Amino acid dipepetide frequency for Marinobacter mobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.481AlaAla: 10.481 ± 0.121	1.066AlaCys: 1.066 ± 0.033	5.981AlaAsp: 5.981 ± 0.075	6.824AlaGlu: 6.824 ± 0.091	3.546AlaPhe: 3.546 ± 0.054	8.446AlaGly: 8.446 ± 0.098	1.839AlaHis: 1.839 ± 0.043	5.521AlaIle: 5.521 ± 0.079	2.763AlaLys: 2.763 ± 0.056	11.874AlaLeu: 11.874 ± 0.136	2.997AlaMet: 2.997 ± 0.06	3.094AlaAsn: 3.094 ± 0.056	4.162AlaPro: 4.162 ± 0.075	3.775AlaGln: 3.775 ± 0.06	6.679AlaArg: 6.679 ± 0.087	6.129AlaSer: 6.129 ± 0.07	4.824AlaThr: 4.824 ± 0.08	7.183AlaVal: 7.183 ± 0.085	1.278AlaTrp: 1.278 ± 0.038	2.287AlaTyr: 2.287 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.835CysAla: 0.835 ± 0.034	0.135CysCys: 0.135 ± 0.012	0.589CysAsp: 0.589 ± 0.026	0.583CysGlu: 0.583 ± 0.021	0.37CysPhe: 0.37 ± 0.019	0.96CysGly: 0.96 ± 0.03	0.343CysHis: 0.343 ± 0.019	0.412CysIle: 0.412 ± 0.019	0.285CysLys: 0.285 ± 0.017	1.034CysLeu: 1.034 ± 0.032	0.196CysMet: 0.196 ± 0.013	0.278CysAsn: 0.278 ± 0.013	0.509CysPro: 0.509 ± 0.022	0.452CysGln: 0.452 ± 0.019	0.688CysArg: 0.688 ± 0.027	0.615CysSer: 0.615 ± 0.024	0.424CysThr: 0.424 ± 0.018	0.644CysVal: 0.644 ± 0.023	0.144CysTrp: 0.144 ± 0.012	0.26CysTyr: 0.26 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.323AspAla: 5.323 ± 0.071	0.541AspCys: 0.541 ± 0.023	3.655AspAsp: 3.655 ± 0.065	3.978AspGlu: 3.978 ± 0.063	2.223AspPhe: 2.223 ± 0.045	4.646AspGly: 4.646 ± 0.077	1.405AspHis: 1.405 ± 0.037	3.265AspIle: 3.265 ± 0.054	1.745AspLys: 1.745 ± 0.038	5.894AspLeu: 5.894 ± 0.085	1.428AspMet: 1.428 ± 0.037	2.048AspAsn: 2.048 ± 0.045	2.878AspPro: 2.878 ± 0.056	2.67AspGln: 2.67 ± 0.045	3.912AspArg: 3.912 ± 0.062	3.307AspSer: 3.307 ± 0.054	2.968AspThr: 2.968 ± 0.052	4.141AspVal: 4.141 ± 0.064	0.992AspTrp: 0.992 ± 0.032	1.911AspTyr: 1.911 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.797GluAla: 6.797 ± 0.093	0.483GluCys: 0.483 ± 0.023	3.161GluAsp: 3.161 ± 0.055	3.688GluGlu: 3.688 ± 0.072	2.155GluPhe: 2.155 ± 0.044	4.319GluGly: 4.319 ± 0.064	1.594GluHis: 1.594 ± 0.045	3.109GluIle: 3.109 ± 0.066	2.279GluLys: 2.279 ± 0.05	7.235GluLeu: 7.235 ± 0.088	1.452GluMet: 1.452 ± 0.039	1.945GluAsn: 1.945 ± 0.046	2.863GluPro: 2.863 ± 0.063	3.675GluGln: 3.675 ± 0.062	4.872GluArg: 4.872 ± 0.077	3.503GluSer: 3.503 ± 0.056	3.112GluThr: 3.112 ± 0.063	4.369GluVal: 4.369 ± 0.064	0.722GluTrp: 0.722 ± 0.025	1.387GluTyr: 1.387 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.319PheAla: 3.319 ± 0.051	0.448PheCys: 0.448 ± 0.019	2.481PheAsp: 2.481 ± 0.045	2.31PheGlu: 2.31 ± 0.05	1.44PhePhe: 1.44 ± 0.044	3.214PheGly: 3.214 ± 0.06	0.874PheHis: 0.874 ± 0.028	1.864PheIle: 1.864 ± 0.041	0.965PheLys: 0.965 ± 0.032	3.459PheLeu: 3.459 ± 0.067	0.895PheMet: 0.895 ± 0.031	1.382PheAsn: 1.382 ± 0.037	1.625PhePro: 1.625 ± 0.046	1.285PheGln: 1.285 ± 0.031	2.446PheArg: 2.446 ± 0.058	2.632PheSer: 2.632 ± 0.056	1.978PheThr: 1.978 ± 0.041	2.546PheVal: 2.546 ± 0.05	0.513PheTrp: 0.513 ± 0.025	1.102PheTyr: 1.102 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.937GlyAla: 6.937 ± 0.1	1.007GlyCys: 1.007 ± 0.032	4.509GlyAsp: 4.509 ± 0.07	4.968GlyGlu: 4.968 ± 0.064	3.398GlyPhe: 3.398 ± 0.061	5.99GlyGly: 5.99 ± 0.086	2.005GlyHis: 2.005 ± 0.042	4.493GlyIle: 4.493 ± 0.067	2.934GlyLys: 2.934 ± 0.058	8.602GlyLeu: 8.602 ± 0.1	2.241GlyMet: 2.241 ± 0.044	2.484GlyAsn: 2.484 ± 0.047	2.552GlyPro: 2.552 ± 0.041	3.569GlyGln: 3.569 ± 0.054	4.741GlyArg: 4.741 ± 0.071	4.47GlySer: 4.47 ± 0.064	3.848GlyThr: 3.848 ± 0.067	5.928GlyVal: 5.928 ± 0.078	1.246GlyTrp: 1.246 ± 0.036	2.566GlyTyr: 2.566 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.866HisAla: 1.866 ± 0.041	0.338HisCys: 0.338 ± 0.018	1.183HisAsp: 1.183 ± 0.035	1.167HisGlu: 1.167 ± 0.033	0.999HisPhe: 0.999 ± 0.029	1.896HisGly: 1.896 ± 0.039	0.739HisHis: 0.739 ± 0.028	1.125HisIle: 1.125 ± 0.031	0.661HisLys: 0.661 ± 0.023	2.422HisLeu: 2.422 ± 0.05	0.492HisMet: 0.492 ± 0.021	0.697HisAsn: 0.697 ± 0.025	1.419HisPro: 1.419 ± 0.038	1.144HisGln: 1.144 ± 0.033	1.569HisArg: 1.569 ± 0.037	1.354HisSer: 1.354 ± 0.035	1.039HisThr: 1.039 ± 0.036	1.259HisVal: 1.259 ± 0.034	0.458HisTrp: 0.458 ± 0.018	0.865HisTyr: 0.865 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.512IleAla: 5.512 ± 0.08	0.499IleCys: 0.499 ± 0.021	3.348IleAsp: 3.348 ± 0.059	3.507IleGlu: 3.507 ± 0.062	1.503IlePhe: 1.503 ± 0.039	4.258IleGly: 4.258 ± 0.071	1.223IleHis: 1.223 ± 0.034	2.363IleIle: 2.363 ± 0.052	1.61IleLys: 1.61 ± 0.044	4.553IleLeu: 4.553 ± 0.077	1.008IleMet: 1.008 ± 0.029	1.97IleAsn: 1.97 ± 0.046	2.529IlePro: 2.529 ± 0.045	1.849IleGln: 1.849 ± 0.041	3.663IleArg: 3.663 ± 0.058	3.245IleSer: 3.245 ± 0.058	2.907IleThr: 2.907 ± 0.055	3.391IleVal: 3.391 ± 0.063	0.527IleTrp: 0.527 ± 0.02	1.241IleTyr: 1.241 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.613LysAla: 3.613 ± 0.065	0.177LysCys: 0.177 ± 0.013	1.739LysAsp: 1.739 ± 0.044	1.777LysGlu: 1.777 ± 0.053	0.84LysPhe: 0.84 ± 0.029	2.416LysGly: 2.416 ± 0.056	0.682LysHis: 0.682 ± 0.025	1.49LysIle: 1.49 ± 0.04	1.373LysLys: 1.373 ± 0.039	3.283LysLeu: 3.283 ± 0.056	0.751LysMet: 0.751 ± 0.027	0.97LysAsn: 0.97 ± 0.034	1.758LysPro: 1.758 ± 0.045	1.413LysGln: 1.413 ± 0.037	2.108LysArg: 2.108 ± 0.047	1.81LysSer: 1.81 ± 0.04	1.791LysThr: 1.791 ± 0.042	2.543LysVal: 2.543 ± 0.052	0.32LysTrp: 0.32 ± 0.016	0.666LysTyr: 0.666 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.733LeuAla: 12.733 ± 0.13	1.022LeuCys: 1.022 ± 0.031	6.474LeuAsp: 6.474 ± 0.072	6.737LeuGlu: 6.737 ± 0.087	3.907LeuPhe: 3.907 ± 0.068	8.084LeuGly: 8.084 ± 0.107	2.067LeuHis: 2.067 ± 0.036	5.331LeuIle: 5.331 ± 0.073	3.963LeuLys: 3.963 ± 0.069	11.285LeuLeu: 11.285 ± 0.14	2.733LeuMet: 2.733 ± 0.053	3.702LeuAsn: 3.702 ± 0.059	5.621LeuPro: 5.621 ± 0.079	4.083LeuGln: 4.083 ± 0.063	6.561LeuArg: 6.561 ± 0.075	7.193LeuSer: 7.193 ± 0.089	6.175LeuThr: 6.175 ± 0.08	7.993LeuVal: 7.993 ± 0.1	1.324LeuTrp: 1.324 ± 0.034	2.466LeuTyr: 2.466 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.14MetAla: 3.14 ± 0.053	0.161MetCys: 0.161 ± 0.012	1.352MetAsp: 1.352 ± 0.034	1.334MetGlu: 1.334 ± 0.036	0.687MetPhe: 0.687 ± 0.028	1.857MetGly: 1.857 ± 0.041	0.458MetHis: 0.458 ± 0.02	1.229MetIle: 1.229 ± 0.034	1.046MetLys: 1.046 ± 0.03	2.576MetLeu: 2.576 ± 0.047	0.668MetMet: 0.668 ± 0.024	0.939MetAsn: 0.939 ± 0.03	1.344MetPro: 1.344 ± 0.03	0.911MetGln: 0.911 ± 0.028	1.274MetArg: 1.274 ± 0.035	1.738MetSer: 1.738 ± 0.038	1.735MetThr: 1.735 ± 0.037	1.853MetVal: 1.853 ± 0.039	0.171MetTrp: 0.171 ± 0.01	0.415MetTyr: 0.415 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.077AsnAla: 3.077 ± 0.059	0.313AsnCys: 0.313 ± 0.016	1.847AsnAsp: 1.847 ± 0.043	1.789AsnGlu: 1.789 ± 0.043	1.047AsnPhe: 1.047 ± 0.027	2.799AsnGly: 2.799 ± 0.057	0.793AsnHis: 0.793 ± 0.028	1.649AsnIle: 1.649 ± 0.042	0.892AsnLys: 0.892 ± 0.034	3.465AsnLeu: 3.465 ± 0.056	0.716AsnMet: 0.716 ± 0.023	1.155AsnAsn: 1.155 ± 0.036	2.22AsnPro: 2.22 ± 0.039	1.418AsnGln: 1.418 ± 0.036	2.348AsnArg: 2.348 ± 0.043	1.648AsnSer: 1.648 ± 0.042	1.708AsnThr: 1.708 ± 0.041	2.049AsnVal: 2.049 ± 0.043	0.46AsnTrp: 0.46 ± 0.021	0.911AsnTyr: 0.911 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.074ProAla: 5.074 ± 0.074	0.346ProCys: 0.346 ± 0.021	3.647ProAsp: 3.647 ± 0.06	4.152ProGlu: 4.152 ± 0.073	1.766ProPhe: 1.766 ± 0.038	4.185ProGly: 4.185 ± 0.063	0.923ProHis: 0.923 ± 0.032	2.012ProIle: 2.012 ± 0.042	1.342ProLys: 1.342 ± 0.036	5.039ProLeu: 5.039 ± 0.072	1.175ProMet: 1.175 ± 0.031	1.328ProAsn: 1.328 ± 0.032	1.905ProPro: 1.905 ± 0.053	1.914ProGln: 1.914 ± 0.045	2.362ProArg: 2.362 ± 0.05	2.564ProSer: 2.564 ± 0.047	2.061ProThr: 2.061 ± 0.047	4.275ProVal: 4.275 ± 0.063	0.715ProTrp: 0.715 ± 0.026	1.16ProTyr: 1.16 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	4.848GlnAla: 4.848 ± 0.076	0.368GlnCys: 0.368 ± 0.019	2.031GlnAsp: 2.031 ± 0.045	2.185GlnGlu: 2.185 ± 0.057	1.486GlnPhe: 1.486 ± 0.04	3.218GlnGly: 3.218 ± 0.047	0.973GlnHis: 0.973 ± 0.029	1.947GlnIle: 1.947 ± 0.037	1.325GlnLys: 1.325 ± 0.039	4.944GlnLeu: 4.944 ± 0.079	1.021GlnMet: 1.021 ± 0.03	1.156GlnAsn: 1.156 ± 0.03	2.267GlnPro: 2.267 ± 0.049	2.508GlnGln: 2.508 ± 0.054	3.208GlnArg: 3.208 ± 0.06	2.521GlnSer: 2.521 ± 0.049	2.121GlnThr: 2.121 ± 0.045	3.183GlnVal: 3.183 ± 0.056	0.722GlnTrp: 0.722 ± 0.026	0.966GlnTyr: 0.966 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	5.489ArgAla: 5.489 ± 0.073	0.605ArgCys: 0.605 ± 0.024	3.727ArgAsp: 3.727 ± 0.067	4.523ArgGlu: 4.523 ± 0.068	2.969ArgPhe: 2.969 ± 0.051	3.896ArgGly: 3.896 ± 0.065	1.772ArgHis: 1.772 ± 0.044	3.637ArgIle: 3.637 ± 0.053	2.441ArgLys: 2.441 ± 0.052	7.747ArgLeu: 7.747 ± 0.093	1.74ArgMet: 1.74 ± 0.042	2.23ArgAsn: 2.23 ± 0.045	2.752ArgPro: 2.752 ± 0.058	3.516ArgGln: 3.516 ± 0.067	4.555ArgArg: 4.555 ± 0.074	3.595ArgSer: 3.595 ± 0.057	2.895ArgThr: 2.895 ± 0.05	4.698ArgVal: 4.698 ± 0.076	1.094ArgTrp: 1.094 ± 0.032	2.211ArgTyr: 2.211 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.862SerAla: 5.862 ± 0.066	0.545SerCys: 0.545 ± 0.023	3.612SerAsp: 3.612 ± 0.056	3.741SerGlu: 3.741 ± 0.061	2.171SerPhe: 2.171 ± 0.041	5.663SerGly: 5.663 ± 0.075	1.469SerHis: 1.469 ± 0.042	2.794SerIle: 2.794 ± 0.057	1.709SerLys: 1.709 ± 0.041	6.75SerLeu: 6.75 ± 0.08	1.448SerMet: 1.448 ± 0.038	1.825SerAsn: 1.825 ± 0.043	2.95SerPro: 2.95 ± 0.059	2.457SerGln: 2.457 ± 0.051	3.986SerArg: 3.986 ± 0.062	3.435SerSer: 3.435 ± 0.06	2.743SerThr: 2.743 ± 0.049	4.29SerVal: 4.29 ± 0.05	0.856SerTrp: 0.856 ± 0.026	1.601SerTyr: 1.601 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.97ThrAla: 4.97 ± 0.078	0.484ThrCys: 0.484 ± 0.02	2.988ThrAsp: 2.988 ± 0.054	2.885ThrGlu: 2.885 ± 0.051	1.853ThrPhe: 1.853 ± 0.04	4.703ThrGly: 4.703 ± 0.063	1.04ThrHis: 1.04 ± 0.032	2.485ThrIle: 2.485 ± 0.049	1.011ThrLys: 1.011 ± 0.036	6.606ThrLeu: 6.606 ± 0.084	1.05ThrMet: 1.05 ± 0.032	1.46ThrAsn: 1.46 ± 0.032	3.113ThrPro: 3.113 ± 0.055	1.66ThrGln: 1.66 ± 0.036	3.28ThrArg: 3.28 ± 0.054	2.916ThrSer: 2.916 ± 0.048	2.694ThrThr: 2.694 ± 0.06	4.113ThrVal: 4.113 ± 0.059	0.646ThrTrp: 0.646 ± 0.025	1.235ThrTyr: 1.235 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.773ValAla: 7.773 ± 0.099	0.77ValCys: 0.77 ± 0.026	4.35ValAsp: 4.35 ± 0.073	4.537ValGlu: 4.537 ± 0.073	2.794ValPhe: 2.794 ± 0.043	4.987ValGly: 4.987 ± 0.07	1.438ValHis: 1.438 ± 0.038	4.217ValIle: 4.217 ± 0.064	2.158ValLys: 2.158 ± 0.049	7.468ValLeu: 7.468 ± 0.093	2.001ValMet: 2.001 ± 0.043	2.379ValAsn: 2.379 ± 0.048	3.463ValPro: 3.463 ± 0.058	2.331ValGln: 2.331 ± 0.045	4.559ValArg: 4.559 ± 0.073	4.88ValSer: 4.88 ± 0.064	4.315ValThr: 4.315 ± 0.068	6.087ValVal: 6.087 ± 0.086	0.875ValTrp: 0.875 ± 0.028	1.705ValTyr: 1.705 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.022TrpAla: 1.022 ± 0.03	0.162TrpCys: 0.162 ± 0.012	0.664TrpAsp: 0.664 ± 0.026	0.599TrpGlu: 0.599 ± 0.022	0.548TrpPhe: 0.548 ± 0.021	0.883TrpGly: 0.883 ± 0.025	0.377TrpHis: 0.377 ± 0.019	0.633TrpIle: 0.633 ± 0.025	0.374TrpLys: 0.374 ± 0.017	2.114TrpLeu: 2.114 ± 0.046	0.354TrpMet: 0.354 ± 0.017	0.429TrpAsn: 0.429 ± 0.019	0.641TrpPro: 0.641 ± 0.024	0.974TrpGln: 0.974 ± 0.031	1.013TrpArg: 1.013 ± 0.029	0.794TrpSer: 0.794 ± 0.03	0.599TrpThr: 0.599 ± 0.021	0.937TrpVal: 0.937 ± 0.031	0.217TrpTrp: 0.217 ± 0.015	0.356TrpTyr: 0.356 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.078TyrAla: 2.078 ± 0.045	0.283TyrCys: 0.283 ± 0.017	1.591TyrAsp: 1.591 ± 0.036	1.435TyrGlu: 1.435 ± 0.039	1.077TyrPhe: 1.077 ± 0.03	2.067TyrGly: 2.067 ± 0.047	0.683TyrHis: 0.683 ± 0.026	1.132TyrIle: 1.132 ± 0.029	0.643TyrLys: 0.643 ± 0.024	3.104TyrLeu: 3.104 ± 0.053	0.523TyrMet: 0.523 ± 0.022	0.831TyrAsn: 0.831 ± 0.027	1.375TyrPro: 1.375 ± 0.037	1.393TyrGln: 1.393 ± 0.033	2.268TyrArg: 2.268 ± 0.049	1.557TyrSer: 1.557 ± 0.041	1.259TyrThr: 1.259 ± 0.032	1.603TyrVal: 1.603 ± 0.038	0.409TyrTrp: 0.409 ± 0.02	0.796TyrTyr: 0.796 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3442 proteins (1144372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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