Amino acid dipepetide frequency for Salinibacter ruber (strain DSM 13855 / M31)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.302AlaAla: 12.302 ± 0.168	0.775AlaCys: 0.775 ± 0.026	7.639AlaAsp: 7.639 ± 0.107	7.35AlaGlu: 7.35 ± 0.108	3.901AlaPhe: 3.901 ± 0.059	8.527AlaGly: 8.527 ± 0.128	2.273AlaHis: 2.273 ± 0.053	3.523AlaIle: 3.523 ± 0.057	1.83AlaLys: 1.83 ± 0.05	12.204AlaLeu: 12.204 ± 0.153	2.08AlaMet: 2.08 ± 0.047	2.272AlaAsn: 2.272 ± 0.053	6.327AlaPro: 6.327 ± 0.101	3.951AlaGln: 3.951 ± 0.067	7.762AlaArg: 7.762 ± 0.103	6.364AlaSer: 6.364 ± 0.098	5.68AlaThr: 5.68 ± 0.075	8.274AlaVal: 8.274 ± 0.112	1.335AlaTrp: 1.335 ± 0.042	2.665AlaTyr: 2.665 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.713CysAla: 0.713 ± 0.028	0.121CysCys: 0.121 ± 0.012	0.401CysAsp: 0.401 ± 0.021	0.353CysGlu: 0.353 ± 0.019	0.261CysPhe: 0.261 ± 0.015	0.704CysGly: 0.704 ± 0.03	0.185CysHis: 0.185 ± 0.012	0.26CysIle: 0.26 ± 0.016	0.115CysLys: 0.115 ± 0.01	0.59CysLeu: 0.59 ± 0.022	0.112CysMet: 0.112 ± 0.01	0.144CysAsn: 0.144 ± 0.012	0.518CysPro: 0.518 ± 0.028	0.175CysGln: 0.175 ± 0.015	0.482CysArg: 0.482 ± 0.024	0.459CysSer: 0.459 ± 0.023	0.452CysThr: 0.452 ± 0.021	0.529CysVal: 0.529 ± 0.024	0.098CysTrp: 0.098 ± 0.011	0.154CysTyr: 0.154 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.458AspAla: 8.458 ± 0.124	0.366AspCys: 0.366 ± 0.02	5.043AspAsp: 5.043 ± 0.086	5.727AspGlu: 5.727 ± 0.098	2.013AspPhe: 2.013 ± 0.05	6.461AspGly: 6.461 ± 0.097	1.481AspHis: 1.481 ± 0.036	2.274AspIle: 2.274 ± 0.049	1.122AspLys: 1.122 ± 0.035	6.802AspLeu: 6.802 ± 0.095	1.016AspMet: 1.016 ± 0.031	1.246AspAsn: 1.246 ± 0.034	4.167AspPro: 4.167 ± 0.064	2.24AspGln: 2.24 ± 0.045	5.806AspArg: 5.806 ± 0.068	3.085AspSer: 3.085 ± 0.062	4.364AspThr: 4.364 ± 0.08	5.704AspVal: 5.704 ± 0.062	1.007AspTrp: 1.007 ± 0.029	1.763AspTyr: 1.763 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	9.096GluAla: 9.096 ± 0.126	0.33GluCys: 0.33 ± 0.022	4.478GluAsp: 4.478 ± 0.077	6.124GluGlu: 6.124 ± 0.114	1.584GluPhe: 1.584 ± 0.049	5.692GluGly: 5.692 ± 0.094	1.798GluHis: 1.798 ± 0.048	2.829GluIle: 2.829 ± 0.069	2.147GluLys: 2.147 ± 0.053	5.135GluLeu: 5.135 ± 0.074	1.616GluMet: 1.616 ± 0.04	1.895GluAsn: 1.895 ± 0.046	3.094GluPro: 3.094 ± 0.067	3.097GluGln: 3.097 ± 0.061	5.917GluArg: 5.917 ± 0.097	3.241GluSer: 3.241 ± 0.058	4.659GluThr: 4.659 ± 0.073	5.251GluVal: 5.251 ± 0.079	0.758GluTrp: 0.758 ± 0.029	1.578GluTyr: 1.578 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.275PheAla: 3.275 ± 0.065	0.31PheCys: 0.31 ± 0.017	2.581PheAsp: 2.581 ± 0.054	2.647PheGlu: 2.647 ± 0.054	1.407PhePhe: 1.407 ± 0.052	3.254PheGly: 3.254 ± 0.067	0.609PheHis: 0.609 ± 0.026	1.064PheIle: 1.064 ± 0.036	0.583PheLys: 0.583 ± 0.025	3.106PheLeu: 3.106 ± 0.07	0.557PheMet: 0.557 ± 0.027	0.967PheAsn: 0.967 ± 0.036	1.545PhePro: 1.545 ± 0.039	1.077PheGln: 1.077 ± 0.034	2.454PheArg: 2.454 ± 0.053	2.261PheSer: 2.261 ± 0.055	1.845PheThr: 1.845 ± 0.044	2.902PheVal: 2.902 ± 0.066	0.452PheTrp: 0.452 ± 0.022	1.049PheTyr: 1.049 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.979GlyAla: 8.979 ± 0.135	0.644GlyCys: 0.644 ± 0.027	5.273GlyAsp: 5.273 ± 0.082	5.041GlyGlu: 5.041 ± 0.092	2.865GlyPhe: 2.865 ± 0.06	7.671GlyGly: 7.671 ± 0.131	1.887GlyHis: 1.887 ± 0.049	3.544GlyIle: 3.544 ± 0.066	1.68GlyLys: 1.68 ± 0.046	8.425GlyLeu: 8.425 ± 0.119	1.685GlyMet: 1.685 ± 0.046	1.896GlyAsn: 1.896 ± 0.051	4.273GlyPro: 4.273 ± 0.075	2.706GlyGln: 2.706 ± 0.059	6.526GlyArg: 6.526 ± 0.097	4.517GlySer: 4.517 ± 0.076	6.394GlyThr: 6.394 ± 0.084	6.111GlyVal: 6.111 ± 0.087	1.207GlyTrp: 1.207 ± 0.038	2.377GlyTyr: 2.377 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.186HisAla: 2.186 ± 0.052	0.23HisCys: 0.23 ± 0.018	1.582HisAsp: 1.582 ± 0.042	1.561HisGlu: 1.561 ± 0.044	0.834HisPhe: 0.834 ± 0.031	1.804HisGly: 1.804 ± 0.054	0.618HisHis: 0.618 ± 0.023	0.76HisIle: 0.76 ± 0.031	0.388HisLys: 0.388 ± 0.02	2.349HisLeu: 2.349 ± 0.052	0.335HisMet: 0.335 ± 0.02	0.481HisAsn: 0.481 ± 0.023	1.593HisPro: 1.593 ± 0.045	0.666HisGln: 0.666 ± 0.026	1.801HisArg: 1.801 ± 0.04	1.05HisSer: 1.05 ± 0.034	1.182HisThr: 1.182 ± 0.035	1.901HisVal: 1.901 ± 0.045	0.318HisTrp: 0.318 ± 0.017	0.633HisTyr: 0.633 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	3.747IleAla: 3.747 ± 0.067	0.284IleCys: 0.284 ± 0.017	3.132IleAsp: 3.132 ± 0.056	3.416IleGlu: 3.416 ± 0.067	1.104IlePhe: 1.104 ± 0.039	3.64IleGly: 3.64 ± 0.067	0.768IleHis: 0.768 ± 0.027	1.263IleIle: 1.263 ± 0.043	0.811IleLys: 0.811 ± 0.029	3.062IleLeu: 3.062 ± 0.06	0.566IleMet: 0.566 ± 0.027	1.024IleAsn: 1.024 ± 0.034	1.96IlePro: 1.96 ± 0.05	1.35IleGln: 1.35 ± 0.038	2.597IleArg: 2.597 ± 0.052	1.976IleSer: 1.976 ± 0.056	2.155IleThr: 2.155 ± 0.045	3.009IleVal: 3.009 ± 0.059	0.342IleTrp: 0.342 ± 0.018	0.893IleTyr: 0.893 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.165LysAla: 2.165 ± 0.051	0.098LysCys: 0.098 ± 0.01	1.238LysAsp: 1.238 ± 0.037	1.646LysGlu: 1.646 ± 0.044	0.483LysPhe: 0.483 ± 0.023	1.605LysGly: 1.605 ± 0.043	0.472LysHis: 0.472 ± 0.025	0.955LysIle: 0.955 ± 0.032	0.8LysLys: 0.8 ± 0.036	1.685LysLeu: 1.685 ± 0.04	0.555LysMet: 0.555 ± 0.025	0.677LysAsn: 0.677 ± 0.027	0.979LysPro: 0.979 ± 0.033	0.978LysGln: 0.978 ± 0.032	1.759LysArg: 1.759 ± 0.044	1.182LysSer: 1.182 ± 0.031	1.5LysThr: 1.5 ± 0.039	1.453LysVal: 1.453 ± 0.043	0.239LysTrp: 0.239 ± 0.016	0.581LysTyr: 0.581 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	9.466LeuAla: 9.466 ± 0.128	0.709LeuCys: 0.709 ± 0.027	7.24LeuAsp: 7.24 ± 0.096	5.937LeuGlu: 5.937 ± 0.1	3.512LeuPhe: 3.512 ± 0.075	7.827LeuGly: 7.827 ± 0.109	2.273LeuHis: 2.273 ± 0.058	3.35LeuIle: 3.35 ± 0.069	2.174LeuLys: 2.174 ± 0.048	9.927LeuLeu: 9.927 ± 0.157	1.722LeuMet: 1.722 ± 0.043	2.432LeuAsn: 2.432 ± 0.058	5.252LeuPro: 5.252 ± 0.074	3.595LeuGln: 3.595 ± 0.057	8.513LeuArg: 8.513 ± 0.109	6.345LeuSer: 6.345 ± 0.083	5.682LeuThr: 5.682 ± 0.081	7.299LeuVal: 7.299 ± 0.117	1.138LeuTrp: 1.138 ± 0.038	2.495LeuTyr: 2.495 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.069MetAla: 2.069 ± 0.054	0.123MetCys: 0.123 ± 0.011	1.246MetAsp: 1.246 ± 0.032	1.319MetGlu: 1.319 ± 0.037	0.457MetPhe: 0.457 ± 0.026	1.588MetGly: 1.588 ± 0.04	0.426MetHis: 0.426 ± 0.019	0.763MetIle: 0.763 ± 0.03	0.576MetLys: 0.576 ± 0.022	1.616MetLeu: 1.616 ± 0.04	0.415MetMet: 0.415 ± 0.023	0.599MetAsn: 0.599 ± 0.026	1.351MetPro: 1.351 ± 0.037	0.717MetGln: 0.717 ± 0.029	1.429MetArg: 1.429 ± 0.041	1.406MetSer: 1.406 ± 0.034	1.234MetThr: 1.234 ± 0.036	1.223MetVal: 1.223 ± 0.039	0.181MetTrp: 0.181 ± 0.014	0.372MetTyr: 0.372 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.72AsnAla: 2.72 ± 0.052	0.168AsnCys: 0.168 ± 0.013	1.549AsnAsp: 1.549 ± 0.042	1.602AsnGlu: 1.602 ± 0.047	0.854AsnPhe: 0.854 ± 0.029	2.202AsnGly: 2.202 ± 0.047	0.508AsnHis: 0.508 ± 0.026	0.993AsnIle: 0.993 ± 0.04	0.475AsnLys: 0.475 ± 0.021	2.286AsnLeu: 2.286 ± 0.048	0.454AsnMet: 0.454 ± 0.022	0.628AsnAsn: 0.628 ± 0.031	1.706AsnPro: 1.706 ± 0.04	0.935AsnGln: 0.935 ± 0.033	1.816AsnArg: 1.816 ± 0.05	1.018AsnSer: 1.018 ± 0.037	1.418AsnThr: 1.418 ± 0.045	2.147AsnVal: 2.147 ± 0.052	0.339AsnTrp: 0.339 ± 0.019	0.695AsnTyr: 0.695 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.697ProAla: 5.697 ± 0.082	0.337ProCys: 0.337 ± 0.021	5.507ProAsp: 5.507 ± 0.09	4.405ProGlu: 4.405 ± 0.065	1.979ProPhe: 1.979 ± 0.046	4.251ProGly: 4.251 ± 0.072	1.268ProHis: 1.268 ± 0.039	1.932ProIle: 1.932 ± 0.043	1.027ProLys: 1.027 ± 0.035	4.761ProLeu: 4.761 ± 0.084	1.146ProMet: 1.146 ± 0.033	1.51ProAsn: 1.51 ± 0.043	3.603ProPro: 3.603 ± 0.074	1.676ProGln: 1.676 ± 0.042	3.235ProArg: 3.235 ± 0.063	4.31ProSer: 4.31 ± 0.078	3.468ProThr: 3.468 ± 0.06	4.474ProVal: 4.474 ± 0.072	0.579ProTrp: 0.579 ± 0.027	1.36ProTyr: 1.36 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.038GlnAla: 4.038 ± 0.067	0.186GlnCys: 0.186 ± 0.015	2.119GlnAsp: 2.119 ± 0.049	2.409GlnGlu: 2.409 ± 0.053	1.264GlnPhe: 1.264 ± 0.036	2.644GlnGly: 2.644 ± 0.058	0.785GlnHis: 0.785 ± 0.028	1.541GlnIle: 1.541 ± 0.037	1.061GlnLys: 1.061 ± 0.037	2.843GlnLeu: 2.843 ± 0.06	0.833GlnMet: 0.833 ± 0.029	1.132GlnAsn: 1.132 ± 0.036	1.706GlnPro: 1.706 ± 0.048	1.595GlnGln: 1.595 ± 0.056	2.746GlnArg: 2.746 ± 0.055	2.248GlnSer: 2.248 ± 0.056	2.166GlnThr: 2.166 ± 0.048	2.645GlnVal: 2.645 ± 0.054	0.492GlnTrp: 0.492 ± 0.028	1.034GlnTyr: 1.034 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.875ArgAla: 7.875 ± 0.1	0.53ArgCys: 0.53 ± 0.026	4.638ArgAsp: 4.638 ± 0.07	4.952ArgGlu: 4.952 ± 0.088	2.825ArgPhe: 2.825 ± 0.057	4.887ArgGly: 4.887 ± 0.072	1.871ArgHis: 1.871 ± 0.052	3.135ArgIle: 3.135 ± 0.055	1.66ArgLys: 1.66 ± 0.044	8.247ArgLeu: 8.247 ± 0.106	1.558ArgMet: 1.558 ± 0.04	1.714ArgAsn: 1.714 ± 0.048	4.688ArgPro: 4.688 ± 0.095	2.843ArgGln: 2.843 ± 0.061	7.252ArgArg: 7.252 ± 0.127	4.634ArgSer: 4.634 ± 0.076	4.882ArgThr: 4.882 ± 0.073	5.588ArgVal: 5.588 ± 0.079	1.118ArgTrp: 1.118 ± 0.036	2.26ArgTyr: 2.26 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.911SerAla: 5.911 ± 0.089	0.358SerCys: 0.358 ± 0.017	3.761SerAsp: 3.761 ± 0.062	3.334SerGlu: 3.334 ± 0.059	2.3SerPhe: 2.3 ± 0.058	5.297SerGly: 5.297 ± 0.08	1.034SerHis: 1.034 ± 0.032	2.472SerIle: 2.472 ± 0.049	1.133SerLys: 1.133 ± 0.035	5.679SerLeu: 5.679 ± 0.09	1.28SerMet: 1.28 ± 0.035	1.466SerAsn: 1.466 ± 0.046	3.728SerPro: 3.728 ± 0.063	1.666SerGln: 1.666 ± 0.047	3.665SerArg: 3.665 ± 0.065	4.251SerSer: 4.251 ± 0.089	3.893SerThr: 3.893 ± 0.068	4.951SerVal: 4.951 ± 0.081	0.66SerTrp: 0.66 ± 0.027	1.493SerTyr: 1.493 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.509ThrAla: 6.509 ± 0.084	0.37ThrCys: 0.37 ± 0.021	4.301ThrAsp: 4.301 ± 0.078	3.857ThrGlu: 3.857 ± 0.067	2.281ThrPhe: 2.281 ± 0.051	5.556ThrGly: 5.556 ± 0.074	1.314ThrHis: 1.314 ± 0.037	2.662ThrIle: 2.662 ± 0.049	1.161ThrLys: 1.161 ± 0.034	6.621ThrLeu: 6.621 ± 0.083	1.064ThrMet: 1.064 ± 0.032	1.518ThrAsn: 1.518 ± 0.033	3.827ThrPro: 3.827 ± 0.062	1.866ThrGln: 1.866 ± 0.044	3.832ThrArg: 3.832 ± 0.062	3.482ThrSer: 3.482 ± 0.058	3.885ThrThr: 3.885 ± 0.074	5.552ThrVal: 5.552 ± 0.09	0.763ThrTrp: 0.763 ± 0.03	1.776ThrTyr: 1.776 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	7.847ValAla: 7.847 ± 0.104	0.591ValCys: 0.591 ± 0.022	5.624ValAsp: 5.624 ± 0.076	5.981ValGlu: 5.981 ± 0.079	2.579ValPhe: 2.579 ± 0.053	6.665ValGly: 6.665 ± 0.104	1.76ValHis: 1.76 ± 0.035	2.517ValIle: 2.517 ± 0.057	1.488ValLys: 1.488 ± 0.041	7.91ValLeu: 7.91 ± 0.103	1.38ValMet: 1.38 ± 0.042	1.896ValAsn: 1.896 ± 0.051	4.467ValPro: 4.467 ± 0.071	3.033ValGln: 3.033 ± 0.059	6.179ValArg: 6.179 ± 0.082	4.538ValSer: 4.538 ± 0.081	4.777ValThr: 4.777 ± 0.075	6.747ValVal: 6.747 ± 0.099	0.853ValTrp: 0.853 ± 0.034	1.893ValTyr: 1.893 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.386TrpAla: 1.386 ± 0.036	0.093TrpCys: 0.093 ± 0.009	0.66TrpAsp: 0.66 ± 0.032	0.599TrpGlu: 0.599 ± 0.026	0.415TrpPhe: 0.415 ± 0.021	1.084TrpGly: 1.084 ± 0.038	0.331TrpHis: 0.331 ± 0.02	0.537TrpIle: 0.537 ± 0.023	0.312TrpLys: 0.312 ± 0.02	1.182TrpLeu: 1.182 ± 0.041	0.324TrpMet: 0.324 ± 0.019	0.356TrpAsn: 0.356 ± 0.02	0.563TrpPro: 0.563 ± 0.027	0.424TrpGln: 0.424 ± 0.021	1.067TrpArg: 1.067 ± 0.035	0.76TrpSer: 0.76 ± 0.027	1.045TrpThr: 1.045 ± 0.032	0.796TrpVal: 0.796 ± 0.027	0.248TrpTrp: 0.248 ± 0.018	0.324TrpTyr: 0.324 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.594TyrAla: 2.594 ± 0.041	0.203TyrCys: 0.203 ± 0.015	2.134TyrAsp: 2.134 ± 0.049	2.06TyrGlu: 2.06 ± 0.046	1.026TyrPhe: 1.026 ± 0.035	2.34TyrGly: 2.34 ± 0.056	0.613TyrHis: 0.613 ± 0.024	0.726TyrIle: 0.726 ± 0.028	0.509TyrLys: 0.509 ± 0.022	2.459TyrLeu: 2.459 ± 0.05	0.412TyrMet: 0.412 ± 0.022	0.662TyrAsn: 0.662 ± 0.027	1.176TyrPro: 1.176 ± 0.039	0.895TyrGln: 0.895 ± 0.032	2.319TyrArg: 2.319 ± 0.059	1.204TyrSer: 1.204 ± 0.042	1.517TyrThr: 1.517 ± 0.046	2.169TyrVal: 2.169 ± 0.042	0.377TyrTrp: 0.377 ± 0.022	0.775TyrTyr: 0.775 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2812 proteins (1007991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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