnVal: 1.781 ± 0.053	0.39AsnTrp: 0.39 ± 0.016	0.577AsnTyr: 0.577 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.816ProAla: 8.816 ± 0.106	0.39ProCys: 0.39 ± 0.016	3.359ProAsp: 3.359 ± 0.06	3.15ProGlu: 3.15 ± 0.054	1.697ProPhe: 1.697 ± 0.034	5.382ProGly: 5.382 ± 0.069	1.119ProHis: 1.119 ± 0.026	1.575ProIle: 1.575 ± 0.034	1.486ProLys: 1.486 ± 0.034	5.916ProLeu: 5.916 ± 0.073	1.302ProMet: 1.302 ± 0.029	1.328ProAsn: 1.328 ± 0.033	3.442ProPro: 3.442 ± 0.07	2.483ProGln: 2.483 ± 0.039	3.416ProArg: 3.416 ± 0.066	2.754ProSer: 2.754 ± 0.044	2.789ProThr: 2.789 ± 0.071	4.607ProVal: 4.607 ± 0.083	0.908ProTrp: 0.908 ± 0.025	0.983ProTyr: 0.983 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	7.308GlnAla: 7.308 ± 0.095	0.317GlnCys: 0.317 ± 0.014	1.728GlnAsp: 1.728 ± 0.031	1.397GlnGlu: 1.397 ± 0.04	1.213GlnPhe: 1.213 ± 0.029	3.579GlnGly: 3.579 ± 0.051	1.052GlnHis: 1.052 ± 0.025	1.365GlnIle: 1.365 ± 0.041	0.866GlnLys: 0.866 ± 0.028	4.327GlnLeu: 4.327 ± 0.063	0.921GlnMet: 0.921 ± 0.022	0.69GlnAsn: 0.69 ± 0.022	2.561GlnPro: 2.561 ± 0.035	2.07GlnGln: 2.07 ± 0.037	4.473GlnArg: 4.473 ± 0.078	1.739GlnSer: 1.739 ± 0.035	1.684GlnThr: 1.684 ± 0.039	3.795GlnVal: 3.795 ± 0.091	0.783GlnTrp: 0.783 ± 0.021	0.628GlnTyr: 0.628 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.78ArgAla: 8.78 ± 0.115	0.675ArgCys: 0.675 ± 0.023	3.702ArgAsp: 3.702 ± 0.051	3.977ArgGlu: 3.977 ± 0.064	2.732ArgPhe: 2.732 ± 0.045	4.988ArgGly: 4.988 ± 0.061	2.07ArgHis: 2.07 ± 0.038	2.926ArgIle: 2.926 ± 0.051	1.685ArgLys: 1.685 ± 0.035	8.732ArgLeu: 8.732 ± 0.115	1.857ArgMet: 1.857 ± 0.034	1.675ArgAsn: 1.675 ± 0.033	3.638ArgPro: 3.638 ± 0.063	3.292ArgGln: 3.292 ± 0.057	5.534ArgArg: 5.534 ± 0.087	3.749ArgSer: 3.749 ± 0.058	3.06ArgThr: 3.06 ± 0.045	5.407ArgVal: 5.407 ± 0.072	1.393ArgTrp: 1.393 ± 0.039	1.618ArgTyr: 1.618 ± 0.039	0.001ArgXaa: 0.001 ± 0.001
Ser	7.061SerAla: 7.061 ± 0.082	0.432SerCys: 0.432 ± 0.021	2.584SerAsp: 2.584 ± 0.05	2.164SerGlu: 2.164 ± 0.037	1.948SerPhe: 1.948 ± 0.043	5.202SerGly: 5.202 ± 0.088	1.116SerHis: 1.116 ± 0.024	1.868SerIle: 1.868 ± 0.041	1.263SerLys: 1.263 ± 0.028	5.609SerLeu: 5.609 ± 0.073	1.115SerMet: 1.115 ± 0.024	1.339SerAsn: 1.339 ± 0.039	2.947SerPro: 2.947 ± 0.04	1.801SerGln: 1.801 ± 0.036	3.339SerArg: 3.339 ± 0.052	2.735SerSer: 2.735 ± 0.059	2.882SerThr: 2.882 ± 0.064	3.933SerVal: 3.933 ± 0.056	0.684SerTrp: 0.684 ± 0.021	1.076SerTyr: 1.076 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.311ThrAla: 6.311 ± 0.113	0.407ThrCys: 0.407 ± 0.015	2.567ThrAsp: 2.567 ± 0.05	2.217ThrGlu: 2.217 ± 0.043	1.445ThrPhe: 1.445 ± 0.037	4.664ThrGly: 4.664 ± 0.114	1.08ThrHis: 1.08 ± 0.027	1.726ThrIle: 1.726 ± 0.061	1.169ThrLys: 1.169 ± 0.032	6.83ThrLeu: 6.83 ± 0.107	0.966ThrMet: 0.966 ± 0.029	1.177ThrAsn: 1.177 ± 0.04	3.654ThrPro: 3.654 ± 0.082	1.957ThrGln: 1.957 ± 0.048	3.322ThrArg: 3.322 ± 0.051	2.457ThrSer: 2.457 ± 0.053	2.843ThrThr: 2.843 ± 0.101	4.325ThrVal: 4.325 ± 0.107	0.758ThrTrp: 0.758 ± 0.022	0.945ThrTyr: 0.945 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.725ValAla: 10.725 ± 0.12	0.696ValCys: 0.696 ± 0.022	4.267ValAsp: 4.267 ± 0.065	3.564ValGlu: 3.564 ± 0.06	2.566ValPhe: 2.566 ± 0.041	5.789ValGly: 5.789 ± 0.065	1.628ValHis: 1.628 ± 0.032	2.664ValIle: 2.664 ± 0.047	2.439ValLys: 2.439 ± 0.046	8.811ValLeu: 8.811 ± 0.092	1.803ValMet: 1.803 ± 0.036	2.311ValAsn: 2.311 ± 0.062	4.238ValPro: 4.238 ± 0.056	3.372ValGln: 3.372 ± 0.043	5.018ValArg: 5.018 ± 0.066	3.978ValSer: 3.978 ± 0.063	4.025ValThr: 4.025 ± 0.102	6.558ValVal: 6.558 ± 0.078	1.011ValTrp: 1.011 ± 0.028	1.357ValTyr: 1.357 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.685TrpAla: 1.685 ± 0.038	0.191TrpCys: 0.191 ± 0.01	0.687TrpAsp: 0.687 ± 0.022	0.478TrpGlu: 0.478 ± 0.018	0.529TrpPhe: 0.529 ± 0.017	1.118TrpGly: 1.118 ± 0.029	0.418TrpHis: 0.418 ± 0.017	0.507TrpIle: 0.507 ± 0.018	0.429TrpLys: 0.429 ± 0.019	2.234TrpLeu: 2.234 ± 0.044	0.409TrpMet: 0.409 ± 0.018	0.419TrpAsn: 0.419 ± 0.02	0.873TrpPro: 0.873 ± 0.026	0.868TrpGln: 0.868 ± 0.028	1.457TrpArg: 1.457 ± 0.036	0.749TrpSer: 0.749 ± 0.024	0.729TrpThr: 0.729 ± 0.025	1.13TrpVal: 1.13 ± 0.027	0.318TrpTrp: 0.318 ± 0.014	0.271TrpTyr: 0.271 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.036	0.191TyrCys: 0.191 ± 0.011	1.093TyrAsp: 1.093 ± 0.034	0.929TyrGlu: 0.929 ± 0.024	0.748TyrPhe: 0.748 ± 0.023	1.68TyrGly: 1.68 ± 0.03	0.421TyrHis: 0.421 ± 0.018	0.65TyrIle: 0.65 ± 0.021	0.57TyrLys: 0.57 ± 0.02	1.98TyrLeu: 1.98 ± 0.04	0.34TyrMet: 0.34 ± 0.015	0.53TyrAsn: 0.53 ± 0.017	0.878TyrPro: 0.878 ± 0.024	0.764TyrGln: 0.764 ± 0.021	1.529TyrArg: 1.529 ± 0.034	1.001TyrSer: 1.001 ± 0.025	1.086TyrThr: 1.086 ± 0.042	1.393TyrVal: 1.393 ± 0.031	0.315TyrTrp: 0.315 ± 0.013	0.445TyrTyr: 0.445 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4891 proteins (1693128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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