Amino acid dipepetide frequency for Nitratireductor basaltis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.803AlaAla: 14.803 ± 0.175	0.983AlaCys: 0.983 ± 0.032	6.517AlaAsp: 6.517 ± 0.086	8.271AlaGlu: 8.271 ± 0.12	4.395AlaPhe: 4.395 ± 0.071	10.06AlaGly: 10.06 ± 0.104	2.149AlaHis: 2.149 ± 0.046	6.525AlaIle: 6.525 ± 0.087	4.058AlaLys: 4.058 ± 0.078	12.675AlaLeu: 12.675 ± 0.133	3.602AlaMet: 3.602 ± 0.066	2.974AlaAsn: 2.974 ± 0.059	4.834AlaPro: 4.834 ± 0.089	3.952AlaGln: 3.952 ± 0.062	8.09AlaArg: 8.09 ± 0.095	6.659AlaSer: 6.659 ± 0.079	5.437AlaThr: 5.437 ± 0.08	8.037AlaVal: 8.037 ± 0.09	1.206AlaTrp: 1.206 ± 0.034	2.516AlaTyr: 2.516 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.866CysAla: 0.866 ± 0.027	0.099CysCys: 0.099 ± 0.011	0.508CysAsp: 0.508 ± 0.022	0.476CysGlu: 0.476 ± 0.021	0.312CysPhe: 0.312 ± 0.016	0.851CysGly: 0.851 ± 0.029	0.223CysHis: 0.223 ± 0.014	0.397CysIle: 0.397 ± 0.018	0.187CysLys: 0.187 ± 0.013	0.77CysLeu: 0.77 ± 0.026	0.175CysMet: 0.175 ± 0.013	0.216CysAsn: 0.216 ± 0.016	0.388CysPro: 0.388 ± 0.02	0.221CysGln: 0.221 ± 0.013	0.549CysArg: 0.549 ± 0.022	0.484CysSer: 0.484 ± 0.02	0.375CysThr: 0.375 ± 0.021	0.578CysVal: 0.578 ± 0.026	0.1CysTrp: 0.1 ± 0.01	0.182CysTyr: 0.182 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.576AspAla: 6.576 ± 0.083	0.443AspCys: 0.443 ± 0.021	3.226AspAsp: 3.226 ± 0.077	4.265AspGlu: 4.265 ± 0.069	2.246AspPhe: 2.246 ± 0.046	5.104AspGly: 5.104 ± 0.111	1.307AspHis: 1.307 ± 0.043	3.242AspIle: 3.242 ± 0.055	1.777AspLys: 1.777 ± 0.041	5.623AspLeu: 5.623 ± 0.083	1.547AspMet: 1.547 ± 0.04	1.463AspAsn: 1.463 ± 0.046	3.105AspPro: 3.105 ± 0.061	1.702AspGln: 1.702 ± 0.039	4.069AspArg: 4.069 ± 0.072	2.206AspSer: 2.206 ± 0.063	2.619AspThr: 2.619 ± 0.06	4.143AspVal: 4.143 ± 0.063	0.912AspTrp: 0.912 ± 0.028	1.511AspTyr: 1.511 ± 0.043	0.001AspXaa: 0.001 ± 0.001
Glu	8.772GluAla: 8.772 ± 0.112	0.408GluCys: 0.408 ± 0.02	3.532GluAsp: 3.532 ± 0.074	4.929GluGlu: 4.929 ± 0.084	2.003GluPhe: 2.003 ± 0.04	5.272GluGly: 5.272 ± 0.082	1.396GluHis: 1.396 ± 0.041	4.077GluIle: 4.077 ± 0.059	3.084GluLys: 3.084 ± 0.054	6.007GluLeu: 6.007 ± 0.075	1.883GluMet: 1.883 ± 0.047	2.206GluAsn: 2.206 ± 0.053	2.997GluPro: 2.997 ± 0.051	2.446GluGln: 2.446 ± 0.052	5.265GluArg: 5.265 ± 0.082	2.649GluSer: 2.649 ± 0.053	3.725GluThr: 3.725 ± 0.056	4.346GluVal: 4.346 ± 0.067	0.809GluTrp: 0.809 ± 0.028	1.147GluTyr: 1.147 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.567PheAla: 4.567 ± 0.072	0.373PheCys: 0.373 ± 0.017	2.6PheAsp: 2.6 ± 0.058	2.428PheGlu: 2.428 ± 0.047	1.646PhePhe: 1.646 ± 0.05	3.678PheGly: 3.678 ± 0.071	0.836PheHis: 0.836 ± 0.03	1.984PheIle: 1.984 ± 0.049	1.125PheLys: 1.125 ± 0.037	3.652PheLeu: 3.652 ± 0.081	0.965PheMet: 0.965 ± 0.03	1.155PheAsn: 1.155 ± 0.036	1.582PhePro: 1.582 ± 0.043	1.075PheGln: 1.075 ± 0.028	2.178PheArg: 2.178 ± 0.051	2.432PheSer: 2.432 ± 0.05	2.102PheThr: 2.102 ± 0.052	2.81PheVal: 2.81 ± 0.051	0.533PheTrp: 0.533 ± 0.027	0.948PheTyr: 0.948 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.827GlyAla: 8.827 ± 0.106	0.778GlyCys: 0.778 ± 0.029	4.333GlyAsp: 4.333 ± 0.089	5.819GlyGlu: 5.819 ± 0.081	3.714GlyPhe: 3.714 ± 0.056	7.093GlyGly: 7.093 ± 0.116	1.832GlyHis: 1.832 ± 0.042	4.842GlyIle: 4.842 ± 0.069	3.389GlyLys: 3.389 ± 0.07	8.487GlyLeu: 8.487 ± 0.102	2.505GlyMet: 2.505 ± 0.056	2.442GlyAsn: 2.442 ± 0.067	3.143GlyPro: 3.143 ± 0.055	2.767GlyGln: 2.767 ± 0.052	5.58GlyArg: 5.58 ± 0.078	4.808GlySer: 4.808 ± 0.071	4.497GlyThr: 4.497 ± 0.091	5.937GlyVal: 5.937 ± 0.079	1.229GlyTrp: 1.229 ± 0.033	2.272GlyTyr: 2.272 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.11HisAla: 2.11 ± 0.045	0.233HisCys: 0.233 ± 0.015	1.253HisAsp: 1.253 ± 0.036	1.349HisGlu: 1.349 ± 0.037	0.913HisPhe: 0.913 ± 0.025	1.881HisGly: 1.881 ± 0.048	0.584HisHis: 0.584 ± 0.029	0.986HisIle: 0.986 ± 0.032	0.601HisLys: 0.601 ± 0.026	2.019HisLeu: 2.019 ± 0.046	0.516HisMet: 0.516 ± 0.023	0.467HisAsn: 0.467 ± 0.02	1.22HisPro: 1.22 ± 0.037	0.623HisGln: 0.623 ± 0.023	1.319HisArg: 1.319 ± 0.034	0.996HisSer: 0.996 ± 0.03	0.825HisThr: 0.825 ± 0.032	1.596HisVal: 1.596 ± 0.037	0.327HisTrp: 0.327 ± 0.018	0.597HisTyr: 0.597 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.377IleAla: 7.377 ± 0.087	0.547IleCys: 0.547 ± 0.024	3.56IleAsp: 3.56 ± 0.064	3.77IleGlu: 3.77 ± 0.064	2.058IlePhe: 2.058 ± 0.051	5.05IleGly: 5.05 ± 0.065	0.981IleHis: 0.981 ± 0.032	2.89IleIle: 2.89 ± 0.063	1.485IleLys: 1.485 ± 0.038	4.938IleLeu: 4.938 ± 0.084	1.231IleMet: 1.231 ± 0.036	1.559IleAsn: 1.559 ± 0.037	2.397IlePro: 2.397 ± 0.043	1.212IleGln: 1.212 ± 0.03	3.409IleArg: 3.409 ± 0.058	3.32IleSer: 3.32 ± 0.055	2.884IleThr: 2.884 ± 0.063	4.105IleVal: 4.105 ± 0.063	0.589IleTrp: 0.589 ± 0.028	1.23IleTyr: 1.23 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.729LysAla: 4.729 ± 0.077	0.166LysCys: 0.166 ± 0.011	1.815LysAsp: 1.815 ± 0.046	2.017LysGlu: 2.017 ± 0.049	0.947LysPhe: 0.947 ± 0.028	2.838LysGly: 2.838 ± 0.058	0.684LysHis: 0.684 ± 0.028	1.786LysIle: 1.786 ± 0.042	1.626LysLys: 1.626 ± 0.051	3.725LysLeu: 3.725 ± 0.062	0.878LysMet: 0.878 ± 0.032	1.03LysAsn: 1.03 ± 0.031	2.234LysPro: 2.234 ± 0.05	1.16LysGln: 1.16 ± 0.036	2.795LysArg: 2.795 ± 0.057	1.979LysSer: 1.979 ± 0.048	1.993LysThr: 1.993 ± 0.044	2.619LysVal: 2.619 ± 0.055	0.373LysTrp: 0.373 ± 0.02	0.616LysTyr: 0.616 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.107LeuAla: 12.107 ± 0.137	0.84LeuCys: 0.84 ± 0.027	5.723LeuAsp: 5.723 ± 0.073	6.341LeuGlu: 6.341 ± 0.08	3.804LeuPhe: 3.804 ± 0.073	8.039LeuGly: 8.039 ± 0.103	1.79LeuHis: 1.79 ± 0.047	5.068LeuIle: 5.068 ± 0.089	4.089LeuLys: 4.089 ± 0.074	9.202LeuLeu: 9.202 ± 0.138	2.399LeuMet: 2.399 ± 0.056	2.758LeuAsn: 2.758 ± 0.053	5.18LeuPro: 5.18 ± 0.065	2.979LeuGln: 2.979 ± 0.054	6.228LeuArg: 6.228 ± 0.089	6.706LeuSer: 6.706 ± 0.082	5.168LeuThr: 5.168 ± 0.074	7.533LeuVal: 7.533 ± 0.098	1.072LeuTrp: 1.072 ± 0.039	2.109LeuTyr: 2.109 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.225MetAla: 3.225 ± 0.056	0.154MetCys: 0.154 ± 0.011	1.3MetAsp: 1.3 ± 0.032	1.482MetGlu: 1.482 ± 0.039	0.813MetPhe: 0.813 ± 0.031	2.072MetGly: 2.072 ± 0.048	0.458MetHis: 0.458 ± 0.019	1.43MetIle: 1.43 ± 0.041	1.248MetLys: 1.248 ± 0.033	2.706MetLeu: 2.706 ± 0.058	0.814MetMet: 0.814 ± 0.032	0.933MetAsn: 0.933 ± 0.03	1.525MetPro: 1.525 ± 0.037	0.929MetGln: 0.929 ± 0.03	2.086MetArg: 2.086 ± 0.051	1.784MetSer: 1.784 ± 0.039	1.755MetThr: 1.755 ± 0.038	1.854MetVal: 1.854 ± 0.042	0.245MetTrp: 0.245 ± 0.015	0.316MetTyr: 0.316 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.445AsnAla: 3.445 ± 0.058	0.231AsnCys: 0.231 ± 0.015	1.603AsnAsp: 1.603 ± 0.059	1.583AsnGlu: 1.583 ± 0.04	1.09AsnPhe: 1.09 ± 0.034	2.651AsnGly: 2.651 ± 0.073	0.56AsnHis: 0.56 ± 0.024	1.61AsnIle: 1.61 ± 0.042	0.813AsnLys: 0.813 ± 0.029	2.673AsnLeu: 2.673 ± 0.053	0.768AsnMet: 0.768 ± 0.027	0.839AsnAsn: 0.839 ± 0.031	1.827AsnPro: 1.827 ± 0.044	0.864AsnGln: 0.864 ± 0.033	1.888AsnArg: 1.888 ± 0.042	1.427AsnSer: 1.427 ± 0.045	1.283AsnThr: 1.283 ± 0.036	2.008AsnVal: 2.008 ± 0.042	0.476AsnTrp: 0.476 ± 0.024	0.736AsnTyr: 0.736 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.34ProAla: 5.34 ± 0.088	0.275ProCys: 0.275 ± 0.017	3.466ProAsp: 3.466 ± 0.059	3.97ProGlu: 3.97 ± 0.072	1.964ProPhe: 1.964 ± 0.041	3.908ProGly: 3.908 ± 0.063	1.031ProHis: 1.031 ± 0.031	2.252ProIle: 2.252 ± 0.046	1.623ProLys: 1.623 ± 0.042	4.492ProLeu: 4.492 ± 0.071	1.156ProMet: 1.156 ± 0.032	1.301ProAsn: 1.301 ± 0.033	2.046ProPro: 2.046 ± 0.059	1.751ProGln: 1.751 ± 0.046	2.685ProArg: 2.685 ± 0.053	2.583ProSer: 2.583 ± 0.051	2.114ProThr: 2.114 ± 0.054	4.058ProVal: 4.058 ± 0.063	0.607ProTrp: 0.607 ± 0.021	1.173ProTyr: 1.173 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.934GlnAla: 3.934 ± 0.067	0.202GlnCys: 0.202 ± 0.012	1.615GlnAsp: 1.615 ± 0.04	1.949GlnGlu: 1.949 ± 0.044	1.062GlnPhe: 1.062 ± 0.032	2.299GlnGly: 2.299 ± 0.046	0.64GlnHis: 0.64 ± 0.026	1.907GlnIle: 1.907 ± 0.045	1.387GlnLys: 1.387 ± 0.036	2.891GlnLeu: 2.891 ± 0.051	1.004GlnMet: 1.004 ± 0.029	0.987GlnAsn: 0.987 ± 0.03	1.737GlnPro: 1.737 ± 0.045	1.213GlnGln: 1.213 ± 0.039	2.423GlnArg: 2.423 ± 0.057	1.806GlnSer: 1.806 ± 0.044	1.731GlnThr: 1.731 ± 0.041	2.317GlnVal: 2.317 ± 0.048	0.356GlnTrp: 0.356 ± 0.019	0.535GlnTyr: 0.535 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.929ArgAla: 6.929 ± 0.088	0.447ArgCys: 0.447 ± 0.021	3.91ArgAsp: 3.91 ± 0.065	4.949ArgGlu: 4.949 ± 0.075	2.972ArgPhe: 2.972 ± 0.059	4.411ArgGly: 4.411 ± 0.064	1.613ArgHis: 1.613 ± 0.045	3.94ArgIle: 3.94 ± 0.064	2.811ArgLys: 2.811 ± 0.052	7.324ArgLeu: 7.324 ± 0.092	2.047ArgMet: 2.047 ± 0.044	2.029ArgAsn: 2.029 ± 0.046	2.978ArgPro: 2.978 ± 0.051	2.603ArgGln: 2.603 ± 0.052	5.018ArgArg: 5.018 ± 0.095	3.666ArgSer: 3.666 ± 0.057	3.001ArgThr: 3.001 ± 0.047	4.482ArgVal: 4.482 ± 0.055	0.836ArgTrp: 0.836 ± 0.03	1.683ArgTyr: 1.683 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.332SerAla: 6.332 ± 0.077	0.433SerCys: 0.433 ± 0.019	3.229SerAsp: 3.229 ± 0.067	3.428SerGlu: 3.428 ± 0.06	2.437SerPhe: 2.437 ± 0.055	5.884SerGly: 5.884 ± 0.091	1.146SerHis: 1.146 ± 0.033	3.023SerIle: 3.023 ± 0.055	1.639SerLys: 1.639 ± 0.039	5.432SerLeu: 5.432 ± 0.061	1.533SerMet: 1.533 ± 0.035	1.532SerAsn: 1.532 ± 0.04	2.489SerPro: 2.489 ± 0.049	1.772SerGln: 1.772 ± 0.04	3.704SerArg: 3.704 ± 0.061	3.174SerSer: 3.174 ± 0.062	2.635SerThr: 2.635 ± 0.056	4.035SerVal: 4.035 ± 0.066	0.732SerTrp: 0.732 ± 0.031	1.327SerTyr: 1.327 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.874ThrAla: 5.874 ± 0.089	0.383ThrCys: 0.383 ± 0.018	2.644ThrAsp: 2.644 ± 0.051	2.663ThrGlu: 2.663 ± 0.055	2.012ThrPhe: 2.012 ± 0.044	5.016ThrGly: 5.016 ± 0.077	1.006ThrHis: 1.006 ± 0.035	2.958ThrIle: 2.958 ± 0.053	1.412ThrLys: 1.412 ± 0.035	5.358ThrLeu: 5.358 ± 0.082	1.257ThrMet: 1.257 ± 0.032	1.409ThrAsn: 1.409 ± 0.044	2.869ThrPro: 2.869 ± 0.059	1.414ThrGln: 1.414 ± 0.037	3.249ThrArg: 3.249 ± 0.058	2.768ThrSer: 2.768 ± 0.052	2.566ThrThr: 2.566 ± 0.059	4.181ThrVal: 4.181 ± 0.086	0.57ThrTrp: 0.57 ± 0.024	1.182ThrTyr: 1.182 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.465ValAla: 8.465 ± 0.101	0.571ValCys: 0.571 ± 0.022	4.15ValAsp: 4.15 ± 0.07	5.26ValGlu: 5.26 ± 0.075	2.781ValPhe: 2.781 ± 0.051	5.338ValGly: 5.338 ± 0.077	1.354ValHis: 1.354 ± 0.034	4.123ValIle: 4.123 ± 0.07	2.502ValLys: 2.502 ± 0.047	7.4ValLeu: 7.4 ± 0.084	1.971ValMet: 1.971 ± 0.046	2.052ValAsn: 2.052 ± 0.04	3.536ValPro: 3.536 ± 0.06	2.017ValGln: 2.017 ± 0.05	4.407ValArg: 4.407 ± 0.062	4.47ValSer: 4.47 ± 0.076	4.333ValThr: 4.333 ± 0.072	5.651ValVal: 5.651 ± 0.078	0.806ValTrp: 0.806 ± 0.026	1.53ValTyr: 1.53 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.131TrpAla: 1.131 ± 0.03	0.149TrpCys: 0.149 ± 0.012	0.628TrpAsp: 0.628 ± 0.024	0.588TrpGlu: 0.588 ± 0.024	0.539TrpPhe: 0.539 ± 0.023	0.805TrpGly: 0.805 ± 0.027	0.296TrpHis: 0.296 ± 0.017	0.602TrpIle: 0.602 ± 0.027	0.501TrpLys: 0.501 ± 0.022	1.508TrpLeu: 1.508 ± 0.042	0.377TrpMet: 0.377 ± 0.019	0.447TrpAsn: 0.447 ± 0.022	0.616TrpPro: 0.616 ± 0.026	0.555TrpGln: 0.555 ± 0.022	0.964TrpArg: 0.964 ± 0.038	0.757TrpSer: 0.757 ± 0.029	0.606TrpThr: 0.606 ± 0.024	0.781TrpVal: 0.781 ± 0.025	0.207TrpTrp: 0.207 ± 0.014	0.26TrpTyr: 0.26 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.337TyrAla: 2.337 ± 0.047	0.245TyrCys: 0.245 ± 0.013	1.474TyrAsp: 1.474 ± 0.043	1.415TyrGlu: 1.415 ± 0.042	0.959TyrPhe: 0.959 ± 0.035	2.044TyrGly: 2.044 ± 0.048	0.529TyrHis: 0.529 ± 0.021	0.949TyrIle: 0.949 ± 0.027	0.652TyrLys: 0.652 ± 0.023	2.254TyrLeu: 2.254 ± 0.045	0.503TyrMet: 0.503 ± 0.023	0.576TyrAsn: 0.576 ± 0.02	1.089TyrPro: 1.089 ± 0.034	0.745TyrGln: 0.745 ± 0.026	1.742TyrArg: 1.742 ± 0.041	1.241TyrSer: 1.241 ± 0.033	1.14TyrThr: 1.14 ± 0.035	1.647TyrVal: 1.647 ± 0.036	0.33TyrTrp: 0.33 ± 0.019	0.58TyrTyr: 0.58 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3449 proteins (1074602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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