Amino acid dipepetide frequency for Marinilabiliaceae bacterium JC017

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.433AlaAla: 4.433 ± 0.064	0.722AlaCys: 0.722 ± 0.02	3.48AlaAsp: 3.48 ± 0.052	3.751AlaGlu: 3.751 ± 0.055	3.408AlaPhe: 3.408 ± 0.054	4.833AlaGly: 4.833 ± 0.073	1.241AlaHis: 1.241 ± 0.029	4.916AlaIle: 4.916 ± 0.065	3.834AlaLys: 3.834 ± 0.051	6.123AlaLeu: 6.123 ± 0.073	1.566AlaMet: 1.566 ± 0.034	3.185AlaAsn: 3.185 ± 0.045	1.946AlaPro: 1.946 ± 0.038	2.351AlaGln: 2.351 ± 0.044	2.751AlaArg: 2.751 ± 0.047	4.047AlaSer: 4.047 ± 0.06	3.324AlaThr: 3.324 ± 0.06	3.985AlaVal: 3.985 ± 0.054	0.742AlaTrp: 0.742 ± 0.023	2.524AlaTyr: 2.524 ± 0.039	0.019AlaXaa: 0.019 ± 0.003
Cys	0.506CysAla: 0.506 ± 0.021	0.159CysCys: 0.159 ± 0.011	0.537CysAsp: 0.537 ± 0.02	0.608CysGlu: 0.608 ± 0.021	0.544CysPhe: 0.544 ± 0.018	0.769CysGly: 0.769 ± 0.023	0.252CysHis: 0.252 ± 0.013	0.659CysIle: 0.659 ± 0.02	0.611CysLys: 0.611 ± 0.019	0.948CysLeu: 0.948 ± 0.026	0.225CysMet: 0.225 ± 0.013	0.53CysAsn: 0.53 ± 0.018	0.445CysPro: 0.445 ± 0.02	0.399CysGln: 0.399 ± 0.016	0.448CysArg: 0.448 ± 0.018	0.657CysSer: 0.657 ± 0.02	0.476CysThr: 0.476 ± 0.02	0.615CysVal: 0.615 ± 0.018	0.113CysTrp: 0.113 ± 0.008	0.434CysTyr: 0.434 ± 0.017	0.002CysXaa: 0.002 ± 0.001
Asp	3.412AspAla: 3.412 ± 0.054	0.494AspCys: 0.494 ± 0.018	3.009AspAsp: 3.009 ± 0.052	3.835AspGlu: 3.835 ± 0.046	3.167AspPhe: 3.167 ± 0.044	3.807AspGly: 3.807 ± 0.083	1.077AspHis: 1.077 ± 0.028	4.101AspIle: 4.101 ± 0.052	3.908AspLys: 3.908 ± 0.052	5.216AspLeu: 5.216 ± 0.059	1.262AspMet: 1.262 ± 0.027	3.114AspAsn: 3.114 ± 0.052	2.029AspPro: 2.029 ± 0.042	1.961AspGln: 1.961 ± 0.034	2.19AspArg: 2.19 ± 0.035	3.015AspSer: 3.015 ± 0.052	2.39AspThr: 2.39 ± 0.045	3.557AspVal: 3.557 ± 0.052	0.796AspTrp: 0.796 ± 0.022	2.85AspTyr: 2.85 ± 0.045	0.015AspXaa: 0.015 ± 0.005
Glu	4.508GluAla: 4.508 ± 0.06	0.453GluCys: 0.453 ± 0.018	3.205GluAsp: 3.205 ± 0.048	4.976GluGlu: 4.976 ± 0.074	2.674GluPhe: 2.674 ± 0.047	4.115GluGly: 4.115 ± 0.055	1.118GluHis: 1.118 ± 0.024	5.059GluIle: 5.059 ± 0.064	5.906GluLys: 5.906 ± 0.075	6.374GluLeu: 6.374 ± 0.077	1.95GluMet: 1.95 ± 0.035	3.772GluAsn: 3.772 ± 0.052	1.746GluPro: 1.746 ± 0.032	2.549GluGln: 2.549 ± 0.04	2.682GluArg: 2.682 ± 0.047	3.387GluSer: 3.387 ± 0.042	3.292GluThr: 3.292 ± 0.042	4.625GluVal: 4.625 ± 0.056	0.769GluTrp: 0.769 ± 0.024	2.483GluTyr: 2.483 ± 0.037	0.017GluXaa: 0.017 ± 0.003
Phe	2.692PheAla: 2.692 ± 0.045	0.546PheCys: 0.546 ± 0.019	3.069PheAsp: 3.069 ± 0.045	3.011PheGlu: 3.011 ± 0.043	2.749PhePhe: 2.749 ± 0.052	3.215PheGly: 3.215 ± 0.048	1.008PheHis: 1.008 ± 0.027	3.643PheIle: 3.643 ± 0.053	3.266PheLys: 3.266 ± 0.052	4.578PheLeu: 4.578 ± 0.067	1.22PheMet: 1.22 ± 0.032	3.079PheAsn: 3.079 ± 0.041	1.753PhePro: 1.753 ± 0.034	1.48PheGln: 1.48 ± 0.031	2.062PheArg: 2.062 ± 0.037	3.94PheSer: 3.94 ± 0.055	2.818PheThr: 2.818 ± 0.044	2.985PheVal: 2.985 ± 0.047	0.633PheTrp: 0.633 ± 0.02	2.112PheTyr: 2.112 ± 0.04	0.02PheXaa: 0.02 ± 0.006
Gly	4.122GlyAla: 4.122 ± 0.059	0.81GlyCys: 0.81 ± 0.031	3.61GlyAsp: 3.61 ± 0.062	4.136GlyGlu: 4.136 ± 0.053	3.505GlyPhe: 3.505 ± 0.046	4.534GlyGly: 4.534 ± 0.088	1.313GlyHis: 1.313 ± 0.031	5.406GlyIle: 5.406 ± 0.07	4.995GlyLys: 4.995 ± 0.061	6.028GlyLeu: 6.028 ± 0.07	1.885GlyMet: 1.885 ± 0.037	3.512GlyAsn: 3.512 ± 0.058	1.545GlyPro: 1.545 ± 0.032	2.219GlyGln: 2.219 ± 0.041	2.601GlyArg: 2.601 ± 0.037	3.975GlySer: 3.975 ± 0.059	3.808GlyThr: 3.808 ± 0.083	4.601GlyVal: 4.601 ± 0.056	0.905GlyTrp: 0.905 ± 0.028	3.125GlyTyr: 3.125 ± 0.053	0.025GlyXaa: 0.025 ± 0.005
His	1.163HisAla: 1.163 ± 0.026	0.261HisCys: 0.261 ± 0.011	0.958HisAsp: 0.958 ± 0.024	1.117HisGlu: 1.117 ± 0.025	1.248HisPhe: 1.248 ± 0.027	1.243HisGly: 1.243 ± 0.03	0.612HisHis: 0.612 ± 0.021	1.452HisIle: 1.452 ± 0.029	1.228HisLys: 1.228 ± 0.032	2.22HisLeu: 2.22 ± 0.039	0.415HisMet: 0.415 ± 0.018	0.988HisAsn: 0.988 ± 0.023	1.07HisPro: 1.07 ± 0.025	0.899HisGln: 0.899 ± 0.026	0.835HisArg: 0.835 ± 0.023	1.162HisSer: 1.162 ± 0.026	1.051HisThr: 1.051 ± 0.023	1.081HisVal: 1.081 ± 0.026	0.299HisTrp: 0.299 ± 0.014	1.025HisTyr: 1.025 ± 0.023	0.008HisXaa: 0.008 ± 0.002
Ile	4.653IleAla: 4.653 ± 0.059	0.752IleCys: 0.752 ± 0.022	4.588IleAsp: 4.588 ± 0.053	4.996IleGlu: 4.996 ± 0.064	3.088IlePhe: 3.088 ± 0.048	4.749IleGly: 4.749 ± 0.07	1.539IleHis: 1.539 ± 0.033	5.409IleIle: 5.409 ± 0.069	5.372IleLys: 5.372 ± 0.074	6.255IleLeu: 6.255 ± 0.082	1.445IleMet: 1.445 ± 0.029	4.499IleAsn: 4.499 ± 0.053	3.189IlePro: 3.189 ± 0.046	2.392IleGln: 2.392 ± 0.038	3.192IleArg: 3.192 ± 0.053	5.299IleSer: 5.299 ± 0.06	4.501IleThr: 4.501 ± 0.061	4.225IleVal: 4.225 ± 0.053	0.796IleTrp: 0.796 ± 0.022	2.731IleTyr: 2.731 ± 0.037	0.03IleXaa: 0.03 ± 0.006
Lys	4.944LysAla: 4.944 ± 0.061	0.533LysCys: 0.533 ± 0.02	3.925LysAsp: 3.925 ± 0.049	6.032LysGlu: 6.032 ± 0.078	2.355LysPhe: 2.355 ± 0.038	4.819LysGly: 4.819 ± 0.063	1.449LysHis: 1.449 ± 0.029	4.944LysIle: 4.944 ± 0.058	6.084LysLys: 6.084 ± 0.078	5.902LysLeu: 5.902 ± 0.061	1.891LysMet: 1.891 ± 0.033	4.154LysAsn: 4.154 ± 0.051	2.378LysPro: 2.378 ± 0.037	2.745LysGln: 2.745 ± 0.046	3.208LysArg: 3.208 ± 0.045	4.069LysSer: 4.069 ± 0.051	4.025LysThr: 4.025 ± 0.052	4.812LysVal: 4.812 ± 0.061	0.901LysTrp: 0.901 ± 0.022	3.018LysTyr: 3.018 ± 0.044	0.023LysXaa: 0.023 ± 0.006
Leu	6.001LeuAla: 6.001 ± 0.068	0.887LeuCys: 0.887 ± 0.022	4.793LeuAsp: 4.793 ± 0.061	5.683LeuGlu: 5.683 ± 0.072	5.029LeuPhe: 5.029 ± 0.067	5.498LeuGly: 5.498 ± 0.077	1.731LeuHis: 1.731 ± 0.033	6.686LeuIle: 6.686 ± 0.084	7.55LeuLys: 7.55 ± 0.075	9.188LeuLeu: 9.188 ± 0.115	2.305LeuMet: 2.305 ± 0.038	5.316LeuAsn: 5.316 ± 0.072	4.002LeuPro: 4.002 ± 0.052	3.177LeuGln: 3.177 ± 0.05	3.595LeuArg: 3.595 ± 0.045	6.934LeuSer: 6.934 ± 0.071	5.145LeuThr: 5.145 ± 0.051	5.729LeuVal: 5.729 ± 0.068	0.93LeuTrp: 0.93 ± 0.027	3.253LeuTyr: 3.253 ± 0.048	0.042LeuXaa: 0.042 ± 0.006
Met	1.992MetAla: 1.992 ± 0.035	0.206MetCys: 0.206 ± 0.011	1.344MetAsp: 1.344 ± 0.029	1.688MetGlu: 1.688 ± 0.033	0.858MetPhe: 0.858 ± 0.026	1.788MetGly: 1.788 ± 0.037	0.479MetHis: 0.479 ± 0.017	1.568MetIle: 1.568 ± 0.032	2.103MetLys: 2.103 ± 0.037	2.055MetLeu: 2.055 ± 0.039	0.654MetMet: 0.654 ± 0.021	1.408MetAsn: 1.408 ± 0.028	1.095MetPro: 1.095 ± 0.026	0.888MetGln: 0.888 ± 0.02	1.033MetArg: 1.033 ± 0.024	1.379MetSer: 1.379 ± 0.031	1.277MetThr: 1.277 ± 0.025	1.77MetVal: 1.77 ± 0.034	0.208MetTrp: 0.208 ± 0.011	0.653MetTyr: 0.653 ± 0.02	0.01MetXaa: 0.01 ± 0.003
Asn	3.277AsnAla: 3.277 ± 0.05	0.566AsnCys: 0.566 ± 0.021	2.938AsnAsp: 2.938 ± 0.055	3.416AsnGlu: 3.416 ± 0.045	2.416AsnPhe: 2.416 ± 0.046	3.938AsnGly: 3.938 ± 0.068	1.29AsnHis: 1.29 ± 0.03	4.118AsnIle: 4.118 ± 0.051	3.979AsnLys: 3.979 ± 0.053	5.019AsnLeu: 5.019 ± 0.064	1.319AsnMet: 1.319 ± 0.027	3.353AsnAsn: 3.353 ± 0.064	2.514AsnPro: 2.514 ± 0.039	2.264AsnGln: 2.264 ± 0.041	2.495AsnArg: 2.495 ± 0.04	3.226AsnSer: 3.226 ± 0.056	3.086AsnThr: 3.086 ± 0.052	3.212AsnVal: 3.212 ± 0.056	0.804AsnTrp: 0.804 ± 0.025	2.583AsnTyr: 2.583 ± 0.04	0.019AsnXaa: 0.019 ± 0.005
Pro	2.478ProAla: 2.478 ± 0.04	0.303ProCys: 0.303 ± 0.015	2.476ProAsp: 2.476 ± 0.04	3.095ProGlu: 3.095 ± 0.04	1.995ProPhe: 1.995 ± 0.035	2.703ProGly: 2.703 ± 0.041	0.78ProHis: 0.78 ± 0.021	2.316ProIle: 2.316 ± 0.037	1.996ProLys: 1.996 ± 0.037	3.255ProLeu: 3.255 ± 0.049	0.791ProMet: 0.791 ± 0.021	1.704ProAsn: 1.704 ± 0.037	0.988ProPro: 0.988 ± 0.026	1.342ProGln: 1.342 ± 0.032	1.238ProArg: 1.238 ± 0.029	2.175ProSer: 2.175 ± 0.043	1.737ProThr: 1.737 ± 0.033	3.154ProVal: 3.154 ± 0.051	0.438ProTrp: 0.438 ± 0.017	1.523ProTyr: 1.523 ± 0.031	0.015ProXaa: 0.015 ± 0.003
Gln	2.365GlnAla: 2.365 ± 0.041	0.299GlnCys: 0.299 ± 0.014	1.569GlnAsp: 1.569 ± 0.03	2.416GlnGlu: 2.416 ± 0.039	1.637GlnPhe: 1.637 ± 0.034	2.058GlnGly: 2.058 ± 0.034	0.714GlnHis: 0.714 ± 0.024	2.539GlnIle: 2.539 ± 0.039	2.817GlnLys: 2.817 ± 0.04	3.893GlnLeu: 3.893 ± 0.061	0.998GlnMet: 0.998 ± 0.025	1.875GlnAsn: 1.875 ± 0.039	1.298GlnPro: 1.298 ± 0.034	1.68GlnGln: 1.68 ± 0.042	1.501GlnArg: 1.501 ± 0.032	2.107GlnSer: 2.107 ± 0.034	1.919GlnThr: 1.919 ± 0.037	2.41GlnVal: 2.41 ± 0.035	0.482GlnTrp: 0.482 ± 0.019	1.435GlnTyr: 1.435 ± 0.031	0.01GlnXaa: 0.01 ± 0.003
Arg	2.221ArgAla: 2.221 ± 0.037	0.386ArgCys: 0.386 ± 0.014	2.134ArgAsp: 2.134 ± 0.041	2.796ArgGlu: 2.796 ± 0.039	2.315ArgPhe: 2.315 ± 0.046	2.219ArgGly: 2.219 ± 0.045	0.88ArgHis: 0.88 ± 0.026	3.369ArgIle: 3.369 ± 0.045	3.289ArgLys: 3.289 ± 0.047	4.176ArgLeu: 4.176 ± 0.063	1.185ArgMet: 1.185 ± 0.027	2.266ArgAsn: 2.266 ± 0.035	1.348ArgPro: 1.348 ± 0.03	1.631ArgGln: 1.631 ± 0.035	1.87ArgArg: 1.87 ± 0.041	2.249ArgSer: 2.249 ± 0.04	1.882ArgThr: 1.882 ± 0.036	2.485ArgVal: 2.485 ± 0.041	0.567ArgTrp: 0.567 ± 0.021	1.924ArgTyr: 1.924 ± 0.038	0.022ArgXaa: 0.022 ± 0.004
Ser	3.79SerAla: 3.79 ± 0.05	0.695SerCys: 0.695 ± 0.019	3.572SerAsp: 3.572 ± 0.055	3.723SerGlu: 3.723 ± 0.049	3.767SerPhe: 3.767 ± 0.045	4.759SerGly: 4.759 ± 0.079	1.345SerHis: 1.345 ± 0.029	4.749SerIle: 4.749 ± 0.052	3.859SerLys: 3.859 ± 0.054	6.206SerLeu: 6.206 ± 0.068	1.464SerMet: 1.464 ± 0.029	3.302SerAsn: 3.302 ± 0.049	2.224SerPro: 2.224 ± 0.037	2.245SerGln: 2.245 ± 0.036	2.515SerArg: 2.515 ± 0.04	4.184SerSer: 4.184 ± 0.063	3.206SerThr: 3.206 ± 0.042	4.225SerVal: 4.225 ± 0.051	0.828SerTrp: 0.828 ± 0.023	2.741SerTyr: 2.741 ± 0.044	0.023SerXaa: 0.023 ± 0.005
Thr	3.364ThrAla: 3.364 ± 0.059	0.5ThrCys: 0.5 ± 0.019	3.138ThrAsp: 3.138 ± 0.062	2.994ThrGlu: 2.994 ± 0.048	2.654ThrPhe: 2.654 ± 0.045	4.26ThrGly: 4.26 ± 0.058	1.088ThrHis: 1.088 ± 0.027	4.461ThrIle: 4.461 ± 0.067	3.066ThrLys: 3.066 ± 0.046	5.026ThrLeu: 5.026 ± 0.06	1.051ThrMet: 1.051 ± 0.024	2.897ThrAsn: 2.897 ± 0.043	2.49ThrPro: 2.49 ± 0.037	1.761ThrGln: 1.761 ± 0.036	1.997ThrArg: 1.997 ± 0.041	3.4ThrSer: 3.4 ± 0.045	3.169ThrThr: 3.169 ± 0.05	3.383ThrVal: 3.383 ± 0.056	0.652ThrTrp: 0.652 ± 0.029	2.171ThrTyr: 2.171 ± 0.045	0.02ThrXaa: 0.02 ± 0.004
Val	4.199ValAla: 4.199 ± 0.054	0.698ValCys: 0.698 ± 0.023	3.764ValAsp: 3.764 ± 0.057	4.123ValGlu: 4.123 ± 0.053	3.468ValPhe: 3.468 ± 0.049	3.754ValGly: 3.754 ± 0.058	1.088ValHis: 1.088 ± 0.028	4.921ValIle: 4.921 ± 0.059	4.681ValLys: 4.681 ± 0.053	5.732ValLeu: 5.732 ± 0.075	1.618ValMet: 1.618 ± 0.034	3.694ValAsn: 3.694 ± 0.051	2.404ValPro: 2.404 ± 0.039	1.775ValGln: 1.775 ± 0.031	2.428ValArg: 2.428 ± 0.041	4.513ValSer: 4.513 ± 0.047	3.657ValThr: 3.657 ± 0.071	4.74ValVal: 4.74 ± 0.057	0.691ValTrp: 0.691 ± 0.021	2.48ValTyr: 2.48 ± 0.041	0.022ValXaa: 0.022 ± 0.004
Trp	0.664TrpAla: 0.664 ± 0.021	0.155TrpCys: 0.155 ± 0.01	0.748TrpAsp: 0.748 ± 0.025	0.795TrpGlu: 0.795 ± 0.022	0.616TrpPhe: 0.616 ± 0.022	0.863TrpGly: 0.863 ± 0.023	0.311TrpHis: 0.311 ± 0.014	0.823TrpIle: 0.823 ± 0.019	0.861TrpLys: 0.861 ± 0.024	1.165TrpLeu: 1.165 ± 0.028	0.361TrpMet: 0.361 ± 0.018	0.683TrpAsn: 0.683 ± 0.023	0.31TrpPro: 0.31 ± 0.015	0.583TrpGln: 0.583 ± 0.018	0.562TrpArg: 0.562 ± 0.019	0.762TrpSer: 0.762 ± 0.025	0.58TrpThr: 0.58 ± 0.019	0.756TrpVal: 0.756 ± 0.023	0.187TrpTrp: 0.187 ± 0.01	0.507TrpTyr: 0.507 ± 0.019	0.008TrpXaa: 0.008 ± 0.002
Tyr	2.385TyrAla: 2.385 ± 0.04	0.506TyrCys: 0.506 ± 0.019	2.333TyrAsp: 2.333 ± 0.042	2.458TyrGlu: 2.458 ± 0.034	2.369TyrPhe: 2.369 ± 0.04	2.71TyrGly: 2.71 ± 0.05	1.01TyrHis: 1.01 ± 0.024	2.52TyrIle: 2.52 ± 0.041	2.78TyrLys: 2.78 ± 0.044	4.075TyrLeu: 4.075 ± 0.056	0.842TyrMet: 0.842 ± 0.024	2.482TyrAsn: 2.482 ± 0.045	1.712TyrPro: 1.712 ± 0.033	1.668TyrGln: 1.668 ± 0.03	1.985TyrArg: 1.985 ± 0.034	2.923TyrSer: 2.923 ± 0.046	2.182TyrThr: 2.182 ± 0.042	2.079TyrVal: 2.079 ± 0.04	0.556TyrTrp: 0.556 ± 0.02	2.038TyrTyr: 2.038 ± 0.036	0.008TyrXaa: 0.008 ± 0.002
Xaa	0.014XaaAla: 0.014 ± 0.003	0.006XaaCys: 0.006 ± 0.002	0.016XaaAsp: 0.016 ± 0.004	0.011XaaGlu: 0.011 ± 0.003	0.017XaaPhe: 0.017 ± 0.004	0.024XaaGly: 0.024 ± 0.005	0.009XaaHis: 0.009 ± 0.003	0.038XaaIle: 0.038 ± 0.007	0.027XaaLys: 0.027 ± 0.006	0.041XaaLeu: 0.041 ± 0.007	0.009XaaMet: 0.009 ± 0.002	0.02XaaAsn: 0.02 ± 0.006	0.016XaaPro: 0.016 ± 0.003	0.013XaaGln: 0.013 ± 0.003	0.024XaaArg: 0.024 ± 0.006	0.021XaaSer: 0.021 ± 0.005	0.017XaaThr: 0.017 ± 0.004	0.023XaaVal: 0.023 ± 0.004	0.004XaaTrp: 0.004 ± 0.002	0.008XaaTyr: 0.008 ± 0.002	0.04XaaXaa: 0.04 ± 0.01

Statistics based on 4913 proteins (1713457 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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