Amino acid dipepetide frequency for Ferrimonas sp. IMCC35002

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.003AlaAla: 9.003 ± 0.099	1.047AlaCys: 1.047 ± 0.032	5.167AlaAsp: 5.167 ± 0.066	5.977AlaGlu: 5.977 ± 0.076	3.382AlaPhe: 3.382 ± 0.058	6.349AlaGly: 6.349 ± 0.086	1.871AlaHis: 1.871 ± 0.039	5.9AlaIle: 5.9 ± 0.073	5.074AlaLys: 5.074 ± 0.068	11.026AlaLeu: 11.026 ± 0.12	2.995AlaMet: 2.995 ± 0.046	3.812AlaAsn: 3.812 ± 0.06	3.542AlaPro: 3.542 ± 0.062	4.818AlaGln: 4.818 ± 0.068	3.953AlaArg: 3.953 ± 0.058	5.964AlaSer: 5.964 ± 0.075	4.787AlaThr: 4.787 ± 0.067	5.969AlaVal: 5.969 ± 0.072	1.117AlaTrp: 1.117 ± 0.029	2.338AlaTyr: 2.338 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.891CysAla: 0.891 ± 0.026	0.18CysCys: 0.18 ± 0.013	0.635CysAsp: 0.635 ± 0.02	0.56CysGlu: 0.56 ± 0.023	0.384CysPhe: 0.384 ± 0.015	1.015CysGly: 1.015 ± 0.031	0.557CysHis: 0.557 ± 0.035	0.517CysIle: 0.517 ± 0.021	0.353CysLys: 0.353 ± 0.017	1.006CysLeu: 1.006 ± 0.028	0.208CysMet: 0.208 ± 0.015	0.321CysAsn: 0.321 ± 0.015	0.506CysPro: 0.506 ± 0.024	0.652CysGln: 0.652 ± 0.022	0.615CysArg: 0.615 ± 0.025	0.7CysSer: 0.7 ± 0.024	0.444CysThr: 0.444 ± 0.02	0.6CysVal: 0.6 ± 0.022	0.147CysTrp: 0.147 ± 0.011	0.326CysTyr: 0.326 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.516AspAla: 5.516 ± 0.069	0.586AspCys: 0.586 ± 0.024	3.444AspAsp: 3.444 ± 0.086	3.592AspGlu: 3.592 ± 0.067	2.187AspPhe: 2.187 ± 0.046	4.552AspGly: 4.552 ± 0.092	1.272AspHis: 1.272 ± 0.034	3.038AspIle: 3.038 ± 0.052	2.742AspLys: 2.742 ± 0.05	5.402AspLeu: 5.402 ± 0.074	1.235AspMet: 1.235 ± 0.027	2.489AspAsn: 2.489 ± 0.055	2.362AspPro: 2.362 ± 0.053	2.231AspGln: 2.231 ± 0.048	2.571AspArg: 2.571 ± 0.046	3.593AspSer: 3.593 ± 0.076	2.855AspThr: 2.855 ± 0.047	3.296AspVal: 3.296 ± 0.053	0.949AspTrp: 0.949 ± 0.027	2.096AspTyr: 2.096 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.722GluAla: 5.722 ± 0.075	0.517GluCys: 0.517 ± 0.022	2.538GluAsp: 2.538 ± 0.049	3.184GluGlu: 3.184 ± 0.062	2.375GluPhe: 2.375 ± 0.044	3.731GluGly: 3.731 ± 0.063	1.52GluHis: 1.52 ± 0.038	3.123GluIle: 3.123 ± 0.046	2.452GluLys: 2.452 ± 0.056	7.87GluLeu: 7.87 ± 0.092	1.678GluMet: 1.678 ± 0.033	1.801GluAsn: 1.801 ± 0.036	2.373GluPro: 2.373 ± 0.058	4.575GluGln: 4.575 ± 0.075	3.717GluArg: 3.717 ± 0.06	3.414GluSer: 3.414 ± 0.048	2.861GluThr: 2.861 ± 0.048	4.601GluVal: 4.601 ± 0.065	0.662GluTrp: 0.662 ± 0.023	1.592GluTyr: 1.592 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.645PheAla: 3.645 ± 0.057	0.442PheCys: 0.442 ± 0.018	2.947PheAsp: 2.947 ± 0.053	2.631PheGlu: 2.631 ± 0.05	1.355PhePhe: 1.355 ± 0.036	3.286PheGly: 3.286 ± 0.059	0.784PheHis: 0.784 ± 0.027	2.135PheIle: 2.135 ± 0.041	1.573PheLys: 1.573 ± 0.031	2.95PheLeu: 2.95 ± 0.059	0.934PheMet: 0.934 ± 0.028	1.716PheAsn: 1.716 ± 0.029	1.275PhePro: 1.275 ± 0.031	1.203PheGln: 1.203 ± 0.032	1.51PheArg: 1.51 ± 0.034	2.917PheSer: 2.917 ± 0.045	2.084PheThr: 2.084 ± 0.044	2.524PheVal: 2.524 ± 0.051	0.504PheTrp: 0.504 ± 0.02	1.21PheTyr: 1.21 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.161GlyAla: 6.161 ± 0.088	1.03GlyCys: 1.03 ± 0.028	4.411GlyAsp: 4.411 ± 0.105	4.691GlyGlu: 4.691 ± 0.079	3.365GlyPhe: 3.365 ± 0.056	5.348GlyGly: 5.348 ± 0.104	1.808GlyHis: 1.808 ± 0.039	4.388GlyIle: 4.388 ± 0.061	3.721GlyLys: 3.721 ± 0.058	7.495GlyLeu: 7.495 ± 0.088	2.165GlyMet: 2.165 ± 0.049	2.698GlyAsn: 2.698 ± 0.066	1.929GlyPro: 1.929 ± 0.039	3.743GlyGln: 3.743 ± 0.058	3.585GlyArg: 3.585 ± 0.057	4.476GlySer: 4.476 ± 0.069	3.353GlyThr: 3.353 ± 0.055	5.49GlyVal: 5.49 ± 0.07	1.097GlyTrp: 1.097 ± 0.03	2.544GlyTyr: 2.544 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.699HisAla: 1.699 ± 0.038	0.42HisCys: 0.42 ± 0.018	1.063HisAsp: 1.063 ± 0.031	1.025HisGlu: 1.025 ± 0.03	1.055HisPhe: 1.055 ± 0.031	1.851HisGly: 1.851 ± 0.039	0.826HisHis: 0.826 ± 0.034	1.13HisIle: 1.13 ± 0.03	0.928HisLys: 0.928 ± 0.027	2.445HisLeu: 2.445 ± 0.045	0.486HisMet: 0.486 ± 0.019	0.912HisAsn: 0.912 ± 0.025	1.333HisPro: 1.333 ± 0.038	1.719HisGln: 1.719 ± 0.041	1.331HisArg: 1.331 ± 0.034	1.528HisSer: 1.528 ± 0.033	1.093HisThr: 1.093 ± 0.027	1.013HisVal: 1.013 ± 0.03	0.498HisTrp: 0.498 ± 0.02	0.951HisTyr: 0.951 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.865IleAla: 5.865 ± 0.078	0.553IleCys: 0.553 ± 0.021	3.904IleAsp: 3.904 ± 0.064	4.318IleGlu: 4.318 ± 0.061	1.554IlePhe: 1.554 ± 0.044	4.395IleGly: 4.395 ± 0.07	1.164IleHis: 1.164 ± 0.029	2.633IleIle: 2.633 ± 0.051	2.506IleLys: 2.506 ± 0.049	4.261IleLeu: 4.261 ± 0.066	1.06IleMet: 1.06 ± 0.033	2.436IleAsn: 2.436 ± 0.042	2.171IlePro: 2.171 ± 0.043	1.949IleGln: 1.949 ± 0.038	2.651IleArg: 2.651 ± 0.044	3.736IleSer: 3.736 ± 0.059	3.21IleThr: 3.21 ± 0.047	3.225IleVal: 3.225 ± 0.054	0.596IleTrp: 0.596 ± 0.022	1.374IleTyr: 1.374 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.672LysAla: 4.672 ± 0.066	0.285LysCys: 0.285 ± 0.017	2.132LysAsp: 2.132 ± 0.044	2.444LysGlu: 2.444 ± 0.051	1.306LysPhe: 1.306 ± 0.032	3.159LysGly: 3.159 ± 0.048	1.019LysHis: 1.019 ± 0.027	1.963LysIle: 1.963 ± 0.041	1.831LysLys: 1.831 ± 0.053	5.166LysLeu: 5.166 ± 0.064	1.235LysMet: 1.235 ± 0.032	1.295LysAsn: 1.295 ± 0.034	2.352LysPro: 2.352 ± 0.056	3.01LysGln: 3.01 ± 0.055	2.776LysArg: 2.776 ± 0.047	2.526LysSer: 2.526 ± 0.047	2.227LysThr: 2.227 ± 0.043	3.574LysVal: 3.574 ± 0.053	0.513LysTrp: 0.513 ± 0.018	1.04LysTyr: 1.04 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.502LeuAla: 11.502 ± 0.105	1.191LeuCys: 1.191 ± 0.036	5.996LeuAsp: 5.996 ± 0.082	6.506LeuGlu: 6.506 ± 0.085	4.076LeuPhe: 4.076 ± 0.069	7.804LeuGly: 7.804 ± 0.097	2.083LeuHis: 2.083 ± 0.039	5.531LeuIle: 5.531 ± 0.074	5.302LeuLys: 5.302 ± 0.074	11.689LeuLeu: 11.689 ± 0.148	3.165LeuMet: 3.165 ± 0.055	4.394LeuAsn: 4.394 ± 0.066	5.456LeuPro: 5.456 ± 0.075	4.192LeuGln: 4.192 ± 0.062	4.591LeuArg: 4.591 ± 0.063	8.458LeuSer: 8.458 ± 0.092	6.685LeuThr: 6.685 ± 0.079	7.566LeuVal: 7.566 ± 0.087	1.424LeuTrp: 1.424 ± 0.043	2.681LeuTyr: 2.681 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.06MetAla: 3.06 ± 0.047	0.184MetCys: 0.184 ± 0.012	1.405MetAsp: 1.405 ± 0.035	1.431MetGlu: 1.431 ± 0.037	0.757MetPhe: 0.757 ± 0.027	1.892MetGly: 1.892 ± 0.046	0.476MetHis: 0.476 ± 0.021	1.3MetIle: 1.3 ± 0.031	1.318MetLys: 1.318 ± 0.028	2.922MetLeu: 2.922 ± 0.052	0.889MetMet: 0.889 ± 0.027	0.987MetAsn: 0.987 ± 0.026	1.288MetPro: 1.288 ± 0.032	1.178MetGln: 1.178 ± 0.032	1.252MetArg: 1.252 ± 0.031	1.784MetSer: 1.784 ± 0.037	1.687MetThr: 1.687 ± 0.036	2.076MetVal: 2.076 ± 0.04	0.252MetTrp: 0.252 ± 0.013	0.412MetTyr: 0.412 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.353AsnAla: 3.353 ± 0.049	0.409AsnCys: 0.409 ± 0.018	2.145AsnAsp: 2.145 ± 0.056	1.938AsnGlu: 1.938 ± 0.038	1.33AsnPhe: 1.33 ± 0.032	2.949AsnGly: 2.949 ± 0.059	0.989AsnHis: 0.989 ± 0.023	1.951AsnIle: 1.951 ± 0.044	1.474AsnLys: 1.474 ± 0.031	4.133AsnLeu: 4.133 ± 0.063	0.806AsnMet: 0.806 ± 0.024	1.508AsnAsn: 1.508 ± 0.04	2.104AsnPro: 2.104 ± 0.046	2.326AsnGln: 2.326 ± 0.053	2.098AsnArg: 2.098 ± 0.042	2.163AsnSer: 2.163 ± 0.044	1.832AsnThr: 1.832 ± 0.041	2.161AsnVal: 2.161 ± 0.038	0.642AsnTrp: 0.642 ± 0.023	1.265AsnTyr: 1.265 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.445ProAla: 3.445 ± 0.054	0.347ProCys: 0.347 ± 0.014	2.348ProAsp: 2.348 ± 0.044	3.482ProGlu: 3.482 ± 0.062	1.625ProPhe: 1.625 ± 0.036	2.753ProGly: 2.753 ± 0.043	0.919ProHis: 0.919 ± 0.032	2.276ProIle: 2.276 ± 0.045	2.322ProLys: 2.322 ± 0.056	4.816ProLeu: 4.816 ± 0.068	1.27ProMet: 1.27 ± 0.032	1.706ProAsn: 1.706 ± 0.039	1.234ProPro: 1.234 ± 0.033	2.296ProGln: 2.296 ± 0.047	1.541ProArg: 1.541 ± 0.032	2.682ProSer: 2.682 ± 0.046	2.168ProThr: 2.168 ± 0.049	3.23ProVal: 3.23 ± 0.05	0.683ProTrp: 0.683 ± 0.026	1.252ProTyr: 1.252 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.131GlnAla: 5.131 ± 0.076	0.487GlnCys: 0.487 ± 0.018	2.145GlnAsp: 2.145 ± 0.042	2.347GlnGlu: 2.347 ± 0.05	2.095GlnPhe: 2.095 ± 0.043	4.101GlnGly: 4.101 ± 0.056	1.43GlnHis: 1.43 ± 0.036	2.574GlnIle: 2.574 ± 0.046	1.755GlnLys: 1.755 ± 0.039	7.054GlnLeu: 7.054 ± 0.099	1.407GlnMet: 1.407 ± 0.032	1.419GlnAsn: 1.419 ± 0.033	2.449GlnPro: 2.449 ± 0.051	4.745GlnGln: 4.745 ± 0.107	3.069GlnArg: 3.069 ± 0.058	3.136GlnSer: 3.136 ± 0.056	2.4GlnThr: 2.4 ± 0.046	3.818GlnVal: 3.818 ± 0.058	0.937GlnTrp: 0.937 ± 0.029	1.355GlnTyr: 1.355 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.854ArgAla: 3.854 ± 0.065	0.593ArgCys: 0.593 ± 0.023	2.523ArgAsp: 2.523 ± 0.041	2.659ArgGlu: 2.659 ± 0.044	2.431ArgPhe: 2.431 ± 0.044	2.978ArgGly: 2.978 ± 0.048	1.406ArgHis: 1.406 ± 0.034	3.011ArgIle: 3.011 ± 0.048	1.966ArgLys: 1.966 ± 0.043	5.877ArgLeu: 5.877 ± 0.082	1.287ArgMet: 1.287 ± 0.027	1.692ArgAsn: 1.692 ± 0.036	1.962ArgPro: 1.962 ± 0.042	3.034ArgGln: 3.034 ± 0.058	2.935ArgArg: 2.935 ± 0.055	2.883ArgSer: 2.883 ± 0.046	2.183ArgThr: 2.183 ± 0.039	3.283ArgVal: 3.283 ± 0.048	0.882ArgTrp: 0.882 ± 0.029	1.925ArgTyr: 1.925 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.723SerAla: 5.723 ± 0.07	0.713SerCys: 0.713 ± 0.026	3.816SerAsp: 3.816 ± 0.084	3.887SerGlu: 3.887 ± 0.061	2.508SerPhe: 2.508 ± 0.05	5.426SerGly: 5.426 ± 0.088	1.594SerHis: 1.594 ± 0.036	3.373SerIle: 3.373 ± 0.052	2.692SerLys: 2.692 ± 0.049	7.169SerLeu: 7.169 ± 0.079	1.662SerMet: 1.662 ± 0.037	2.334SerAsn: 2.334 ± 0.05	2.582SerPro: 2.582 ± 0.041	3.492SerGln: 3.492 ± 0.06	3.097SerArg: 3.097 ± 0.044	4.041SerSer: 4.041 ± 0.077	2.89SerThr: 2.89 ± 0.05	4.412SerVal: 4.412 ± 0.057	0.969SerTrp: 0.969 ± 0.029	1.905SerTyr: 1.905 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.579ThrAla: 4.579 ± 0.05	0.44ThrCys: 0.44 ± 0.022	2.832ThrAsp: 2.832 ± 0.048	3.183ThrGlu: 3.183 ± 0.048	1.671ThrPhe: 1.671 ± 0.038	4.026ThrGly: 4.026 ± 0.066	1.094ThrHis: 1.094 ± 0.03	2.792ThrIle: 2.792 ± 0.052	2.1ThrLys: 2.1 ± 0.038	6.88ThrLeu: 6.88 ± 0.076	1.101ThrMet: 1.101 ± 0.032	1.751ThrAsn: 1.751 ± 0.039	2.842ThrPro: 2.842 ± 0.041	2.745ThrGln: 2.745 ± 0.055	2.243ThrArg: 2.243 ± 0.041	2.978ThrSer: 2.978 ± 0.058	2.776ThrThr: 2.776 ± 0.047	3.533ThrVal: 3.533 ± 0.057	0.559ThrTrp: 0.559 ± 0.023	1.252ThrTyr: 1.252 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	7.169ValAla: 7.169 ± 0.089	0.683ValCys: 0.683 ± 0.022	4.332ValAsp: 4.332 ± 0.058	4.603ValGlu: 4.603 ± 0.059	2.327ValPhe: 2.327 ± 0.047	4.651ValGly: 4.651 ± 0.063	1.278ValHis: 1.278 ± 0.026	4.151ValIle: 4.151 ± 0.055	2.952ValLys: 2.952 ± 0.042	6.586ValLeu: 6.586 ± 0.085	2.01ValMet: 2.01 ± 0.04	2.868ValAsn: 2.868 ± 0.046	2.666ValPro: 2.666 ± 0.048	2.344ValGln: 2.344 ± 0.044	3.007ValArg: 3.007 ± 0.047	4.789ValSer: 4.789 ± 0.063	4.072ValThr: 4.072 ± 0.056	5.565ValVal: 5.565 ± 0.074	0.758ValTrp: 0.758 ± 0.021	1.645ValTyr: 1.645 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.931TrpAla: 0.931 ± 0.025	0.159TrpCys: 0.159 ± 0.011	0.645TrpAsp: 0.645 ± 0.024	0.531TrpGlu: 0.531 ± 0.023	0.627TrpPhe: 0.627 ± 0.023	0.885TrpGly: 0.885 ± 0.028	0.431TrpHis: 0.431 ± 0.018	0.615TrpIle: 0.615 ± 0.026	0.473TrpLys: 0.473 ± 0.019	1.997TrpLeu: 1.997 ± 0.053	0.376TrpMet: 0.376 ± 0.018	0.451TrpAsn: 0.451 ± 0.018	0.6TrpPro: 0.6 ± 0.02	1.448TrpGln: 1.448 ± 0.037	0.868TrpArg: 0.868 ± 0.024	0.805TrpSer: 0.805 ± 0.026	0.511TrpThr: 0.511 ± 0.021	0.925TrpVal: 0.925 ± 0.029	0.216TrpTrp: 0.216 ± 0.014	0.371TrpTyr: 0.371 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.171TyrAla: 2.171 ± 0.044	0.352TyrCys: 0.352 ± 0.015	1.584TyrAsp: 1.584 ± 0.034	1.317TyrGlu: 1.317 ± 0.036	1.214TyrPhe: 1.214 ± 0.03	2.346TyrGly: 2.346 ± 0.046	0.783TyrHis: 0.783 ± 0.027	1.16TyrIle: 1.16 ± 0.031	0.991TyrLys: 0.991 ± 0.03	3.546TyrLeu: 3.546 ± 0.06	0.581TyrMet: 0.581 ± 0.023	0.986TyrAsn: 0.986 ± 0.031	1.368TyrPro: 1.368 ± 0.029	2.154TyrGln: 2.154 ± 0.039	1.953TyrArg: 1.953 ± 0.042	1.712TyrSer: 1.712 ± 0.039	1.26TyrThr: 1.26 ± 0.035	1.594TyrVal: 1.594 ± 0.036	0.462TyrTrp: 0.462 ± 0.019	0.907TyrTyr: 0.907 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4149 proteins (1391800 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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