Amino acid dipepetide frequency for Alistipes sp. An66

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.078AlaAla: 11.078 ± 0.169
1.301AlaCys: 1.301 ± 0.04
5.534AlaAsp: 5.534 ± 0.082
6.826AlaGlu: 6.826 ± 0.106
3.368AlaPhe: 3.368 ± 0.073
7.506AlaGly: 7.506 ± 0.11
1.396AlaHis: 1.396 ± 0.039
4.299AlaIle: 4.299 ± 0.082
3.255AlaLys: 3.255 ± 0.076
8.633AlaLeu: 8.633 ± 0.115
2.095AlaMet: 2.095 ± 0.053
2.772AlaAsn: 2.772 ± 0.053
3.48AlaPro: 3.48 ± 0.072
2.933AlaGln: 2.933 ± 0.061
5.878AlaArg: 5.878 ± 0.102
4.939AlaSer: 4.939 ± 0.096
4.694AlaThr: 4.694 ± 0.087
6.766AlaVal: 6.766 ± 0.108
1.219AlaTrp: 1.219 ± 0.042
2.971AlaTyr: 2.971 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.021CysAla: 1.021 ± 0.033
0.25CysCys: 0.25 ± 0.021
0.823CysAsp: 0.823 ± 0.028
0.792CysGlu: 0.792 ± 0.032
0.521CysPhe: 0.521 ± 0.023
1.282CysGly: 1.282 ± 0.037
0.257CysHis: 0.257 ± 0.018
0.701CysIle: 0.701 ± 0.03
0.418CysLys: 0.418 ± 0.022
0.966CysLeu: 0.966 ± 0.034
0.264CysMet: 0.264 ± 0.016
0.499CysAsn: 0.499 ± 0.029
0.664CysPro: 0.664 ± 0.031
0.286CysGln: 0.286 ± 0.017
1.052CysArg: 1.052 ± 0.037
0.803CysSer: 0.803 ± 0.029
0.728CysThr: 0.728 ± 0.03
0.777CysVal: 0.777 ± 0.028
0.155CysTrp: 0.155 ± 0.014
0.534CysTyr: 0.534 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.12AspAla: 5.12 ± 0.082
0.643AspCys: 0.643 ± 0.026
3.172AspAsp: 3.172 ± 0.066
3.818AspGlu: 3.818 ± 0.07
2.839AspPhe: 2.839 ± 0.058
5.074AspGly: 5.074 ± 0.1
0.953AspHis: 0.953 ± 0.035
3.128AspIle: 3.128 ± 0.059
2.356AspLys: 2.356 ± 0.062
5.056AspLeu: 5.056 ± 0.079
1.236AspMet: 1.236 ± 0.036
2.266AspAsn: 2.266 ± 0.052
3.032AspPro: 3.032 ± 0.064
1.251AspGln: 1.251 ± 0.04
4.27AspArg: 4.27 ± 0.079
2.841AspSer: 2.841 ± 0.069
2.868AspThr: 2.868 ± 0.057
3.657AspVal: 3.657 ± 0.07
0.929AspTrp: 0.929 ± 0.033
2.639AspTyr: 2.639 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
6.023GluAla: 6.023 ± 0.102
0.67GluCys: 0.67 ± 0.028
2.677GluAsp: 2.677 ± 0.058
5.017GluGlu: 5.017 ± 0.091
2.566GluPhe: 2.566 ± 0.059
4.749GluGly: 4.749 ± 0.071
1.361GluHis: 1.361 ± 0.039
4.402GluIle: 4.402 ± 0.079
3.456GluLys: 3.456 ± 0.072
6.108GluLeu: 6.108 ± 0.093
1.911GluMet: 1.911 ± 0.05
2.918GluAsn: 2.918 ± 0.054
2.385GluPro: 2.385 ± 0.065
2.614GluGln: 2.614 ± 0.057
4.936GluArg: 4.936 ± 0.083
3.338GluSer: 3.338 ± 0.061
3.629GluThr: 3.629 ± 0.066
4.617GluVal: 4.617 ± 0.085
0.967GluTrp: 0.967 ± 0.033
2.512GluTyr: 2.512 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.691PheAla: 3.691 ± 0.059
0.569PheCys: 0.569 ± 0.022
2.989PheAsp: 2.989 ± 0.054
2.561PheGlu: 2.561 ± 0.057
1.792PhePhe: 1.792 ± 0.055
3.473PheGly: 3.473 ± 0.069
0.75PheHis: 0.75 ± 0.03
2.169PheIle: 2.169 ± 0.054
1.433PheLys: 1.433 ± 0.04
3.501PheLeu: 3.501 ± 0.073
0.948PheMet: 0.948 ± 0.03
1.685PheAsn: 1.685 ± 0.048
1.701PhePro: 1.701 ± 0.044
0.988PheGln: 0.988 ± 0.04
3.149PheArg: 3.149 ± 0.07
2.833PheSer: 2.833 ± 0.065
2.643PheThr: 2.643 ± 0.056
2.805PheVal: 2.805 ± 0.058
0.559PheTrp: 0.559 ± 0.025
1.658PheTyr: 1.658 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
6.191GlyAla: 6.191 ± 0.102
1.194GlyCys: 1.194 ± 0.038
4.186GlyAsp: 4.186 ± 0.074
4.971GlyGlu: 4.971 ± 0.076
3.305GlyPhe: 3.305 ± 0.069
5.777GlyGly: 5.777 ± 0.102
1.461GlyHis: 1.461 ± 0.042
5.06GlyIle: 5.06 ± 0.075
3.646GlyLys: 3.646 ± 0.071
6.371GlyLeu: 6.371 ± 0.098
2.061GlyMet: 2.061 ± 0.053
3.027GlyAsn: 3.027 ± 0.068
1.789GlyPro: 1.789 ± 0.049
2.209GlyGln: 2.209 ± 0.053
5.026GlyArg: 5.026 ± 0.105
4.693GlySer: 4.693 ± 0.08
4.635GlyThr: 4.635 ± 0.086
5.695GlyVal: 5.695 ± 0.096
1.245GlyTrp: 1.245 ± 0.036
3.558GlyTyr: 3.558 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.522HisAla: 1.522 ± 0.043
0.294HisCys: 0.294 ± 0.018
1.02HisAsp: 1.02 ± 0.038
0.999HisGlu: 0.999 ± 0.031
0.908HisPhe: 0.908 ± 0.033
1.29HisGly: 1.29 ± 0.041
0.412HisHis: 0.412 ± 0.024
1.183HisIle: 1.183 ± 0.036
0.705HisLys: 0.705 ± 0.03
1.702HisLeu: 1.702 ± 0.041
0.367HisMet: 0.367 ± 0.021
0.752HisAsn: 0.752 ± 0.028
1.113HisPro: 1.113 ± 0.04
0.408HisGln: 0.408 ± 0.021
1.277HisArg: 1.277 ± 0.036
0.925HisSer: 0.925 ± 0.032
1.073HisThr: 1.073 ± 0.037
1.104HisVal: 1.104 ± 0.035
0.205HisTrp: 0.205 ± 0.015
0.802HisTyr: 0.802 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.444IleAla: 5.444 ± 0.093
0.769IleCys: 0.769 ± 0.025
3.949IleAsp: 3.949 ± 0.076
4.003IleGlu: 4.003 ± 0.073
2.166IlePhe: 2.166 ± 0.053
4.298IleGly: 4.298 ± 0.08
1.018IleHis: 1.018 ± 0.035
2.844IleIle: 2.844 ± 0.071
1.994IleLys: 1.994 ± 0.064
5.108IleLeu: 5.108 ± 0.083
0.936IleMet: 0.936 ± 0.034
2.026IleAsn: 2.026 ± 0.061
2.928IlePro: 2.928 ± 0.064
1.446IleGln: 1.446 ± 0.046
4.449IleArg: 4.449 ± 0.077
3.507IleSer: 3.507 ± 0.063
3.306IleThr: 3.306 ± 0.065
4.239IleVal: 4.239 ± 0.075
0.64IleTrp: 0.64 ± 0.027
2.151IleTyr: 2.151 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
3.61LysAla: 3.61 ± 0.079
0.417LysCys: 0.417 ± 0.017
1.997LysAsp: 1.997 ± 0.053
3.005LysGlu: 3.005 ± 0.078
1.492LysPhe: 1.492 ± 0.04
3.112LysGly: 3.112 ± 0.068
0.768LysHis: 0.768 ± 0.03
2.967LysIle: 2.967 ± 0.066
2.322LysLys: 2.322 ± 0.067
3.545LysLeu: 3.545 ± 0.086
1.389LysMet: 1.389 ± 0.039
1.939LysAsn: 1.939 ± 0.051
1.741LysPro: 1.741 ± 0.042
1.568LysGln: 1.568 ± 0.055
2.795LysArg: 2.795 ± 0.061
2.419LysSer: 2.419 ± 0.059
2.459LysThr: 2.459 ± 0.05
2.891LysVal: 2.891 ± 0.066
0.574LysTrp: 0.574 ± 0.027
1.878LysTyr: 1.878 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
8.378LeuAla: 8.378 ± 0.12
1.423LeuCys: 1.423 ± 0.045
5.5LeuAsp: 5.5 ± 0.082
4.959LeuGlu: 4.959 ± 0.089
4.239LeuPhe: 4.239 ± 0.076
6.277LeuGly: 6.277 ± 0.098
1.821LeuHis: 1.821 ± 0.049
4.426LeuIle: 4.426 ± 0.091
4.176LeuLys: 4.176 ± 0.092
9.496LeuLeu: 9.496 ± 0.146
2.132LeuMet: 2.132 ± 0.051
3.507LeuAsn: 3.507 ± 0.078
4.362LeuPro: 4.362 ± 0.074
2.691LeuGln: 2.691 ± 0.053
6.768LeuArg: 6.768 ± 0.092
5.988LeuSer: 5.988 ± 0.091
5.964LeuThr: 5.964 ± 0.101
5.496LeuVal: 5.496 ± 0.095
1.228LeuTrp: 1.228 ± 0.042
3.349LeuTyr: 3.349 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.231MetAla: 2.231 ± 0.059
0.229MetCys: 0.229 ± 0.016
1.18MetAsp: 1.18 ± 0.035
1.567MetGlu: 1.567 ± 0.048
0.827MetPhe: 0.827 ± 0.03
1.6MetGly: 1.6 ± 0.049
0.4MetHis: 0.4 ± 0.021
1.356MetIle: 1.356 ± 0.043
1.865MetLys: 1.865 ± 0.043
2.381MetLeu: 2.381 ± 0.048
0.662MetMet: 0.662 ± 0.027
1.188MetAsn: 1.188 ± 0.036
1.21MetPro: 1.21 ± 0.037
1.015MetGln: 1.015 ± 0.038
1.592MetArg: 1.592 ± 0.037
1.387MetSer: 1.387 ± 0.038
1.526MetThr: 1.526 ± 0.044
1.293MetVal: 1.293 ± 0.038
0.277MetTrp: 0.277 ± 0.016
0.674MetTyr: 0.674 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.213AsnAla: 3.213 ± 0.064
0.411AsnCys: 0.411 ± 0.021
2.15AsnAsp: 2.15 ± 0.052
1.973AsnGlu: 1.973 ± 0.052
1.666AsnPhe: 1.666 ± 0.04
3.32AsnGly: 3.32 ± 0.074
0.638AsnHis: 0.638 ± 0.03
2.526AsnIle: 2.526 ± 0.055
1.506AsnLys: 1.506 ± 0.048
3.67AsnLeu: 3.67 ± 0.058
0.932AsnMet: 0.932 ± 0.032
1.758AsnAsn: 1.758 ± 0.056
2.414AsnPro: 2.414 ± 0.054
1.078AsnGln: 1.078 ± 0.043
2.777AsnArg: 2.777 ± 0.054
2.087AsnSer: 2.087 ± 0.057
2.238AsnThr: 2.238 ± 0.066
2.434AsnVal: 2.434 ± 0.056
0.513AsnTrp: 0.513 ± 0.027
1.816AsnTyr: 1.816 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
4.459ProAla: 4.459 ± 0.101
0.43ProCys: 0.43 ± 0.024
3.132ProAsp: 3.132 ± 0.059
4.182ProGlu: 4.182 ± 0.071
1.767ProPhe: 1.767 ± 0.051
3.143ProGly: 3.143 ± 0.066
0.758ProHis: 0.758 ± 0.03
1.936ProIle: 1.936 ± 0.043
1.645ProLys: 1.645 ± 0.048
3.617ProLeu: 3.617 ± 0.063
1.03ProMet: 1.03 ± 0.034
1.363ProAsn: 1.363 ± 0.036
0.988ProPro: 0.988 ± 0.036
1.52ProGln: 1.52 ± 0.04
2.316ProArg: 2.316 ± 0.054
2.444ProSer: 2.444 ± 0.046
2.311ProThr: 2.311 ± 0.053
3.411ProVal: 3.411 ± 0.072
0.552ProTrp: 0.552 ± 0.026
1.624ProTyr: 1.624 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.574GlnAla: 2.574 ± 0.061
0.276GlnCys: 0.276 ± 0.019
1.217GlnAsp: 1.217 ± 0.038
1.928GlnGlu: 1.928 ± 0.053
1.164GlnPhe: 1.164 ± 0.038
2.03GlnGly: 2.03 ± 0.042
0.613GlnHis: 0.613 ± 0.025
2.019GlnIle: 2.019 ± 0.05
1.459GlnLys: 1.459 ± 0.041
2.873GlnLeu: 2.873 ± 0.065
0.883GlnMet: 0.883 ± 0.028
1.398GlnAsn: 1.398 ± 0.051
1.449GlnPro: 1.449 ± 0.045
1.416GlnGln: 1.416 ± 0.045
2.055GlnArg: 2.055 ± 0.05
1.694GlnSer: 1.694 ± 0.044
2.032GlnThr: 2.032 ± 0.054
1.944GlnVal: 1.944 ± 0.047
0.43GlnTrp: 0.43 ± 0.02
1.233GlnTyr: 1.233 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.075ArgAla: 5.075 ± 0.078
0.849ArgCys: 0.849 ± 0.035
3.4ArgAsp: 3.4 ± 0.056
4.999ArgGlu: 4.999 ± 0.099
3.238ArgPhe: 3.238 ± 0.064
3.915ArgGly: 3.915 ± 0.07
1.414ArgHis: 1.414 ± 0.044
5.073ArgIle: 5.073 ± 0.088
2.999ArgLys: 2.999 ± 0.067
6.479ArgLeu: 6.479 ± 0.103
2.161ArgMet: 2.161 ± 0.059
2.976ArgAsn: 2.976 ± 0.064
2.615ArgPro: 2.615 ± 0.053
2.42ArgGln: 2.42 ± 0.058
5.162ArgArg: 5.162 ± 0.103
3.49ArgSer: 3.49 ± 0.068
4.012ArgThr: 4.012 ± 0.072
4.076ArgVal: 4.076 ± 0.082
1.062ArgTrp: 1.062 ± 0.033
2.997ArgTyr: 2.997 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.96SerAla: 4.96 ± 0.089
0.796SerCys: 0.796 ± 0.033
3.357SerAsp: 3.357 ± 0.072
3.549SerGlu: 3.549 ± 0.068
2.634SerPhe: 2.634 ± 0.057
5.181SerGly: 5.181 ± 0.095
1.003SerHis: 1.003 ± 0.038
3.205SerIle: 3.205 ± 0.056
2.344SerLys: 2.344 ± 0.046
5.527SerLeu: 5.527 ± 0.098
1.348SerMet: 1.348 ± 0.041
1.982SerAsn: 1.982 ± 0.054
2.378SerPro: 2.378 ± 0.058
1.716SerGln: 1.716 ± 0.05
3.404SerArg: 3.404 ± 0.061
3.379SerSer: 3.379 ± 0.081
3.118SerThr: 3.118 ± 0.069
4.353SerVal: 4.353 ± 0.079
0.859SerTrp: 0.859 ± 0.034
2.441SerTyr: 2.441 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
5.439ThrAla: 5.439 ± 0.093
0.552ThrCys: 0.552 ± 0.022
3.409ThrAsp: 3.409 ± 0.065
3.447ThrGlu: 3.447 ± 0.071
2.587ThrPhe: 2.587 ± 0.056
4.802ThrGly: 4.802 ± 0.079
0.937ThrHis: 0.937 ± 0.035
3.284ThrIle: 3.284 ± 0.072
2.042ThrLys: 2.042 ± 0.045
6.246ThrLeu: 6.246 ± 0.085
1.21ThrMet: 1.21 ± 0.038
1.942ThrAsn: 1.942 ± 0.048
3.396ThrPro: 3.396 ± 0.059
1.608ThrGln: 1.608 ± 0.047
3.188ThrArg: 3.188 ± 0.061
3.248ThrSer: 3.248 ± 0.068
3.544ThrThr: 3.544 ± 0.072
4.665ThrVal: 4.665 ± 0.08
0.784ThrTrp: 0.784 ± 0.037
2.086ThrTyr: 2.086 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
6.413ValAla: 6.413 ± 0.097
1.004ValCys: 1.004 ± 0.037
3.997ValAsp: 3.997 ± 0.068
4.97ValGlu: 4.97 ± 0.073
2.478ValPhe: 2.478 ± 0.053
4.993ValGly: 4.993 ± 0.085
1.073ValHis: 1.073 ± 0.042
3.811ValIle: 3.811 ± 0.069
3.075ValLys: 3.075 ± 0.062
6.032ValLeu: 6.032 ± 0.086
1.664ValMet: 1.664 ± 0.048
2.578ValAsn: 2.578 ± 0.057
2.869ValPro: 2.869 ± 0.064
1.954ValGln: 1.954 ± 0.051
4.671ValArg: 4.671 ± 0.083
4.459ValSer: 4.459 ± 0.091
4.256ValThr: 4.256 ± 0.086
5.601ValVal: 5.601 ± 0.1
0.946ValTrp: 0.946 ± 0.034
2.356ValTyr: 2.356 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.984TrpAla: 0.984 ± 0.037
0.194TrpCys: 0.194 ± 0.017
0.711TrpAsp: 0.711 ± 0.026
0.887TrpGlu: 0.887 ± 0.034
0.653TrpPhe: 0.653 ± 0.03
1.079TrpGly: 1.079 ± 0.037
0.3TrpHis: 0.3 ± 0.021
0.856TrpIle: 0.856 ± 0.035
0.622TrpLys: 0.622 ± 0.029
1.292TrpLeu: 1.292 ± 0.034
0.373TrpMet: 0.373 ± 0.021
0.719TrpAsn: 0.719 ± 0.03
0.373TrpPro: 0.373 ± 0.025
0.574TrpGln: 0.574 ± 0.029
0.88TrpArg: 0.88 ± 0.033
0.897TrpSer: 0.897 ± 0.039
0.813TrpThr: 0.813 ± 0.032
0.874TrpVal: 0.874 ± 0.036
0.249TrpTrp: 0.249 ± 0.018
0.545TrpTyr: 0.545 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.519TyrAla: 3.519 ± 0.06
0.523TyrCys: 0.523 ± 0.023
2.747TyrAsp: 2.747 ± 0.058
2.403TyrGlu: 2.403 ± 0.049
1.686TyrPhe: 1.686 ± 0.042
3.199TyrGly: 3.199 ± 0.08
0.727TyrHis: 0.727 ± 0.029
1.976TyrIle: 1.976 ± 0.056
1.569TyrLys: 1.569 ± 0.044
3.578TyrLeu: 3.578 ± 0.065
0.86TyrMet: 0.86 ± 0.034
1.825TyrAsn: 1.825 ± 0.057
1.741TyrPro: 1.741 ± 0.043
0.994TyrGln: 0.994 ± 0.033
2.767TyrArg: 2.767 ± 0.063
2.163TyrSer: 2.163 ± 0.051
2.566TyrThr: 2.566 ± 0.061
2.499TyrVal: 2.499 ± 0.054
0.482TyrTrp: 0.482 ± 0.026
1.754TyrTyr: 1.754 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2381 proteins (895525 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski