Amino acid dipepetide frequency for Colorado tick fever virus (strain USA/Florio N-7180) (CTFV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.899AlaAla: 7.899 ± 1.551
0.727AlaCys: 0.727 ± 0.246
3.741AlaAsp: 3.741 ± 0.809
5.404AlaGlu: 5.404 ± 0.376
3.326AlaPhe: 3.326 ± 0.32
5.092AlaGly: 5.092 ± 0.66
1.663AlaHis: 1.663 ± 0.301
3.845AlaIle: 3.845 ± 0.376
3.118AlaLys: 3.118 ± 0.431
8.21AlaLeu: 8.21 ± 1.028
2.39AlaMet: 2.39 ± 0.513
2.91AlaAsn: 2.91 ± 0.448
3.118AlaPro: 3.118 ± 0.952
3.637AlaGln: 3.637 ± 0.778
4.885AlaArg: 4.885 ± 0.699
5.3AlaSer: 5.3 ± 1.003
2.286AlaThr: 2.286 ± 0.384
5.3AlaVal: 5.3 ± 0.575
1.039AlaTrp: 1.039 ± 0.304
2.079AlaTyr: 2.079 ± 0.438
0.0AlaXaa: 0.0 ± 0.0
Cys
0.312CysAla: 0.312 ± 0.146
0.624CysCys: 0.624 ± 0.235
1.247CysAsp: 1.247 ± 0.282
1.559CysGlu: 1.559 ± 0.321
0.935CysPhe: 0.935 ± 0.225
1.247CysGly: 1.247 ± 0.402
0.416CysHis: 0.416 ± 0.239
0.416CysIle: 0.416 ± 0.185
0.624CysLys: 0.624 ± 0.178
0.935CysLeu: 0.935 ± 0.257
0.208CysMet: 0.208 ± 0.14
0.831CysAsn: 0.831 ± 0.24
1.143CysPro: 1.143 ± 0.347
0.727CysGln: 0.727 ± 0.201
0.624CysArg: 0.624 ± 0.248
1.247CysSer: 1.247 ± 0.262
0.831CysThr: 0.831 ± 0.288
1.143CysVal: 1.143 ± 0.276
0.208CysTrp: 0.208 ± 0.147
0.52CysTyr: 0.52 ± 0.229
0.104CysXaa: 0.104 ± 0.122
Asp
3.014AspAla: 3.014 ± 0.487
1.143AspCys: 1.143 ± 0.224
3.222AspAsp: 3.222 ± 0.614
3.741AspGlu: 3.741 ± 0.392
3.118AspPhe: 3.118 ± 0.418
4.053AspGly: 4.053 ± 0.707
1.455AspHis: 1.455 ± 0.322
2.806AspIle: 2.806 ± 0.502
1.559AspLys: 1.559 ± 0.375
4.885AspLeu: 4.885 ± 0.544
1.663AspMet: 1.663 ± 0.55
1.767AspAsn: 1.767 ± 0.603
2.91AspPro: 2.91 ± 0.462
2.286AspGln: 2.286 ± 0.35
3.741AspArg: 3.741 ± 0.712
3.014AspSer: 3.014 ± 0.688
2.806AspThr: 2.806 ± 0.457
5.092AspVal: 5.092 ± 0.405
0.831AspTrp: 0.831 ± 0.394
2.182AspTyr: 2.182 ± 0.485
0.0AspXaa: 0.0 ± 0.0
Glu
5.196GluAla: 5.196 ± 0.43
1.143GluCys: 1.143 ± 0.368
3.637GluAsp: 3.637 ± 0.73
4.261GluGlu: 4.261 ± 0.883
2.494GluPhe: 2.494 ± 0.338
4.469GluGly: 4.469 ± 0.494
1.351GluHis: 1.351 ± 0.332
3.118GluIle: 3.118 ± 0.468
2.91GluLys: 2.91 ± 0.469
5.924GluLeu: 5.924 ± 0.674
2.079GluMet: 2.079 ± 0.331
1.247GluAsn: 1.247 ± 0.221
2.182GluPro: 2.182 ± 0.393
2.494GluGln: 2.494 ± 0.653
4.885GluArg: 4.885 ± 0.733
3.949GluSer: 3.949 ± 0.776
2.91GluThr: 2.91 ± 0.548
5.3GluVal: 5.3 ± 0.645
1.559GluTrp: 1.559 ± 0.397
2.079GluTyr: 2.079 ± 0.525
0.0GluXaa: 0.0 ± 0.0
Phe
2.806PheAla: 2.806 ± 0.458
1.039PheCys: 1.039 ± 0.351
2.286PheAsp: 2.286 ± 0.569
2.286PheGlu: 2.286 ± 0.405
1.975PhePhe: 1.975 ± 0.41
3.845PheGly: 3.845 ± 0.635
1.351PheHis: 1.351 ± 0.37
2.39PheIle: 2.39 ± 0.481
1.663PheLys: 1.663 ± 0.366
2.702PheLeu: 2.702 ± 0.515
0.312PheMet: 0.312 ± 0.148
1.767PheAsn: 1.767 ± 0.222
3.014PhePro: 3.014 ± 0.483
1.871PheGln: 1.871 ± 0.599
2.286PheArg: 2.286 ± 0.49
4.261PheSer: 4.261 ± 0.494
1.975PheThr: 1.975 ± 0.523
4.157PheVal: 4.157 ± 0.524
0.312PheTrp: 0.312 ± 0.169
1.871PheTyr: 1.871 ± 0.475
0.0PheXaa: 0.0 ± 0.0
Gly
5.716GlyAla: 5.716 ± 0.677
1.767GlyCys: 1.767 ± 0.592
3.845GlyAsp: 3.845 ± 0.901
4.157GlyGlu: 4.157 ± 0.513
3.534GlyPhe: 3.534 ± 0.997
5.82GlyGly: 5.82 ± 1.073
1.351GlyHis: 1.351 ± 0.304
3.014GlyIle: 3.014 ± 0.537
2.598GlyLys: 2.598 ± 0.61
6.132GlyLeu: 6.132 ± 0.783
2.806GlyMet: 2.806 ± 0.455
2.598GlyAsn: 2.598 ± 0.495
2.806GlyPro: 2.806 ± 0.68
2.598GlyGln: 2.598 ± 0.29
4.989GlyArg: 4.989 ± 0.746
2.91GlySer: 2.91 ± 0.3
4.053GlyThr: 4.053 ± 0.776
6.651GlyVal: 6.651 ± 0.642
1.767GlyTrp: 1.767 ± 0.37
2.286GlyTyr: 2.286 ± 0.22
0.0GlyXaa: 0.0 ± 0.0
His
1.975HisAla: 1.975 ± 0.512
0.208HisCys: 0.208 ± 0.153
1.767HisAsp: 1.767 ± 0.595
1.351HisGlu: 1.351 ± 0.392
1.559HisPhe: 1.559 ± 0.459
1.039HisGly: 1.039 ± 0.307
1.247HisHis: 1.247 ± 0.296
1.039HisIle: 1.039 ± 0.254
0.208HisLys: 0.208 ± 0.129
2.702HisLeu: 2.702 ± 0.592
0.831HisMet: 0.831 ± 0.362
0.52HisAsn: 0.52 ± 0.234
0.624HisPro: 0.624 ± 0.309
1.039HisGln: 1.039 ± 0.325
1.039HisArg: 1.039 ± 0.254
1.143HisSer: 1.143 ± 0.392
0.831HisThr: 0.831 ± 0.304
3.326HisVal: 3.326 ± 0.764
0.416HisTrp: 0.416 ± 0.15
1.039HisTyr: 1.039 ± 0.471
0.0HisXaa: 0.0 ± 0.0
Ile
2.91IleAla: 2.91 ± 0.44
0.831IleCys: 0.831 ± 0.246
2.806IleAsp: 2.806 ± 0.519
2.39IleGlu: 2.39 ± 0.551
2.079IlePhe: 2.079 ± 0.415
3.014IleGly: 3.014 ± 0.66
1.143IleHis: 1.143 ± 0.303
2.39IleIle: 2.39 ± 0.563
1.975IleLys: 1.975 ± 0.363
6.236IleLeu: 6.236 ± 1.055
1.663IleMet: 1.663 ± 0.294
1.559IleAsn: 1.559 ± 0.367
2.39IlePro: 2.39 ± 0.492
1.975IleGln: 1.975 ± 0.457
3.326IleArg: 3.326 ± 0.513
2.494IleSer: 2.494 ± 0.387
2.598IleThr: 2.598 ± 0.48
3.222IleVal: 3.222 ± 0.494
0.416IleTrp: 0.416 ± 0.415
1.247IleTyr: 1.247 ± 0.472
0.0IleXaa: 0.0 ± 0.0
Lys
2.702LysAla: 2.702 ± 0.504
0.312LysCys: 0.312 ± 0.133
1.767LysAsp: 1.767 ± 0.242
2.079LysGlu: 2.079 ± 0.379
1.975LysPhe: 1.975 ± 0.453
3.118LysGly: 3.118 ± 0.675
0.416LysHis: 0.416 ± 0.21
2.286LysIle: 2.286 ± 0.456
1.351LysLys: 1.351 ± 0.38
4.781LysLeu: 4.781 ± 0.562
1.455LysMet: 1.455 ± 0.305
0.935LysAsn: 0.935 ± 0.26
1.247LysPro: 1.247 ± 0.542
1.247LysGln: 1.247 ± 0.287
2.494LysArg: 2.494 ± 0.414
2.182LysSer: 2.182 ± 0.411
3.637LysThr: 3.637 ± 0.718
3.741LysVal: 3.741 ± 0.679
0.624LysTrp: 0.624 ± 0.332
1.039LysTyr: 1.039 ± 0.301
0.0LysXaa: 0.0 ± 0.0
Leu
7.691LeuAla: 7.691 ± 0.853
1.039LeuCys: 1.039 ± 0.22
4.053LeuAsp: 4.053 ± 0.426
6.132LeuGlu: 6.132 ± 0.889
3.43LeuPhe: 3.43 ± 0.529
7.067LeuGly: 7.067 ± 0.505
2.598LeuHis: 2.598 ± 0.557
4.053LeuIle: 4.053 ± 0.572
3.845LeuLys: 3.845 ± 0.949
10.393LeuLeu: 10.393 ± 1.157
3.222LeuMet: 3.222 ± 0.511
3.637LeuAsn: 3.637 ± 0.559
5.092LeuPro: 5.092 ± 0.514
2.806LeuGln: 2.806 ± 0.298
7.795LeuArg: 7.795 ± 0.948
6.963LeuSer: 6.963 ± 0.886
6.132LeuThr: 6.132 ± 0.932
5.82LeuVal: 5.82 ± 0.859
1.767LeuTrp: 1.767 ± 0.6
3.118LeuTyr: 3.118 ± 0.629
0.0LeuXaa: 0.0 ± 0.0
Met
2.079MetAla: 2.079 ± 0.335
0.416MetCys: 0.416 ± 0.165
1.663MetAsp: 1.663 ± 0.427
1.767MetGlu: 1.767 ± 0.508
1.247MetPhe: 1.247 ± 0.352
1.975MetGly: 1.975 ± 0.442
0.624MetHis: 0.624 ± 0.278
1.767MetIle: 1.767 ± 0.399
1.247MetLys: 1.247 ± 0.351
3.014MetLeu: 3.014 ± 0.504
1.039MetMet: 1.039 ± 0.282
0.624MetAsn: 0.624 ± 0.265
0.935MetPro: 0.935 ± 0.292
0.727MetGln: 0.727 ± 0.306
2.079MetArg: 2.079 ± 0.348
1.975MetSer: 1.975 ± 0.309
2.079MetThr: 2.079 ± 0.424
2.39MetVal: 2.39 ± 0.562
0.52MetTrp: 0.52 ± 0.218
1.039MetTyr: 1.039 ± 0.339
0.0MetXaa: 0.0 ± 0.0
Asn
2.079AsnAla: 2.079 ± 0.451
0.416AsnCys: 0.416 ± 0.164
2.39AsnAsp: 2.39 ± 0.574
1.247AsnGlu: 1.247 ± 0.289
1.351AsnPhe: 1.351 ± 0.454
2.598AsnGly: 2.598 ± 0.493
0.727AsnHis: 0.727 ± 0.232
1.663AsnIle: 1.663 ± 0.341
0.727AsnLys: 0.727 ± 0.35
3.949AsnLeu: 3.949 ± 0.639
0.727AsnMet: 0.727 ± 0.229
1.351AsnAsn: 1.351 ± 0.45
2.182AsnPro: 2.182 ± 0.293
1.455AsnGln: 1.455 ± 0.257
1.975AsnArg: 1.975 ± 0.498
1.559AsnSer: 1.559 ± 0.437
1.455AsnThr: 1.455 ± 0.245
3.326AsnVal: 3.326 ± 0.423
0.727AsnTrp: 0.727 ± 0.23
1.247AsnTyr: 1.247 ± 0.262
0.0AsnXaa: 0.0 ± 0.0
Pro
4.573ProAla: 4.573 ± 0.805
0.624ProCys: 0.624 ± 0.292
2.702ProAsp: 2.702 ± 0.494
3.949ProGlu: 3.949 ± 0.712
2.079ProPhe: 2.079 ± 0.516
3.118ProGly: 3.118 ± 0.767
1.039ProHis: 1.039 ± 0.34
2.079ProIle: 2.079 ± 0.496
1.039ProLys: 1.039 ± 0.291
3.845ProLeu: 3.845 ± 0.703
1.039ProMet: 1.039 ± 0.302
1.455ProAsn: 1.455 ± 0.505
3.326ProPro: 3.326 ± 0.66
2.182ProGln: 2.182 ± 0.399
2.494ProArg: 2.494 ± 0.402
3.326ProSer: 3.326 ± 0.686
2.806ProThr: 2.806 ± 0.491
3.845ProVal: 3.845 ± 0.76
0.624ProTrp: 0.624 ± 0.243
1.143ProTyr: 1.143 ± 0.29
0.0ProXaa: 0.0 ± 0.0
Gln
4.365GlnAla: 4.365 ± 0.893
0.416GlnCys: 0.416 ± 0.165
1.351GlnAsp: 1.351 ± 0.318
1.871GlnGlu: 1.871 ± 0.492
1.351GlnPhe: 1.351 ± 0.402
3.118GlnGly: 3.118 ± 0.521
0.624GlnHis: 0.624 ± 0.215
1.871GlnIle: 1.871 ± 0.366
1.871GlnLys: 1.871 ± 0.316
4.053GlnLeu: 4.053 ± 0.488
0.935GlnMet: 0.935 ± 0.367
1.455GlnAsn: 1.455 ± 0.564
0.935GlnPro: 0.935 ± 0.265
1.455GlnGln: 1.455 ± 0.428
2.39GlnArg: 2.39 ± 0.615
1.767GlnSer: 1.767 ± 0.349
2.494GlnThr: 2.494 ± 0.457
2.91GlnVal: 2.91 ± 0.698
0.624GlnTrp: 0.624 ± 0.281
0.624GlnTyr: 0.624 ± 0.211
0.0GlnXaa: 0.0 ± 0.0
Arg
4.989ArgAla: 4.989 ± 0.843
0.727ArgCys: 0.727 ± 0.261
5.404ArgAsp: 5.404 ± 0.931
5.82ArgGlu: 5.82 ± 0.799
2.182ArgPhe: 2.182 ± 0.334
4.781ArgGly: 4.781 ± 0.527
1.975ArgHis: 1.975 ± 0.499
2.598ArgIle: 2.598 ± 0.607
3.222ArgLys: 3.222 ± 0.547
6.963ArgLeu: 6.963 ± 0.971
1.871ArgMet: 1.871 ± 0.476
2.39ArgAsn: 2.39 ± 0.628
4.989ArgPro: 4.989 ± 0.586
3.014ArgGln: 3.014 ± 0.733
5.3ArgArg: 5.3 ± 1.046
3.118ArgSer: 3.118 ± 0.557
3.949ArgThr: 3.949 ± 0.571
5.092ArgVal: 5.092 ± 0.74
1.247ArgTrp: 1.247 ± 0.269
2.39ArgTyr: 2.39 ± 0.472
0.0ArgXaa: 0.0 ± 0.0
Ser
4.781SerAla: 4.781 ± 0.865
1.247SerCys: 1.247 ± 0.325
2.079SerAsp: 2.079 ± 0.402
5.092SerGlu: 5.092 ± 0.802
2.702SerPhe: 2.702 ± 0.423
4.157SerGly: 4.157 ± 0.675
1.975SerHis: 1.975 ± 0.573
2.806SerIle: 2.806 ± 0.682
2.494SerLys: 2.494 ± 0.738
6.444SerLeu: 6.444 ± 0.588
2.39SerMet: 2.39 ± 0.486
1.975SerAsn: 1.975 ± 0.567
2.39SerPro: 2.39 ± 0.626
1.767SerGln: 1.767 ± 0.643
5.3SerArg: 5.3 ± 0.56
4.885SerSer: 4.885 ± 0.946
3.949SerThr: 3.949 ± 0.558
4.781SerVal: 4.781 ± 0.634
1.143SerTrp: 1.143 ± 0.218
2.182SerTyr: 2.182 ± 0.341
0.0SerXaa: 0.0 ± 0.0
Thr
3.43ThrAla: 3.43 ± 0.777
0.831ThrCys: 0.831 ± 0.227
3.949ThrAsp: 3.949 ± 0.513
1.767ThrGlu: 1.767 ± 0.354
2.598ThrPhe: 2.598 ± 0.372
3.741ThrGly: 3.741 ± 0.707
1.247ThrHis: 1.247 ± 0.398
2.079ThrIle: 2.079 ± 0.62
3.326ThrLys: 3.326 ± 0.631
5.716ThrLeu: 5.716 ± 1.005
1.663ThrMet: 1.663 ± 0.35
1.975ThrAsn: 1.975 ± 0.421
2.286ThrPro: 2.286 ± 0.588
0.935ThrGln: 0.935 ± 0.25
3.949ThrArg: 3.949 ± 0.729
5.092ThrSer: 5.092 ± 0.648
3.222ThrThr: 3.222 ± 0.573
3.222ThrVal: 3.222 ± 0.512
1.039ThrTrp: 1.039 ± 0.209
2.079ThrTyr: 2.079 ± 0.408
0.0ThrXaa: 0.0 ± 0.0
Val
6.547ValAla: 6.547 ± 0.838
1.455ValCys: 1.455 ± 0.421
4.677ValAsp: 4.677 ± 0.729
4.157ValGlu: 4.157 ± 0.531
3.534ValPhe: 3.534 ± 0.719
5.612ValGly: 5.612 ± 0.904
1.871ValHis: 1.871 ± 0.543
3.845ValIle: 3.845 ± 0.446
3.014ValLys: 3.014 ± 0.499
5.404ValLeu: 5.404 ± 0.758
1.663ValMet: 1.663 ± 0.413
2.598ValAsn: 2.598 ± 0.371
3.741ValPro: 3.741 ± 0.484
2.598ValGln: 2.598 ± 0.633
7.587ValArg: 7.587 ± 0.784
6.859ValSer: 6.859 ± 0.634
4.157ValThr: 4.157 ± 0.728
7.483ValVal: 7.483 ± 1.373
0.727ValTrp: 0.727 ± 0.197
3.222ValTyr: 3.222 ± 0.508
0.0ValXaa: 0.0 ± 0.0
Trp
0.935TrpAla: 0.935 ± 0.348
0.312TrpCys: 0.312 ± 0.191
0.52TrpAsp: 0.52 ± 0.181
0.935TrpGlu: 0.935 ± 0.207
0.935TrpPhe: 0.935 ± 0.391
0.312TrpGly: 0.312 ± 0.213
0.104TrpHis: 0.104 ± 0.104
0.935TrpIle: 0.935 ± 0.322
1.143TrpLys: 1.143 ± 0.315
1.767TrpLeu: 1.767 ± 0.354
0.935TrpMet: 0.935 ± 0.37
0.52TrpAsn: 0.52 ± 0.159
0.624TrpPro: 0.624 ± 0.277
0.312TrpGln: 0.312 ± 0.156
1.871TrpArg: 1.871 ± 0.398
0.624TrpSer: 0.624 ± 0.167
0.831TrpThr: 0.831 ± 0.368
1.559TrpVal: 1.559 ± 0.357
0.104TrpTrp: 0.104 ± 0.104
0.831TrpTyr: 0.831 ± 0.32
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.975TyrAla: 1.975 ± 0.452
0.624TyrCys: 0.624 ± 0.312
2.182TyrAsp: 2.182 ± 0.51
3.222TyrGlu: 3.222 ± 0.816
1.767TyrPhe: 1.767 ± 0.501
3.222TyrGly: 3.222 ± 0.494
0.727TyrHis: 0.727 ± 0.215
1.663TyrIle: 1.663 ± 0.34
1.455TyrLys: 1.455 ± 0.475
2.598TyrLeu: 2.598 ± 0.361
0.208TyrMet: 0.208 ± 0.127
1.039TyrAsn: 1.039 ± 0.324
1.351TyrPro: 1.351 ± 0.307
1.351TyrGln: 1.351 ± 0.462
3.014TyrArg: 3.014 ± 0.346
1.871TyrSer: 1.871 ± 0.419
1.143TyrThr: 1.143 ± 0.228
2.39TyrVal: 2.39 ± 0.448
0.416TyrTrp: 0.416 ± 0.224
1.455TyrTyr: 1.455 ± 0.363
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.104XaaArg: 0.104 ± 0.122
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (9623 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski