Amino acid dipepetide frequency for Streptococcus satellite phage Javan541

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.831AlaAla: 3.831 ± 1.364
0.426AlaCys: 0.426 ± 0.428
3.831AlaAsp: 3.831 ± 0.972
6.811AlaGlu: 6.811 ± 1.547
2.98AlaPhe: 2.98 ± 1.062
3.406AlaGly: 3.406 ± 0.852
0.426AlaHis: 0.426 ± 0.428
7.237AlaIle: 7.237 ± 1.578
6.811AlaLys: 6.811 ± 1.481
8.94AlaLeu: 8.94 ± 1.79
2.554AlaMet: 2.554 ± 1.128
3.406AlaAsn: 3.406 ± 1.583
0.851AlaPro: 0.851 ± 0.539
3.831AlaGln: 3.831 ± 1.043
1.703AlaArg: 1.703 ± 0.834
3.406AlaSer: 3.406 ± 0.913
3.831AlaThr: 3.831 ± 1.531
2.98AlaVal: 2.98 ± 0.802
0.851AlaTrp: 0.851 ± 0.525
2.98AlaTyr: 2.98 ± 1.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.851CysAsp: 0.851 ± 0.584
0.426CysGlu: 0.426 ± 0.328
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.426CysIle: 0.426 ± 0.386
0.426CysLys: 0.426 ± 0.426
0.426CysLeu: 0.426 ± 0.428
0.426CysMet: 0.426 ± 0.386
0.426CysAsn: 0.426 ± 0.386
0.851CysPro: 0.851 ± 0.793
0.0CysGln: 0.0 ± 0.0
0.426CysArg: 0.426 ± 0.328
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.426CysVal: 0.426 ± 0.397
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.554AspAla: 2.554 ± 0.891
0.426AspCys: 0.426 ± 0.386
2.554AspAsp: 2.554 ± 1.077
5.109AspGlu: 5.109 ± 1.328
2.554AspPhe: 2.554 ± 0.752
2.554AspGly: 2.554 ± 1.041
0.426AspHis: 0.426 ± 0.426
4.683AspIle: 4.683 ± 1.196
3.406AspLys: 3.406 ± 1.111
5.96AspLeu: 5.96 ± 1.797
0.426AspMet: 0.426 ± 0.46
8.089AspAsn: 8.089 ± 1.655
0.0AspPro: 0.0 ± 0.0
0.851AspGln: 0.851 ± 0.525
2.129AspArg: 2.129 ± 0.998
2.129AspSer: 2.129 ± 0.79
4.683AspThr: 4.683 ± 1.489
0.851AspVal: 0.851 ± 0.975
0.426AspTrp: 0.426 ± 0.397
2.554AspTyr: 2.554 ± 1.028
0.0AspXaa: 0.0 ± 0.0
Glu
8.94GluAla: 8.94 ± 1.408
0.426GluCys: 0.426 ± 0.46
4.683GluAsp: 4.683 ± 1.681
5.534GluGlu: 5.534 ± 1.475
1.703GluPhe: 1.703 ± 0.824
0.851GluGly: 0.851 ± 0.793
0.426GluHis: 0.426 ± 0.397
4.257GluIle: 4.257 ± 1.918
5.96GluLys: 5.96 ± 1.959
15.326GluLeu: 15.326 ± 2.143
2.129GluMet: 2.129 ± 0.977
3.831GluAsn: 3.831 ± 1.07
1.703GluPro: 1.703 ± 0.84
5.534GluGln: 5.534 ± 1.25
4.257GluArg: 4.257 ± 1.571
2.98GluSer: 2.98 ± 0.83
7.663GluThr: 7.663 ± 1.476
2.554GluVal: 2.554 ± 0.822
0.426GluTrp: 0.426 ± 0.443
3.831GluTyr: 3.831 ± 1.853
0.0GluXaa: 0.0 ± 0.0
Phe
2.129PheAla: 2.129 ± 0.96
0.0PheCys: 0.0 ± 0.0
2.129PheAsp: 2.129 ± 0.87
2.129PheGlu: 2.129 ± 1.028
0.0PhePhe: 0.0 ± 0.0
2.129PheGly: 2.129 ± 0.877
0.851PheHis: 0.851 ± 0.493
4.257PheIle: 4.257 ± 1.285
3.406PheLys: 3.406 ± 1.14
2.98PheLeu: 2.98 ± 0.826
0.0PheMet: 0.0 ± 0.362
2.554PheAsn: 2.554 ± 0.828
0.426PhePro: 0.426 ± 0.375
0.851PheGln: 0.851 ± 0.628
0.426PheArg: 0.426 ± 0.328
2.129PheSer: 2.129 ± 0.733
1.277PheThr: 1.277 ± 0.694
0.851PheVal: 0.851 ± 0.749
0.0PheTrp: 0.0 ± 0.0
2.129PheTyr: 2.129 ± 0.767
0.0PheXaa: 0.0 ± 0.0
Gly
2.98GlyAla: 2.98 ± 0.618
0.426GlyCys: 0.426 ± 0.328
2.129GlyAsp: 2.129 ± 1.322
3.406GlyGlu: 3.406 ± 1.239
2.129GlyPhe: 2.129 ± 0.979
1.703GlyGly: 1.703 ± 0.823
0.426GlyHis: 0.426 ± 0.328
2.129GlyIle: 2.129 ± 0.871
5.109GlyLys: 5.109 ± 1.404
5.109GlyLeu: 5.109 ± 1.95
1.277GlyMet: 1.277 ± 0.955
2.129GlyAsn: 2.129 ± 0.803
0.0GlyPro: 0.0 ± 0.0
1.277GlyGln: 1.277 ± 0.714
2.98GlyArg: 2.98 ± 1.022
2.554GlySer: 2.554 ± 0.792
0.426GlyThr: 0.426 ± 0.426
4.683GlyVal: 4.683 ± 1.13
0.426GlyTrp: 0.426 ± 0.397
3.406GlyTyr: 3.406 ± 0.657
0.0GlyXaa: 0.0 ± 0.0
His
1.703HisAla: 1.703 ± 0.687
0.0HisCys: 0.0 ± 0.0
1.703HisAsp: 1.703 ± 0.973
1.277HisGlu: 1.277 ± 0.758
1.277HisPhe: 1.277 ± 0.697
1.277HisGly: 1.277 ± 0.61
0.426HisHis: 0.426 ± 0.46
0.426HisIle: 0.426 ± 0.328
0.426HisLys: 0.426 ± 0.451
2.129HisLeu: 2.129 ± 0.93
0.0HisMet: 0.0 ± 0.0
1.277HisAsn: 1.277 ± 0.957
0.426HisPro: 0.426 ± 0.487
0.0HisGln: 0.0 ± 0.0
0.851HisArg: 0.851 ± 0.485
0.426HisSer: 0.426 ± 0.328
0.851HisThr: 0.851 ± 0.656
0.851HisVal: 0.851 ± 0.515
0.0HisTrp: 0.0 ± 0.0
1.703HisTyr: 1.703 ± 0.609
0.0HisXaa: 0.0 ± 0.0
Ile
5.109IleAla: 5.109 ± 1.496
0.851IleCys: 0.851 ± 0.584
2.554IleAsp: 2.554 ± 1.145
5.109IleGlu: 5.109 ± 1.472
0.851IlePhe: 0.851 ± 0.555
1.277IleGly: 1.277 ± 0.605
1.703IleHis: 1.703 ± 0.74
3.831IleIle: 3.831 ± 1.194
8.089IleLys: 8.089 ± 1.806
5.534IleLeu: 5.534 ± 1.37
0.851IleMet: 0.851 ± 0.63
3.831IleAsn: 3.831 ± 0.884
1.277IlePro: 1.277 ± 0.704
2.98IleGln: 2.98 ± 0.857
0.426IleArg: 0.426 ± 0.375
8.089IleSer: 8.089 ± 1.536
4.683IleThr: 4.683 ± 0.841
2.129IleVal: 2.129 ± 1.09
0.0IleTrp: 0.0 ± 0.0
2.554IleTyr: 2.554 ± 1.028
0.0IleXaa: 0.0 ± 0.0
Lys
7.237LysAla: 7.237 ± 2.156
0.0LysCys: 0.0 ± 0.0
4.257LysAsp: 4.257 ± 1.25
11.069LysGlu: 11.069 ± 1.918
2.129LysPhe: 2.129 ± 0.802
3.831LysGly: 3.831 ± 1.586
2.554LysHis: 2.554 ± 0.857
4.257LysIle: 4.257 ± 1.229
9.791LysLys: 9.791 ± 2.111
6.386LysLeu: 6.386 ± 2.269
0.426LysMet: 0.426 ± 0.487
5.96LysAsn: 5.96 ± 1.514
5.109LysPro: 5.109 ± 1.905
4.683LysGln: 4.683 ± 1.339
4.683LysArg: 4.683 ± 1.149
6.811LysSer: 6.811 ± 1.502
6.386LysThr: 6.386 ± 0.981
7.237LysVal: 7.237 ± 1.499
0.0LysTrp: 0.0 ± 0.0
4.683LysTyr: 4.683 ± 1.483
0.0LysXaa: 0.0 ± 0.0
Leu
9.791LeuAla: 9.791 ± 2.414
0.0LeuCys: 0.0 ± 0.0
7.663LeuAsp: 7.663 ± 1.441
7.663LeuGlu: 7.663 ± 2.316
2.129LeuPhe: 2.129 ± 0.875
8.089LeuGly: 8.089 ± 1.612
1.277LeuHis: 1.277 ± 0.611
4.257LeuIle: 4.257 ± 1.267
9.366LeuLys: 9.366 ± 1.53
8.94LeuLeu: 8.94 ± 1.803
2.98LeuMet: 2.98 ± 0.88
7.663LeuAsn: 7.663 ± 2.042
3.406LeuPro: 3.406 ± 0.907
2.98LeuGln: 2.98 ± 1.053
4.683LeuArg: 4.683 ± 1.319
9.791LeuSer: 9.791 ± 2.432
7.237LeuThr: 7.237 ± 1.172
4.257LeuVal: 4.257 ± 1.558
0.426LeuTrp: 0.426 ± 0.451
2.554LeuTyr: 2.554 ± 0.947
0.0LeuXaa: 0.0 ± 0.0
Met
1.703MetAla: 1.703 ± 0.916
0.0MetCys: 0.0 ± 0.0
1.703MetAsp: 1.703 ± 0.824
2.129MetGlu: 2.129 ± 0.844
0.0MetPhe: 0.0 ± 0.0
0.426MetGly: 0.426 ± 0.375
0.851MetHis: 0.851 ± 0.691
1.703MetIle: 1.703 ± 0.955
1.703MetLys: 1.703 ± 0.8
1.703MetLeu: 1.703 ± 0.672
0.0MetMet: 0.0 ± 0.0
1.703MetAsn: 1.703 ± 1.01
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
0.851MetArg: 0.851 ± 0.596
0.426MetSer: 0.426 ± 0.46
3.831MetThr: 3.831 ± 1.059
1.277MetVal: 1.277 ± 0.708
0.0MetTrp: 0.0 ± 0.0
0.426MetTyr: 0.426 ± 0.434
0.0MetXaa: 0.0 ± 0.0
Asn
5.109AsnAla: 5.109 ± 1.638
0.851AsnCys: 0.851 ± 0.493
1.277AsnAsp: 1.277 ± 0.641
5.96AsnGlu: 5.96 ± 1.417
1.703AsnPhe: 1.703 ± 0.836
5.109AsnGly: 5.109 ± 1.246
0.426AsnHis: 0.426 ± 0.328
4.683AsnIle: 4.683 ± 1.071
4.257AsnLys: 4.257 ± 0.907
5.96AsnLeu: 5.96 ± 1.659
1.277AsnMet: 1.277 ± 0.793
7.237AsnAsn: 7.237 ± 1.369
2.554AsnPro: 2.554 ± 1.003
1.703AsnGln: 1.703 ± 0.83
3.406AsnArg: 3.406 ± 1.048
2.98AsnSer: 2.98 ± 1.173
8.514AsnThr: 8.514 ± 2.361
2.554AsnVal: 2.554 ± 0.834
0.426AsnTrp: 0.426 ± 0.428
2.98AsnTyr: 2.98 ± 1.236
0.0AsnXaa: 0.0 ± 0.0
Pro
1.703ProAla: 1.703 ± 0.767
0.0ProCys: 0.0 ± 0.0
0.426ProAsp: 0.426 ± 0.487
2.129ProGlu: 2.129 ± 0.946
0.426ProPhe: 0.426 ± 0.375
0.0ProGly: 0.0 ± 0.0
0.426ProHis: 0.426 ± 0.496
2.554ProIle: 2.554 ± 1.043
3.406ProLys: 3.406 ± 1.547
4.257ProLeu: 4.257 ± 1.863
0.426ProMet: 0.426 ± 0.421
2.129ProAsn: 2.129 ± 0.712
0.851ProPro: 0.851 ± 0.552
0.426ProGln: 0.426 ± 0.386
2.98ProArg: 2.98 ± 1.021
0.851ProSer: 0.851 ± 0.493
0.0ProThr: 0.0 ± 0.0
1.703ProVal: 1.703 ± 0.953
0.0ProTrp: 0.0 ± 0.0
1.703ProTyr: 1.703 ± 0.6
0.0ProXaa: 0.0 ± 0.0
Gln
5.534GlnAla: 5.534 ± 1.098
0.0GlnCys: 0.0 ± 0.0
0.851GlnAsp: 0.851 ± 0.484
4.257GlnGlu: 4.257 ± 1.617
1.703GlnPhe: 1.703 ± 0.789
1.703GlnGly: 1.703 ± 0.685
1.277GlnHis: 1.277 ± 0.959
2.129GlnIle: 2.129 ± 1.253
3.831GlnLys: 3.831 ± 1.149
3.406GlnLeu: 3.406 ± 1.303
0.0GlnMet: 0.0 ± 0.0
2.129GlnAsn: 2.129 ± 1.092
1.277GlnPro: 1.277 ± 0.866
3.831GlnGln: 3.831 ± 1.168
1.277GlnArg: 1.277 ± 0.582
1.703GlnSer: 1.703 ± 0.697
3.406GlnThr: 3.406 ± 1.14
1.277GlnVal: 1.277 ± 0.721
0.0GlnTrp: 0.0 ± 0.0
1.277GlnTyr: 1.277 ± 0.627
0.0GlnXaa: 0.0 ± 0.0
Arg
2.554ArgAla: 2.554 ± 0.699
0.0ArgCys: 0.0 ± 0.0
2.129ArgAsp: 2.129 ± 0.875
2.129ArgGlu: 2.129 ± 1.307
1.277ArgPhe: 1.277 ± 0.823
1.277ArgGly: 1.277 ± 1.04
1.277ArgHis: 1.277 ± 0.604
4.257ArgIle: 4.257 ± 1.167
4.257ArgLys: 4.257 ± 0.755
4.683ArgLeu: 4.683 ± 1.122
2.554ArgMet: 2.554 ± 0.832
2.98ArgAsn: 2.98 ± 1.056
0.851ArgPro: 0.851 ± 0.547
1.703ArgGln: 1.703 ± 0.915
3.406ArgArg: 3.406 ± 1.334
2.554ArgSer: 2.554 ± 1.254
1.703ArgThr: 1.703 ± 0.995
1.277ArgVal: 1.277 ± 0.723
1.277ArgTrp: 1.277 ± 0.651
2.554ArgTyr: 2.554 ± 0.791
0.0ArgXaa: 0.0 ± 0.0
Ser
2.98SerAla: 2.98 ± 0.992
0.0SerCys: 0.0 ± 0.0
5.109SerAsp: 5.109 ± 1.552
2.554SerGlu: 2.554 ± 1.395
2.129SerPhe: 2.129 ± 0.944
3.406SerGly: 3.406 ± 1.026
0.851SerHis: 0.851 ± 0.489
3.406SerIle: 3.406 ± 1.034
9.791SerLys: 9.791 ± 1.955
4.257SerLeu: 4.257 ± 0.959
0.426SerMet: 0.426 ± 0.328
3.831SerAsn: 3.831 ± 1.494
1.277SerPro: 1.277 ± 0.627
2.554SerGln: 2.554 ± 0.875
1.277SerArg: 1.277 ± 0.765
1.703SerSer: 1.703 ± 0.973
5.109SerThr: 5.109 ± 0.956
2.554SerVal: 2.554 ± 0.98
1.277SerTrp: 1.277 ± 0.728
3.406SerTyr: 3.406 ± 1.01
0.0SerXaa: 0.0 ± 0.0
Thr
5.109ThrAla: 5.109 ± 1.08
0.0ThrCys: 0.0 ± 0.0
2.98ThrAsp: 2.98 ± 1.166
5.109ThrGlu: 5.109 ± 1.723
3.406ThrPhe: 3.406 ± 1.32
3.831ThrGly: 3.831 ± 1.354
1.703ThrHis: 1.703 ± 1.075
2.98ThrIle: 2.98 ± 1.116
6.386ThrLys: 6.386 ± 1.884
9.366ThrLeu: 9.366 ± 1.35
1.277ThrMet: 1.277 ± 0.7
2.554ThrAsn: 2.554 ± 0.98
2.554ThrPro: 2.554 ± 0.63
3.831ThrGln: 3.831 ± 1.359
1.703ThrArg: 1.703 ± 0.762
3.831ThrSer: 3.831 ± 0.965
6.386ThrThr: 6.386 ± 1.954
5.109ThrVal: 5.109 ± 1.564
0.0ThrTrp: 0.0 ± 0.0
3.406ThrTyr: 3.406 ± 1.322
0.0ThrXaa: 0.0 ± 0.0
Val
0.851ValAla: 0.851 ± 0.63
0.851ValCys: 0.851 ± 0.793
2.554ValAsp: 2.554 ± 1.001
3.831ValGlu: 3.831 ± 1.612
1.703ValPhe: 1.703 ± 0.687
1.703ValGly: 1.703 ± 0.671
1.277ValHis: 1.277 ± 0.827
2.554ValIle: 2.554 ± 1.085
6.811ValLys: 6.811 ± 1.432
4.683ValLeu: 4.683 ± 1.219
1.277ValMet: 1.277 ± 0.886
3.406ValAsn: 3.406 ± 1.669
1.703ValPro: 1.703 ± 0.741
0.0ValGln: 0.0 ± 0.0
2.98ValArg: 2.98 ± 1.193
1.277ValSer: 1.277 ± 0.76
4.257ValThr: 4.257 ± 1.235
3.406ValVal: 3.406 ± 1.455
0.0ValTrp: 0.0 ± 0.0
2.98ValTyr: 2.98 ± 0.761
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.851TrpAsp: 0.851 ± 0.525
1.277TrpGlu: 1.277 ± 0.732
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.851TrpLys: 0.851 ± 0.493
0.851TrpLeu: 0.851 ± 0.645
0.0TrpMet: 0.0 ± 0.0
0.426TrpAsn: 0.426 ± 0.397
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.426TrpArg: 0.426 ± 0.428
0.426TrpSer: 0.426 ± 0.328
0.0TrpThr: 0.0 ± 0.0
0.426TrpVal: 0.426 ± 0.428
0.426TrpTrp: 0.426 ± 0.328
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.277TyrAla: 1.277 ± 0.653
0.851TyrCys: 0.851 ± 0.508
2.129TyrAsp: 2.129 ± 0.836
5.109TyrGlu: 5.109 ± 1.3
2.98TyrPhe: 2.98 ± 1.212
2.129TyrGly: 2.129 ± 0.804
0.426TyrHis: 0.426 ± 0.434
1.703TyrIle: 1.703 ± 0.76
3.406TyrLys: 3.406 ± 1.279
4.257TyrLeu: 4.257 ± 1.274
1.703TyrMet: 1.703 ± 0.758
3.406TyrAsn: 3.406 ± 1.163
1.277TyrPro: 1.277 ± 0.582
3.831TyrGln: 3.831 ± 1.091
3.831TyrArg: 3.831 ± 1.436
3.831TyrSer: 3.831 ± 1.585
1.277TyrThr: 1.277 ± 0.656
1.703TyrVal: 1.703 ± 0.854
0.0TyrTrp: 0.0 ± 0.0
1.703TyrTyr: 1.703 ± 0.847
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2350 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski